Detailed information for compound 66268

Basic information

Technical information
  • TDR Targets ID: 66268
  • Name: (3-chloro-4-fluorophenyl)-[4-[[[6-(diethylami no)pyridin-2-yl]methylamino]methyl]-4-fluorop iperidin-1-yl]methanone
  • MW: 450.952 | Formula: C23H29ClF2N4O
  • H donors: 1 H acceptors: 2 LogP: 4.05 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(c1cccc(n1)CNCC1(F)CCN(CC1)C(=O)c1ccc(c(c1)Cl)F)CC
  • InChi: 1S/C23H29ClF2N4O/c1-3-29(4-2)21-7-5-6-18(28-21)15-27-16-23(26)10-12-30(13-11-23)22(31)17-8-9-20(25)19(24)14-17/h5-9,14,27H,3-4,10-13,15-16H2,1-2H3
  • InChiKey: UJWLUMAAOUJRIN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3-chloro-4-fluoro-phenyl)-[4-[[[6-(diethylamino)-2-pyridyl]methylamino]methyl]-4-fluoro-1-piperidyl]methanone
  • (3-chloro-4-fluorophenyl)-[4-[[[6-(diethylamino)-2-pyridyl]methylamino]methyl]-4-fluoro-1-piperidinyl]methanone
  • (3-chloro-4-fluoro-phenyl)-[4-[[[6-(diethylamino)pyridin-2-yl]methylamino]methyl]-4-fluoro-piperidin-1-yl]methanone
  • (3-chloro-4-fluoro-phenyl)-[4-[[[6-(diethylamino)-2-pyridyl]methylamino]methyl]-4-fluoro-piperidino]methanone
  • (3-chloro-4-fluorophenyl)-[4-[[(6-diethylaminopyridin-2-yl)methylamino]methyl]-4-fluoropiperidin-1-yl]methanone
  • (3-chloro-4-fluoro-phenyl)-[4-[[(6-diethylamino-2-pyridyl)methylamino]methyl]-4-fluoro-1-piperidyl]methanone
  • (3-chloro-4-fluorophenyl)-[4-[[(6-diethylamino-2-pyridyl)methylamino]methyl]-4-fluoro-1-piperidinyl]methanone
  • (3-chloro-4-fluoro-phenyl)-[4-[[(6-diethylaminopyridin-2-yl)methylamino]methyl]-4-fluoro-piperidin-1-yl]methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi ecdysteroid receptor 0.0092 0.057 0.0796
Loa Loa (eye worm) hypothetical protein 0.0044 0.0187 0.0261
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0092 0.057 0.057
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0213 0.0221
Echinococcus multilocularis FTZ F1 alpha 0.0092 0.057 0.0593
Schistosoma mansoni flap endonuclease-1 0.0024 0.0034 0.0034
Loa Loa (eye worm) RNA binding protein 0.0065 0.0354 0.0494
Brugia malayi TAR-binding protein 0.0065 0.0354 0.0494
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0092 0.057 0.0796
Brugia malayi Nuclear hormone receptor E75 0.0044 0.0187 0.0261
Loa Loa (eye worm) hypothetical protein 0.0092 0.057 0.0796
Brugia malayi orphan nuclear receptor NR2E1 0.0044 0.0187 0.0261
Brugia malayi hypothetical protein 0.0037 0.0134 0.0187
Loa Loa (eye worm) hypothetical protein 0.0092 0.057 0.0796
Giardia lamblia Flap structure-specific endonuclease 0.0027 0.0054 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0065 0.0354 0.0494
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0213 0.0213
Brugia malayi tailless protein 0.0044 0.0187 0.0261
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0092 0.057 0.0796
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0354 0.0354
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0047 0.0066
Trypanosoma brucei DNA polymerase eta, putative 0.0046 0.0205 0.0286
Echinococcus multilocularis nuclear receptor nhr 48 0.0044 0.0187 0.0194
Loa Loa (eye worm) hypothetical protein 0.0049 0.0228 0.0318
Echinococcus granulosus nuclear receptor nhr 48 0.0044 0.0187 0.0187
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0092 0.057 0.0796
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0044 0.0187 0.0261
Loa Loa (eye worm) hypothetical protein 0.0092 0.057 0.0796
Loa Loa (eye worm) hypothetical protein 0.0044 0.0187 0.0261
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0213 0.0213
Brugia malayi nuclear receptor NHR-88 0.0044 0.0187 0.0261
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0092 0.057 0.057
Brugia malayi nuclear receptor NHR-88 0.0092 0.057 0.0796
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0932 0.7161 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0092 0.057 0.0796
Leishmania major flap endonuclease-1 (FEN-1), putative 0.0027 0.0054 0.0076
Schistosoma mansoni nuclear receptor nhr-48 0.0044 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0044 0.0187 0.0261
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0044 0.0187 0.0187
Schistosoma mansoni thyroid hormone receptor 0.0092 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.0092 0.057 0.0796
Mycobacterium ulcerans DNA polymerase IV 0.002 0 0.5
