Detailed information for compound 662435

Basic information

Technical information
  • TDR Targets ID: 662435
  • Name: N-(2-bromo-4,5-dimethylphenyl)-2-phenylpropan amide
  • MW: 332.235 | Formula: C17H18BrNO
  • H donors: 1 H acceptors: 1 LogP: 4.68 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(C(c1ccccc1)C)Nc1cc(C)c(cc1Br)C
  • InChi: 1S/C17H18BrNO/c1-11-9-15(18)16(10-12(11)2)19-17(20)13(3)14-7-5-4-6-8-14/h4-10,13H,1-3H3,(H,19,20)
  • InChiKey: CIRQQYLHGFBIBW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(2-bromo-4,5-dimethyl-phenyl)-2-phenyl-propanamide
  • N-(2-bromo-4,5-dimethyl-phenyl)-2-phenyl-propionamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0014 0.0155 0.0205
Schistosoma mansoni tar DNA-binding protein 0.013 0.5483 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1547 0.282
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0421 0.0482
Trypanosoma cruzi DNA polymerase eta, putative 0.0037 0.1207 0.3108
Leishmania major DNA polymerase eta, putative 0.0037 0.1207 0.3108
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.1086 0.1086
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0421 0.0768
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0421 0.0768
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.1145 0.1144
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0421 0.0768
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0421 0.0482
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0035 0.1145 0.0755
Leishmania major DNA polymerase kappa, putative 0.0039 0.1308 0.3387
Loa Loa (eye worm) hypothetical protein 0.0067 0.257 0.2944
Loa Loa (eye worm) glutathione reductase 0.004 0.1337 0.1532
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0014 0.0155 0.0592
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0155 0.0205
Schistosoma mansoni hypothetical protein 0.0032 0.0998 0.1819
Giardia lamblia Kinase, PLK 0.0091 0.3704 1
Schistosoma mansoni transient receptor potential channel 0.007 0.2731 0.4981
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0029 0.0848 0.1547
Schistosoma mansoni hypothetical protein 0.0032 0.0998 0.1819
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0023 0.057 0.1049
Loa Loa (eye worm) hypothetical protein 0.002 0.0421 0.0482
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0091 0.3704 0.6756
Schistosoma mansoni tar DNA-binding protein 0.013 0.5483 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0039 0.1308 0.1308
Loa Loa (eye worm) hypothetical protein 0.0064 0.2434 0.2789
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0421 0.0482
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3704 0.3704
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.1145 0.1144
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.3654 0.8837
Echinococcus granulosus TRP transient receptor potential channel 0.0039 0.1329 0.2424
Leishmania major trypanothione reductase 0.004 0.1337 0.3467
Brugia malayi casein kinase II, putaitve 0.001 0.0001 0.0001
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0998 0.1819
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.1308 0.3387
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0998 0.1143
Toxoplasma gondii thioredoxin reductase 0.004 0.1337 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0421 0.0482
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1308 0.3387
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.08 0.1458
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0421 0.0768
Trichomonas vaginalis glutathione reductase, putative 0.0014 0.0155 0.0155
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.1596 0.1595
Schistosoma mansoni DNA polymerase IV / kappa 0.0012 0.0081 0.0147
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.3233 0.5897
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3704 0.3704
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.1308 1
Plasmodium vivax basic transcription factor 3b, putative 0.0034 0.1086 0.8005
Brugia malayi Csnk2b protein 0.0035 0.1145 0.1311
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0029 0.0848 0.1547
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0014 0.0155 0.0592
Loa Loa (eye worm) transcription factor SMAD2 0.0121 0.507 0.5808
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0421 0.0768
Leishmania major DNA polymerase eta, putative 0.0064 0.2434 0.6495
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0155 0.0205
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0014 0.0155 0.0205
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0014 0.0155 0.0606
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0201 0.8729 1
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0972 0.246
Mycobacterium tuberculosis Probable reductase 0.009 0.3654 0.8837
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.1547 0.282
Toxoplasma gondii NAC domain-containing protein 0.0034 0.1086 0.8005
Brugia malayi nuclear receptor NHR-88 0.002 0.0421 0.0482
Schistosoma mansoni terminal deoxycytidyl transferase 0.0039 0.1308 0.2386
Schistosoma mansoni transient receptor potential channel 0.0106 0.437 0.797
