Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | hydroxyacylglutathione hydrolase | 0.0079 | 0.301 | 1 |
Echinococcus granulosus | hydroxyacylglutathione hydrolase | 0.0079 | 0.301 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0871 | 0.2893 |
Leishmania major | hydroxyacylglutathione hydrolase, putative,glyoxalase II, putative | 0.0079 | 0.301 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.003 | 0.0871 | 0.2893 |
Echinococcus granulosus | GPCR family 2 | 0.0016 | 0.025 | 0.083 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.005 | 0.1753 | 0.2007 |
Brugia malayi | hypothetical protein | 0.0079 | 0.301 | 0.3447 |
Mycobacterium leprae | conserved hypothetical protein | 0.0079 | 0.301 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0029 | 0.0822 | 0.2732 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0034 | 0.1057 | 0.1211 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.003 | 0.0871 | 0.2893 |
Brugia malayi | metallo-beta-lactamase superfamily protein | 0.0079 | 0.301 | 0.3447 |
Leishmania major | hypothetical protein, conserved | 0.0079 | 0.301 | 0.5 |
Trypanosoma cruzi | metallo-beta-lactamase-like protein, putative | 0.0079 | 0.301 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0016 | 0.025 | 0.0286 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.301 | 1 |
Trypanosoma brucei | metallo-beta-lactamase-like protein, putative | 0.0079 | 0.301 | 0.5 |
Echinococcus granulosus | metallo beta lactamase domain containing protein | 0.0079 | 0.301 | 1 |
Treponema pallidum | ribonuclease Z | 0.0079 | 0.301 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0016 | 0.025 | 0.083 |
Onchocerca volvulus | Putative hydrolase PNKD | 0.0079 | 0.301 | 0.301 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.025 | 0.083 |
Mycobacterium ulcerans | hypothetical protein | 0.0079 | 0.301 | 0.5 |
Echinococcus granulosus | metallo beta lactamase domain containing protein | 0.0079 | 0.301 | 1 |
Mycobacterium tuberculosis | Possible hydrolase | 0.0079 | 0.301 | 0.5 |
Trypanosoma cruzi | hydroxyacylglutathione hydrolase, putative | 0.0079 | 0.301 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0079 | 0.301 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0238 | 1 | 1 |
Plasmodium falciparum | cytosolic glyoxalase II | 0.0079 | 0.301 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0871 | 0.2893 |
Plasmodium vivax | hydroxyacyl glutathione hydrolase, putative | 0.0079 | 0.301 | 1 |
Echinococcus multilocularis | metallo beta lactamase domain containing protein | 0.0079 | 0.301 | 1 |
Toxoplasma gondii | hydroxyacylglutathione hydrolase | 0.0079 | 0.301 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.025 | 0.083 |
Mycobacterium ulcerans | hypothetical protein | 0.0079 | 0.301 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.301 | 0.3447 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.301 | 1 |
Trypanosoma cruzi | glyoxalase II | 0.0079 | 0.301 | 0.5 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.003 | 0.0871 | 0.2893 |
Mycobacterium leprae | Beta-lactamase-like protein | 0.0079 | 0.301 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.1057 | 0.1211 |
Mycobacterium tuberculosis | Conserved protein | 0.0079 | 0.301 | 0.5 |
Trypanosoma brucei | cleavage and polyadenylation specificity factor subunit, putative | 0.0079 | 0.301 | 0.5 |
Onchocerca volvulus | 0.0079 | 0.301 | 0.301 | |
Echinococcus granulosus | zinc phosphodiesterase | 0.0079 | 0.301 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.003 | 0.0871 | 0.0997 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.005 | 0.1753 | 0.2007 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0871 | 0.0997 |
Mycobacterium tuberculosis | Possible hydrolase | 0.0079 | 0.301 | 0.5 |
Trypanosoma cruzi | metallo-beta-lactamase-like protein, putative | 0.0079 | 0.301 | 0.5 |
Brugia malayi | HSF-type DNA-binding domain containing protein | 0.01 | 0.3927 | 0.4497 |
Entamoeba histolytica | heat shock transcription factor, putative | 0.01 | 0.3927 | 1 |
Entamoeba histolytica | heat shock transcription factor, putative | 0.01 | 0.3927 | 1 |
Entamoeba histolytica | heat shock transcription factor, putative | 0.01 | 0.3927 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.025 | 0.083 |
Onchocerca volvulus | Heat shock factor protein 2 homolog | 0.01 | 0.3927 | 0.3927 |
Echinococcus multilocularis | metallo beta lactamase domain containing protein | 0.0079 | 0.301 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0079 | 0.301 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.301 | 0.3447 |
Trypanosoma brucei | glyoxalase II | 0.0079 | 0.301 | 0.5 |
Mycobacterium ulcerans | Zn-dependent glyoxylase | 0.0079 | 0.301 | 0.5 |