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0354 0.0354
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0092 0.057 0.0796
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0092 0.057 0.0796
Onchocerca volvulus 0.0092 0.057 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0092 0.057 0.0593
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0354 0.0354
Brugia malayi Nuclear hormone receptor-like 1 0.0092 0.057 0.0796
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0932 0.7161 1
Trypanosoma cruzi flap endonuclease-1 (FEN-1), putative 0.0027 0.0054 0.0076
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0092 0.057 0.0593
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0932 0.7161 1
Echinococcus granulosus tar DNA binding protein 0.0065 0.0354 0.0354
Schistosoma mansoni hypothetical protein 0.0173 0.1207 0.1207
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0092 0.057 0.0796
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0049 0.0228 0.0237
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0044 0.0187 0.0194
Trypanosoma cruzi DNA polymerase eta, putative 0.0032 0.0098 0.0137
Echinococcus multilocularis transcription factor Dp 1 0.0539 0.408 0.4242
Loa Loa (eye worm) hypothetical protein 0.0046 0.0205 0.0286
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0092 0.057 0.0593
Plasmodium vivax flap endonuclease 1, putative 0.0027 0.0054 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0092 0.057 0.057
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0092 0.057 0.0796
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0092 0.057 0.0796
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0932 0.7161 1
Brugia malayi ecdysone receptor 0.0044 0.0187 0.0261
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0044 0.0187 0.0187
Echinococcus granulosus geminin 0.0173 0.1207 0.1207
Schistosoma mansoni thyroid hormone receptor 0.0092 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.0044 0.0187 0.0261
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0092 0.057 0.0593
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0047 0.0066
Loa Loa (eye worm) flap endonuclease-1 0.0027 0.0054 0.0076
Echinococcus granulosus flap endonuclease 1 0.0027 0.0054 0.0054
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0092 0.057 0.057
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0049 0.0228 0.0228
Schistosoma mansoni nuclear receptor 0.0044 0.0187 0.0187
Toxoplasma gondii flap structure-specific endonuclease 1, putative 0.0027 0.0054 0.1335
Brugia malayi nuclear hormone receptor family member odr-7 0.0044 0.0187 0.0261
Echinococcus granulosus ecdysone induced protein 78C 0.0092 0.057 0.057
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0092 0.057 0.057
Loa Loa (eye worm) hypothetical protein 0.0044 0.0187 0.0261
Leishmania major DNA polymerase eta, putative 0.0046 0.0205 0.0286
Loa Loa (eye worm) TAR-binding protein 0.0065 0.0354 0.0494
Loa Loa (eye worm) hypothetical protein 0.03 0.22 0.3072
Loa Loa (eye worm) hypothetical protein 0.0044 0.0187 0.0261
Plasmodium falciparum flap endonuclease 1 0.0027 0.0054 1
Brugia malayi nuclear hormone receptor family member nhr-6 0.0044 0.0187 0.0261
Loa Loa (eye worm) hypothetical protein 0.03 0.22 0.3072
Brugia malayi photoreceptor-specific nuclear receptor 0.0092 0.057 0.0796
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0092 0.057 0.0796
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0092 0.057 0.0796
Schistosoma mansoni hypothetical protein 0.0173 0.1207 0.1207
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0932 0.7161 1
Trichomonas vaginalis flap endonuclease-1, putative 0.0027 0.0054 1
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.1244 0.9617 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0092 0.057 1
Brugia malayi hypothetical protein 0.0026 0.0047 0.0066
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0044 0.0187 0.0187
Entamoeba histolytica Flap nuclease, putative 0.0027 0.0054 0.0076
Brugia malayi steroid hormone receptor 0.0092 0.057 0.0796
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0092 0.057 0.0796
Loa Loa (eye worm) hypothetical protein 0.0044 0.0187 0.0261
Echinococcus granulosus dna polymerase eta 0.0046 0.0205 0.0205
