Detailed information for compound 66294

Basic information

Technical information
  • TDR Targets ID: 66294
  • Name: 2-(cyclohexylmethyl)-1-[2-[3-(1-phenylethyl)p henyl]propyl]piperidine
  • MW: 403.643 | Formula: C29H41N
  • H donors: 0 H acceptors: 0 LogP: 8.81 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1cccc(c1)C(c1ccccc1)C)CN1CCCCC1CC1CCCCC1
  • InChi: 1S/C29H41N/c1-23(22-30-19-10-9-18-29(30)20-25-12-5-3-6-13-25)27-16-11-17-28(21-27)24(2)26-14-7-4-8-15-26/h4,7-8,11,14-17,21,23-25,29H,3,5-6,9-10,12-13,18-20,22H2,1-2H3
  • InChiKey: OREMYNOLMRLGSV-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nAChR subunit 0.0019 0.0191 0.0709
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0146 0.0432
Schistosoma mansoni hypothetical protein 0.0018 0.0146 0.0499
Brugia malayi Cation transporter family protein 0.0019 0.0191 0.022
Echinococcus granulosus g protein coupled receptor 0.0018 0.0146 0.0432
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0191 0.0661
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0191 0.022
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0191 0.022
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0146 0.0432
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0018 0.0146 0.0432
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0117 0.0366
Brugia malayi hypothetical protein 0.0018 0.0146 0.0168
Echinococcus granulosus alpha 1A adrenergic receptor 0.0018 0.0146 0.0432
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0018 0.0146 0.0432
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0018 0.0146 0.0168
Brugia malayi hypothetical protein 0.0018 0.0146 0.0168
Echinococcus multilocularis neuropeptide s receptor 0.0018 0.0146 0.0432
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0019 0.0191 0.0661
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0019 0.0191 0.0661
Brugia malayi Tachykinin-like peptides receptor 99D 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Echinococcus granulosus neuropeptide receptor A26 0.0018 0.0146 0.0432
Echinococcus multilocularis lamin 0.0028 0.0563 0.2544
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0146 0.0432
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0146 0.0432
Brugia malayi G protein-coupled receptor 0.0018 0.0146 0.0168
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0019 0.0191 0.022
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0019 0.0191 0.022
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0146 0.0432
Echinococcus granulosus dro:myosuppressin receptor 0.0018 0.0146 0.0432
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0191 0.0661
Echinococcus multilocularis G protein coupled receptor 139 0.0018 0.0146 0.0432
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0023 0.0364 0.1536
Brugia malayi hypothetical protein 0.0018 0.0146 0.0168
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0018 0.0146 0.0499
Onchocerca volvulus 0.0028 0.0563 0.0423
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Echinococcus multilocularis lamin dm0 0.0028 0.0563 0.2544
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Echinococcus granulosus peptide allatostatin:somatostatin 0.0018 0.0146 0.0432
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0146 0.0499
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0018 0.0146 0.0499
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0146 0.0499
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0146 0.0432
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0019 0.0191 0.022
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0018 0.0146 0.0499
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0146 0.0432
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0061 0.5
Brugia malayi AKH receptor 0.0018 0.0146 0.0168
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0146 0.0432
Echinococcus granulosus neuropeptide receptor 0.0018 0.0146 0.0432
Echinococcus multilocularis G-protein coupled receptor, putative 0.0018 0.0146 0.0432
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0019 0.0191 0.022
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0693 0.3033
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0191 0.0661
Schistosoma mansoni neuropeptide f receptor 76f 0.0018 0.0146 0.0499
Brugia malayi G-protein coupled receptor 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0191 0.0661
Echinococcus granulosus g-protein coupled receptor 0.0018 0.0146 0.0432
Echinococcus granulosus glycine receptor subunit beta 0.0019 0.0191 0.0661
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0146 0.0432
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0146 0.0499
Loa Loa (eye worm) hypothetical protein 0.0039 0.1076 0.1235
Schistosoma mansoni amine GPCR 0.0018 0.0146 0.0499
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0563 0.0646
Brugia malayi isocitrate dehydrogenase 0.0016 0.0061 0.007
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0019 0.0191 0.0661
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0191 0.0661
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0019 0.0191 0.022
Schistosoma mansoni amine GPCR 0.0018 0.0146 0.0499
Echinococcus multilocularis serotonin receptor 0.0018 0.0146 0.0432
Echinococcus granulosus methyl CpG binding domain protein 2 0.0018 0.0117 0.0286
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Brugia malayi hypothetical protein 0.0018 0.0146 0.0168
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0146 0.0432
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Echinococcus granulosus lamin dm0 0.0028 0.0563 0.2544
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.1459 0.6587
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0146 0.0432
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0966 0.4586
Loa Loa (eye worm) hypothetical protein 0.0073 0.253 0.2906
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0018 0.0146 0.0168
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0018 0.0146 0.0432
