Detailed information for compound 662227

Basic information

Technical information
  • TDR Targets ID: 662227
  • Name: [4-[(3-nitrophenyl)methyl]piperazin-1-yl]-thi ophen-2-ylmethanone
  • MW: 331.389 | Formula: C16H17N3O3S
  • H donors: 0 H acceptors: 3 LogP: 2.53 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1cccc(c1)CN1CCN(CC1)C(=O)c1cccs1
  • InChi: 1S/C16H17N3O3S/c20-16(15-5-2-10-23-15)18-8-6-17(7-9-18)12-13-3-1-4-14(11-13)19(21)22/h1-5,10-11H,6-9,12H2
  • InChiKey: RFBYKNLZAYHRTD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [4-[(3-nitrophenyl)methyl]piperazin-1-yl]-(2-thienyl)methanone
  • [4-[(3-nitrophenyl)methyl]-1-piperazinyl]-(2-thienyl)methanone
  • [4-(3-nitrobenzyl)piperazin-1-yl]-(2-thienyl)methanone
  • [4-[(3-nitrophenyl)methyl]piperazin-1-yl]-thiophen-2-yl-methanone
  • Oprea1_357026
  • STK010151

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.0139 0.2221
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0095
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0189
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0277 0.032
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0089 0.0914 0.8514
Loa Loa (eye worm) hypothetical protein 0.0098 0.1026 0.1399
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0277 0.203
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0139 0.0177
Mycobacterium leprae Probable lipase LipE 0.0037 0.0292 0.0751
Trypanosoma brucei trypanothione reductase 0.0039 0.0315 0.5238
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.07 0.0848
Brugia malayi jmjC domain containing protein 0.0018 0.0069 0.0082
Loa Loa (eye worm) histone deacetylase 3 0.0062 0.0593 0.0808
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0292 0.0292
Schistosoma mansoni histone deacetylase 1 2 3 0.0018 0.006 0.0062
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0139 0.0155
Plasmodium falciparum histone deacetylase 1 0.0062 0.0593 1
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.1329 0.1619
Echinococcus granulosus GTP binding nuclear protein Ran 0.004 0.0328 0.0402
Plasmodium vivax glutathione reductase, putative 0.0039 0.0315 0.3324
Schistosoma mansoni aminopeptidase A (M01 family) 0.0024 0.0139 0.0159
Onchocerca volvulus 0.0024 0.0139 0.0095
Echinococcus granulosus cpg binding protein 0.0032 0.0234 0.0286
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0062 0.0593 0.0698
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0068 0.0664 0.0664
Brugia malayi isocitrate dehydrogenase 0.005 0.045 0.0602
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0232 0.0831
Loa Loa (eye worm) hypothetical protein 0.0037 0.0292 0.0399
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.006 0.0867
Schistosoma mansoni histone deacetylase 4 5 0.0018 0.006 0.0062
Echinococcus multilocularis geminin 0.0195 0.2193 0.2193
Onchocerca volvulus 0.0051 0.0461 0.0483
Loa Loa (eye worm) PHD-finger family protein 0.0057 0.0535 0.0729
Schistosoma mansoni cpg binding protein 0.0032 0.0234 0.0275
Loa Loa (eye worm) glutathione reductase 0.0039 0.0315 0.0429
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0277 0.0778
Toxoplasma gondii histone deacetylase HDAC3 0.0062 0.0593 0.4419
Loa Loa (eye worm) hypothetical protein 0.0214 0.2428 0.331
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0139 0.2221
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0009 0.0012
Trypanosoma brucei Aminopeptidase M1, putative 0.0024 0.0139 0.2221
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0321 0.0321
Schistosoma mansoni hypothetical protein 0.0068 0.0664 0.0803
Trypanosoma cruzi trypanothione reductase, putative 0.0039 0.0315 0.5238
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.2145 0.2621
Echinococcus multilocularis GPCR, family 2 0.0068 0.0664 0.0664
Loa Loa (eye worm) aminopeptidase N 0.0024 0.0139 0.0189
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0024 0.0139 0.2221
Leishmania major histone deacetylase, putative 0.0018 0.006 0.0383
Brugia malayi Inositol-1 0.0036 0.0277 0.0366
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0139 0.0139
Trypanosoma cruzi histone deacetylase 1, putative 0.0062 0.0593 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0187 0.2099 0.2573