Schistosoma mansoni | hydroxyacylglutathione hydrolase (Glyoxalase II) (Glx II) | 0.0079 | 0.301 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0079 | 0.301 | 0.5 |
Echinococcus granulosus | ETHE1 protein | 0.0079 | 0.301 | 1 |
Mycobacterium ulcerans | hydrolase | 0.0079 | 0.301 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 0.025 | 0.0286 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0079 | 0.301 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0079 | 0.301 | 0.5 |
Brugia malayi | Chain A, Human Glyoxalase Ii With Cacodylate And Acetate Ions Present In The Active Site. | 0.0079 | 0.301 | 0.3447 |
Mycobacterium tuberculosis | Conserved protein | 0.0079 | 0.301 | 0.5 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.025 | 0.083 |
Plasmodium vivax | unspecified product | 0.0079 | 0.301 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1753 | 0.2007 |
Trypanosoma cruzi | hydroxyacylglutathione hydrolase, putative | 0.0079 | 0.301 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.301 | 0.3447 |
Giardia lamblia | Hydroxyacylglutathione hydrolase | 0.0079 | 0.301 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0079 | 0.301 | 0.5 |
Trypanosoma cruzi | metallo-beta-lactamase superfamily, putative | 0.0079 | 0.301 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0079 | 0.301 | 0.5 |
Leishmania major | cleavage and polyadenylation specificity factor, putative | 0.0079 | 0.301 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.025 | 0.083 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0016 | 0.025 | 0.083 |
Brugia malayi | metallo-beta-lactamase superfamily protein | 0.0079 | 0.301 | 0.3447 |
Giardia lamblia | Metallo-beta-lactamase superfamily protein | 0.0079 | 0.301 | 0.5 |
Echinococcus multilocularis | zinc phosphodiesterase | 0.0079 | 0.301 | 1 |
Trypanosoma cruzi | glyoxalase II | 0.0079 | 0.301 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | metallo-beta-lactamase superfamily hydrolase | 0.0079 | 0.301 | 0.5 |
Schistosoma mansoni | zinc phosphodiesterase | 0.0079 | 0.301 | 1 |
Loa Loa (eye worm) | hydroxyacylglutathione hydrolase cytoplasmic | 0.0079 | 0.301 | 0.3447 |
Schistosoma mansoni | zinc phosphodiesterase | 0.0079 | 0.301 | 1 |
Giardia lamblia | Hydroxyacylglutathione hydrolase | 0.0079 | 0.301 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0016 | 0.025 | 0.0286 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0016 | 0.025 | 0.0286 |
Trypanosoma brucei | hydroxyacylglutathione hydrolase, putative | 0.0079 | 0.301 | 0.5 |
Leishmania major | metallo-beta-lactamase family-like protein | 0.0079 | 0.301 | 0.5 |
Leishmania major | metallo-beta-lactamase family protein-like protein | 0.0079 | 0.301 | 0.5 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0016 | 0.025 | 0.083 |
Loa Loa (eye worm) | hypothetical protein | 0.0079 | 0.301 | 0.3447 |
Loa Loa (eye worm) | metallo-beta-lactamase superfamily protein | 0.0079 | 0.301 | 0.3447 |
Mycobacterium leprae | conserved hypothetical protein | 0.0079 | 0.301 | 0.5 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.003 | 0.0871 | 0.2893 |
Echinococcus multilocularis | ETHE1 protein | 0.0079 | 0.301 | 1 |
Loa Loa (eye worm) | hydroxyacylglutathione hydrolase | 0.0079 | 0.301 | 0.3447 |
Trypanosoma cruzi | metallo-beta-lactamase superfamily, putative | 0.0079 | 0.301 | 0.5 |
Chlamydia trachomatis | ribonuclease Z | 0.0079 | 0.301 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.1057 | 0.3512 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0209 | 0.8732 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.301 | 1 |
Mycobacterium leprae | POSSIBLE HYDROLASE | 0.0079 | 0.301 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0016 | 0.025 | 0.083 |
Mycobacterium ulcerans | hypothetical protein | 0.0079 | 0.301 | 0.5 |
Mycobacterium ulcerans | beta lactamase-like protein | 0.0079 | 0.301 | 0.5 |
Onchocerca volvulus | 0.003 | 0.0871 | 0.0871 | |
Toxoplasma gondii | metallo-beta-lactamase domain-containing protein | 0.0079 | 0.301 | 1 |
Brugia malayi | ethe1-prov protein | 0.0079 | 0.301 | 0.3447 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.3927 | 0.4497 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.005 | 0.1753 | 0.2007 |
Brugia malayi | Pre-SET motif family protein | 0.0209 | 0.8732 | 1 |
Mycobacterium ulcerans | glyoxalase II, GloB | 0.0079 | 0.301 | 0.5 |
Trypanosoma cruzi | glyoxalase II | 0.0079 | 0.301 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.003 | 0.0871 | 0.2893 |
Onchocerca volvulus | 0.0079 | 0.301 | 0.301 | |
Onchocerca volvulus | Hydroxyacylglutathione hydrolase, mitochondrial homolog | 0.0079 | 0.301 | 0.301 |
Mycobacterium tuberculosis | Beta lactamase like protein | 0.0079 | 0.301 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.