Detailed information for compound 662289

Basic information

Technical information
  • TDR Targets ID: 662289
  • Name: 1-(4-methoxyphenyl)-N-[(2-methylphenyl)methyl ]-5-oxopyrrolidine-3-carboxamide
  • MW: 338.4 | Formula: C20H22N2O3
  • H donors: 1 H acceptors: 2 LogP: 2.1 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)N1CC(CC1=O)C(=O)NCc1ccccc1C
  • InChi: 1S/C20H22N2O3/c1-14-5-3-4-6-15(14)12-21-20(24)16-11-19(23)22(13-16)17-7-9-18(25-2)10-8-17/h3-10,16H,11-13H2,1-2H3,(H,21,24)
  • InChiKey: JOVZZRRXHWNQEN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-(4-methoxyphenyl)-N-[(2-methylphenyl)methyl]-5-oxo-pyrrolidine-3-carboxamide
  • 1-(4-methoxyphenyl)-N-[(2-methylphenyl)methyl]-5-oxo-3-pyrrolidinecarboxamide
  • 5-keto-1-(4-methoxyphenyl)-N-(2-methylbenzyl)pyrrolidine-3-carboxamide
  • ST066022
  • 1-(4-Methoxy-phenyl)-5-oxo-pyrrolidine-3-carboxylic acid 2-methyl-benzylamide
  • BAS 06303282
  • Oprea1_069808

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Cathepsin L-like precursor 0.003 0.0058 0.0095
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0014 0.0184
Loa Loa (eye worm) hypothetical protein 0.0052 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0107 0.0312 0.0578
Schistosoma mansoni microtubule-associated protein tau 0.225 0.7414 0.8525
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.011 0.0324 0.032
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0033
Trypanosoma brucei trypanothione reductase 0.0044 0.0105 0.2975
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0112 0.033 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0032 0.0179
Entamoeba histolytica acyl-CoA synthetase, putative 0.0022 0.0032 0.0179
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0219 0.0684 0.068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0058 0.083
Echinococcus multilocularis isocitrate dehydrogenase 0.0015 0.0008 0.0003
Trypanosoma cruzi trypanothione reductase, putative 0.0015 0.001 0.0055
Echinococcus granulosus cathepsin l1 0.003 0.0058 0.0053
Schistosoma mansoni transcription factor LCR-F1 0.0064 0.0171 0.0192
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0016 0.001 0.0075
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0219 0.0684 0.068
Brugia malayi tailless protein 0.0052 0.0131 0.0235
Echinococcus multilocularis FTZ F1 alpha 0.0219 0.0684 0.068
Loa Loa (eye worm) hypothetical protein 0.0219 0.0684 0.1286
Schistosoma mansoni methyl-cpg binding protein mbd 0.0146 0.0441 0.0503
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.003 0.0058 0.083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0219 0.0684 0.1286
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0055 0.0058
Echinococcus granulosus tar DNA binding protein 0.0113 0.0333 0.0329
Plasmodium vivax SET domain protein, putative 0.0029 0.0055 0.0376
Schistosoma mansoni hypothetical protein 0.0729 0.2373 0.2726
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0219 0.0684 0.068
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0113 0.0333 0.0618
Onchocerca volvulus 0.0022 0.0032 0.0024
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0025 0.036
Loa Loa (eye worm) protein-tyrosine phosphatase 0.0369 0.1181 0.2232
Brugia malayi TAR-binding protein 0.0113 0.0333 0.0618
Brugia malayi Steroid receptor seven-up type 2 0.0219 0.0684 0.1286
Trypanosoma cruzi major cysteine proteinase, putative 0.0089 0.0255 0.754
Brugia malayi ecdysteroid receptor 0.1602 0.5266 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0219 0.0684 0.068
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0101 0.0293 0.8844
Entamoeba histolytica kinesin, putative 0.0394 0.1263 1
Schistosoma mansoni zinc finger protein 0.0052 0.0131 0.0146
Toxoplasma gondii aldehyde dehydrogenase 0.0051 0.0129 0.0968
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0335 1
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0052 0.0131 0.0235
Mycobacterium tuberculosis Probable reductase 0.0101 0.0293 0.8844
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0112 0.1611
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0052 0.0131 0.0127
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0046 0.0112 0.3183
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0015 0.001 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0058 0.0382
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0167 0.0511 0.0507
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0081 0.0228 0.1744
Echinococcus multilocularis kinesin family 1 0.303 1 1
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0016 0.001 0.0006
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0044 0.0105 0.3025
Onchocerca volvulus 0.0052 0.0131 0.0213
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0051 0.0129 0.3709
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0058 0.083
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0032 0.1036
Trichomonas vaginalis set domain proteins, putative 0.0222 0.0696 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.0511 0.0957
Brugia malayi Nuclear hormone receptor-like 1 0.0167 0.0511 0.0957
Trichomonas vaginalis bromodomain-containing protein, putative 0.004 0.0091 0.1305