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.004 0.0328 0.2415
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.0139 0.0376
Onchocerca volvulus 0.009 0.0928 0.1045
Mycobacterium ulcerans beta-lactamase 0.0037 0.0292 0.0822
Echinococcus multilocularis jumonji domain containing 1A 0.0018 0.0069 0.0069
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0018 0.0069 0.1028
Schistosoma mansoni glutaminase 0.0299 0.3451 0.4223
Loa Loa (eye worm) isocitrate dehydrogenase 0.005 0.045 0.0614
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0024 0.0139 0.0139
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0202 0.0237
Plasmodium falciparum glutathione reductase 0.0039 0.0315 0.5238
Schistosoma mansoni hypothetical protein 0.0068 0.0664 0.0803
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.045 0.3339
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.005 0.045 0.0552
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.0139 0.2221
Brugia malayi hypothetical protein 0.025 0.2856 0.3886
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0292 0.0338
Trypanosoma brucei Aminopeptidase M1, putative 0.0024 0.0139 0.2221
Loa Loa (eye worm) hypothetical protein 0.0037 0.0292 0.0399
Mycobacterium ulcerans lipase LipD 0.0037 0.0292 0.0822
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0069 0.0095
Loa Loa (eye worm) hypothetical protein 0.0057 0.0535 0.0729
Brugia malayi latrophilin 2 splice variant baaae 0.0146 0.1612 0.2187
Entamoeba histolytica hypothetical protein 0.0037 0.0292 0.4261
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0593 0.0698
Echinococcus granulosus histone deacetylase 3 0.0062 0.0593 0.0726
Brugia malayi histone deacetylase 11 0.0018 0.006 0.0069
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0069 0.102
Entamoeba histolytica hypothetical protein 0.0044 0.0377 0.5885
Plasmodium vivax hypothetical protein, conserved 0.0057 0.0535 0.572
Echinococcus granulosus neuropeptide s receptor 0.046 0.5391 0.6608
Schistosoma mansoni hypothetical protein 0.0195 0.2193 0.268
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.005 0.045 0.0541
Echinococcus granulosus leukotriene A 4 hydrolase 0.0455 0.5334 0.6538
Echinococcus granulosus microtubule associated protein 2 0.069 0.8158 1
Trypanosoma brucei histone deacetylase 2 0.0018 0.006 0.0867
Echinococcus multilocularis GTP binding nuclear protein Ran 0.004 0.0328 0.0328
Loa Loa (eye worm) TATA binding protein associated factor 0.0024 0.0139 0.0189
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0139 0.0981
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0277 0.032
Schistosoma mansoni jumonji domain containing protein 0.0149 0.1636 0.1997
Plasmodium falciparum histone deacetylase 2 0.0018 0.006 0.0867
Trypanosoma cruzi Aminopeptidase M1, putative 0.0024 0.0139 0.2221
Echinococcus granulosus GPCR family 2 0.0068 0.0664 0.0814
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1329 0.3834
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0292 0.0292
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0292 0.0358
Schistosoma mansoni hypothetical protein 0.0057 0.0535 0.0645
Schistosoma mansoni hypothetical protein 0.0195 0.2193 0.268
Schistosoma mansoni hypothetical protein 0.0019 0.0072 0.0077
Trypanosoma brucei importin beta-1 subunit, putative 0.0054 0.0501 0.8423
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0292 0.0347
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0455 0.5334 0.6534
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0292 0.3079
Onchocerca volvulus 0.0037 0.0292 0.028
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0292 0.0399
Echinococcus multilocularis phd:f box containing protein 0.0018 0.0069 0.0069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.2145 0.2145
Echinococcus multilocularis snurportin 1 0.0579 0.6819 0.6819
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0024 0.0139 0.2221
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0139 0.0139
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.2145 0.2621
Brugia malayi Thioredoxin reductase 0.0039 0.0315 0.0417
