Detailed information for compound 662944

Basic information

Technical information
  • TDR Targets ID: 662944
  • Name: 6-bromo-N-(2-methoxy-5-nitrophenyl)quinazolin -4-amine
  • MW: 375.177 | Formula: C15H11BrN4O3
  • H donors: 1 H acceptors: 4 LogP: 3.91 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1Nc1ncnc2c1cc(Br)cc2)[N+](=O)[O-]
  • InChi: 1S/C15H11BrN4O3/c1-23-14-5-3-10(20(21)22)7-13(14)19-15-11-6-9(16)2-4-12(11)17-8-18-15/h2-8H,1H3,(H,17,18,19)
  • InChiKey: JIBVWIURXCVUHL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-bromo-N-(2-methoxy-5-nitro-phenyl)quinazolin-4-amine
  • 6-bromo-N-(2-methoxy-5-nitrophenyl)-4-quinazolinamine
  • (6-bromoquinazolin-4-yl)-(2-methoxy-5-nitro-phenyl)amine
  • Oprea1_835269
  • ZINC00955720

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi UDP-galactopyranose mutase 0.0047 0.04 0.1051
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0252 0.7581
Loa Loa (eye worm) hypothetical protein 0.016 0.1843 0.5643
Loa Loa (eye worm) hypothetical protein 0.0097 0.1038 0.317
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0252 0.0657
Plasmodium vivax lysine-specific histone demethylase 1, putative 0.0047 0.04 1
Brugia malayi SWIRM domain containing protein 0.0047 0.04 0.0953
Brugia malayi Papain family cysteine protease containing protein 0.0016 0.0006 0.0014
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0252 0.7581
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0255 0.059
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1671 0.4442
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0256 0.0301
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0364 0.0431
Brugia malayi hypothetical protein 0.0024 0.011 0.0263
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0044 0.0355 0.0932
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0252 0.0246
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0075 0.0757 0.0752
Loa Loa (eye worm) hypothetical protein 0.0035 0.0252 0.0756
Toxoplasma gondii ABC1 family protein 0.0035 0.0252 0.5708
Toxoplasma gondii histone lysine-specific demethylase LSD1/BHC110/KDMA1A 0.0047 0.04 0.9132
Echinococcus multilocularis protein patched 0.0042 0.0331 0.0325
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0587 0.1481
Trypanosoma cruzi major cysteine proteinase, putative 0.0048 0.0418 0.11
Plasmodium vivax hypothetical protein, conserved 0.0047 0.04 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0252 0.0261
Echinococcus multilocularis 0.0047 0.04 0.0394
Entamoeba histolytica hypothetical protein 0.0075 0.0757 0.7279
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0036 0.0255 0.0265
Toxoplasma gondii LsmAD domain-containing protein 0.0024 0.011 0.2422
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0587 0.1481
Loa Loa (eye worm) hypothetical protein 0.0146 0.1659 0.5079
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0264 0.3168 0.9714
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0036 0.0255 0.5779
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0036 0.092
Entamoeba histolytica hypothetical protein 0.0075 0.0757 0.7279
Plasmodium falciparum lysine-specific histone demethylase 1, putative 0.0047 0.04 1
Loa Loa (eye worm) hypothetical protein 0.0042 0.0331 0.0998
Echinococcus granulosus microtubule associated protein 2 0.0667 0.8318 1
Loa Loa (eye worm) TAR-binding protein 0.0264 0.3168 0.9714
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.1569 0.1564
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0256 0.7691
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0252 0.0296
Leishmania major mitochondrial DNA polymerase beta 0.031 0.3755 1
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0252 0.0582
Mycobacterium tuberculosis Conserved protein 0.0035 0.0252 0.0281
Mycobacterium ulcerans beta-lactamase 0.0035 0.0252 0.0261
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0036 0.0256 0.0666
Schistosoma mansoni hypothetical protein 0.0164 0.1891 0.2268
Schistosoma mansoni ap endonuclease 0.0019 0.0036 0.0036
Schistosoma mansoni inositol monophosphatase 0.0036 0.0255 0.03
Schistosoma mansoni ap endonuclease 0.0019 0.0036 0.0036
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0036 0.0759
Schistosoma mansoni patched 1 0.0042 0.0331 0.0391
Schistosoma mansoni cellular tumor antigen P53 0.0049 0.0421 0.05
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.011 0.0279
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0252 0.0281
Schistosoma mansoni hypothetical protein 0.0075 0.0757 0.0904
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0252 0.0756
Schistosoma mansoni tar DNA-binding protein 0.0264 0.3168 0.3804