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0049 0.0228 0.0228
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0092 0.057 0.057
Brugia malayi hypothetical protein 0.0049 0.0228 0.0318
Echinococcus granulosus Nuclear hormone receptor HR96 0.0044 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0049 0.0228 0.0318
Loa Loa (eye worm) hypothetical protein 0.0044 0.0187 0.0261
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0213 0.0221
Leishmania major DNA polymerase eta, putative 0.0032 0.0098 0.0137
Schistosoma mansoni retinoic acid receptor RXR 0.1293 1 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0049 0.0228 0.0318
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0092 0.057 1
Echinococcus multilocularis serotonin receptor 0.03 0.22 0.2287
Schistosoma mansoni DNA polymerase eta 0.0046 0.0205 0.0205
Onchocerca volvulus Bile acid receptor homolog 0.0092 0.057 1
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0044 0.0187 0.0187
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0092 0.057 0.057
Brugia malayi nuclear receptor NHR-67 0.0044 0.0187 0.0261
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.0228 0.0318
Loa Loa (eye worm) hypothetical protein 0.0049 0.0228 0.0318
Echinococcus multilocularis serotonin receptor 0.03 0.22 0.2287
Entamoeba histolytica hypothetical protein 0.0037 0.0134 0.0187
Trypanosoma brucei flap endonuclease-1 (FEN-1), putative 0.0027 0.0054 0.0076
Loa Loa (eye worm) hypothetical protein 0.0049 0.0228 0.0318
Brugia malayi Nuclear hormone receptor E75 0.0044 0.0187 0.0261
Brugia malayi Nuclear hormone receptor-like 1 0.0049 0.0228 0.0318
Loa Loa (eye worm) hypothetical protein 0.0044 0.0187 0.0261
Entamoeba histolytica hypothetical protein 0.0037 0.0134 0.0187
Echinococcus multilocularis dna polymerase eta 0.0046 0.0205 0.0213
Brugia malayi ImpB/MucB/SamB family protein 0.0046 0.0205 0.0286
Trypanosoma cruzi DNA polymerase eta, putative 0.0046 0.0205 0.0286
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0092 0.057 0.0796
Loa Loa (eye worm) steroid hormone receptor 0.0092 0.057 0.0796
Brugia malayi Flap endonuclease-1 0.0027 0.0054 0.0076
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0092 0.057 0.0593
Loa Loa (eye worm) hypothetical protein 0.0092 0.057 0.0796
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.002 0 0.5
Brugia malayi nuclear hormone receptor 0.0092 0.057 0.0796
Loa Loa (eye worm) hypothetical protein 0.0044 0.0187 0.0261
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0092 0.057 0.057
Echinococcus multilocularis tar DNA binding protein 0.0065 0.0354 0.0368
Loa Loa (eye worm) nuclear receptor NHR-67 0.0044 0.0187 0.0261
Brugia malayi hypothetical protein 0.0049 0.0228 0.0318
Schistosoma mansoni nuclear hormone receptor 0.0092 0.057 0.057
Brugia malayi hypothetical protein 0.0044 0.0187 0.0261
Schistosoma mansoni RAR-like nuclear receptor 0.0092 0.057 0.057
Brugia malayi hypothetical protein 0.0044 0.0187 0.0261
Echinococcus granulosus biogenic amine 5HT receptor 0.03 0.22 0.22
Echinococcus granulosus Nuclear hormone receptor HR96 0.0044 0.0187 0.0187
Brugia malayi conserved hypotetical protein 0.0044 0.0187 0.0261
Brugia malayi nuclear receptor RXR 0.0044 0.0187 0.0261
Loa Loa (eye worm) hypothetical protein 0.0044 0.0187 0.0261
Brugia malayi RNA recognition motif domain containing protein 0.0065 0.0354 0.0494
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0354 0.0354
Loa Loa (eye worm) hypothetical protein 0.0092 0.057 0.0796
Loa Loa (eye worm) hypothetical protein 0.0092 0.057 0.0796
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0932 0.7161 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0213 0.0213
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0187 0.0187
Schistosoma mansoni nuclear hormone receptor 0.0044 0.0187 0.0187
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0092 0.057 0.0796
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0044 0.0187 0.0194
Schistosoma mansoni zinc finger protein 0.0044 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0026 0.0047 0.0066
Loa Loa (eye worm) hypothetical protein 0.0049 0.0228 0.0318
Echinococcus multilocularis flap endonuclease 1 0.0027 0.0054 0.0056
Schistosoma mansoni steroid hormone receptor ad4bp 0.0092 0.057 0.057