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0123 0.1329 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0928 0.1128
Brugia malayi jmjC domain containing protein 0.0071 0.07 0.0943
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0189
Loa Loa (eye worm) thioredoxin reductase 0.0039 0.0315 0.0429
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0292 0.1056
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0292 0.1056
Echinococcus granulosus jumonji domain containing 1A 0.0018 0.0069 0.0085
Echinococcus granulosus histone deacetylase 6 0.0018 0.006 0.0074
Echinococcus multilocularis isocitrate dehydrogenase 0.005 0.045 0.045
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0277 0.4593
Brugia malayi hypothetical protein 0.0037 0.0292 0.0386
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.045 0.045
Brugia malayi Histone deacetylase 1 0.0062 0.0593 0.0796
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0024 0.0139 0.2221
Giardia lamblia PHD finger protein 15 0.0057 0.0535 0.9014
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0535 0.3983
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0579 0.6819 0.9297
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0139 0.0139
Mycobacterium tuberculosis Probable dehydrogenase 0.0089 0.0914 0.3374
Brugia malayi jmjC domain containing protein 0.0018 0.0069 0.0082
Toxoplasma gondii histone deacetylase HDAC5 0.0018 0.006 0.0383
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0277 0.4593
Trichomonas vaginalis importin beta-1, putative 0.0044 0.0377 0.044
Echinococcus granulosus JmjC domain containing protein 4 0.0018 0.0069 0.0085
Loa Loa (eye worm) beta-lactamase 0.0037 0.0292 0.0399
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0068 0.0664 0.0814
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0024 0.0139 0.2221
Echinococcus granulosus histone lysine methyltransferase setb 0.009 0.0928 0.1138
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0292 0.4852
Plasmodium falciparum JmjC domain-containing protein, putative 0.0018 0.0069 0.1028
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0139 0.141
Echinococcus multilocularis lysine specific demethylase 5A 0.0069 0.068 0.068
Schistosoma mansoni ran 0.004 0.0328 0.0391
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0593 0.0698
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.004 0.0328 0.5466
Loa Loa (eye worm) jmjC domain-containing protein 0.0071 0.07 0.0955
Loa Loa (eye worm) CXXC zinc finger family protein 0.003 0.0213 0.029
Schistosoma mansoni histone deacetylase 0.0062 0.0593 0.0716
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0069 0.0071
Echinococcus granulosus histone deacetylase 6 0.0018 0.006 0.0074
Echinococcus multilocularis importin subunit beta 1 0.0054 0.0501 0.0501
Loa Loa (eye worm) hypothetical protein 0.0146 0.1612 0.2197
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0187 0.2099 0.2099
Echinococcus granulosus histone deacetylase 6 0.0018 0.006 0.0074
Entamoeba histolytica hypothetical protein 0.0037 0.0292 0.4261
Brugia malayi Pre-SET motif family protein 0.009 0.0928 0.1254
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0593 0.0698
Echinococcus granulosus lysine specific demethylase 6a 0.0018 0.0069 0.0085
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.004 0.0328 0.0435
Onchocerca volvulus 0.0707 0.8368 1
Schistosoma mansoni hypothetical protein 0.0146 0.1612 0.1966
Schistosoma mansoni histone deacetylase 4 5 0.0018 0.006 0.0062
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0044 0.0377 0.044
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0089 0.0914 0.3374
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0072 0.1076
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0139 0.017
Brugia malayi jmjC domain containing protein 0.0018 0.0069 0.0082
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0139 0.2221
Loa Loa (eye worm) histone deacetylase 0.0018 0.006 0.0082
Echinococcus granulosus histone deacetylase 7 0.0018 0.006 0.0074
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0069 0.102
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0024 0.0139 0.0159