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0052 0.0131 0.0213
Leishmania major cathepsin L-like protease 0.003 0.0058 0.1524
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.001 0.0055
Brugia malayi Nuclear hormone receptor-like 1 0.0167 0.0511 0.0957
Schistosoma mansoni thyroid hormone receptor 0.0219 0.0684 0.0782
Toxoplasma gondii cathepsin CPL 0.003 0.0058 0.0398
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0058 0.083
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.0378 0.0703
Plasmodium vivax vivapain-2 0.003 0.0058 0.0398
Brugia malayi nuclear hormone receptor family member odr-7 0.0052 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0277 0.0878 0.1655
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0022 0.0032 0.1036
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0032 0.0047
Echinococcus granulosus histone lysine methyltransferase setb 0.0107 0.0312 0.0308
Loa Loa (eye worm) hypothetical protein 0.0052 0.0131 0.0235
Entamoeba histolytica hypothetical protein 0.0064 0.0171 0.1288
Echinococcus granulosus arachidonate 5 lipoxygenase 0.011 0.0324 0.032
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0032 0.0747
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0219 0.0684 0.068
Brugia malayi hypothetical protein 0.0167 0.0511 0.0957
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0016 0.001 0.0075
Schistosoma mansoni tar DNA-binding protein 0.0113 0.0333 0.0378
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0015 0.0008 0.0004
Echinococcus granulosus thioredoxin glutathione reductase 0.0044 0.0105 0.0101
Schistosoma mansoni thyroid hormone receptor 0.0219 0.0684 0.0782
Brugia malayi F/Y-rich N-terminus family protein 0.0017 0.0014 0.0012
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0219 0.0684 0.1286
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0104 0.0303 0.9003
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0016 0.001 0.0007
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0081 0.0228 0.1757
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.001 0.0055
Plasmodium vivax vivapain-2 0.003 0.0058 0.0398
Echinococcus granulosus tyrosine protein phosphatase non receptor type 0.0369 0.1181 0.1177
Echinococcus granulosus histone acetyltransferase KAT2B 0.004 0.0091 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0042 0.0598
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0081 0.0228 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0167 0.0511 0.0583
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0219 0.0684 0.1286
Loa Loa (eye worm) hypothetical protein 0.0052 0.0131 0.0235
Brugia malayi hypothetical protein 0.0064 0.0171 0.0311
Plasmodium falciparum cysteine proteinase falcipain 1 0.0015 0.001 0.0016
Trypanosoma cruzi cysteine peptidase, putative 0.0114 0.0335 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0041 0.0596
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0219 0.0684 0.068
Toxoplasma gondii kinesin motor domain-containing protein 0.0394 0.1263 1
Loa Loa (eye worm) cysteine protease 0.003 0.0058 0.0095
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0022 0.0031 0.0718
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0058 0.083
Brugia malayi nuclear hormone receptor family member nhr-6 0.0052 0.0131 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0058 0.083
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0219 0.0684 0.068
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0081 0.0228 0.3282
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0058 0.083
Onchocerca volvulus Bile acid receptor homolog 0.1602 0.5266 1
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0015 0.001 0.0055
Brugia malayi Nuclear hormone receptor E75 0.0052 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0052 0.0131 0.0235
Brugia malayi RNA binding protein 0.0113 0.0333 0.0618
Trypanosoma cruzi cysteine peptidase, putative 0.0114 0.0335 1
Loa Loa (eye worm) hypothetical protein 0.0219 0.0684 0.1286
Trichomonas vaginalis inositol monophosphatase, putative 0.0081 0.0228 0.3282
Entamoeba histolytica hypothetical protein 0.0064 0.0171 0.1288
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0058 0.083
Echinococcus multilocularis Polycystic kidney disease protein 0.0018 0.002 0.0016
Schistosoma mansoni retinoic acid receptor RXR 0.0219 0.0684 0.0782
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.0129 0.0144
Entamoeba histolytica cysteine proteinase, putative 0.002 0.0025 0.0122
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0015 0.001 0.0061
Schistosoma mansoni inositol monophosphatase 0.0081 0.0228 0.0258
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0219 0.0684 0.0782
Trypanosoma cruzi cysteine peptidase, putative 0.0114 0.0335 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0219 0.0684 0.068
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0058 0.083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.001 0.0148
Brugia malayi Cathepsin L-like precursor 0.002 0.0025 0.0033
Loa Loa (eye worm) hypothetical protein 0.0219 0.0684 0.1286
Plasmodium falciparum thioredoxin reductase 0.0044 0.0105 0.0776
