Detailed information for compound 662115

Basic information

Technical information
  • TDR Targets ID: 662115
  • Name: [4-[(3-bromophenyl)methyl]piperazin-1-yl]-(2- methoxyphenyl)methanone
  • MW: 389.286 | Formula: C19H21BrN2O2
  • H donors: 0 H acceptors: 1 LogP: 3.35 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1C(=O)N1CCN(CC1)Cc1cccc(c1)Br
  • InChi: 1S/C19H21BrN2O2/c1-24-18-8-3-2-7-17(18)19(23)22-11-9-21(10-12-22)14-15-5-4-6-16(20)13-15/h2-8,13H,9-12,14H2,1H3
  • InChiKey: UCBDKIDTSXPFKK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-[(3-bromophenyl)methyl]-1-piperazinyl]-(2-methoxyphenyl)methanone
  • [4-(3-bromobenzyl)piperazin-1-yl]-(2-methoxyphenyl)methanone
  • Oprea1_084741
  • Oprea1_796919
  • BAS 01376290
  • [4-(3-Bromo-benzyl)-piperazin-1-yl]-(2-methoxy-phenyl)-methanone
  • ST5009006

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0089 0.2324 0.324
Echinococcus multilocularis neutral alpha glucosidase AB 0.0037 0.0804 0.0791
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0159 0.0169
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0105 0.5
Trichomonas vaginalis esterase, putative 0.0038 0.0842 0.087
Echinococcus multilocularis muscleblind protein 0.0299 0.8532 0.8529
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0096 0.2535 0.2524
Brugia malayi isocitrate dehydrogenase 0.0032 0.0661 0.0775
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0105 0.0091
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0842 0.0829
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0104 0.2787 1
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1126 0.1205
Loa Loa (eye worm) hypothetical protein 0.0014 0.0116 0.0119
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0015 0.0159 0.0145
Brugia malayi Thioredoxin reductase 0.0039 0.0855 0.1002
Echinococcus granulosus cpg binding protein 0.003 0.0594 0.0581
Echinococcus multilocularis importin subunit beta 1 0.0028 0.054 0.0526
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0661 0.0648
Brugia malayi Glycosyl hydrolases family 31 protein 0.0014 0.0116 0.0136
Schistosoma mansoni glutaminase 0.0273 0.7769 0.7765
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0842 0.087
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0105 0.0091
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0842 0.087
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0017 0.0207 0.0193
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0014 0.0116 0.0398
Brugia malayi Glycosyl hydrolases family 31 protein 0.0037 0.0804 0.0942
Giardia lamblia Fructose-bisphosphate aldolase 0.03 0.8568 1
Echinococcus multilocularis tumor protein p63 0.0329 0.9424 0.9423
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.4647 0.4639
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0855 0.1094
Loa Loa (eye worm) hypothetical protein 0.0038 0.0842 0.0965
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.8568 1
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0842 0.1076
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.1549 0.5853
Echinococcus multilocularis lysine specific demethylase 5A 0.0057 0.1399 0.1387
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0099 0.2616 0.5553
Schistosoma mansoni cpg binding protein 0.003 0.0594 0.0581
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0382 0.0327
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.8568 1
Brugia malayi Importin beta-1 subunit 0.0028 0.054 0.0633
Brugia malayi glutathione reductase 0.0039 0.0855 0.1002
Echinococcus granulosus lysosomal alpha glucosidase 0.0167 0.4647 0.4639
Leishmania major trypanothione reductase 0.0039 0.0855 0.3039
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0661 0.2073
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.032 0.0254
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0097 0.2572 0.2561
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0089 0.2324 0.324
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0014 0.0017
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0104 0.2787 0.3168
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.2372 0.2361
Echinococcus granulosus neutral alpha glucosidase AB 0.0037 0.0804 0.0791
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.032 0.0801
Trichomonas vaginalis maltase-glucoamylase, putative 0.0014 0.0116 0.0013
Echinococcus multilocularis lysine specific demethylase 6a 0.0015 0.0159 0.0145
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2572 0.2914
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0096 0.2535 0.317
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.032 0.0306
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0116 0.0044
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0105 0.0124
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0842 0.0961
Schistosoma mansoni hypothetical protein 0.0064 0.1584 0.1572
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0057 0.1399 0.1387
Schistosoma mansoni phd/f-box containing protein 0.0015 0.0159 0.0145
Brugia malayi nuclear receptor NHR-88 0.001 0.0014 0.0017