Loa Loa (eye worm) thioredoxin reductase 0.004 0.1337 0.1532
Brugia malayi ImpB/MucB/SamB family protein 0.0039 0.1308 0.1499
Plasmodium falciparum basic transcription factor 3b, putative 0.0034 0.1086 0.8005
Brugia malayi TAR-binding protein 0.013 0.5483 0.6282
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.3704 1
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0421 0.0482
Echinococcus granulosus short transient receptor potential channel 6 0.007 0.2731 0.4981
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0421 0.0482
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0421 0.0768
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0155 0.0205
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0032 0.0972 0.246
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0155 0.0205
Loa Loa (eye worm) hypothetical protein 0.0106 0.437 0.5007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0421 0.0482
Schistosoma mansoni hypothetical protein 0.0032 0.0998 0.1819
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0421 0.0482
Entamoeba histolytica hypothetical protein 0.0023 0.057 0.1539
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0037 0.1207 0.8964
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0998 0.1819
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0421 0.0768
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0421 0.0768
Echinococcus granulosus GPCR family 2 0.0032 0.0998 0.1819
Trichomonas vaginalis mercuric reductase, putative 0.0014 0.0155 0.0155
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.1086 0.2775
Brugia malayi Transient-receptor-potential like protein 0.0039 0.1329 0.1523
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1308 0.3387
Loa Loa (eye worm) casein kinase II 0.001 0.0001 0.0001
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.1308 0.3387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0848 0.1547
Giardia lamblia DINP protein human, muc B family 0.0039 0.1308 0.353
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.1086 0.1086
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.3233 0.5897
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0155 0.0205
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1547 0.282
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0421 0.0768
Echinococcus multilocularis short transient receptor potential channel 6 0.007 0.2731 0.4981
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0998 0.1819
Trypanosoma brucei trypanothione reductase 0.004 0.1337 0.3467
Loa Loa (eye worm) hypothetical protein 0.002 0.0421 0.0482
Brugia malayi nuclear hormone receptor 0.002 0.0421 0.0482
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0014 0.0155 0.0283
Schistosoma mansoni nuclear hormone receptor 0.002 0.0421 0.0768
Toxoplasma gondii peptidylprolyl isomerase 0.0032 0.0972 0.7096
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3704 0.3704
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0039 0.1308 0.2386
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0421 0.0482
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1308 0.3387
Mycobacterium tuberculosis Conserved hypothetical protein 0.0039 0.1308 0.2912
Schistosoma mansoni thyroid hormone receptor 0.002 0.0421 0.0768
Plasmodium falciparum glutathione reductase 0.0014 0.0155 0.0592
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0155 0.0205
Echinococcus granulosus expressed protein 0.0032 0.1007 0.1837
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0091 0.3704 1
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0421 0.0768
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.1007 0.1154
Plasmodium vivax casein kinase II beta chain, putative 0.0035 0.1145 0.8468
Trypanosoma cruzi polo-like protein kinase, putative 0.0091 0.3704 1
Onchocerca volvulus Casein kinase II subunit beta homolog 0.0035 0.1145 0.0755
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0421 0.0768
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.057 0.3898
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0014 0.0155 0.0205
Trypanosoma brucei unspecified product 0.0027 0.0756 0.1863
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0035 0.1145 0.3089
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0023 0.057 1
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.057 0.399
Schistosoma mansoni casein kinase II beta subunit 0.0035 0.1145 0.2087
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0014 0.0155 0.0592
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0035 0.1145 0.2936
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.01 0.4114 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.4171 0.4779
Entamoeba histolytica transcription factor BTF3, putative 0.0034 0.1086 0.2932
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0421 0.0482
Brugia malayi glutathione reductase 0.004 0.1337 0.1532
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0998 0.1143
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0014 0.0155 0.0592
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0155 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1308 0.3387
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0421 0.0768
