TDR Targets

Basic information

Technical information

TDR Targets ID: 662554
Name: 3-(2-chloro-6-fluorophenyl)-N-[2-(4-chlorophe nyl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide
MW: 393.239 | Formula: C19H15Cl2FN2O2
H donors: 1 H acceptors: 2 LogP: 5.02 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(cc1)CCNC(=O)c1c(C)onc1c1c(F)cccc1Cl
InChi: 1S/C19H15Cl2FN2O2/c1-11-16(18(24-26-11)17-14(21)3-2-4-15(17)22)19(25)23-10-9-12-5-7-13(20)8-6-12/h2-8H,9-10H2,1H3,(H,23,25)
InChiKey: DOUXSSZBGRRNNV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

3-(2-chloro-6-fluoro-phenyl)-N-[2-(4-chlorophenyl)ethyl]-5-methyl-isoxazole-4-carboxamide
3-(2-chloro-6-fluorophenyl)-N-[2-(4-chlorophenyl)ethyl]-5-methyl-4-isoxazolecarboxamide
3-(2-chloro-6-fluoro-phenyl)-N-[2-(4-chlorophenyl)ethyl]-5-methyl-1,2-oxazole-4-carboxamide
ZINC00649575
IVK/9455044
AK-968/41024801

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.295	1
Schistosoma mansoni	hypothetical protein	0.0032	0.0897	0.0868
Brugia malayi	Bromodomain containing protein	0.0038	0.1256	0.1145
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.295	1
Brugia malayi	PAS domain containing protein	0.0054	0.2226	0.2127
Toxoplasma gondii	exonuclease III APE	0.0039	0.1302	0.4716
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.2621	0.2785
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.2621	0.9271
Trypanosoma cruzi	major cysteine proteinase, putative	0.0052	0.2088	0.695
Loa Loa (eye worm)	cytochrome P450	0.002	0.0125	0.0125
Echinococcus granulosus	cytochrome P450 2K1	0.002	0.0125	0.001
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0181	0.0181
Schistosoma mansoni	hypothetical protein	0.0032	0.0897	0.0868
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0032	0.0897	0.0782
Brugia malayi	hypothetical protein	0.0074	0.3446	0.3363
Trypanosoma cruzi	cytochrome P450, putative	0.0029	0.072	0.2105
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0032	0.0897	0.0868
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0297	0.0201
Leishmania major	cathepsin L-like protease	0.0066	0.295	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.295	1
Brugia malayi	Bromodomain containing protein	0.0074	0.3491	0.3408
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.295	1
Loa Loa (eye worm)	hypothetical protein	0.018	1	1
Trypanosoma cruzi	cytochrome P450, putative	0.0029	0.072	0.2105
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0032	0.0897	0.0868
Schistosoma mansoni	hypothetical protein	0.002	0.0125	0.001
Schistosoma mansoni	hypothetical protein	0.0032	0.0897	0.0868
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0032	0.0897	0.0868
Echinococcus multilocularis	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0063	0.2818	0.3004
Brugia malayi	Cytochrome P450 family protein	0.0029	0.072	0.0602
Mycobacterium leprae	putative cytochrome p450	0.002	0.0125	0.5
Echinococcus granulosus	geminin	0.0166	0.9109	1
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.1302	0.5
Loa Loa (eye worm)	hypothetical protein	0.0042	0.1521	0.1521
Mycobacterium leprae	Conserved hypothetical protein	0.002	0.0125	0.5
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.2818	1
Brugia malayi	Cytochrome P450 family protein	0.0062	0.2715	0.2623
Entamoeba histolytica	hypothetical protein	0.0074	0.3446	1
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0897	0.0897
Brugia malayi	bHLH-PAS transcription factor	0.004	0.1368	0.1258
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.295	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0102	0.516	0.516
Schistosoma mansoni	hypothetical protein	0.0069	0.3187	0.3414
Brugia malayi	latrophilin 2 splice variant baaae	0.0069	0.3187	0.31
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.295	1
Leishmania major	apurinic/apyrimidinic endonuclease-redox protein	0.0039	0.1302	0.4167
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0032	0.0897	0.0897
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease	0.0039	0.1302	0.4167
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.295	1
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0297	0.0201
Brugia malayi	PHD-finger family protein	0.0025	0.0441	0.032
Leishmania major	cytochrome p450-like protein	0.0029	0.072	0.2105
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.006	0.2621	0.2785
Loa Loa (eye worm)	CYP4Cod1	0.0029	0.072	0.072
Echinococcus multilocularis	DNA (apurinic or apyrimidinic site) lyase	0.0039	0.1302	0.1319
Schistosoma mansoni	aldehyde dehydrogenase	0.006	0.2621	0.2785
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0039	0.1302	0.5
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0039	0.1302	0.5
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.295	1
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0074	0.3446	0.3703
Schistosoma mansoni	hypothetical protein	0.0166	0.9109	1
Schistosoma mansoni	hypothetical protein	0.0074	0.3446	0.3703
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.295	1
Leishmania major	cathepsin L-like protease	0.0066	0.295	1
Mycobacterium ulcerans	cytochrome P450 185A4 Cyp185A4	0.0029	0.072	0.2208
Echinococcus multilocularis	GPCR, family 2	0.0032	0.0897	0.0868
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0059	0.2559	0.2716