Onchocerca volvulus 0.0052 0.0131 0.0213
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0046 0.0112 0.3183
Schistosoma mansoni cathepsin F (C01 family) 0.003 0.0058 0.0061
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.001 0.0141
Schistosoma mansoni hypothetical protein 0.0158 0.0483 0.0551
Plasmodium falciparum thioredoxin reductase 0.0015 0.001 0.0014
Toxoplasma gondii target of rapamycin (TOR), putative 0.0034 0.0073 0.0518
Plasmodium vivax thioredoxin reductase, putative 0.0044 0.0105 0.0776
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0015 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0052 0.0131 0.0235
Leishmania major cysteine peptidase A (CPA) 0.003 0.0058 0.1524
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.002 0.0016
Brugia malayi nuclear hormone receptor 0.0219 0.0684 0.1286
Loa Loa (eye worm) hypothetical protein 0.003 0.0058 0.0095
Loa Loa (eye worm) hypothetical protein 0.0219 0.0684 0.1286
Brugia malayi nuclear receptor RXR 0.0052 0.0131 0.0235
Echinococcus granulosus ecdysone induced protein 78C 0.0219 0.0684 0.068
Echinococcus multilocularis thyroid hormone receptor alpha 0.0219 0.0684 0.068
Brugia malayi Nuclear hormone receptor E75 0.0052 0.0131 0.0235
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0219 0.0684 0.1265
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0112 0.1611
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0052 0.0131 0.0127
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.001 0.0055
Schistosoma mansoni lipoxygenase 0.0077 0.0214 0.0241
Onchocerca volvulus 0.003 0.0058 0.0072
Onchocerca volvulus 0.003 0.0058 0.0072
Mycobacterium tuberculosis Probable oxidoreductase 0.0112 0.033 1
Brugia malayi Kinesin motor domain containing protein 0.0394 0.1263 0.2388
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0219 0.0684 0.0782
Echinococcus granulosus cathepsin L cysteine protease 0.0015 0.001 0.0005
Entamoeba histolytica cysteine proteinase, putative 0.003 0.0058 0.0382
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0219 0.0684 0.1286
Trypanosoma cruzi cysteine proteinase, putative 0.0015 0.001 0.0061
Echinococcus granulosus Nuclear hormone receptor HR96 0.0052 0.0131 0.0127
Schistosoma mansoni tar DNA-binding protein 0.0113 0.0333 0.0378
Onchocerca volvulus Cathepsin L homolog 0.003 0.0058 0.0072
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.001 0.0055
Schistosoma mansoni methyl-cpg binding protein mbd 0.0177 0.0545 0.0622
Plasmodium falciparum LCCL domain-containing protein 0.0018 0.002 0.0097
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0058 0.083
Trypanosoma cruzi target of rapamycin kinase 3 0.0037 0.0081 0.223
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.0228 0.6732
Echinococcus multilocularis dnaJ subfamily B 0.0729 0.2373 0.237
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.001 0.0148
Plasmodium vivax kinesin-5 0.0394 0.1263 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0335 1
Onchocerca volvulus 0.0029 0.0055 0.0067
Loa Loa (eye worm) phosphatidylinositol 3 0.0016 0.001 0.0005
Brugia malayi conserved hypotetical protein 0.0052 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0052 0.0131 0.0235
Plasmodium vivax acyl-CoA synthetase, putative 0.0017 0.0014 0.0047
Entamoeba histolytica acetyltransferase, GNAT family 0.0036 0.008 0.0559
Echinococcus granulosus cathepsin L 0.0015 0.001 0.0005
Toxoplasma gondii thioredoxin reductase 0.0044 0.0105 0.0776
Echinococcus granulosus Nuclear hormone receptor HR96 0.0052 0.0131 0.0127
Echinococcus granulosus FTZ F1 alpha 0.0219 0.0684 0.068
Echinococcus granulosus nuclear receptor nhr 48 0.0052 0.0131 0.0127
Schistosoma mansoni cathepsin F (C01 family) 0.003 0.0058 0.0061
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0129 0.5473
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0037 0.0081 0.223
Echinococcus multilocularis cathepsin L cysteine protease 0.003 0.0058 0.0053
Plasmodium vivax glutathione reductase, putative 0.0044 0.0105 0.0776
Loa Loa (eye worm) hypothetical protein 0.0167 0.0511 0.0957
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0011 0.0091
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0219 0.0684 0.0782
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0037 0.0081 0.223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0073 0.1047
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0033
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0046 0.0112 0.0108
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.0312 0.0354
Loa Loa (eye worm) hypothetical protein 0.0219 0.0684 0.1286
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0015 0.001 0.0014
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0057 0.0146 0.0264
Plasmodium falciparum glutathione reductase 0.0015 0.001 0.0014
Schistosoma mansoni cathepsin F (C01 family) 0.002 0.0025 0.0024
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0032 0.0747
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0046 0.0112 0.3183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0335 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.0511 0.0957
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0084 0.0236 0.0232