Toxoplasma gondii NADPH-glutathione reductase 0.0014 0.0155 0.0592
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.1596 0.1595
Onchocerca volvulus 0.0029 0.0848 0.0446
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.3654 0.8837
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0032 0.0972 0.2623
Brugia malayi serine/threonine-protein kinase plk-2 0.0091 0.3704 0.4244
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0421 0.0768
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.1145 0.1144
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0421 0.0482
Schistosoma mansoni tar DNA-binding protein 0.013 0.5483 1
Plasmodium falciparum thioredoxin reductase 0.0014 0.0155 0.0592
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.3654 0.8837
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.1337 0.2985
Brugia malayi Pre-SET motif family protein 0.0029 0.0848 0.0972
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0421 0.0482
Plasmodium falciparum casein kinase II beta chain 0.0035 0.1145 0.8468
Schistosoma mansoni transient receptor potential channel 0.007 0.2731 0.4981
Schistosoma mansoni tar DNA-binding protein 0.013 0.5483 1
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3704 0.3704
Echinococcus multilocularis transcription factor btf3 0.0034 0.1086 0.1981
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.1145 0.1144
Loa Loa (eye worm) MH2 domain-containing protein 0.0121 0.507 0.5808
Loa Loa (eye worm) RNA binding protein 0.013 0.5483 0.6282
Trichomonas vaginalis conserved hypothetical protein 0.0034 0.1086 0.1086
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0014 0.0155 0.0205
Schistosoma mansoni thyroid hormone receptor 0.002 0.0421 0.0768
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.1007 0.1154
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.057 0.1351
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.3654 0.8701
Echinococcus multilocularis dna polymerase kappa 0.0039 0.1308 0.2386
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.1308 0.3387
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0014 0.0155 0.0178
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0421 0.0482
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.4171 0.4779
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1308 0.3387
Brugia malayi ecdysteroid receptor 0.002 0.0421 0.0482
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0421 0.0768
Trypanosoma brucei polo-like protein kinase 0.0091 0.3704 1
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.057 0.1351
Trypanosoma brucei DNA polymerase eta, putative 0.0064 0.2434 0.6495
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0023 0.057 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.057 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1547 0.282
Loa Loa (eye worm) hypothetical protein 0.0081 0.3233 0.3704
Loa Loa (eye worm) hypothetical protein 0.0012 0.0081 0.0093
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3704 0.3704
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.013 0.5483 0.6282
Echinococcus multilocularis GPCR, family 2 0.0032 0.0998 0.1819
Brugia malayi polk-prov protein 0.0012 0.0081 0.0093
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1547 0.282
Schistosoma mansoni coup transcription factor 0.002 0.0421 0.0768
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0998 0.1143
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0029 0.0848 0.6108
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0039 0.1308 0.2912
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3704 0.3704
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0014 0.0155 0.0606
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0421 0.0482
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.1547 0.282
Schistosoma mansoni rotamase 0.0032 0.1007 0.1837
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0091 0.3704 0.4244
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.1308 0.3387
Schistosoma mansoni kinase 0.0046 0.1651 0.301
Brugia malayi Thioredoxin reductase 0.004 0.1337 0.1532
Loa Loa (eye worm) hypothetical protein 0.002 0.0421 0.0482
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0756 0.1863
Trypanosoma cruzi transcription factor btf3, putative 0.0034 0.1086 0.2775
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.1145 0.1144
Loa Loa (eye worm) hypothetical protein 0.0039 0.1329 0.1523
Brugia malayi ImpB/MucB/SamB family protein 0.0064 0.2434 0.2789
Plasmodium falciparum casein kinase II beta chain 0.0035 0.1145 0.8468
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0421 0.0768
Trypanosoma brucei unspecified product 0.0027 0.0756 0.1863
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.3233 0.5897
Loa Loa (eye worm) hypothetical protein 0.002 0.0421 0.0482
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.1145 0.1144
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0014 0.0155 0.0205
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.1308 0.3387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0848 0.1547
Giardia lamblia DNA damage repair protein 0.0012 0.0081 0.0217