Schistosoma mansoni	single-minded	0.0054	0.2226	0.2346
Loa Loa (eye worm)	hypoxia-induced factor 1	0.0166	0.9142	0.9142
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0297	0.0201
Mycobacterium tuberculosis	Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI)	0.0039	0.1302	0.4372
Brugia malayi	Latrophilin receptor protein 2	0.0032	0.0897	0.0782
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.006	0.2621	0.8838
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0074	0.3446	0.3703
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.295	1
Loa Loa (eye worm)	hypothetical protein	0.0102	0.516	0.516
Schistosoma mansoni	hypothetical protein	0.0166	0.9109	1
Mycobacterium tuberculosis	Probable short-chain type dehydrogenase/reductase	0.0063	0.2818	1
Plasmodium vivax	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.1302	0.5
Trypanosoma brucei	apurinic/apyrimidinic endonuclease, putative	0.0039	0.1302	0.4167
Leishmania major	cathepsin L-like protease	0.0066	0.295	1
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.006	0.2621	0.9271
Brugia malayi	exodeoxyribonuclease III family protein	0.0039	0.1302	0.1192
Loa Loa (eye worm)	hypothetical protein	0.004	0.1405	0.1405
Loa Loa (eye worm)	exodeoxyribonuclease III family protein	0.0039	0.1302	0.1302
Brugia malayi	3-hydroxyacyl-CoA dehydrogenase type II	0.0063	0.2818	0.2726
Loa Loa (eye worm)	3-hydroxyacyl-CoA dehydrogenase type II	0.0059	0.2555	0.2555
Mycobacterium ulcerans	short-chain type dehydrogenase/reductase	0.0063	0.2818	1
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0039	0.1302	0.5
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0102	0.516	0.5098
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.072	0.072
Trypanosoma cruzi	cysteine peptidase, putative	0.0066	0.295	1
Toxoplasma gondii	aldehyde dehydrogenase	0.006	0.2621	1
Echinococcus granulosus	DNA apurinic or apyrimidinic site lyase	0.0039	0.1302	0.1319
Schistosoma mansoni	hypothetical protein	0.0032	0.0897	0.0868
Schistosoma mansoni	cytochrome P450	0.002	0.0125	0.001
Echinococcus multilocularis	transfer RNA-Lys	0.004	0.1368	0.1392
Loa Loa (eye worm)	hypothetical protein	0.0038	0.126	0.126
Trypanosoma brucei	cytochrome P450, putative	0.0029	0.072	0.2105
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0036	0.1112	0.1107
Loa Loa (eye worm)	cytochrome P450 family protein	0.0062	0.2715	0.2715
Trypanosoma cruzi	cysteine peptidase, clan CA, family C1, cathepsin L-like, putative	0.006	0.26	0.8763
Mycobacterium ulcerans	exodeoxyribonuclease III protein XthA	0.0039	0.1302	0.4372
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0036	0.1112	0.1107
Schistosoma mansoni	ap endonuclease	0.0039	0.1302	0.1319
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.295	1
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.295	1
Brugia malayi	Cytochrome P450 family protein	0.0029	0.072	0.0602
Echinococcus granulosus	single minded 2	0.004	0.1368	0.1392
Schistosoma mansoni	3-hydroxyacyl-CoA dehydrogenase	0.0063	0.2818	0.3004
Schistosoma mansoni	ap endonuclease	0.0039	0.1302	0.1319
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.006	0.2621	0.2785
Brugia malayi	hypoxia-induced factor 1	0.0166	0.9142	0.9131
Schistosoma mansoni	transcription factor LCR-F1	0.0074	0.3446	0.3703
Echinococcus multilocularis	geminin	0.0166	0.9109	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.2621	0.9271
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0039	0.1302	0.5
Mycobacterium ulcerans	putative regulatory protein	0.004	0.1368	0.4615
Entamoeba histolytica	hypothetical protein	0.0074	0.3446	1
Entamoeba histolytica	hypothetical protein	0.0074	0.3446	1
Trypanosoma cruzi	apurinic/apyrimidinic endonuclease, putative	0.0039	0.1302	0.4167
Echinococcus multilocularis		0.002	0.0125	0.001
Leishmania major	3-oxoacyl-(acyl-carrier protein) reductase, putative	0.0063	0.2818	0.9532
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0059	0.2559	0.2716
Echinococcus granulosus	GPCR family 2	0.0032	0.0897	0.0868
Echinococcus granulosus	3 hydroxyacyl coenzyme A dehydrogenase type 2	0.0063	0.2818	0.3004
Schistosoma mansoni	bromodomain containing protein	0.0063	0.2777	0.2959
Trypanosoma cruzi	cruzipain precursor, putative	0.0066	0.295	1
Loa Loa (eye worm)	hypothetical protein	0.0069	0.3187	0.3187
Onchocerca volvulus		0.004	0.1368	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0102	0.516	0.5098
Trypanosoma brucei	cysteine peptidase, Clan CA, family C1, Cathepsin L-like	0.0066	0.295	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.006	0.2621	0.9271
Schistosoma mansoni	aryl hydrocarbon receptor	0.0054	0.2226	0.2346
Entamoeba histolytica	hypothetical protein	0.0074	0.3446	1
Schistosoma mansoni	hypothetical protein	0.002	0.0181	0.0072
Loa Loa (eye worm)	hypothetical protein	0.007	0.323	0.323
Trichomonas vaginalis	ap endonuclease, putative	0.0039	0.1302	0.5
Loa Loa (eye worm)	cytochrome P450 family protein	0.0029	0.072	0.072
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0032	0.0897	0.0868

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

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Bibliographic References

No literature references available for this target.

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Detailed information for compound 662554