Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0031 | 0.0124 | 0.0069 |
Plasmodium vivax | hypothetical protein, conserved | 0.0039 | 0.036 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0124 | 0.0187 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0218 | 0.0504 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0039 | 0.036 | 0.0133 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0029 | 0.0055 | 0.0083 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3276 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0102 | 0.2202 | 0.3327 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0218 | 0.0504 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.036 | 0.8969 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0401 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.004 | 0.0401 | 0.0348 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0776 | 0.1173 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0108 | 0.2394 | 0.3617 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0.0124 | 0.3082 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0064 | 0.1096 | 0.1656 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.0055 | 0.0083 |
Onchocerca volvulus | 0.0054 | 0.079 | 1 | |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.004 | 0.0401 | 1 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0251 | 0.6619 | 0.6601 |
Brugia malayi | beta-lactamase | 0.0039 | 0.036 | 0.0544 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0.0124 | 0.3437 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0038 | 0.0316 | 0.0477 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0039 | 0.036 | 0.0544 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.0401 | 0.1075 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0038 | 0.0316 | 0.0262 |
Onchocerca volvulus | 0.0039 | 0.036 | 0.415 | |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.036 | 0.0133 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.0401 | 1 |
Brugia malayi | Inositol-1 | 0.004 | 0.0401 | 0.0606 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0316 | 0.081 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.036 | 0.0544 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.036 | 0.0544 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0031 | 0.0124 | 0.0187 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0102 | 0.2202 | 0.2159 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0039 | 0.036 | 0.0133 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0401 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.0031 | 0.0124 | 0.5 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0051 | 0.0721 | 0.109 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0039 | 0.036 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0124 | 0.0213 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.036 | 0.0946 |
Echinococcus multilocularis | tumor protein p63 | 0.0366 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.036 | 0.0544 |
Echinococcus multilocularis | tar DNA binding protein | 0.0138 | 0.3276 | 0.3238 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0039 | 0.036 | 0.0133 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0138 | 0.3276 | 0.4949 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0034 | 0.0218 | 0.0329 |
Mycobacterium leprae | Probable lipase LipE | 0.0039 | 0.036 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0218 | 0.0163 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.037 | 0.0317 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.037 | 0.0979 |
Brugia malayi | beta-lactamase family protein | 0.0039 | 0.036 | 0.0544 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0038 | 0.0316 | 0.081 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0038 | 0.0316 | 0.0262 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.004 | 0.0401 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3276 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0218 | 0.0504 |
Brugia malayi | Bromodomain containing protein | 0.0031 | 0.0124 | 0.0187 |
Schistosoma mansoni | survival motor neuron protein | 0.0051 | 0.0721 | 0.2069 |
Schistosoma mansoni | inositol monophosphatase | 0.004 | 0.0401 | 0.1075 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.004 | 0.006 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.004 | 0.0401 | 0.0348 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0039 | 0.036 | 0.0306 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0039 | 0.036 | 0.0946 |
Echinococcus multilocularis | GPCR, family 2 | 0.0034 | 0.0218 | 0.0163 |
Loa Loa (eye worm) | intermediate filament protein | 0.0029 | 0.0055 | 0.0083 |
Echinococcus granulosus | GPCR family 2 | 0.0034 | 0.0218 | 0.0163 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0029 | 0.0055 | 0.0083 |
Toxoplasma gondii | ABC1 family protein | 0.0039 | 0.036 | 0.8969 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0054 | 0.079 | 0.228 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0043 | 0.0481 | 0.0429 |