Loa Loa (eye worm) hypothetical protein 0.0047 0.04 0.121
Brugia malayi beta-lactamase family protein 0.0035 0.0252 0.0601
Schistosoma mansoni transcription factor LCR-F1 0.0075 0.0757 0.0904
Entamoeba histolytica hypothetical protein 0.0075 0.0757 0.7279
Loa Loa (eye worm) hypothetical protein 0.0036 0.0256 0.0767
Plasmodium falciparum protoporphyrinogen oxidase 0.0047 0.04 1
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0587 0.1481
Mycobacterium ulcerans dehydrogenase 0.0047 0.04 0.0439
Trypanosoma cruzi PAB1-binding protein , putative 0.0024 0.011 0.0279
Loa Loa (eye worm) hypothetical protein 0.0049 0.0421 0.1276
Plasmodium vivax hypothetical protein, conserved 0.0047 0.04 1
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0252 0.0281
Mycobacterium ulcerans protoporphyrinogen oxidase 0.0047 0.04 0.0439
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0044 0.0355 0.0859
Loa Loa (eye worm) hypothetical protein 0.0035 0.0252 0.0756
Mycobacterium ulcerans oxidoreductase 0.0047 0.04 0.0439
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0036 0.0256 0.061
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0331 1
Echinococcus granulosus ubiquitin specific protease 41 0.0036 0.0256 0.0301
Loa Loa (eye worm) hypothetical protein 0.0047 0.04 0.121
Echinococcus granulosus tumor protein p63 0.0333 0.405 0.4865
Schistosoma mansoni hypothetical protein 0.004 0.0311 0.0368
Schistosoma mansoni hypothetical protein 0.004 0.0311 0.0368
Mycobacterium ulcerans hypothetical protein 0.0035 0.0252 0.0261
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0014
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0014
Trypanosoma brucei mitochondrial DNA polymerase beta 0.031 0.3755 1
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.1057 0.1264
Echinococcus multilocularis protein dispatched 1 0.0047 0.0406 0.04
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0587 0.1481
Leishmania major cathepsin L-like protease 0.0062 0.0587 0.1549
Schistosoma mansoni alzheimer's disease beta-amyloid related 0.0125 0.1401 0.1679
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0252 0.7581
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.011 0.2652
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0252 0.7581
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0147 0.1671 0.4398
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0587 0.1481
Schistosoma mansoni tar DNA-binding protein 0.0264 0.3168 0.3804
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0047 0.04 1
Echinococcus granulosus lysine specific histone demethylase 1A 0.0047 0.04 0.0474
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.3755 1
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0252 0.0261
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0364 0.0358
Schistosoma mansoni hypothetical protein 0.004 0.0311 0.0368
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0014
Toxoplasma gondii exonuclease III APE 0.0019 0.0036 0.0693
Brugia malayi beta-lactamase family protein 0.0035 0.0252 0.0601
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0252 0.0281
Brugia malayi beta-lactamase 0.0035 0.0252 0.0601
Schistosoma mansoni tar DNA-binding protein 0.0264 0.3168 0.3804
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0252 0.0296
Brugia malayi RNA binding protein 0.0264 0.3168 0.7556
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0587 0.1481
Brugia malayi Niemann-Pick C1 protein precursor 0.0097 0.1038 0.2475
Leishmania major cathepsin L-like protease 0.0062 0.0587 0.1549
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0256 0.0301
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0252 0.6251
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0331 0.0325
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0252 0.7581
Brugia malayi hypothetical protein 0.0075 0.0757 0.1805
Schistosoma mansoni microtubule-associated protein tau 0.0667 0.8318 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0252 0.0281
Schistosoma mansoni amine oxidase 0.0047 0.04 0.0474
Plasmodium vivax ataxin-2 like protein, putative 0.0024 0.011 0.2652
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0036 0.0759
Mycobacterium leprae PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) 0.0047 0.04 1
Echinococcus multilocularis microtubule associated protein 2 0.0667 0.8318 0.8317
Onchocerca volvulus 0.0035 0.0252 0.134
Schistosoma mansoni tar DNA-binding protein 0.0264 0.3168 0.3804
Trypanosoma brucei PAB1-binding protein , putative 0.0024 0.011 0.0201
Echinococcus granulosus lysine specific histone demethylase 1A 0.0047 0.04 0.0474
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0036 0.0255 0.2416
