Detailed information for compound 662912

Basic information

Technical information
  • TDR Targets ID: 662912
  • Name: 2-[(4-ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl )sulfanyl]-N-[3-(trifluoromethyl)phenyl]aceta mide
  • MW: 407.413 | Formula: C18H16F3N5OS
  • H donors: 1 H acceptors: 4 LogP: 2.95 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCn1c(SCC(=O)Nc2cccc(c2)C(F)(F)F)nnc1c1ccncc1
  • InChi: 1S/C18H16F3N5OS/c1-2-26-16(12-6-8-22-9-7-12)24-25-17(26)28-11-15(27)23-14-5-3-4-13(10-14)18(19,20)21/h3-10H,2,11H2,1H3,(H,23,27)
  • InChiKey: DUSAREBNDWWCEV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[[4-ethyl-5-(4-pyridyl)-1,2,4-triazol-3-yl]sulfanyl]-N-[3-(trifluoromethyl)phenyl]acetamide
  • 2-[[4-ethyl-5-(4-pyridyl)-1,2,4-triazol-3-yl]thio]-N-[3-(trifluoromethyl)phenyl]acetamide
  • 2-[(4-ethyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)sulfanyl]-N-[3-(trifluoromethyl)phenyl]ethanamide
  • BAS 02071311
  • ZINC00907587
  • ST5081108

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei PAB1-binding protein , putative 0.005 0.0425 0.321
Loa Loa (eye worm) hypothetical protein 0.0089 0.0926 0.2825
Schistosoma mansoni hypothetical protein 0.0034 0.0216 0.0214
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.104 0.1167
Schistosoma mansoni thyroid hormone receptor 0.0053 0.0468 0.0505
Schistosoma mansoni microtubule-associated protein tau 0.0699 0.8678 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0053 0.0468 0.1359
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0031 0.0058
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0116 0.1259 0.1371
Brugia malayi photoreceptor-specific nuclear receptor 0.0053 0.0468 0.1359
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0031 0.5
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0025 0.0109 0.0079
Schistosoma mansoni tar DNA-binding protein 0.0272 0.3246 0.3718
Brugia malayi RNA recognition motif domain containing protein 0.0272 0.3246 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.104 0.1012
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0031 0.0034
Loa Loa (eye worm) hypothetical protein 0.0053 0.0468 0.1409
Echinococcus granulosus thyroid hormone receptor alpha 0.0025 0.0109 0.0091
Mycobacterium tuberculosis Conserved protein 0.0116 0.1259 0.1371
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0216 0.0575
Echinococcus multilocularis GPCR, family 2 0.0034 0.0216 0.0186
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0217 0.1512
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0053 0.0468 0.1359
Mycobacterium ulcerans lipase LipD 0.0116 0.1259 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0034 0.0217 0.1512
Echinococcus multilocularis tar DNA binding protein 0.0272 0.3246 0.3225
Leishmania major hypothetical protein, conserved 0.005 0.0425 0.321
Brugia malayi MH2 domain containing protein 0.0136 0.1517 0.4621
Brugia malayi hypothetical protein 0.0025 0.0109 0.0244
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0468 0.0505
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0098 0.104 0.1012
Echinococcus multilocularis microtubule associated protein 2 0.0699 0.8678 0.8674
Loa Loa (eye worm) hypothetical protein 0.0073 0.0711 0.2162
Echinococcus granulosus GPCR family 2 0.0034 0.0216 0.0214
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0053 0.0468 0.0438
Brugia malayi isocitrate dehydrogenase 0.0034 0.0217 0.0577
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0053 0.0468 0.1359
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0217 0.0186
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0022 0.0074 0.0044
Loa Loa (eye worm) hypothetical protein 0.0028 0.0148 0.0419
Loa Loa (eye worm) hypothetical protein 0.0053 0.0468 0.1409
Mycobacterium tuberculosis Probable esterase LipL 0.0116 0.1259 0.1371
Brugia malayi Nuclear hormone receptor-like 1 0.0053 0.0468 0.1359
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0088 0.0095
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.03
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0053 0.0468 0.0505
Schistosoma mansoni coup transcription factor 0.0053 0.0468 0.0505
Schistosoma mansoni nuclear hormone receptor 0.0053 0.0468 0.0505
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.026 0.1861
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0053 0.0468 0.1359
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0053 0.0468 0.0505
Brugia malayi beta-lactamase 0.0116 0.1259 0.382
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.026 0.1861
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0034 0.0217 0.4951
Schistosoma mansoni tar DNA-binding protein 0.0272 0.3246 0.3718