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0019 0.0191 0.0661
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Brugia malayi Dopamine receptor protein 1 0.0018 0.0146 0.0168
Brugia malayi neuropeptide F receptor 0.0018 0.0146 0.0168
Echinococcus multilocularis somatostatin receptor 0.0018 0.0146 0.0432
Echinococcus granulosus allatostatin A receptor 0.0018 0.0146 0.0432
Echinococcus multilocularis sex peptide receptor 0.0018 0.0146 0.0432
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0146 0.0432
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0061 0.2035 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Brugia malayi PHD-finger family protein 0.0026 0.047 0.054
Loa Loa (eye worm) hypothetical protein 0.0048 0.1459 0.1676
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0018 0.0146 0.0499
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0146 0.0499
Echinococcus granulosus serotonin receptor 0.0018 0.0146 0.0432
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0146 0.0168
Schistosoma mansoni methyl-cpg binding protein mbd 0.0018 0.0117 0.0366
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0146 0.0499
Schistosoma mansoni amine GPCR 0.0018 0.0146 0.0499
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Loa Loa (eye worm) hypothetical protein 0.0027 0.0541 0.0621
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0191 0.0661
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0191 0.0709
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0019 0.0191 0.022
Echinococcus multilocularis zinc finger protein 0.002 0.0231 0.086
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Brugia malayi putative neuropeptide receptor 0.0018 0.0146 0.0168
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0191 0.022
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0146 0.0432
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0146 0.0499
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0018 0.0146 0.0499
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0019 0.0191 0.0661
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0146 0.0432
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0018 0.0146 0.0432
Schistosoma mansoni nAChR subunit 0.0019 0.0191 0.0709
Echinococcus granulosus fmrfamide receptor 0.0018 0.0146 0.0432
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0191 0.022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0019 0.0191 0.022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Brugia malayi Melatonin receptor type 1A 0.0018 0.0146 0.0168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0146 0.0499
Brugia malayi Bromodomain containing protein 0.0039 0.1072 0.1232
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Brugia malayi excitatory GABA receptor EXP-1A 0.0019 0.0191 0.022
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0146 0.0432
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0146 0.0432
Echinococcus granulosus 7tm_1 domain containing protein 0.0018 0.0146 0.0432
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Echinococcus granulosus fetal alzheimer antigen falz 0.0023 0.0364 0.1536
Echinococcus multilocularis serotonin receptor 0.0018 0.0146 0.0432
Loa Loa (eye worm) ACC-1 protein 0.0019 0.0191 0.022
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0146 0.0432
Brugia malayi Pre-SET motif family protein 0.0214 0.8707 1
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0061 0.0104
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0018 0.0146 0.0499
Schistosoma mansoni opsin-like receptor 0.0018 0.0146 0.0499
Brugia malayi hypothetical protein 0.0018 0.0146 0.0168
Brugia malayi sulfakinin receptor protein 0.0018 0.0146 0.0168
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0146 0.0432
Schistosoma mansoni nAChR subunit 0.0019 0.0191 0.0709
Echinococcus granulosus intermediate filament protein 0.0028 0.0563 0.2544
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0191 0.022
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0146 0.0432
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0048 0.1459 0.7085
Echinococcus granulosus nAChR subunit 0.0019 0.0191 0.0661
Brugia malayi hypothetical protein 0.0018 0.0146 0.0168
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0191 0.022
Onchocerca volvulus 0.0031 0.0693 0.0555
Brugia malayi hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0018 0.0146 0.0168
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0061 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0146 0.0432
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0018 0.0146 0.0432
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0146 0.0499
Schistosoma mansoni neuropeptide receptor 0.0018 0.0146 0.0499
Echinococcus multilocularis orexin receptor type 2 0.0018 0.0146 0.0432
Plasmodium vivax SET domain protein, putative 0.0031 0.0693 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0061 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0018 0.0117 0.0286
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0146 0.0432
Echinococcus granulosus tachykinin peptides receptor 99D 0.0018 0.0146 0.0432
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Echinococcus granulosus neuropeptide receptor 0.0018 0.0146 0.0432
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0191 0.0709
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0146 0.0499
Brugia malayi G-protein coupled receptor 0.0018 0.0146 0.0168
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0191 0.022
Brugia malayi putative neuropeptide receptor NPR1 0.0018 0.0146 0.0168
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0018 0.0146 0.0168
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0146 0.0499
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0019 0.0191 0.022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0563 0.0646
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0191 0.0661
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0643 0.2951