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0364 0.0431
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0044 0.0364 0.0431
Plasmodium falciparum ataxin-2 like protein, putative 0.0024 0.011 0.2652
Trichomonas vaginalis esterase, putative 0.0035 0.0252 0.7581
Leishmania major hypothetical protein, conserved 0.0035 0.0252 0.0657
Leishmania major UDP-galactopyranose mutase 0.0047 0.04 0.1051
Loa Loa (eye worm) hypothetical protein 0.0047 0.04 0.121
Schistosoma mansoni hypothetical protein 0.0164 0.1891 0.2268
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0044 0.0364 0.0868
Echinococcus granulosus tar DNA binding protein 0.0264 0.3168 0.3804
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0252 0.0261
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0355 0.0932
Trypanosoma cruzi cruzipain precursor, putative 0.0062 0.0587 0.1549
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0587 0.1481
Toxoplasma gondii histone lysine-specific demethylase 0.0047 0.04 0.9132
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0036 0.5
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0255 0.0665
Onchocerca volvulus 0.0047 0.04 0.2145
Mycobacterium tuberculosis Conserved hypothetical protein 0.0163 0.1883 0.2402
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0036 0.0255 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0252 0.0756
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0036 0.0085
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0255 0.0665
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0036 0.003
Echinococcus granulosus inositol monophosphatase 1 0.0036 0.0255 0.03
Schistosoma mansoni tar DNA-binding protein 0.0264 0.3168 0.3804
Schistosoma mansoni Lysine-specific histone demethylase 1 0.0047 0.04 0.0474
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0036 0.0256 0.0301
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0587 0.1481
Loa Loa (eye worm) inositol-1 0.0036 0.0255 0.0766
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0667 0.8328 1
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0036 0.0255 0.0665
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0044 0.0355 0.0932
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0036 0.0256 1
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0255 0.7675
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0256 0.7691
Trichomonas vaginalis inositol monophosphatase, putative 0.0036 0.0255 0.7675
Brugia malayi amine oxidase, flavin-containing family protein 0.0047 0.04 0.0953
Loa Loa (eye worm) hypothetical protein 0.0073 0.0728 0.2218
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0056 0.0518 0.1367
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0014
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0053 0.0477 0.1257
Echinococcus multilocularis geminin 0.0164 0.1891 0.1886
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0044 0.0364 0.11
Plasmodium vivax protoporphyrinogen oxidase, putative 0.0047 0.04 1
Onchocerca volvulus 0.016 0.1843 1
Brugia malayi hypothetical protein 0.0047 0.04 0.0953
Mycobacterium ulcerans hypothetical protein 0.0163 0.1883 0.2228
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0252 0.0601
Chlamydia trachomatis protoporphyrinogen oxidase 0.0047 0.04 0.5
Loa Loa (eye worm) hypothetical protein 0.0035 0.0252 0.0756
Leishmania major cathepsin L-like protease 0.0062 0.0587 0.1549
Echinococcus multilocularis ubiquitin specific protease 41 0.0036 0.0256 0.025
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0331 0.0391
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0036 0.008
Schistosoma mansoni Protoporphyrinogen oxidase chloroplast/mitochondrial precursor 0.0047 0.04 0.0474
Echinococcus multilocularis lysine specific histone demethylase 1A 0.0047 0.04 0.0394
Loa Loa (eye worm) hypothetical protein 0.0047 0.04 0.121
Loa Loa (eye worm) hypothetical protein 0.0271 0.3261 1
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0256 0.0666
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0587 0.1481
Mycobacterium tuberculosis Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) 0.062 0.7727 1
Loa Loa (eye worm) beta-lactamase 0.0035 0.0252 0.0756
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0364 0.0431
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0252 0.0657
Echinococcus multilocularis expressed conserved protein 0.0091 0.0963 0.0957
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0252 0.0296
Echinococcus multilocularis tar DNA binding protein 0.0264 0.3168 0.3164
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0036 0.0256 0.7691
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0252 0.2325