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0023
Loa Loa (eye worm) hypothetical protein 0.0219 0.0684 0.1286
Leishmania major phosphatidylinositol 3-kinase, putative 0.0016 0.001 0.0075
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.0228 0.6732
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0015 0.001 0.0056
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0042 0.0598
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0052 0.0131 0.0127
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0058 0.083
Schistosoma mansoni loxhd1 0.0018 0.002 0.0018
Onchocerca volvulus Protein ultraspiracle homolog 0.0219 0.0684 0.1265
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0219 0.0684 0.1286
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.002 0.0016
Brugia malayi glutathione reductase 0.0044 0.0105 0.0185
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0022 0.0032 0.1036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0081 0.116
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0051 0.0129 0.0125
Echinococcus granulosus inositol monophosphatase 1 0.0081 0.0228 0.0224
Brugia malayi hypothetical protein 0.0018 0.002 0.0023
Loa Loa (eye worm) hypothetical protein 0.0167 0.0511 0.0957
Schistosoma mansoni protein tyrosine phosphatase non-receptor type nt1 0.0369 0.1181 0.1354
Brugia malayi CXXC zinc finger family protein 0.0051 0.0128 0.0229
Onchocerca volvulus 0.003 0.0058 0.0072
Brugia malayi photoreceptor-specific nuclear receptor 0.0219 0.0684 0.1286
Brugia malayi hypothetical protein 0.0018 0.002 0.0023
Echinococcus granulosus cysteine protease 0.0015 0.001 0.0005
Brugia malayi Cathepsin L-like precursor 0.003 0.0058 0.0095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0081 0.116
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0011 0.0091
Giardia lamblia GTOR 0.0046 0.0112 0.0817
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.001 0.0055
Entamoeba histolytica cysteine protease, putative 0.003 0.0058 0.0382
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0017 0.0015 0.001
Onchocerca volvulus 0.0057 0.0146 0.0241
Leishmania major cathepsin L-like protease 0.003 0.0058 0.1524
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0015 0.001 0.0006
Loa Loa (eye worm) steroid hormone receptor 0.0219 0.0684 0.1286
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.003 0.0058 0.0095
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0219 0.0684 0.1286
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0219 0.0684 0.068
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0081 0.116
Brugia malayi Cathepsin L-like precursor 0.003 0.0058 0.0095
Plasmodium falciparum kinesin-5 0.0394 0.1263 1
Echinococcus multilocularis cysteine protease 0.003 0.0058 0.0053
Echinococcus granulosus cathepsin L cysteine proteinase 0.003 0.0058 0.0053
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0015 0.001 0.0055
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0011
Brugia malayi Cathepsin L-like precursor 0.003 0.0058 0.0095
Loa Loa (eye worm) histone methyltransferase 0.0017 0.0015 0.0013
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0041 0.0596
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0062 0.0886
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0032 0.076
Onchocerca volvulus 0.0219 0.0684 0.1265
Loa Loa (eye worm) inositol-1 0.0081 0.0228 0.0419
Schistosoma mansoni hypothetical protein 0.2636 0.8696 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0058 0.083
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0131 0.0146
Schistosoma mansoni coup transcription factor 0.0219 0.0684 0.0782
Schistosoma mansoni hypothetical protein 0.0018 0.002 0.0018
Loa Loa (eye worm) doublecortin family protein 0.0018 0.002 0.0023
Brugia malayi MBD3 protein 0.0149 0.0454 0.0848
Schistosoma mansoni lipoxygenase 0.011 0.0324 0.0368
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0219 0.0684 0.1286
Entamoeba histolytica hypothetical protein 0.0064 0.0171 0.1288
Plasmodium vivax vivapain-1 0.0015 0.001 0.0016
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0015 0.001 0.0055
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0177 0.0545 0.0541
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.0228 0.6732
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0015 0.0008 0.0003
Echinococcus granulosus geminin 0.0158 0.0483 0.0479
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0219 0.0684 0.068
Echinococcus multilocularis cathepsin l cysteine peptidase 0.003 0.0058 0.0053
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0052 0.0131 0.0146
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0167 0.0511 0.0507
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.005 0.0725
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0081 0.0228 1
Schistosoma mansoni nuclear receptor 0.0052 0.0131 0.0146
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0101 0.0293 0.8844
Schistosoma mansoni nuclear hormone receptor 0.0052 0.0131 0.0146
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0058 0.083
Echinococcus multilocularis cathepsin l cysteine peptidase 0.003 0.0058 0.0053