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0455 0.5334 0.5334
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0039 0.0315 0.114
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0928 0.1128
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0139 0.0139
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0277 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0044 0.0377 0.044
Plasmodium vivax histone deacetylase, putative 0.0018 0.006 0.055
Brugia malayi histone deacetylase 3 (HD3) 0.0062 0.0593 0.0796
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.005 0.045 0.045
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0139 0.017
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0123 0.1329 0.1629
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0191 0.2145 0.2916
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.006 0.0867
Echinococcus multilocularis histone deacetylase 0.0018 0.006 0.006
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0321 0.0394
Brugia malayi TATA binding protein associated factor 0.0024 0.0139 0.0177
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0057 0.0535 0.0645
Schistosoma mansoni histone deacetylase hda2 0.0018 0.006 0.0062
Leishmania major hypothetical protein, conserved 0.0037 0.0292 0.2144
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0292 0.0338
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0277 0.034
Entamoeba histolytica Ran family GTPase 0.004 0.0328 0.4951
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0139 0.017
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0139 0.0177
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0009 0.0009
Loa Loa (eye worm) glutaminase 2 0.0299 0.3451 0.4705
Brugia malayi PHD-finger family protein 0.002 0.0093 0.0114
Brugia malayi glutathione reductase 0.0039 0.0315 0.0417
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0024 0.0139 0.0139
Brugia malayi CXXC zinc finger family protein 0.003 0.0213 0.0278
Loa Loa (eye worm) jmjC domain-containing protein 0.0118 0.1267 0.1727
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0069 0.0081
Brugia malayi hypothetical protein 0.0209 0.237 0.3222
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0277 0.032
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0277 0.0277
Leishmania major hypothetical protein, conserved 0.0018 0.0069 0.0454
Brugia malayi Latrophilin receptor protein 2 0.0068 0.0664 0.0894
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0292 0.1056
Echinococcus multilocularis histone deacetylase 3 0.0062 0.0593 0.0593
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0069 0.0071
Schistosoma mansoni hypothetical protein 0.0432 0.5051 0.6188
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0069 0.1028
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0069 0.0069
Brugia malayi histone deacetylase 1 (HD1) 0.0062 0.0593 0.0796
Echinococcus multilocularis neuropeptide receptor A26 0.046 0.5391 0.5391
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.045 0.045
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0068 0.0664 0.0664
Loa Loa (eye worm) hypothetical protein 0.0054 0.0501 0.0682
Toxoplasma gondii histone deacetylase HDAC1 0.0018 0.006 0.0383
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0214 0.2428 0.331
Loa Loa (eye worm) hypothetical protein 0.0037 0.0292 0.0399
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.004 0.0328 0.5466
Loa Loa (eye worm) inositol-1 0.0036 0.0277 0.0378
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0292 0.0338
Entamoeba histolytica aminopeptidase, putative 0.0024 0.0139 0.1337
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.005 0.045 0.7557
Mycobacterium ulcerans glutaminase 0.0299 0.3451 1
Echinococcus multilocularis histone deacetylase 8 0.0018 0.006 0.006
Plasmodium falciparum histone deacetylase, putative 0.0018 0.006 0.0867
Schistosoma mansoni hypothetical protein 0.0051 0.0461 0.0554
Loa Loa (eye worm) histone deacetylase 7A 0.0018 0.006 0.0082
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0062 0.0593 0.0698
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0098 0.1033 0.3818