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0804 0.0814
Brugia malayi beta-lactamase family protein 0.0038 0.0842 0.0987
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0099 0.2616 0.3667
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1549 0.1883
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0661 0.2073
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1549 0.1883
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0804 0.0825
Brugia malayi jmjC domain containing protein 0.0015 0.0159 0.0186
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.087 0.0857
Echinococcus multilocularis lysosomal alpha glucosidase 0.0167 0.4647 0.4639
Loa Loa (eye worm) beta-lactamase 0.0038 0.0842 0.0965
Loa Loa (eye worm) hypothetical protein 0.0028 0.054 0.0613
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0015 0.0159 0.02
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0159 0.0169
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.1584 0.1832
Schistosoma mansoni alpha-glucosidase 0.0144 0.3959 0.395
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0804 0.2833
Brugia malayi Latrophilin receptor protein 2 0.0064 0.1584 0.1857
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0804 0.0825
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0014 0.0017
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0116 0.0013
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0201 0.5638 0.6608
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.1584 0.1572
Echinococcus multilocularis phd:f box containing protein 0.0015 0.0159 0.0145
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0014 0.0017
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0014 0.0017
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0842 0.0987
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0096 0.2535 0.9851
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0104 0.2787 1
Echinococcus multilocularis geminin 0.0349 1 1
Leishmania major alpha glucosidase II subunit, putative 0.0037 0.0804 0.2833
Schistosoma mansoni alpha-glucosidase 0.0144 0.3959 0.395
Brugia malayi serine/threonine-protein kinase plk-2 0.0097 0.2572 0.3014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0014 0.0017
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0842 0.0965
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0842 0.1076
Brugia malayi jmjC domain containing protein 0.0059 0.1447 0.1696
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0015 0.0159 0.02
Leishmania major glycosyl hydrolase-like protein 0.0014 0.0116 0.0044
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0097 0.2572 0.2561
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0033 0.0689 0.0852
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0014 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.8568 1
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0013 0.0105 0.5
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0037 0.0804 0.0814
Loa Loa (eye worm) hypothetical protein 0.0299 0.8532 0.9937
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0014 0.0116 0.0044
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0842 0.2747
Echinococcus multilocularis jumonji domain containing 1A 0.0015 0.0159 0.0145
Onchocerca volvulus 0.0028 0.0547 0.2081
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0661 0.0648
Onchocerca volvulus 0.0048 0.113 0.4363
Loa Loa (eye worm) jmjC domain-containing protein 0.0015 0.0159 0.0169
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0037 0.0804 0.0921
Treponema pallidum fructose-bisphosphate aldolase 0.03 0.8568 1
Mycobacterium tuberculosis Conserved protein 0.0038 0.0842 0.1076
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.1549 0.1537
Echinococcus granulosus muscleblind protein 0.0299 0.8532 0.8529
Echinococcus granulosus GPCR family 2 0.0064 0.1584 0.1572
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.032 0.0801
Mycobacterium tuberculosis Probable reductase 0.0089 0.2324 0.324
Entamoeba histolytica Ran family GTPase 0.0021 0.032 0.0241
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.032 0.0375
Brugia malayi Calcitonin receptor-like protein seb-1 0.0201 0.5638 0.6608
Entamoeba histolytica serine/threonine protein kinase, putative 0.0097 0.2572 0.2905
Echinococcus multilocularis JmjC domain containing protein 4 0.0015 0.0159 0.0145
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0661 0.2254
Schistosoma mansoni alpha glucosidase 0.0037 0.0804 0.0791
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2372 0.2361
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0097 0.2572 0.2983
Trichomonas vaginalis maltase-glucoamylase, putative 0.0037 0.0804 0.0825
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0147 0.4036 0.5129
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2572 0.2914
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0014 0.0017
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0014 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.8568 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0147 0.4036 0.5741