Toxoplasma gondii ck2 beta subunit 0.0035 0.1145 0.8468
Echinococcus granulosus tar DNA binding protein 0.013 0.5483 1
Plasmodium vivax glutathione reductase, putative 0.004 0.1337 1
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0039 0.1308 0.3387
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.1145 0.1144
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.1007 0.1007
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0421 0.0768
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.1547 0.1772
Loa Loa (eye worm) hypothetical protein 0.002 0.0421 0.0482
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.3654 0.8837
Brugia malayi RNA recognition motif domain containing protein 0.013 0.5483 0.6282
Schistosoma mansoni transient receptor potential channel 4 0.0106 0.437 0.797
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0421 0.0768
Echinococcus granulosus transcription factor btf3 0.0034 0.1086 0.1981
Trypanosoma brucei unspecified product 0.0039 0.1308 0.3387
Trichomonas vaginalis CAMK family protein kinase 0.0091 0.3704 0.3704
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0421 0.0482
Trypanosoma brucei Casein kinase II subunit beta, putative 0.0035 0.1145 0.2936
Schistosoma mansoni DNA polymerase eta 0.0064 0.2434 0.4439
Echinococcus granulosus histone lysine methyltransferase setb 0.0029 0.0848 0.1547
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0421 0.0482
Loa Loa (eye worm) hypothetical protein 0.0036 0.1168 0.1338
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.3654 0.8837
Trichomonas vaginalis rotamase, putative 0.0032 0.0972 0.0972
Toxoplasma gondii casein kinase ii regulatory subunit protein 0.0035 0.1145 0.8468
Loa Loa (eye worm) TAR-binding protein 0.013 0.5483 0.6282
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.2702 0.3096
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0155 0.0205
Echinococcus granulosus casein kinase ii subunit beta 0.0035 0.1145 0.2087
Giardia lamblia NADH oxidase lateral transfer candidate 0.0014 0.0155 0.0417
Echinococcus multilocularis transient receptor potential ion channel A 0.0102 0.4209 0.7676
Brugia malayi steroid hormone receptor 0.002 0.0421 0.0482
Echinococcus multilocularis expressed protein 0.0032 0.1007 0.1837
Schistosoma mansoni serine/threonine protein kinase 0.0091 0.3704 0.6756
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0014 0.0155 0.0283
Trichomonas vaginalis DNA polymerase eta, putative 0.0039 0.1308 0.1308
Onchocerca volvulus Serine\/threonine kinase homolog 0.0091 0.3704 0.3427
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.057 0.3898
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0014 0.0155 0.0205
Schistosoma mansoni transcription factor btf3 0.0034 0.1086 0.1981
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.1361 0.2482
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0756 0.1863
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0421 0.0768
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.1145 0.1144
Trypanosoma cruzi DNA polymerase kappa, putative 0.0039 0.1308 0.3387
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.3233 0.3704
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0014 0.0155 0.0283
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0421 0.0768
Echinococcus multilocularis short transient receptor potential channel 6 0.007 0.2731 0.4981
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0421 0.0768
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.057 0.399
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0032 0.0972 0.246
Trypanosoma cruzi Casein kinase II subunit beta, putative 0.0035 0.1145 0.2936
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.057 0.3898
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.1145 0.1144
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.4171 0.4779
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0039 0.1308 0.2386
Echinococcus multilocularis casein kinase ii subunit beta 0.0035 0.1145 0.2087
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.01 0.4114 1
Loa Loa (eye worm) Csnk2b protein 0.0035 0.1145 0.1311
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.1361 0.2482
Echinococcus granulosus FTZ F1 alpha 0.002 0.0421 0.0768
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0421 0.0482
Trypanosoma brucei DNA polymerase IV, putative 0.0039 0.1308 0.3387
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0039 0.1329 0.2424
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0029 0.0848 0.1547
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0421 0.0482
Trypanosoma brucei DNA polymerase kappa, putative 0.0027 0.0756 0.1863
Leishmania major basic transcription factor 3a, putative 0.0034 0.1086 0.2775
Trichomonas vaginalis set domain proteins, putative 0.0229 1 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1308 0.3387
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0029 0.0848 0.1547
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0421 0.0482
Trypanosoma cruzi trypanothione reductase, putative 0.0014 0.0155 0.0205
Brugia malayi MH2 domain containing protein 0.0121 0.507 0.5808