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0094 0.0925
Toxoplasma gondii aminopeptidase n, putative 0.0024 0.0139 0.0981
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0123 0.1329 0.1329
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0292 0.1056
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0018 0.0069 0.0454
Entamoeba histolytica hypothetical protein 0.0037 0.0292 0.4261
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0068 0.0664 0.0814
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0277 0.4593
Schistosoma mansoni importin beta-1 0.0054 0.0501 0.0603
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.006 0.0867
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0018 0.0069 0.0454
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.004 0.0328 0.5466
Plasmodium vivax thioredoxin reductase, putative 0.0039 0.0315 0.3324
Onchocerca volvulus 0.0024 0.0139 0.0095
Brugia malayi beta-lactamase 0.0037 0.0292 0.0386
Plasmodium vivax JmjC domain containing protein 0.0018 0.0069 0.0652
Plasmodium vivax histone deacetylase 2, putative 0.0018 0.006 0.055
Entamoeba histolytica histone deacetylase, putative 0.0062 0.0593 1
Loa Loa (eye worm) hypothetical protein 0.025 0.2856 0.3894
Loa Loa (eye worm) latrophilin receptor protein 2 0.0068 0.0664 0.0905
Echinococcus multilocularis JmjC domain containing protein 4 0.0018 0.0069 0.0069
Trypanosoma cruzi histone deacetylase 1, putative 0.0062 0.0593 1
Toxoplasma gondii isocitrate dehydrogenase 0.005 0.045 0.3339
Echinococcus multilocularis dnaJ subfamily B 0.0432 0.5051 0.5051
Mycobacterium tuberculosis Conserved protein 0.0037 0.0292 0.1056
Loa Loa (eye worm) hypothetical protein 0.002 0.0093 0.0127
Toxoplasma gondii histone deacetylase HDAC4 0.0018 0.006 0.0383
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0069 0.0451
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0069 0.0173
Trypanosoma brucei histone deacetylase 4 0.0018 0.006 0.0867
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0139 0.017
Trichomonas vaginalis set domain proteins, putative 0.0707 0.8368 1
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0662 0.0801
Toxoplasma gondii isocitrate dehydrogenase 0.005 0.045 0.3339
Trichomonas vaginalis esterase, putative 0.0037 0.0292 0.0338
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0292 0.1056
Trypanosoma brucei aminopeptidase, putative 0.0024 0.0139 0.2221
Schistosoma mansoni cpg binding protein 0.0032 0.0234 0.0275
Mycobacterium tuberculosis Conserved protein 0.0037 0.0292 0.1056
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0455 0.5334 0.7272
Mycobacterium tuberculosis Conserved protein 0.0037 0.0292 0.1056
Trypanosoma brucei histone deacetylase, putative 0.0018 0.006 0.0867
Toxoplasma gondii histone deacetylase HDAC2 0.0062 0.0593 0.4419
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.005 0.045 0.045
Schistosoma mansoni inositol monophosphatase 0.0036 0.0277 0.0329
Schistosoma mansoni hypothetical protein 0.0068 0.0664 0.0803
Brugia malayi jmjC domain containing protein 0.0018 0.0069 0.0082
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0292 0.1056
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0292 0.1056
Echinococcus granulosus histone deacetylase 1 0.0062 0.0593 0.0726
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0069 0.102
Schistosoma mansoni inositol monophosphatase 0.0036 0.0277 0.0329
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.009 0.0111
Trypanosoma brucei isocitrate dehydrogenase, putative 0.005 0.045 0.7557
Echinococcus multilocularis cpg binding protein 0.0032 0.0234 0.0234
Echinococcus granulosus neuropeptide receptor A26 0.046 0.5391 0.6608
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.005 0.045 0.7557
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.2145 0.263
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0593 0.0698
Brugia malayi Isocitrate dehydrogenase 0.005 0.045 0.0602
Mycobacterium tuberculosis Probable oxidoreductase 0.0098 0.1033 0.3818
Trichomonas vaginalis ran, putative 0.004 0.0328 0.0381
Brugia malayi Pre-SET motif family protein 0.0622 0.7335 1
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.006 0.0867
