Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | transcription factor LCR-F1 | 0.0113 | 0.299 | 0.3587 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0047 | 0.0888 | 0.0888 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.299 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0057 | 0.1214 | 0.1214 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0113 | 0.299 | 1 |
Schistosoma mansoni | glutaminase | 0.0282 | 0.8335 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0893 | 0.2985 |
Schistosoma mansoni | hypothetical protein | 0.0113 | 0.299 | 0.3587 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0047 | 0.0893 | 0.1071 |
Loa Loa (eye worm) | glutaminase 2 | 0.0282 | 0.8335 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Brugia malayi | glutaminase DH11.1 | 0.0282 | 0.8335 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0047 | 0.0888 | 0.0888 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0.1107 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0893 | 0.1071 |
Brugia malayi | hypothetical protein | 0.0113 | 0.299 | 0.3587 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0334 | 1 | 1 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0158 | 0.4415 | 0.4415 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0334 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0176 | 0.4982 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.299 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0893 | 0.1071 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0113 | 0.299 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | glutaminase | 0.0282 | 0.8335 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | glutaminase, putative | 0.0282 | 0.8335 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0047 | 0.0893 | 0.1071 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0158 | 0.4415 | 0.4415 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0047 | 0.0888 | 0.0888 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0 | 0.5 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0047 | 0.0888 | 0.0888 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0047 | 0.0893 | 0.2985 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0047 | 0.0893 | 0.1071 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0893 | 0.2985 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.299 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0334 | 1 | 1 |
Loa Loa (eye worm) | glutaminase | 0.0282 | 0.8335 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0047 | 0.0893 | 0.2985 |
Mycobacterium ulcerans | hypothetical protein | 0.0176 | 0.4982 | 0.5977 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0158 | 0.4415 | 0.4415 |
Entamoeba histolytica | hypothetical protein | 0.0113 | 0.299 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.