Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0 | 0.5 |
Plasmodium vivax | sentrin-specific protease 1, putative | 0.0046 | 0.5783 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 1 | 1 |
Echinococcus multilocularis | sentrin specific protease 1 | 0.0046 | 0.5783 | 0.5783 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 1 | 1 |
Brugia malayi | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0046 | 0.5783 | 0.5783 |
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 1 | 1 |
Plasmodium falciparum | sentrin-specific protease 1 | 0.0046 | 0.5783 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.5783 | 0.5783 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0046 | 0.5783 | 0.5783 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0066 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 1 | 1 |
Trichomonas vaginalis | Clan CE, family C48, Ulp1-like cysteine peptidase | 0.0046 | 0.5783 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 1 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0066 | 1 | 1 |
Schistosoma mansoni | family C48 unassigned peptidase (C48 family) | 0.0046 | 0.5783 | 0.5783 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0 | 0.5 |
Toxoplasma gondii | Ulp1 protease family, C-terminal catalytic domain-containing protein | 0.0046 | 0.5783 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0 | 0.5 |
Echinococcus granulosus | sentrin specific protease 1 | 0.0046 | 0.5783 | 0.5783 |
Entamoeba histolytica | Ulp1 protease family, C-terminal catalytic domain containing protein | 0.0046 | 0.5783 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0066 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.