Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0137 | 0.0168 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.0258 | 0.0316 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0258 | 0.0891 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0258 | 0.0891 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.0258 | 0.0891 |
Echinococcus granulosus | lamin | 0.0029 | 0.0825 | 0.2855 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0258 | 0.0891 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.1178 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0066 | 0.2421 | 0.2973 |
Echinococcus multilocularis | cytoplasmic intermediate filament protein | 0.0014 | 0.0161 | 0.0555 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.109 | 0.3771 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0037 | 0.1178 | 0.1446 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2421 | 0.8375 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0037 | 0.1178 | 0.4074 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.1178 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0825 | 0.1014 |
Schistosoma mansoni | lamin | 0.0029 | 0.0825 | 0.2855 |
Loa Loa (eye worm) | hypothetical protein | 0.0196 | 0.8142 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.109 | 0.1339 |
Loa Loa (eye worm) | TAR-binding protein | 0.0066 | 0.2421 | 0.2973 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.1178 | 0.4074 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.1178 | 0.5 |
Echinococcus granulosus | tar DNA binding protein | 0.0066 | 0.2421 | 0.8375 |
Echinococcus multilocularis | tar DNA binding protein | 0.0066 | 0.2421 | 0.8375 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1178 | 0.1446 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0076 | 0.289 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.1178 | 0.5 |
Toxoplasma gondii | ABC1 family protein | 0.0037 | 0.1178 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0258 | 0.0891 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0825 | 0.1014 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0825 | 0.1014 |
Schistosoma mansoni | lamin | 0.0029 | 0.0825 | 0.2855 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.0258 | 0.0316 |
Echinococcus multilocularis | lamin dm0 | 0.0029 | 0.0825 | 0.2855 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0137 | 0.0168 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0258 | 0.0891 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.0258 | 0.0891 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0037 | 0.1178 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0037 | 0.1178 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.289 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.289 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.289 | 0.5 |
Brugia malayi | hypothetical protein | 0.0076 | 0.289 | 0.355 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.289 | 1 |
Brugia malayi | TAR-binding protein | 0.0066 | 0.2421 | 0.2973 |
Loa Loa (eye worm) | beta-lactamase | 0.0037 | 0.1178 | 0.1446 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.0258 | 0.0891 |
Onchocerca volvulus | 0.0029 | 0.0825 | 0.1014 | |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1178 | 0.1446 |
Brugia malayi | RNA binding protein | 0.0066 | 0.2421 | 0.2973 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.1178 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2421 | 0.8375 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0037 | 0.1178 | 0.5 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0825 | 0.1014 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1178 | 0.1446 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.0258 | 0.0891 |
Mycobacterium ulcerans | beta-lactamase | 0.0037 | 0.1178 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.0258 | 0.0891 |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.1178 | 0.1446 |
Onchocerca volvulus | 0.0037 | 0.1178 | 0.1446 | |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1807 | 0.222 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2421 | 0.8375 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0037 | 0.1178 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1178 | 0.1446 |
Onchocerca volvulus | 0.0029 | 0.0825 | 0.1014 | |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.0258 | 0.0316 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2421 | 0.8375 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.109 | 0.1339 |
Echinococcus granulosus | lamin dm0 | 0.0029 | 0.0825 | 0.2855 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0037 | 0.1178 | 0.4074 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1807 | 0.222 |
Echinococcus multilocularis | lamin | 0.0029 | 0.0825 | 0.2855 |
Trichomonas vaginalis | esterase, putative | 0.0037 | 0.1178 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0066 | 0.2421 | 0.8375 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0037 | 0.1178 | 0.1446 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1178 | 0.1446 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0825 | 0.1014 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0037 | 0.1178 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0037 | 0.1178 | 0.5 |
Mycobacterium leprae | conserved hypothetical protein | 0.0037 | 0.1178 | 0.5 |
Brugia malayi | cytoplasmic intermediate filament protein | 0.0016 | 0.0229 | 0.0281 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0037 | 0.1178 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.0258 | 0.0316 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0076 | 0.289 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1807 | 0.222 |
Echinococcus granulosus | intermediate filament protein | 0.0029 | 0.0825 | 0.2855 |
Brugia malayi | N-terminal motif family protein | 0.0196 | 0.8142 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0076 | 0.289 | 0.5 |
Echinococcus multilocularis | musashi | 0.0029 | 0.0825 | 0.2855 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0066 | 0.2421 | 0.2973 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1807 | 0.222 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0037 | 0.1178 | 0.4074 |
Schistosoma mansoni | intermediate filament proteins | 0.0029 | 0.0825 | 0.2855 |
Loa Loa (eye worm) | RNA binding protein | 0.0066 | 0.2421 | 0.2973 |
Onchocerca volvulus | Rap guanine nucleotide exchange factor 1 homolog | 0.0196 | 0.8142 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0016 | 0.0229 | 0.0281 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0161 | 0.0197 |
Onchocerca volvulus | 0.0037 | 0.1178 | 0.1446 | |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0037 | 0.1178 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0037 | 0.1178 | 0.5 |
Onchocerca volvulus | 0.0037 | 0.1178 | 0.1446 | |
Brugia malayi | beta-lactamase family protein | 0.0037 | 0.1178 | 0.1446 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.1178 | 0.1446 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 0.1178 | 0.5 |
Echinococcus granulosus | cytoplasmic intermediate filament protein | 0.0014 | 0.0161 | 0.0555 |
Brugia malayi | beta-lactamase | 0.0037 | 0.1178 | 0.1446 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0802 | 0.0985 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0076 | 0.289 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.