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0073 0.1047
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0219 0.0684 0.1286
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.001 0.0055
Echinococcus granulosus tumor protein p63 0.0744 0.2424 0.2421
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0016 0.001 0.0075
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0058 0.083
Onchocerca volvulus 0.0109 0.032 0.0571
Brugia malayi RNA recognition motif domain containing protein 0.0113 0.0333 0.0618
Toxoplasma gondii histone lysine methyltransferase SET1 0.0101 0.0294 0.2283
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0135 0.0408 0.0464
Leishmania major cathepsin L-like protease 0.003 0.0058 0.1524
Schistosoma mansoni cellular tumor antigen P53 0.0109 0.032 0.0363
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0219 0.0684 0.1286
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0058 0.0838
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0048 0.0044
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0081 0.116
Loa Loa (eye worm) hypothetical protein 0.0052 0.0131 0.0235
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0219 0.0684 0.0782
Loa Loa (eye worm) glutathione reductase 0.0044 0.0105 0.0185
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0052 0.0131 0.0127
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0167 0.0511 0.0957
Loa Loa (eye worm) MBD3 protein 0.0149 0.0454 0.0848
Schistosoma mansoni RAR-like nuclear receptor 0.0219 0.0684 0.0782
Schistosoma mansoni nuclear hormone receptor 0.0219 0.0684 0.0782
Treponema pallidum NADH oxidase 0.0015 0.001 0.5
Echinococcus multilocularis geminin 0.0158 0.0483 0.0479
Loa Loa (eye worm) acetyltransferase 0.0135 0.0408 0.076
Brugia malayi hypothetical protein 0.0277 0.0878 0.1655
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0051 0.0129 0.0125
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.004 0.0091 0.1305
Loa Loa (eye worm) hypothetical protein 0.0052 0.0131 0.0235
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0052 0.0131 0.0127
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0058 0.083
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0008 0.0003
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.005 0.0712
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0046 0.0112 0.0198
Brugia malayi hypothetical protein 0.0167 0.0511 0.0957
Echinococcus multilocularis ecdysone induced protein 78C 0.0219 0.0684 0.068
Loa Loa (eye worm) hypothetical protein 0.0052 0.0131 0.0235
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0335 1
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.001 0.0004
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0015 0.001 0.0061
Echinococcus granulosus survival motor neuron protein 1 0.0277 0.0878 0.0874
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0084 0.0236 0.0232
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0058 0.083
Echinococcus granulosus cathepsin l cysteine peptidase 0.003 0.0058 0.0053
Entamoeba histolytica hypothetical protein 0.0064 0.0171 0.1288
Schistosoma mansoni inositol monophosphatase 0.0081 0.0228 0.0258
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0335 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0064 0.0171 0.0167
Trypanosoma cruzi cysteine peptidase, putative 0.003 0.0058 0.1524
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0046 0.0112 0.0816
Trypanosoma cruzi cysteine protease, putative 0.0015 0.001 0.0061
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0046 0.0112 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.005 0.0725
Entamoeba histolytica acyl-coA synthetase, putative 0.0022 0.0032 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0041 0.0596
Echinococcus granulosus histone acetyltransferase KAT2B 0.0132 0.0395 0.0391
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0167 0.0511 0.0583
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0015 0.001 0.0055
Schistosoma mansoni kinesin eg-5 0.0394 0.1263 0.1449
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0058 0.083
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0015 0.001 0.0014
Brugia malayi ecdysone receptor 0.0052 0.0131 0.0235
Brugia malayi Bromodomain containing protein 0.0084 0.0236 0.0435
Giardia lamblia Kinesin-5 0.0394 0.1263 1
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.001 0.0055
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0055 0.0051
Brugia malayi Cathepsin L-like precursor 0.003 0.0058 0.0095
Mycobacterium ulcerans hypothetical protein 0.0022 0.0032 0.1036
Brugia malayi Papain family cysteine protease containing protein 0.0015 0.001 0.0004
Onchocerca volvulus 0.003 0.0058 0.0072
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0011 0.0091
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0135 0.0408 0.0403
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.002 0.0025 0.036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.001 0.0148
Loa Loa (eye worm) DR-78 0.0052 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0078 0.0216 0.0396
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0129 0.5473