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0547 0.0621
Plasmodium falciparum importin beta, putative 0.0028 0.054 0.1619
Onchocerca volvulus 0.0038 0.0842 0.3236
Echinococcus granulosus jumonji domain containing 1A 0.0015 0.0159 0.0145
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0096 0.2535 0.9851
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0116 0.0013
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0301 0.8585 1
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.113 0.1117
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.1126 0.1205
Brugia malayi jmjC domain containing protein 0.0015 0.0159 0.0186
Schistosoma mansoni jumonji domain containing protein 0.0057 0.1399 0.1387
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0842 0.087
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0382 0.1123
Schistosoma mansoni phosphatidylserine receptor 0.0015 0.0159 0.0145
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0842 0.2986
Trichomonas vaginalis ran, putative 0.0021 0.032 0.0254
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.1447 0.1435
Echinococcus granulosus lysine specific demethylase 6a 0.0015 0.0159 0.0145
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0037 0.0804 0.0825
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2372 0.2361
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.1584 0.1572
Mycobacterium ulcerans beta-lactamase 0.0038 0.0842 0.0961
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0089 0.2324 0.324
Brugia malayi CXXC zinc finger family protein 0.0028 0.0547 0.0641
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0096 0.2535 0.2524
Brugia malayi nuclear hormone receptor 0.001 0.0014 0.0017
Loa Loa (eye worm) hypothetical protein 0.0064 0.1584 0.1832
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0661 0.0812
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0063 0.1554 0.5404
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.2572 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.032 0.0801
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0104 0.2787 0.3168
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0104 0.2787 0.3168
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0842 0.1076
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.087 0.0857
Mycobacterium ulcerans hypothetical protein 0.0038 0.0842 0.0961
Trypanosoma brucei polo-like protein kinase 0.0097 0.2572 1
Trichomonas vaginalis glutaminase, putative 0.0273 0.7769 0.9056
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.8568 1
Brugia malayi Muscleblind-like protein 0.0299 0.8532 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0037 0.0804 0.0825
Trypanosoma brucei trypanothione reductase 0.0039 0.0855 0.3039
Trypanosoma brucei glucosidase, putative 0.0037 0.0804 0.2833
Echinococcus granulosus snurportin 1 0.0301 0.8585 0.8583
Onchocerca volvulus 0.0097 0.2565 0.9973
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0842 0.087
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.1447 0.1671
Loa Loa (eye worm) hypothetical protein 0.0137 0.3762 0.4372
Onchocerca volvulus 0.0038 0.0842 0.3236
Schistosoma mansoni protein phosphatase 2C 0.0015 0.0159 0.0145
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.8568 1
Mycobacterium ulcerans lipase LipD 0.0038 0.0842 0.0961
Echinococcus granulosus phd:f box containing protein 0.0015 0.0159 0.0145
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0382 0.0327
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.2372 0.2361
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0096 0.2535 0.2524
Schistosoma mansoni hypothetical protein 0.0064 0.1584 0.1572
Echinococcus granulosus JmjC domain containing protein 4 0.0015 0.0159 0.0145
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0855 0.2795
Schistosoma mansoni kinase 0.0049 0.1163 0.1151
Schistosoma mansoni cpg binding protein 0.003 0.0594 0.0581
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0159 0.0217
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2572 0.2914
Toxoplasma gondii HEAT repeat-containing protein 0.0028 0.054 0.1619
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0116 0.0013
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0201 0.5638 0.6561
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0063 0.1554 0.1891
Loa Loa (eye worm) glutaminase 2 0.0273 0.7769 0.9047
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0804 0.2833
Mycobacterium tuberculosis Probable dehydrogenase 0.0089 0.2324 0.324
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0804 0.0825
Trypanosoma brucei glycosyl hydrolase-like protein 0.0014 0.0116 0.0044
Mycobacterium ulcerans glutaminase 0.0273 0.7769 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.032 0.087
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1549 0.1537
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.1584 0.1857
Schistosoma mansoni importin beta-1 0.0028 0.054 0.0526
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.1549 0.1883