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0036 0.0255 0.7675
Onchocerca volvulus 0.0035 0.0252 0.134
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0587 0.1481
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2693 0.3455
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.031 0.3755 1
Schistosoma mansoni hypothetical protein 0.004 0.0311 0.0368
Onchocerca volvulus 0.0049 0.0421 0.2262
Mycobacterium ulcerans monoamine oxidase 0.0047 0.04 0.0439
Onchocerca volvulus 0.0035 0.0252 0.134
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0036 0.029
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0044 0.0364 0.0431
Leishmania major hypothetical protein, conserved 0.0024 0.011 0.0279
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0147 0.1671 0.4442
Schistosoma mansoni amine oxidase 0.0047 0.04 0.0474
Brugia malayi hypothetical protein 0.016 0.1843 0.4395
Loa Loa (eye worm) hypothetical protein 0.0035 0.0252 0.0756
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0256 0.0591
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0036 0.0036
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0587 0.1549
Schistosoma mansoni inositol monophosphatase 0.0036 0.0255 0.03
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0036 0.0256 0.0666
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0331 0.0998
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0587 0.1549
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0036 0.0092
Mycobacterium tuberculosis Possible oxidoreductase 0.0047 0.04 0.0473
Echinococcus granulosus geminin 0.0164 0.1891 0.2268
Echinococcus granulosus Niemann Pick C1 protein 0.0097 0.1038 0.1241
Mycobacterium tuberculosis Conserved protein 0.0035 0.0252 0.0281
Mycobacterium ulcerans flavin-containing monoamine oxidase AofH 0.0667 0.8328 1
Loa Loa (eye worm) hypothetical protein 0.0035 0.0252 0.0756
Loa Loa (eye worm) hypothetical protein 0.0047 0.04 0.121
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0036 0.008
Toxoplasma gondii hypothetical protein 0.005 0.0437 1
Loa Loa (eye worm) hypothetical protein 0.0047 0.04 0.121
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0036 0.092
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.1569 0.1881
Trypanosoma cruzi cysteine peptidase, putative 0.0062 0.0587 0.1549
Entamoeba histolytica hypothetical protein 0.0075 0.0757 0.7279
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0252 0.0281
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0036 0.0256 0.2421
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0062 0.0587 0.1481
Echinococcus multilocularis tumor protein p63 0.0333 0.405 0.4046
Loa Loa (eye worm) hypothetical protein 0.0051 0.045 0.1365
Loa Loa (eye worm) hypothetical protein 0.0024 0.011 0.0321
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0036 0.0256 0.0301
Echinococcus granulosus expressed conserved protein 0.0091 0.0963 0.1151
Mycobacterium leprae Probable lipase LipE 0.0035 0.0252 0.2325
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0036 0.008
Echinococcus multilocularis Niemann Pick C1 protein 0.0097 0.1038 0.1032
Trypanosoma cruzi UDP-galactopyranose mutase 0.0047 0.04 0.1051
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0252 0.0281
Echinococcus multilocularis inositol monophosphatase 1 0.0036 0.0255 0.0249
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0014
Brugia malayi TAR-binding protein 0.0264 0.3168 0.7556
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0252 0.0281
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0036 0.0256 0.025
Echinococcus multilocularis protoporphyrinogen oxidase 0.0047 0.04 0.0394
Brugia malayi CHE-14 protein 0.0042 0.0331 0.0789
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0032 0.0207 0.0223
Brugia malayi Inositol-1 0.0036 0.0255 0.0608
Mycobacterium tuberculosis Conserved hypothetical protein 0.0047 0.04 0.0473
Brugia malayi RNA recognition motif domain containing protein 0.0264 0.3168 0.7556
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0044 0.0364 0.0358
Mycobacterium tuberculosis Conserved protein 0.0035 0.0252 0.0281
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0097 0.1038 1
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0331 0.0391
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0036 0.0256 0.025
Brugia malayi Cathepsin L-like precursor 0.0016 0.0006 0.0014
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0075 0.0757 0.0904
Loa Loa (eye worm) RNA binding protein 0.0264 0.3168 0.9714
Brugia malayi Amyloid A4 extracellular domain containing protein 0.0344 0.4192 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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