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0112 0.033 1
Brugia malayi Doublecortin family protein 0.0018 0.002 0.0023
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0055 0.0376
Brugia malayi nuclear receptor NHR-88 0.0052 0.0131 0.0235
Brugia malayi Pre-SET motif family protein 0.0029 0.0055 0.009
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0219 0.0684 0.1286
Schistosoma mansoni cpg binding protein 0.0051 0.0128 0.0143
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0017 0.0015 0.001
Echinococcus granulosus Polycystic kidney disease protein 0.0018 0.002 0.0016
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0101 0.0293 0.8844
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.005 0.0712
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0112 0.1611
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0019 0.0023 0.0449
Brugia malayi Cathepsin L-like precursor 0.002 0.0025 0.0033
Onchocerca volvulus 0.003 0.0058 0.0072
Echinococcus granulosus thyroid hormone receptor alpha 0.0052 0.0131 0.0127
Echinococcus multilocularis tumor protein p63 0.0744 0.2424 0.2421
Onchocerca volvulus 0.003 0.0058 0.0072
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0219 0.0684 0.1286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0081 0.116
Brugia malayi hypothetical protein 0.0052 0.0131 0.0235
Loa Loa (eye worm) RNA binding protein 0.0113 0.0333 0.0618
Schistosoma mansoni polycystin 1-related 0.0018 0.002 0.0018
Echinococcus granulosus lipoxygenase domain containing protein 0.0018 0.002 0.0016
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.004 0.0091 0.0661
Trypanosoma cruzi cysteine proteinase, putative 0.0015 0.001 0.0061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0073 0.1047
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0015 0.001 0.0003
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0219 0.0684 0.1286
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0015 0.001 0.0141
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0107 0.0312 0.0354
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.001 0.0006
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0052 0.0131 0.0127
Echinococcus multilocularis cysteine protease 0.003 0.0058 0.0053
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0335 1
Echinococcus granulosus RUN 0.0018 0.002 0.0016
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0011
Schistosoma mansoni tar DNA-binding protein 0.0113 0.0333 0.0378
Loa Loa (eye worm) ctsf protein 0.003 0.0058 0.0095
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0015 0.001 0.0014
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0011
Loa Loa (eye worm) fibroinase 0.003 0.0058 0.0095
Leishmania major 4-coumarate:coa ligase-like protein 0.0022 0.0032 0.0747
Loa Loa (eye worm) kinesin-like protein KLP2 0.0394 0.1263 0.2388
Plasmodium vivax multidomain scavenger receptor, putative 0.0018 0.002 0.0097
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0022 0.0032 0.1036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0016 0.0011 0.0091
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0032 0.0047
Brugia malayi steroid hormone receptor 0.0219 0.0684 0.1286
Echinococcus multilocularis thioredoxin glutathione reductase 0.0044 0.0105 0.0101
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0219 0.0684 0.1286
Brugia malayi Cathepsin L-like precursor 0.003 0.0058 0.0095
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0335 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0219 0.0684 0.0782
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0052 0.0131 0.0146
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0047
Brugia malayi nuclear receptor NHR-67 0.0052 0.0131 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0058 0.083
Brugia malayi cathepsin L-like precursor 0.002 0.0025 0.0033
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0196 0.0607 0.1139
Brugia malayi Thioredoxin reductase 0.0044 0.0105 0.0185
Onchocerca volvulus Cathepsin F homolog 0.003 0.0058 0.0072
Loa Loa (eye worm) hypothetical protein 0.002 0.0025 0.0033
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0335 1
Loa Loa (eye worm) hypothetical protein 0.0109 0.032 0.0593
Schistosoma mansoni mixed-lineage leukemia protein mll 0.011 0.0322 0.0365
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0032 0.1036
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.005 0.0725
Loa Loa (eye worm) hypothetical protein 0.0052 0.0131 0.0235
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0058 0.083
Echinococcus multilocularis tar DNA binding protein 0.0113 0.0333 0.0329
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0022 0.0032 0.076
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0219 0.0684 0.1286
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0042 0.0598
Loa Loa (eye worm) hypothetical protein 0.0052 0.0131 0.0235
Echinococcus multilocularis survival motor neuron protein 1 0.0277 0.0878 0.0874
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0058 0.083
Loa Loa (eye worm) hypothetical protein 0.0018 0.002 0.0023
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.001 0.0055
Echinococcus multilocularis RUN 0.0018 0.002 0.0016