Schistosoma mansoni | jumonji domain containing protein | 0.0081 | 0.1587 | 0.4757 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.036 | 0.0133 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0401 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0039 | 0.036 | 0.8969 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.036 | 0.0544 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0039 | 0.036 | 0.0133 |
Schistosoma mansoni | hypothetical protein | 0.0074 | 0.1387 | 0.4134 |
Loa Loa (eye worm) | inositol-1 | 0.004 | 0.0401 | 0.0606 |
Schistosoma mansoni | hypothetical protein | 0.0034 | 0.0218 | 0.0504 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0039 | 0.036 | 0.0306 |
Loa Loa (eye worm) | RNA binding protein | 0.0138 | 0.3276 | 0.4949 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.004 | 0.0401 | 1 |
Brugia malayi | TAR-binding protein | 0.0138 | 0.3276 | 0.4949 |
Brugia malayi | PHD-finger family protein | 0.0031 | 0.0124 | 0.0187 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.036 | 0.0544 |
Brugia malayi | hypothetical protein | 0.0039 | 0.037 | 0.056 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.004 | 0.0401 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.004 | 0.0401 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0721 | 0.2069 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.004 | 0.0401 | 1 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.004 | 0.0401 | 1 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0034 | 0.0218 | 0.0329 |
Echinococcus granulosus | jumonji domain containing protein | 0.0043 | 0.0481 | 0.0429 |
Loa Loa (eye worm) | hypothetical protein | 0.0251 | 0.6619 | 1 |
Onchocerca volvulus | 0.0039 | 0.036 | 0.415 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0039 | 0.036 | 0.8969 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.079 | 0.1193 |
Brugia malayi | RNA binding protein | 0.0138 | 0.3276 | 0.4949 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.1387 | 0.2095 |
Mycobacterium leprae | conserved hypothetical protein | 0.0039 | 0.036 | 1 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0251 | 0.6619 | 0.6601 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3276 | 1 |
Onchocerca volvulus | Alhambra homolog | 0.0031 | 0.0124 | 0.0933 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0034 | 0.0218 | 0.0329 |
Echinococcus granulosus | tar DNA binding protein | 0.0138 | 0.3276 | 0.3238 |
Mycobacterium tuberculosis | Conserved protein | 0.0039 | 0.036 | 0.0133 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0031 | 0.0124 | 0.0069 |
Loa Loa (eye worm) | TAR-binding protein | 0.0138 | 0.3276 | 0.4949 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0031 | 0.0124 | 0.0213 |
Onchocerca volvulus | 0.0051 | 0.0721 | 0.9073 | |
Loa Loa (eye worm) | hypothetical protein | 0.0108 | 0.2394 | 0.3617 |
Plasmodium falciparum | phd finger protein, putative | 0.0031 | 0.0124 | 1 |
Brugia malayi | intermediate filament protein | 0.0029 | 0.0055 | 0.0083 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0034 | 0.0218 | 0.0163 |
Loa Loa (eye worm) | beta-lactamase | 0.0039 | 0.036 | 0.0544 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0108 | 0.2394 | 0.3617 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0218 | 0.0329 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0039 | 0.036 | 0.0133 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0074 | 0.1387 | 0.2095 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0102 | 0.2202 | 0.2159 |
Echinococcus multilocularis | peregrin | 0.0031 | 0.0124 | 0.0069 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0039 | 0.036 | 0.8969 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0249 | 0.6555 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0138 | 0.3276 | 0.4949 |
Brugia malayi | hypothetical protein | 0.0251 | 0.6619 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3276 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0218 | 0.0163 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0108 | 0.2394 | 0.3617 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0.0124 | 0.3082 |
Echinococcus granulosus | peregrin | 0.0031 | 0.0124 | 0.0069 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0039 | 0.036 | 0.0544 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0039 | 0.036 | 0.0133 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0034 | 0.0218 | 0.0163 |
Schistosoma mansoni | tar DNA-binding protein | 0.0138 | 0.3276 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.037 | 0.0317 |
Brugia malayi | jmjC domain containing protein | 0.0038 | 0.0316 | 0.0477 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.036 | 0.0544 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.036 | 0.0544 |
Onchocerca volvulus | 0.0039 | 0.036 | 0.415 | |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.037 | 0.0979 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.