Echinococcus granulosus tar DNA binding protein 0.0272 0.3246 0.3718
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0233
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0216 0.0214
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0217 0.0186
Loa Loa (eye worm) DR-78 0.0025 0.0109 0.03
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0053 0.0468 0.1359
Echinococcus granulosus ecdysone induced protein 78C 0.0053 0.0468 0.0505
Toxoplasma gondii isocitrate dehydrogenase 0.0034 0.0217 0.1512
Plasmodium vivax ataxin-2 like protein, putative 0.005 0.0425 0.3312
Schistosoma mansoni hypothetical protein 0.0351 0.4255 0.4885
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0116 0.1259 0.3856
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.03
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0088 0.0605
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0216 0.0186
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0088 0.0605
Brugia malayi orphan nuclear receptor NR2E1 0.0025 0.0109 0.0244
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.1138 0.3482
Schistosoma mansoni hypothetical protein 0.0034 0.0216 0.0214
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0028 0.0148 0.0135
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0088 0.0474
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0053 0.0468 0.1409
Brugia malayi nuclear receptor NHR-88 0.0025 0.0109 0.0244
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0425 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.03
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0217 0.1512
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0028 0.0148 0.0419
Mycobacterium ulcerans hypothetical protein 0.0116 0.1259 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0053 0.0468 0.1409
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0089 0.0926 0.7487
Loa Loa (eye worm) isocitrate dehydrogenase 0.0034 0.0217 0.0632
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0031 0.5
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0034 0.0217 0.1512
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.104 0.1167
Echinococcus multilocularis ecdysone induced protein 78C 0.0053 0.0468 0.0438
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0053 0.0468 0.0505
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0233
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0053 0.0468 0.0505
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0098 0.104 0.1167
Echinococcus multilocularis isocitrate dehydrogenase 0.0034 0.0217 0.0186
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0034 0.0217 0.0236
Entamoeba histolytica transcription factor BTF3, putative 0.0037 0.026 0.1912
Plasmodium vivax hypothetical protein, conserved 0.0116 0.1259 1
Brugia malayi steroid hormone receptor 0.0053 0.0468 0.1359
Loa Loa (eye worm) hypothetical protein 0.0028 0.0148 0.0419
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0053 0.0468 0.1359
Entamoeba histolytica hypothetical protein 0.0113 0.1226 1
Loa Loa (eye worm) TAR-binding protein 0.0272 0.3246 1
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0053 0.0468 0.0505
Loa Loa (eye worm) hypothetical protein 0.0053 0.0468 0.1409
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0109 0.0185
Echinococcus multilocularis thyroid hormone receptor alpha 0.0053 0.0468 0.0438
Loa Loa (eye worm) hypothetical protein 0.0053 0.0468 0.1409
Plasmodium vivax basic transcription factor 3b, putative 0.0037 0.026 0.1984
Loa Loa (eye worm) hypothetical protein 0.0116 0.1259 0.3856
Brugia malayi nuclear hormone receptor 0.0053 0.0468 0.1359
Leishmania major hypothetical protein, conserved 0.0116 0.1259 1
Mycobacterium ulcerans esterase/lipase LipP 0.0116 0.1259 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0053 0.0468 0.1359
Echinococcus granulosus beta LACTamase domain containing family member 0.0116 0.1259 0.142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0053 0.0468 0.1409
Brugia malayi conserved hypotetical protein 0.0025 0.0109 0.0244
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0116 0.1259 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0025 0.0109 0.0185
Loa Loa (eye worm) ICD-1 protein 0.0037 0.026 0.0765
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0053 0.0468 0.1409
Echinococcus granulosus transcription factor btf3 0.0037 0.026 0.0264
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0034 0.0217 0.0186
Echinococcus granulosus microtubule associated protein 2 0.0699 0.8678 1
Loa Loa (eye worm) steroid hormone receptor 0.0053 0.0468 0.1409
Entamoeba histolytica hypothetical protein 0.0113 0.1226 1