Toxoplasma gondii PHD-finger domain-containing protein 0.0019 0.0072 0.0476
Echinococcus granulosus histone deacetylase 8 0.0018 0.006 0.0074
Echinococcus multilocularis PHD finger protein rhinoceros 0.0057 0.0535 0.0535
Leishmania major trypanothione reductase 0.0039 0.0315 0.2315
Trichomonas vaginalis glutaminase, putative 0.0299 0.3451 0.4117
Trypanosoma cruzi histone deacetylase, putative 0.0018 0.006 0.0867
Echinococcus granulosus snurportin 1 0.0579 0.6819 0.8359
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0069 0.0095
Brugia malayi glutaminase DH11.1 0.0299 0.3451 0.4698
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0098 0.1033 0.3818
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.005 0.045 0.4796
Brugia malayi Bromodomain containing protein 0.0057 0.0535 0.0717
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0292 0.0822
Echinococcus multilocularis peregrin 0.0057 0.0535 0.0535
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0593 0.0698
Toxoplasma gondii exonuclease III APE 0.0018 0.0069 0.0451
Onchocerca volvulus 0.003 0.0213 0.0184
Loa Loa (eye worm) hypothetical protein 0.0068 0.0664 0.0905
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0089 0.0914 0.3374
Echinococcus multilocularis jumonji domain containing protein 0.0079 0.0804 0.0804
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0292 0.0386
Loa Loa (eye worm) jmjC domain-containing protein 0.0018 0.0069 0.0095
Echinococcus granulosus phd:f box containing protein 0.0018 0.0069 0.0085
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0069 0.2221
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.009 0.0928 0.1128
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0292 0.0751
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.009 0.0928 0.0928
Schistosoma mansoni aldehyde dehydrogenase 0.0123 0.1329 0.1619
Leishmania major histone deacetylase, putative 0.0062 0.0593 0.4419
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0292 0.4852
Echinococcus multilocularis histone deacetylase 1 0.0062 0.0593 0.0593
Leishmania major histone deacetylase, putative 0.0062 0.0593 0.4419
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0277 0.3979
Echinococcus multilocularis survival motor neuron protein 1 0.025 0.2856 0.2856
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0139 0.0981
Schistosoma mansoni jumonji domain containing protein 0.0018 0.0069 0.0074
Plasmodium falciparum thioredoxin reductase 0.0039 0.0315 0.5238
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.004 0.0328 0.0447
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0068 0.0664 0.0894
Loa Loa (eye worm) hypothetical protein 0.0062 0.0593 0.0808
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0236 0.269 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0214 0.2428 0.3302
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0139 0.0981
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0292 0.0347
Loa Loa (eye worm) hypothetical protein 0.0024 0.0139 0.0189
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.009 0.0928 0.1128
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0089 0.0914 0.3374
Echinococcus multilocularis histone deacetylase 7 0.0018 0.006 0.006
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0019 0.0072 0.1076
Brugia malayi Histone deacetylase family protein 0.0018 0.006 0.0069
Trypanosoma brucei histone deacetylase 1 0.0062 0.0593 1
Schistosoma mansoni microtubule-associated protein tau 0.069 0.8158 1
Echinococcus granulosus importin subunit beta 1 0.0054 0.0501 0.0614
Brugia malayi hypothetical protein 0.0024 0.0139 0.0177
Plasmodium vivax histone deacetylase, putative 0.0018 0.006 0.055
Plasmodium falciparum importin beta, putative 0.0054 0.0501 0.8423
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0069 0.0647
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0024 0.0139 0.0159
Trypanosoma brucei importin beta-1 subunit, putative 0.0054 0.0501 0.8423
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0018 0.0069 0.1028
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1329 0.3834
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.005 0.045 0.1644