Schistosoma mansoni biogenic amine (5HT) receptor 0.03 0.22 0.22
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0932 0.7161 0.7446
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0092 0.057 0.057
Entamoeba histolytica hypothetical protein 0.0037 0.0134 0.0187
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0044 0.0187 0.0261
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0213 0.0297
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0932 0.7161 1
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0092 0.057 0.057
Leishmania major hypothetical protein, conserved 0.0026 0.0047 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0092 0.057 0.0796
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0092 0.057 0.0796
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0092 0.057 0.0796
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0092 0.057 0.0796
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0213 0.0213
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0092 0.057 0.0593
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0213 0.0297
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0044 0.0187 0.0194
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0049 0.0228 0.0228
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0213 0.0213
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0092 0.057 0.057
Schistosoma mansoni tar DNA-binding protein 0.0065 0.0354 0.0354
Brugia malayi nuclear receptor RXR 0.0049 0.0228 0.0318
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0092 0.057 0.0796
Brugia malayi nuclear hormone receptor 0.0044 0.0187 0.0261
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0134 0.0139
Echinococcus granulosus thyroid hormone receptor alpha 0.0044 0.0187 0.0187
Loa Loa (eye worm) hypothetical protein 0.0044 0.0187 0.0261
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0134 0.0134
Echinococcus granulosus FTZ F1 alpha 0.0092 0.057 0.057
Entamoeba histolytica hypothetical protein 0.0037 0.0134 0.0187
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0092 0.057 0.057
Mycobacterium ulcerans DNA polymerase IV 0.002 0 0.5
Echinococcus multilocularis geminin 0.0173 0.1207 0.1255
Loa Loa (eye worm) nuclear hormone receptor 0.0044 0.0187 0.0261
Schistosoma mansoni coup transcription factor 0.0092 0.057 0.057
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0932 0.7161 0.7161
Brugia malayi RNA binding protein 0.0065 0.0354 0.0494
Loa Loa (eye worm) hypothetical protein 0.0044 0.0187 0.0261
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0092 0.057 0.0796
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0134 0.0134
Schistosoma mansoni nuclear receptor 0.0044 0.0187 0.0187
Loa Loa (eye worm) DR-78 0.0044 0.0187 0.0261
Echinococcus granulosus transcription factor Dp 1 0.0539 0.408 0.408
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0047 0.0066
Loa Loa (eye worm) hypothetical protein 0.0092 0.057 0.0796
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0032 0.0098 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0092 0.057 0.0593
Brugia malayi Steroid receptor seven-up type 2 0.0092 0.057 0.0796
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0932 0.7161 0.7161
Mycobacterium tuberculosis Conserved hypothetical protein 0.002 0 0.5
Echinococcus multilocularis ecdysone induced protein 78C 0.0092 0.057 0.0593
Schistosoma mansoni hypothetical protein 0.0037 0.0134 0.0134
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0044 0.0187 0.0194

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 0.11 mg kg-1 Effective intraperitoneal dose of the compound was determined in vivo in rat after 15 mins to induce lower lip retraction ChEMBL. 10229633
ED50 (functional) = 1 mg kg-1 Induction of lower lip retraction in rat 60 min after administration, effective peroral dose determined in vivo ChEMBL. 10229633
Log EC50 (functional) = 7.83 In vitro effective concentration required to inhibit forskolin-stimulated cAMP levels in HA7 cells expressing human 5-HT1A receptor ChEMBL. 10229633
Log Ki (binding) = 8.94 Binding affinity towards 5-hydroxytryptamine 1A receptor in rat cortex using [3H]-8-OH-DPAT as a radioligand ChEMBL. 10229633

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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