Onchocerca volvulus Bile acid receptor homolog 0.0053 0.0468 0.3246
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0109 0.0244
Mycobacterium leprae conserved hypothetical protein 0.0116 0.1259 1
Echinococcus granulosus nuclear receptor nhr 48 0.0025 0.0109 0.0091
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0022 0.0074 0.005
Brugia malayi ecdysteroid receptor 0.0053 0.0468 0.1359
Mycobacterium tuberculosis Conserved protein 0.0116 0.1259 0.1371
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0088 0.0095
Brugia malayi nuclear receptor NHR-88 0.0053 0.0468 0.1359
Echinococcus multilocularis transcription factor btf3 0.0037 0.026 0.0229
Loa Loa (eye worm) RNA binding protein 0.0272 0.3246 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0053 0.0468 0.0438
Loa Loa (eye worm) hypothetical protein 0.0116 0.1259 0.3856
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.03
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.1259 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0053 0.0468 0.1409
Plasmodium falciparum basic transcription factor 3b, putative 0.0037 0.026 0.5989
Onchocerca volvulus 0.0116 0.1259 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0468 0.1409
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0053 0.0468 0.1409
Schistosoma mansoni retinoic acid receptor RXR 0.0053 0.0468 0.0505
Loa Loa (eye worm) hypothetical protein 0.0106 0.1138 0.3482
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.1259 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.1259 0.3856
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0088 0.0605
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0088 0.0605
Onchocerca volvulus 0.0116 0.1259 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0136 0.1517 0.4652
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0109 0.0091
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0053 0.0468 0.3246
Leishmania major basic transcription factor 3a, putative 0.0037 0.026 0.1861
Brugia malayi tailless protein 0.0025 0.0109 0.0244
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0012 0.0013
Loa Loa (eye worm) nuclear hormone receptor 0.0025 0.0109 0.03
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0028 0.0148 0.0135
Echinococcus multilocularis nuclear receptor nhr 48 0.0025 0.0109 0.0079
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0739 0.918 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.03
Brugia malayi hypothetical protein 0.0028 0.0148 0.0363
Schistosoma mansoni thyroid hormone receptor 0.0053 0.0468 0.0505
Brugia malayi nuclear hormone receptor 0.0025 0.0109 0.0244
Brugia malayi nuclear hormone receptor family member odr-7 0.0025 0.0109 0.0244
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0088 0.0176
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0031 0.5
Mycobacterium tuberculosis Probable lipase LipD 0.0116 0.1259 0.1371
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.03
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0031 0.0151
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0053 0.0468 0.0505
Schistosoma mansoni hypothetical protein 0.0034 0.0216 0.0214
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.104 0.1167
Schistosoma mansoni steroid hormone receptor ad4bp 0.0053 0.0468 0.0505
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0216 0.0214
Brugia malayi beta-NAC-like protein 0.0037 0.026 0.0711
Schistosoma mansoni nuclear receptor 0.0025 0.0109 0.0091
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0109 0.0091
Toxoplasma gondii ABC1 family protein 0.0116 0.1259 1
Schistosoma mansoni hypothetical protein 0.0022 0.0074 0.005
Schistosoma mansoni tar DNA-binding protein 0.0272 0.3246 0.3718
Brugia malayi hypothetical protein 0.0028 0.0148 0.0363
Echinococcus multilocularis FTZ F1 alpha 0.0053 0.0468 0.0438
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.03
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0216 0.0186
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0088 0.0461
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0468 0.0438
Toxoplasma gondii NAC domain-containing protein 0.0037 0.026 0.1861
Loa Loa (eye worm) hypothetical protein 0.0023 0.0088 0.0233
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0217 0.1512
Trichomonas vaginalis penicillin-binding protein, putative 0.0116 0.1259 1
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0053 0.0468 0.1359
Schistosoma mansoni hypothetical protein 0.0034 0.0216 0.0214
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.03
Mycobacterium leprae Probable lipase LipE 0.0116 0.1259 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0031 0.0456