Plasmodium vivax SET domain protein, putative 0.0029 0.0848 0.6108
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0421 0.0768
Plasmodium falciparum glutathione reductase 0.004 0.1337 1
Mycobacterium ulcerans DNA polymerase IV 0.0039 0.1308 1
Mycobacterium tuberculosis Probable oxidoreductase 0.01 0.4114 1
Entamoeba histolytica deoxycytidyl transferase, putative 0.0039 0.1308 0.353
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0421 0.0482
Echinococcus granulosus transient receptor potential gamma protein 0.0106 0.437 0.797
Brugia malayi beta-NAC-like protein 0.0034 0.1086 0.1245
Loa Loa (eye worm) hypothetical protein 0.0032 0.0998 0.1143
Loa Loa (eye worm) hypothetical protein 0.0029 0.0848 0.0972
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0014 0.0155 0.0205
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0421 0.0768
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.1337 0.3467
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.1547 0.282
Plasmodium vivax thioredoxin reductase, putative 0.004 0.1337 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0421 0.0482
Loa Loa (eye worm) hypothetical protein 0.002 0.0421 0.0482
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.057 0.3898
Echinococcus granulosus dna polymerase kappa 0.0039 0.1308 0.2386
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.1145 0.1144
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0972 0.246
Echinococcus multilocularis transient receptor potential gamma protein 0.0106 0.437 0.797
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0035 0.1145 0.3089
Entamoeba histolytica hypothetical protein 0.0034 0.1086 0.2932
Schistosoma mansoni hypothetical protein 0.0069 0.2702 0.4928
Entamoeba histolytica casein kinase II regulatory subunit family protein 0.0035 0.1145 0.3089
Echinococcus multilocularis tar DNA binding protein 0.013 0.5483 1
Echinococcus granulosus transient receptor potential ion channel A 0.0102 0.4209 0.7676
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0421 0.0768
Brugia malayi RNA binding protein 0.013 0.5483 0.6282
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0421 0.0768
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.1145 0.1144
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0039 0.1308 0.1499
Loa Loa (eye worm) ICD-1 protein 0.0034 0.1086 0.1245
Schistosoma mansoni tar DNA-binding protein 0.013 0.5483 1
Schistosoma mansoni hypothetical protein 0.0032 0.0998 0.1819
Loa Loa (eye worm) hypothetical protein 0.0069 0.2702 0.3096
Trypanosoma brucei transcription factor BTF3, putative 0.0034 0.1086 0.2775
Entamoeba histolytica serine/threonine protein kinase, putative 0.0091 0.3704 1
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.1145 0.1144
Leishmania major protein kinase ck2 regulatory subunit, putative 0.0035 0.1145 0.2936
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0421 0.0482
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.1145 0.1144
Plasmodium vivax casein kinase II beta chain, putative 0.0035 0.1145 0.8468
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.1547 0.1772
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.1145 0.1144
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0014 0.0155 0.0606
Echinococcus granulosus short transient receptor potential channel 6 0.007 0.2731 0.4981
Giardia lamblia Casein kinase II beta chain 0.0035 0.1145 0.3089
Trichomonas vaginalis casein kinase II beta chain, putative 0.0035 0.1145 0.1144
Brugia malayi Pre-SET motif family protein 0.0201 0.8729 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1308 0.3387
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0421 0.0482
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.01 0.4114 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1308 0.3387
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0091 0.3704 0.6756
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0998 0.1819
Trichomonas vaginalis rotamase, putative 0.0032 0.1007 0.1007
Plasmodium falciparum thioredoxin reductase 0.004 0.1337 1
Trypanosoma cruzi DNA polymerase eta, putative 0.0064 0.2434 0.6495
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0421 0.0482
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0014 0.0155 0.0592
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0421 0.0482
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0039 0.1308 0.2386
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0421 0.0482
Echinococcus multilocularis dna polymerase eta 0.0064 0.2434 0.4439
Onchocerca volvulus 0.0081 0.3233 0.2936
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0421 0.0768
Echinococcus granulosus dna polymerase eta 0.0064 0.2434 0.4439
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0421 0.0768
Loa Loa (eye worm) hypothetical protein 0.0102 0.4171 0.4779
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0014 0.0155 0.0205
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1308 0.3387
Trypanosoma brucei DNA polymerase kappa, putative 0.0039 0.1308 0.3387

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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