Detailed information for compound 662384

Basic information

Technical information
  • TDR Targets ID: 662384
  • Name: 2-bromo-N-cyclopropylbenzamide
  • MW: 240.096 | Formula: C10H10BrNO
  • H donors: 1 H acceptors: 1 LogP: 2.44 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(c1ccccc1Br)NC1CC1
  • InChi: 1S/C10H10BrNO/c11-9-4-2-1-3-8(9)10(13)12-7-5-6-7/h1-4,7H,5-6H2,(H,12,13)
  • InChiKey: NRICRLWCYABOSB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-bromo-N-cyclopropyl-benzamide
  • AK-968/33905020
  • A0789/0036944
  • ZINC00356133

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi PHD-finger family protein 0.0055 0.0215 0.0115
Schistosoma mansoni lipoxygenase 0.009 0.1016 0.1442
Echinococcus granulosus geminin 0.0352 0.705 1
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0128 0.1901 0.2595
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.005 0.0101 0.0101
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0101 0.0008
Schistosoma mansoni lozenge 0.006 0.0346 0.0491
Schistosoma mansoni bromodomain containing protein 0.0139 0.2147 0.3045
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0131 0.1966 0.2689
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0079 0.077 0.0969
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0101 0.0008
Loa Loa (eye worm) hypothetical protein 0.0084 0.0893 0.0893
Schistosoma mansoni hypothetical protein 0.0352 0.705 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0101 0.0144
Loa Loa (eye worm) hypothetical protein 0.0481 1 1
Echinococcus multilocularis Protein lozenge 0.006 0.0346 0.036
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.005 0.0101 0.0008
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0131 0.1966 0.2689
Loa Loa (eye worm) runx1 0.006 0.0346 0.0346
Brugia malayi Bromodomain containing protein 0.0084 0.0889 0.0796
Brugia malayi hypothetical protein 0.03 0.5856 0.5813
Onchocerca volvulus 0.0481 1 1
Loa Loa (eye worm) hypothetical protein 0.0094 0.1108 0.1108
Echinococcus multilocularis geminin 0.0352 0.705 1
Schistosoma mansoni hypothetical protein 0.0352 0.705 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0101 0.0144
Loa Loa (eye worm) hypothetical protein 0.0481 1 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0079 0.077 0.0969
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0049 0.0096 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.005 0.0101 0.0144
Loa Loa (eye worm) hypothetical protein 0.03 0.5856 0.5856
Schistosoma mansoni lipoxygenase 0.0128 0.1901 0.2696
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.005 0.0101 0.0008
Loa Loa (eye worm) hypothetical protein 0.0155 0.2521 0.2521
Loa Loa (eye worm) hypothetical protein 0.0089 0.1012 0.1012
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0128 0.1901 0.2595
Brugia malayi Bromodomain containing protein 0.0164 0.2736 0.2662

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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