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0088 0.0474
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0053 0.0468 0.0505
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0034 0.0217 0.0186
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.026 0.1861
Loa Loa (eye worm) hypothetical protein 0.0116 0.1259 0.3856
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0053 0.0468 0.1359
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.03
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0053 0.0468 0.0438
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.1138 0.3444
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0148 0.0363
Schistosoma mansoni transcription factor btf3 0.0037 0.026 0.0264
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0116 0.1259 0.1371
Brugia malayi Nuclear hormone receptor-like 1 0.0028 0.0148 0.0363
Loa Loa (eye worm) hypothetical protein 0.0053 0.0468 0.1409
Toxoplasma gondii LsmAD domain-containing protein 0.005 0.0425 0.321
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0053 0.0468 0.0505
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0088 0.0605
Schistosoma mansoni tar DNA-binding protein 0.0272 0.3246 0.3718
Schistosoma mansoni nuclear hormone receptor 0.0025 0.0109 0.0091
Trypanosoma brucei transcription factor BTF3, putative 0.0037 0.026 0.1861
Schistosoma mansoni tar DNA-binding protein 0.0272 0.3246 0.3718
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0425 0.321
Brugia malayi hypothetical protein 0.0113 0.1226 0.3718
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0053 0.0468 0.1359
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0031 0.0151
Entamoeba histolytica hypothetical protein 0.0113 0.1226 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0113 0.1226 0.1199
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0109 0.0079
Trichomonas vaginalis esterase, putative 0.0116 0.1259 1
Trypanosoma brucei hypothetical protein, conserved 0.0116 0.1259 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.1259 0.142
Brugia malayi beta-lactamase family protein 0.0116 0.1259 0.382
Entamoeba histolytica Acid sphingomyelinase-like phosphodiesterase, putative 0.0089 0.0926 0.7487
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0025 0.0109 0.0244
Mycobacterium ulcerans hypothetical protein 0.0023 0.0088 0.0605
Brugia malayi nuclear hormone receptor family member nhr-6 0.0025 0.0109 0.0244
Onchocerca volvulus 0.0025 0.0109 0.0185
Brugia malayi hypothetical protein 0.0032 0.02 0.0525
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.03
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0028 0.0148 0.0135
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0012 0.5
Echinococcus granulosus Nuclear hormone receptor HR96 0.0025 0.0109 0.0091
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0053 0.0468 0.0505
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0034 0.0217 0.0215
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0053 0.0468 0.0505
Echinococcus multilocularis beta LACTamase domain containing family member 0.0116 0.1259 0.1232
Brugia malayi TAR-binding protein 0.0272 0.3246 1
Mycobacterium tuberculosis Probable lipase LipE 0.0116 0.1259 0.1371
Loa Loa (eye worm) hypothetical protein 0.0116 0.1259 0.3856
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0025 0.0109 0.03
Schistosoma mansoni transcription factor LCR-F1 0.0113 0.1226 0.1382
Loa Loa (eye worm) hypothetical protein 0.0053 0.0468 0.1409
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0053 0.0468 0.0438
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.03
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0088 0.0605
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0034 0.0217 0.0215
Brugia malayi hypothetical protein 0.0025 0.0109 0.0244
Trypanosoma cruzi PAB1-binding protein , putative 0.005 0.0425 0.321
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0025 0.0109 0.0079
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0216 0.063
Brugia malayi nuclear receptor RXR 0.0025 0.0109 0.0244
Onchocerca volvulus 0.0053 0.0468 0.3246
Schistosoma mansoni hypothetical protein 0.0351 0.4255 0.4885
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0053 0.0468 0.1409
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.03
Brugia malayi Nuclear hormone receptor E75 0.0025 0.0109 0.0244
Onchocerca volvulus 0.0025 0.0109 0.0185
Loa Loa (eye worm) hypothetical protein 0.0028 0.0148 0.0419
Onchocerca volvulus Protein ultraspiracle homolog 0.0053 0.0468 0.3246
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0098 0.104 0.3179