Leishmania major cathepsin L-like protease 0.003 0.0058 0.1524
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0017 0.0014 1
Echinococcus granulosus microtubule associated protein 2 0.225 0.7414 0.7412
Trypanosoma cruzi cysteine peptidase (N-terminal), putative 0.0015 0.001 0.0061
Schistosoma mansoni nuclear receptor 0.0052 0.0131 0.0146
Trichomonas vaginalis glutathione reductase, putative 0.0015 0.001 0.0138
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.001 0.0075
Schistosoma mansoni nuclear receptor nhr-48 0.0052 0.0131 0.0146
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0011
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0015 0.001 0.0055
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.001 0.0006
Loa Loa (eye worm) CXXC zinc finger family protein 0.0051 0.0128 0.0229
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0073 0.1047
Brugia malayi Nuclear hormone receptor-like 1 0.0219 0.0684 0.1286
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0073 0.02 0.5637
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0058 0.083
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0016 0.001 0.0075
Mycobacterium ulcerans aldehyde dehydrogenase 0.0051 0.0129 0.5473
Schistosoma mansoni rab6-interacting 0.0018 0.002 0.0018
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0081 0.0228 0.6732
Loa Loa (eye worm) hypothetical protein 0.0219 0.0684 0.1286
Schistosoma mansoni tar DNA-binding protein 0.0113 0.0333 0.0378
Schistosoma mansoni SmCL2-like peptidase (C01 family) 0.0015 0.001 0.0006
Echinococcus multilocularis microtubule associated protein 2 0.225 0.7414 0.7412
Brugia malayi acetyltransferase, GNAT family protein 0.0135 0.0408 0.076
Onchocerca volvulus 0.002 0.0025 0.001
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0008 0.0003
Loa Loa (eye worm) nuclear hormone receptor 0.0052 0.0131 0.0235
Brugia malayi nuclear receptor NHR-88 0.0219 0.0684 0.1286
Brugia malayi hypothetical protein 0.0052 0.0131 0.0235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0042 0.0598
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0112 0.033 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.004 0.0091 0.0661
Onchocerca volvulus 0.0222 0.0696 0.1288
Echinococcus multilocularis cathepsin L 0.0015 0.001 0.0005
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0101 0.0293 0.8844
Mycobacterium tuberculosis Probable dehydrogenase 0.0101 0.0293 0.8844
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.001 0.0148
Giardia lamblia Histone acetyltransferase GCN5 0.0036 0.008 0.056
Echinococcus granulosus methyl CpG binding domain protein 2 0.0177 0.0545 0.0541
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0058 0.083
Echinococcus multilocularis tyrosine protein phosphatase non receptor type 0.0369 0.1181 0.1177
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0081 0.0228 0.3282
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0219 0.0684 0.1286
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0073 0.02 0.5969
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0016 0.001 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0014 0.0011
Plasmodium falciparum histone acetyltransferase GCN5 0.0036 0.008 0.0574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0335 1
Loa Loa (eye worm) hypothetical protein 0.0167 0.0511 0.0957
Onchocerca volvulus 0.003 0.0058 0.0072
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0015 0.0008 0.0003
Schistosoma mansoni hypothetical protein 0.0057 0.0146 0.0163
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0219 0.0684 0.1286
Schistosoma mansoni cpg binding protein 0.0054 0.0138 0.0154
Schistosoma mansoni hypothetical protein 0.0158 0.0483 0.0551
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0015 0.001 0.0014
Toxoplasma gondii NADPH-glutathione reductase 0.0015 0.001 0.0014
Loa Loa (eye worm) TAR-binding protein 0.0113 0.0333 0.0618
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0015 0.001 0.0005
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0046 0.0112 0.3183
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0052 0.0131 0.0235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0016 0.001 0.0148
Schistosoma mansoni cpg binding protein 0.0054 0.0138 0.0154
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.003 0.0058 0.083
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0073 0.1047
Trypanosoma cruzi cysteine peptidase, putative 0.0015 0.001 0.0061
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0046 0.0112 0.3183
Trichomonas vaginalis mercuric reductase, putative 0.0015 0.001 0.0138
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.003 0.0058 0.083
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.0378 0.0703
Trypanosoma cruzi cruzipain precursor, putative 0.0114 0.0335 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0052 0.0131 0.0127
Echinococcus multilocularis cpg binding protein 0.0054 0.0138 0.0134
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0219 0.0684 0.068
Loa Loa (eye worm) phosphatidylinositol 3 0.0046 0.0112 0.0198
Loa Loa (eye worm) thioredoxin reductase 0.0044 0.0105 0.0185