Mycobacterium tuberculosis Probable oxidoreductase 0.0099 0.2616 0.3667
Plasmodium vivax importin-beta 2, putative 0.0028 0.054 0.1619
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2572 0.2914
Onchocerca volvulus Serine\/threonine kinase homolog 0.0097 0.2572 1
Schistosoma mansoni ran 0.0021 0.032 0.0306
Plasmodium falciparum thioredoxin reductase 0.0039 0.0855 0.2795
Brugia malayi beta-lactamase family protein 0.0038 0.0842 0.0987
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0842 0.087
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0842 0.2986
Mycobacterium tuberculosis Conserved protein 0.0038 0.0842 0.1076
Giardia lamblia Kinase, PLK 0.0097 0.2572 0.2914
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0014 0.0017
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0855 0.3039
Brugia malayi jmjC domain containing protein 0.0015 0.0159 0.0186
Loa Loa (eye worm) hypothetical protein 0.0038 0.0842 0.0965
Schistosoma mansoni hypothetical protein 0.0349 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.1549 0.1537
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.2372 0.278
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0842 0.0961
Loa Loa (eye worm) hypothetical protein 0.0038 0.0842 0.0965
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0661 0.0648
Echinococcus multilocularis muscleblind protein 1 0.0299 0.8532 0.8529
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0015 0.0159 0.0217
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0804 0.0825
Schistosoma mansoni cpg binding protein 0.0028 0.0547 0.0533
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0245 0.6952 1
Brugia malayi beta-lactamase 0.0038 0.0842 0.0987
Schistosoma mansoni hypothetical protein 0.0064 0.1584 0.1572
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0842 0.2986
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0017 0.0207 0.0193
Brugia malayi RNA, U transporter 1 0.008 0.2073 0.243
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0661 0.0648
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.032 0.087
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2572 0.2914
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0014 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2572 0.2914
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.1549 0.5383
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.032 0.0306
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.8568 1
Leishmania major hypothetical protein, conserved 0.0038 0.0842 0.2986
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.1584 0.1572
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0089 0.2324 0.4639
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.1549 0.2108
Brugia malayi glutaminase DH11.1 0.0273 0.7769 0.9106
Leishmania major importin beta-1 subunit, putative 0.0023 0.0382 0.1123
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0116 0.0013
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0661 0.2254
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0842 0.1076
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.1447 0.1435
Schistosoma mansoni ran 0.0021 0.032 0.0306
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0661 0.2073
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0089 0.2324 0.324
Brugia malayi jmjC domain containing protein 0.0015 0.0159 0.0186
Loa Loa (eye worm) hypothetical protein 0.0038 0.0842 0.0965
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.1549 0.1537
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.032 0.087
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.8568 1
Schistosoma mansoni jumonji domain containing protein 0.0015 0.0159 0.0145
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0661 0.0755
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0032 0.0645 0.2187
Loa Loa (eye worm) hypothetical protein 0.0015 0.0159 0.0169
Schistosoma mansoni hypothetical protein 0.0349 1 1
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0661 0.2073
Echinococcus multilocularis GPCR, family 2 0.0064 0.1584 0.1572
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0842 0.1076
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0014 0.0017
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.03 0.8568 1
Schistosoma mansoni hypothetical protein 0.0301 0.8585 0.8583
Echinococcus granulosus importin subunit beta 1 0.0028 0.054 0.0526
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0104 0.2787 1
Brugia malayi latrophilin 2 splice variant baaae 0.0137 0.3762 0.4409
Toxoplasma gondii histone lysine methyltransferase SET1 0.0054 0.1297 0.4443
Toxoplasma gondii thioredoxin reductase 0.0039 0.0855 0.2795
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.032 0.0357
Loa Loa (eye worm) hypothetical protein 0.0015 0.0159 0.0169
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0842 0.0829
Loa Loa (eye worm) hypothetical protein 0.0038 0.0842 0.0965
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.2372 0.2361