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0025 0.0109 0.0091
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0116 0.1259 0.142
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0034 0.0217 0.164
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0116 0.1259 0.382
Schistosoma mansoni RAR-like nuclear receptor 0.0053 0.0468 0.0505
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0088 0.0461
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.1138 0.3444
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0088 0.0474
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0053 0.0468 0.1359
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0025 0.0109 0.0091
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0025 0.0109 0.0091
Loa Loa (eye worm) hypothetical protein 0.0028 0.0148 0.0419
Trypanosoma cruzi hypothetical protein, conserved 0.0116 0.1259 1
Plasmodium falciparum ataxin-2 like protein, putative 0.005 0.0425 1
Schistosoma mansoni nuclear receptor 0.0025 0.0109 0.0091
Loa Loa (eye worm) hypothetical protein 0.0028 0.0148 0.0419
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0272 0.3246 1
Loa Loa (eye worm) beta-lactamase 0.0116 0.1259 0.3856
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0098 0.104 0.1167
Echinococcus granulosus geminin 0.0351 0.4255 0.4885
Brugia malayi nuclear receptor RXR 0.0028 0.0148 0.0363
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0088 0.0176
Loa Loa (eye worm) hypothetical protein 0.0116 0.1259 0.3856
Brugia malayi Isocitrate dehydrogenase 0.0034 0.0217 0.0577
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0053 0.0468 0.0505
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0116 0.1259 0.1371
Echinococcus multilocularis geminin 0.0351 0.4255 0.4237
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0088 0.0176
Trypanosoma cruzi transcription factor btf3, putative 0.0037 0.026 0.1861
Brugia malayi Steroid receptor seven-up type 2 0.0053 0.0468 0.1359
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0113 0.1226 0.1382
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.1259 1
Loa Loa (eye worm) hypothetical protein 0.005 0.0425 0.1277
Entamoeba histolytica hypothetical protein 0.0113 0.1226 1
Loa Loa (eye worm) transcription factor SMAD2 0.0136 0.1517 0.4652
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0088 0.0605
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.026 0.1861
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.1259 1
Trichomonas vaginalis D-aminoacylase, putative 0.0116 0.1259 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0216 0.0575
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0053 0.0468 0.1359
Schistosoma mansoni hypothetical protein 0.0073 0.0711 0.0787
Loa Loa (eye worm) nuclear receptor NHR-67 0.0025 0.0109 0.03
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0025 0.0109 0.0091
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0028 0.0148 0.0117
Brugia malayi beta-lactamase family protein 0.0116 0.1259 0.382
Loa Loa (eye worm) hypothetical protein 0.0025 0.0109 0.03
Schistosoma mansoni nuclear receptor nhr-48 0.0025 0.0109 0.0091
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0098 0.104 0.3139
Brugia malayi ecdysone receptor 0.0025 0.0109 0.0244
Schistosoma mansoni hypothetical protein 0.0113 0.1226 0.1382
Onchocerca volvulus 0.0116 0.1259 1
Loa Loa (eye worm) hypothetical protein 0.0053 0.0468 0.1409
Mycobacterium ulcerans beta-lactamase 0.0116 0.1259 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0216 0.063
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0053 0.0468 0.1359
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.0711 0.2116
Brugia malayi hypothetical protein 0.005 0.0425 0.1226
Mycobacterium tuberculosis Conserved protein 0.0116 0.1259 0.1371
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0025 0.0109 0.0079
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0053 0.0468 0.0505
Schistosoma mansoni zinc finger protein 0.0025 0.0109 0.0091
Entamoeba histolytica hypothetical protein 0.0037 0.026 0.1912
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0088 0.0461
Brugia malayi nuclear receptor NHR-67 0.0025 0.0109 0.0244
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0034 0.0217 0.1512
Mycobacterium tuberculosis Probable hydrolase 0.0116 0.1259 0.1371
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0025 0.0109 0.0079
Echinococcus granulosus FTZ F1 alpha 0.0053 0.0468 0.0505
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0053 0.0468 0.0438
Brugia malayi RNA binding protein 0.0272 0.3246 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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