Brugia malayi MH2 domain containing protein 0.0126 0.0378 0.0703
Onchocerca volvulus Cathepsin L homolog 0.003 0.0058 0.0072
Echinococcus granulosus dnaJ subfamily B 0.0729 0.2373 0.237
Brugia malayi nuclear receptor RXR 0.0167 0.0511 0.0957
Schistosoma mansoni aldehyde dehydrogenase 0.0051 0.0129 0.0144
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0015 0.0008 0.0003
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0015 0.001 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0055 0.0058
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0032 0.1036
Onchocerca volvulus 0.0051 0.0128 0.0207
Plasmodium vivax vivapain-3 0.0015 0.001 0.0016
Leishmania major trypanothione reductase 0.0044 0.0105 0.2975
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0032 0.0047
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0219 0.0684 0.0782
Brugia malayi Cathepsin L-like cysteine proteinase 0.002 0.0025 0.0033
Brugia malayi Protein-tyrosine phosphatase containing protein 0.0369 0.1181 0.2232
Echinococcus granulosus cpg binding protein 0.0054 0.0138 0.0134
Brugia malayi Papain family cysteine protease containing protein 0.003 0.0058 0.0095
Plasmodium vivax histone acetyltransferase GCN5, putative 0.004 0.0091 0.0661
Brugia malayi Inositol-1 0.0081 0.0228 0.0419
Plasmodium falciparum glutathione reductase 0.0044 0.0105 0.0776
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0335 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0131 0.0235
Loa Loa (eye worm) nuclear receptor NHR-67 0.0052 0.0131 0.0235
Echinococcus multilocularis inositol monophosphatase 1 0.0081 0.0228 0.0224
Echinococcus granulosus cathepsin l1 0.002 0.0025 0.0021
Leishmania major cathepsin L-like protease 0.0114 0.0335 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0101 0.0293 0.8749
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0016 0.001 0.0005
Echinococcus multilocularis cathepsin L cysteine protease 0.003 0.0058 0.0053
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0051 0.0129 0.3772
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0052 0.0131 0.0213
Loa Loa (eye worm) papain family cysteine protease containing protein 0.003 0.0058 0.0095
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0047
Plasmodium vivax unspecified product 0.0015 0.001 0.0016
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0219 0.0684 0.1286
Schistosoma mansoni hypothetical protein 0.0064 0.0171 0.0192
Plasmodium falciparum cysteine proteinase falcipain 3 0.003 0.0058 0.0398
Plasmodium falciparum cysteine proteinase falcipain 2a 0.003 0.0058 0.0398
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0219 0.0684 0.1286
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0032 0.1036
Schistosoma mansoni rab6-interacting 0.0018 0.002 0.0018
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0017 0.0014 0.0188
Brugia malayi Pre-SET motif family protein 0.0196 0.0607 0.1139
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0046 0.0112 0.3183
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0114 0.0335 1
Leishmania major cathepsin L-like protease 0.003 0.0058 0.1524
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0015 0.001 0.0055
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0015 0.001 0.0055
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0073 0.1047
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.003 0.0058 0.083
Brugia malayi orphan nuclear receptor NR2E1 0.0052 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0022 0.0032 0.0047
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0046 0.0112 0.0108
Echinococcus multilocularis lipoxygenase domain containing protein 0.0018 0.002 0.0016
Trypanosoma cruzi trypanothione reductase, putative 0.0044 0.0105 0.2975
Schistosoma mansoni tar DNA-binding protein 0.0113 0.0333 0.0378
Leishmania major cathepsin L-like protease 0.0114 0.0335 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.009 0.1289
Loa Loa (eye worm) hypothetical protein 0.1602 0.5266 1
Plasmodium falciparum acyl-CoA synthetase 0.0017 0.0014 0.0047
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0219 0.0684 0.0782
Leishmania major cathepsin L-like protease 0.0114 0.0335 1
Plasmodium falciparum cysteine proteinase falcipain 2b 0.003 0.0058 0.0398
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0107 0.0312 0.0308
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0046 0.0112 0.0816
Schistosoma mansoni survival motor neuron protein 0.0057 0.0146 0.0163
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0052 0.0131 0.0127
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0073 0.1047
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0064 0.0171 0.0167
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0219 0.0684 0.1286
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0219 0.0684 0.068
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0219 0.0684 0.068
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0219 0.0684 0.1286
Brugia malayi nuclear hormone receptor 0.0052 0.0131 0.0235
Loa Loa (eye worm) hypothetical protein 0.0052 0.0131 0.0235

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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