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.03 0.8568 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.1486 0.1474
Brugia malayi jmjC domain containing protein 0.0057 0.1399 0.164
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0014 0.0017
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0661 0.2254
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0014 0.0017
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0096 0.2535 0.2941
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.054 0.1761
Onchocerca volvulus 0.0038 0.0842 0.3236
Loa Loa (eye worm) glutathione reductase 0.0039 0.0855 0.098
Loa Loa (eye worm) hypothetical protein 0.0299 0.8532 0.9937
Trypanosoma brucei importin beta-1 subunit, putative 0.0028 0.054 0.1761
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0105 0.0091
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0014 0.0116 0.0013
Plasmodium vivax glutathione reductase, putative 0.0039 0.0855 0.2795
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.0031 0.0618 0.2077
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0116 0.0013
Schistosoma mansoni hypothetical protein 0.0064 0.1584 0.1572
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0147 0.4036 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0842 0.0829
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0804 0.0825
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0104 0.2787 0.3168
Brugia malayi ecdysteroid receptor 0.001 0.0014 0.0017
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0855 0.098
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0096 0.2535 0.2871
Trichomonas vaginalis alpha-glucosidase, putative 0.0014 0.0116 0.0013
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0661 0.2254
Loa Loa (eye worm) hypothetical protein 0.0038 0.0842 0.0965
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0097 0.2572 1
Echinococcus multilocularis snurportin 1 0.0301 0.8585 0.8583
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0099 0.2616 0.3667
Toxoplasma gondii ABC1 family protein 0.0038 0.0842 0.2747
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.2372 0.2361
Echinococcus multilocularis cpg binding protein 0.003 0.0594 0.0581
Brugia malayi Glycosyl hydrolases family 31 protein 0.0167 0.4647 0.5447
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0014 0.0017
Trichomonas vaginalis CAMK family protein kinase 0.0097 0.2572 0.2914
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0661 0.0648
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0096 0.2535 0.9851
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0842 0.0829
Echinococcus granulosus tumor protein p63 0.0329 0.9424 0.9423
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0037 0.0804 0.2606
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0096 0.2535 1
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0014 0.0017
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0015 0.0159 0.0217
Entamoeba histolytica hypothetical protein 0.0023 0.0382 0.0315
Plasmodium vivax JmjC domain containing protein 0.0015 0.0159 0.02
Schistosoma mansoni hypothetical protein 0.0137 0.3762 0.3753
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0014 0.0017
Leishmania major hypothetical protein, conserved 0.0015 0.0159 0.0217
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.1584 0.1572
Loa Loa (eye worm) glutaminase 0.0273 0.7769 0.9047
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0661 0.0648
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0057 0.1399 0.1387
Trypanosoma cruzi polo-like protein kinase, putative 0.0097 0.2572 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0842 0.1076
Plasmodium falciparum JmjC domain-containing protein, putative 0.0015 0.0159 0.02
Schistosoma mansoni serine/threonine protein kinase 0.0097 0.2572 0.2561
Mycobacterium tuberculosis Conserved protein 0.0038 0.0842 0.1076
Plasmodium falciparum glutathione reductase 0.0039 0.0855 0.2795
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0382 0.0327
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0661 0.0775
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.2372 0.2361
Leishmania major GTP-binding protein, putative 0.0021 0.032 0.087
Loa Loa (eye worm) hypothetical protein 0.0201 0.5638 0.6561
Trichomonas vaginalis alpha-glucosidase, putative 0.0037 0.0804 0.0825
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.1447 0.1435
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0167 0.4647 0.5405
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0661 0.2254
Brugia malayi steroid hormone receptor 0.001 0.0014 0.0017
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0842 0.1076
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0661 0.0648
Loa Loa (eye worm) hypothetical protein 0.0048 0.113 0.1302
Loa Loa (eye worm) hypothetical protein 0.0015 0.0159 0.0169
Brugia malayi glucose-6-phosphate dehydrogenase 0.0096 0.2535 0.2971
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.2372 0.2751

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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