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0019 0.0072 0.0476
Plasmodium vivax importin-beta 2, putative 0.0054 0.0501 0.5345
Plasmodium falciparum phd finger protein, putative 0.0057 0.0535 0.9014
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0051 0.0461 0.0617
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0292 0.4852
Leishmania major histone deacetylase, putative 0.0018 0.006 0.0383
Echinococcus granulosus histone deacetylase 0.0018 0.006 0.0074
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0024 0.0139 0.141
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0277 0.203
Mycobacterium tuberculosis Probable reductase 0.0089 0.0914 0.3374
Toxoplasma gondii thioredoxin reductase 0.0039 0.0315 0.2315
Echinococcus multilocularis microtubule associated protein 2 0.069 0.8158 0.8158
Leishmania major GTP-binding protein, putative 0.004 0.0328 0.2415
Loa Loa (eye worm) hypothetical protein 0.009 0.0928 0.1266
Loa Loa (eye worm) hypothetical protein 0.0037 0.0292 0.0399
Toxoplasma gondii aldehyde dehydrogenase 0.0123 0.1329 1
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0024 0.0139 0.0159
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0191 0.2145 0.2925
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0292 0.0822
Echinococcus granulosus jumonji domain containing protein 0.0079 0.0804 0.0986
Loa Loa (eye worm) hypothetical protein 0.0037 0.0292 0.0399
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0069 0.102
Echinococcus granulosus survival motor neuron protein 1 0.025 0.2856 0.3501
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.0062 0.0593 0.0698
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0094 0.1458
Onchocerca volvulus 0.0024 0.0139 0.0095
Trypanosoma cruzi aminopeptidase, putative 0.0024 0.0139 0.2221
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0191 0.2145 0.2621
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0223 0.0292
Loa Loa (eye worm) histone deacetylase 11 0.0018 0.006 0.0082
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0018 0.0069 0.102
Brugia malayi beta-lactamase family protein 0.0037 0.0292 0.0386
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0292 0.0338
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0139 0.017
Toxoplasma gondii ABC1 family protein 0.0037 0.0292 0.2144
Echinococcus multilocularis histone deacetylase 6 0.0018 0.006 0.006
Echinococcus granulosus PHD finger protein rhinoceros 0.0057 0.0535 0.0656
Brugia malayi Importin beta-1 subunit 0.0054 0.0501 0.067
Loa Loa (eye worm) hypothetical protein 0.0018 0.0069 0.0095
Brugia malayi Histone deacetylase family protein 0.0018 0.006 0.0069
Mycobacterium ulcerans aldehyde dehydrogenase 0.0123 0.1329 0.3834
Schistosoma mansoni cpg binding protein 0.003 0.0213 0.025
Toxoplasma gondii HEAT repeat-containing protein 0.0054 0.0501 0.3722
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0009 0.5
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.009 0.0928 0.6963
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0139 0.0155
Giardia lamblia Histone deacetylase 0.0062 0.0593 1
Plasmodium vivax SET domain protein, putative 0.009 0.0928 1
Schistosoma mansoni jumonji/arid domain-containing protein 0.0071 0.07 0.0848
Brugia malayi Peptidase family M1 containing protein 0.0024 0.0139 0.0177
Echinococcus multilocularis lysine specific demethylase 6a 0.0018 0.0069 0.0069
Toxoplasma gondii histone lysine methyltransferase SET1 0.0061 0.0579 0.4318
Echinococcus multilocularis histone deacetylase 6 0.0018 0.006 0.006
Entamoeba histolytica hypothetical protein 0.0037 0.0292 0.4261
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.045 0.7557
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0069 0.0084
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0024 0.0139 0.017
Mycobacterium ulcerans hypothetical protein 0.0037 0.0292 0.0822
Echinococcus granulosus geminin 0.0195 0.2193 0.2689
Trichomonas vaginalis histone deacetylase, putative 0.0062 0.0593 0.0698
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.004 0.0328 0.5466
Schistosoma mansoni histone deacetylase hda2 0.0018 0.006 0.0062