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0146 0.0432
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0146 0.0432
Schistosoma mansoni opsin-like receptor 0.0018 0.0146 0.0499
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0146 0.0168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0146 0.0499
Echinococcus multilocularis g-protein coupled receptor 0.0018 0.0146 0.0432
Brugia malayi Dopamine receptor 0.0018 0.0146 0.0168
Schistosoma mansoni alpha-1 adrenergic receptor 0.0018 0.0146 0.0499
Echinococcus granulosus hypothetical protein 0.0018 0.0146 0.0432
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0966 0.4586
Schistosoma mansoni amine GPCR 0.0018 0.0146 0.0499
Trichomonas vaginalis set domain proteins, putative 0.0243 1 0.5
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0018 0.0146 0.0432
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0146 0.0499
Onchocerca volvulus 0.0019 0.0191 0.0046
Echinococcus granulosus somatostatin receptor 0.0018 0.0146 0.0432
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0146 0.0432
Schistosoma mansoni hypothetical protein 0.0018 0.0146 0.0499
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0018 0.0146 0.0168
Onchocerca volvulus 0.0019 0.0191 0.0046
Brugia malayi hypothetical protein 0.0018 0.0146 0.0168
Echinococcus multilocularis glycine receptor subunit beta 0.0019 0.0191 0.0661
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0146 0.0168
Brugia malayi Cation transporter family protein 0.0019 0.0191 0.022
Brugia malayi hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) melatonin receptor type 1A 0.0018 0.0146 0.0168
Brugia malayi G protein-coupled receptor F59B2.13 0.0018 0.0146 0.0168
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0146 0.0432
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Brugia malayi Pre-SET motif family protein 0.0031 0.0693 0.0795
Brugia malayi ORL1-like opioid receptor 0.0018 0.0146 0.0168
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0061 1
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0019 0.0191 0.022
Schistosoma mansoni lamin 0.0028 0.0563 0.2432
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0019 0.0191 0.022
Onchocerca volvulus Putative nachr subunit 0.0019 0.0191 0.0046
Schistosoma mansoni biogenic amine receptor 0.0018 0.0146 0.0499
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Brugia malayi hypothetical protein 0.0018 0.0146 0.0168
Echinococcus granulosus g protein coupled receptor 0.0018 0.0146 0.0432
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0019 0.0191 0.0661
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0146 0.0432
Echinococcus granulosus zinc finger protein 0.002 0.0231 0.086
Onchocerca volvulus 0.0019 0.0191 0.0046
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0018 0.0146 0.0432
Schistosoma mansoni bromodomain containing protein 0.0065 0.2195 1
Schistosoma mansoni nAChR subunit 0.0019 0.0191 0.0709
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0061 1
Brugia malayi Dopamine receptor protein 2 0.0018 0.0146 0.0168
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0146 0.0432
Brugia malayi larval opioid receptor 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0044 0.1268 0.1456
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0048 0.1459 0.6587
Loa Loa (eye worm) hypothetical protein 0.0028 0.0563 0.0646
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0019 0.0191 0.0661
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0146 0.0432
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0146 0.0432
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0061 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0693 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.8707 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0019 0.0191 0.022
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0146 0.0432
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0146 0.0432
Schistosoma mansoni adenoreceptor 0.0018 0.0146 0.0499
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0019 0.0191 0.0661
Schistosoma mansoni hypothetical protein 0.0018 0.0146 0.0499
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0019 0.0191 0.0661
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0061 0.007
Echinococcus multilocularis neuropeptide FF receptor 2 0.0018 0.0146 0.0432
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0061 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0146 0.0432
Brugia malayi neuropeptide F receptor 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0191 0.022
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0019 0.0191 0.022
Brugia malayi intermediate filament protein 0.0028 0.0563 0.0646
Brugia malayi Serotonin receptor 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0191 0.0661
Schistosoma mansoni neuropeptide receptor 0.0018 0.0146 0.0499
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0019 0.0191 0.0709
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Echinococcus multilocularis nAChR subunit 0.0019 0.0191 0.0661
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0146 0.0499
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Schistosoma mansoni biogenic amine receptor 0.0018 0.0146 0.0499
Echinococcus granulosus orexin receptor type 2 0.0018 0.0146 0.0432
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0019 0.0191 0.022
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0019 0.0191 0.0661
Echinococcus multilocularis musashi 0.0028 0.0563 0.2544
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0019 0.0191 0.022
Schistosoma mansoni intermediate filament proteins 0.0028 0.0563 0.2432
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0146 0.0499
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0146 0.0432
Loa Loa (eye worm) PHD-finger family protein 0.0021 0.0278 0.0319
Brugia malayi follicle stimulating hormone receptor 0.0018 0.0146 0.0168
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0563 0.0646