Brugia malayi Calcitonin receptor-like protein seb-1 0.0214 0.2428 0.3302
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0086 0.0881 0.108
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0292 0.0358
Schistosoma mansoni ap endonuclease 0.0018 0.0069 0.0073
Leishmania major importin beta-1 subunit, putative 0.0044 0.0377 0.2786
Loa Loa (eye worm) peptidase family M1 containing protein 0.0024 0.0139 0.0189
Brugia malayi beta-lactamase family protein 0.0037 0.0292 0.0386
Echinococcus granulosus peregrin 0.0057 0.0535 0.0656
Plasmodium vivax histone deacetylase 1, putative 0.0062 0.0593 0.6346
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0191 0.2145 0.263
Schistosoma mansoni protein phosphatase 2C 0.0018 0.0069 0.0074
Trypanosoma brucei histone deacetylase 3 0.0018 0.006 0.0867
Brugia malayi RNA, U transporter 1 0.0154 0.1705 0.2314
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0292 0.0338
Toxoplasma gondii aminopeptidase N protein 0.0024 0.0139 0.0981
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0622 0.7335 1
Schistosoma mansoni phosphatidylserine receptor 0.0018 0.0069 0.0074
Schistosoma mansoni ap endonuclease 0.0018 0.0069 0.0073
Echinococcus granulosus dnaJ subfamily B 0.0432 0.5051 0.6192
Schistosoma mansoni ran 0.004 0.0328 0.0391
Brugia malayi PHD-finger family protein 0.0057 0.0535 0.0717
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.009 0.009
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0292 0.0347
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0069 0.0222
Treponema pallidum exodeoxyribonuclease (exoA) 0.0018 0.0069 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0089 0.0914 0.3374
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0024 0.0139 0.0155
Onchocerca volvulus 0.0037 0.0292 0.028
Schistosoma mansoni histone deacetylase 0.0062 0.0593 0.0716
Echinococcus granulosus aminopeptidase N 0.0024 0.0139 0.017
Echinococcus multilocularis histone deacetylase 6 0.0018 0.006 0.006
Loa Loa (eye worm) histone deacetylase 1 0.0062 0.0593 0.0808
Echinococcus multilocularis neuropeptide s receptor 0.046 0.5391 0.5391
Echinococcus granulosus lysine specific demethylase 5A 0.0071 0.07 0.0859
Schistosoma mansoni survival motor neuron protein 0.0051 0.0461 0.0554
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0069 0.0094
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0024 0.0139 0.2221
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.004 0.0328 0.3468
Brugia malayi jmjC domain containing protein 0.0187 0.2099 0.2853
Loa Loa (eye worm) hypothetical protein 0.0018 0.006 0.0082
Trypanosoma cruzi importin beta-1 subunit, putative 0.0044 0.0377 0.6305
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0191 0.2145 0.2145
Schistosoma mansoni hypothetical protein 0.0068 0.0664 0.0803
Loa Loa (eye worm) hypothetical protein 0.0037 0.0292 0.0399
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0024 0.0139 0.0981
Onchocerca volvulus Alhambra homolog 0.0057 0.0535 0.0572
Mycobacterium ulcerans aminopeptidase N PepN 0.0024 0.0139 0.0376
Echinococcus multilocularis aminopeptidase N 0.0024 0.0139 0.0139
Loa Loa (eye worm) glutaminase 0.0299 0.3451 0.4705
Schistosoma mansoni hypothetical protein 0.0037 0.0292 0.0347
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.004 0.0328 0.5466
Schistosoma mansoni phd/f-box containing protein 0.0018 0.0069 0.0074
Toxoplasma gondii aminopeptidase N, putative 0.0024 0.0139 0.0981
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0123 0.1329 0.4923
Schistosoma mansoni hypothetical protein 0.0579 0.6819 0.8357
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0098 0.1033 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.005 0.045 0.7557
Onchocerca volvulus 0.0037 0.0292 0.028
Brugia malayi hypothetical protein 0.0024 0.0139 0.0177
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.009 0.0928 0.0928
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0018 0.0069 0.0074
Toxoplasma gondii PHD-finger domain-containing protein 0.0057 0.0535 0.3983
Brugia malayi AF-10 protein 0.0019 0.0072 0.0086

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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