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0146 0.0432
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0019 0.0191 0.0661
Schistosoma mansoni histamine h1 receptor 0.0018 0.0146 0.0499
Echinococcus granulosus neuropeptide FF receptor 2 0.0018 0.0146 0.0432
Echinococcus granulosus g protein coupled receptor 0.0018 0.0146 0.0432
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0019 0.0191 0.0661
Brugia malayi GnHR receptor homolog 0.0018 0.0146 0.0168
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0018 0.0146 0.0432
Brugia malayi Bromodomain containing protein 0.0077 0.2722 0.3127
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0146 0.0432
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0019 0.0191 0.0709
Echinococcus granulosus lamin 0.0028 0.0563 0.2544
Schistosoma mansoni neuropeptide receptor 0.0018 0.0146 0.0499
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0146 0.0499
Schistosoma mansoni nAChR subunit 0.0019 0.0191 0.0709
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0191 0.0661
Schistosoma mansoni myosin xvIII 0.0018 0.0146 0.0499
Schistosoma mansoni neuropeptide receptor 0.0018 0.0146 0.0499
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0146 0.0432
Echinococcus granulosus glycine receptor subunit alpha 1 0.0019 0.0191 0.0661
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0019 0.0191 0.0661
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0146 0.0432
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0018 0.0146 0.0432
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0018 0.0146 0.0432
Schistosoma mansoni lamin 0.0028 0.0563 0.2432
Schistosoma mansoni nAChR subunit 0.0019 0.0191 0.0709
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0018 0.0146 0.0168
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0146 0.0499
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0018 0.0146 0.0499
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0019 0.0191 0.0709
Onchocerca volvulus 0.0028 0.0563 0.0423
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0146 0.0432
Schistosoma mansoni growth hormone secretagogue receptor 0.0018 0.0146 0.0499
Brugia malayi Serotonin receptor 0.0018 0.0146 0.0168
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0146 0.0432
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0146 0.0432
Brugia malayi Cation transporter family protein 0.0019 0.0191 0.022
Echinococcus multilocularis neuropeptide receptor A26 0.0018 0.0146 0.0432
Schistosoma mansoni hypothetical protein 0.0018 0.0146 0.0499
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Loa Loa (eye worm) bromodomain containing protein 0.0018 0.0145 0.0166
Echinococcus multilocularis dro:myosuppressin receptor 0.0018 0.0146 0.0432
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0146 0.0432
Onchocerca volvulus 0.0019 0.0191 0.0046
Loa Loa (eye worm) hypothetical protein 0.0042 0.1182 0.1357
Onchocerca volvulus 0.0019 0.0191 0.0046
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Schistosoma mansoni opsin-like receptor 0.0018 0.0146 0.0499
Loa Loa (eye worm) TYRA-2 protein 0.0018 0.0146 0.0168
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0146 0.0499
Schistosoma mansoni nAChR subunit 0.0019 0.0191 0.0709
Brugia malayi RE15519p 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Onchocerca volvulus 0.0019 0.0191 0.0046
Schistosoma mansoni hypothetical protein 0.0021 0.0278 0.1112
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0018 0.0146 0.0432
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0146 0.0432
Echinococcus granulosus neuropeptide s receptor 0.0018 0.0146 0.0432
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0061 0.2035 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0693 0.3201
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0019 0.0191 0.0709
Schistosoma mansoni biogenic amine receptor 0.0018 0.0146 0.0499
Echinococcus granulosus histone lysine methyltransferase setb 0.0048 0.1459 0.7085
Loa Loa (eye worm) LGC-31 protein 0.0019 0.0191 0.022
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0146 0.0168
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0146 0.0432
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Echinococcus granulosus 7TM GPCR rhodopsin 0.0018 0.0146 0.0432
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0061 0.007
Schistosoma mansoni amine GPCR 0.0018 0.0146 0.0499
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0146 0.0432
Loa Loa (eye worm) hypothetical protein 0.0019 0.0191 0.022
Echinococcus multilocularis allatostatin A receptor 0.0018 0.0146 0.0432
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0019 0.0191 0.022
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0364 0.151
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0146 0.0499
Echinococcus granulosus sex peptide receptor 0.0018 0.0146 0.0432
Schistosoma mansoni zinc finger protein 0.002 0.0231 0.0891
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Echinococcus granulosus G protein coupled receptor 139 0.0018 0.0146 0.0432
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0693 0.3033
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0018 0.0146 0.0499
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168
Loa Loa (eye worm) hypothetical protein 0.0018 0.0146 0.0168

Activities

Activity type Activity value Assay description Source Reference
Inhibition (functional) = 0 % The mean increase in paw volume was compared between drug treated groups and placebo to calculate the percent inhibition in rats at 0.02 mmol/kg by carrageenin Edema Assay; 0-19 ChEMBL. 6502598
Inhibition (functional) = 30 % The percent inhibition was calculated from the average differences in hind paw volume between the adjuvant injected controls and the adjuvant-injected medicated rats at 0.08 mmol/kg; 30-39 ChEMBL. 6502598

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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