Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.1283 | 0.1283 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0026 | 0.0682 | 0.0682 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0026 | 0.0682 | 0.0682 |
Mycobacterium tuberculosis | Probable dihydroorotate dehydrogenase PyrD | 0.0161 | 1 | 1 |
Mycobacterium leprae | Probable dihydroorotate dehydrogenase PyrD | 0.0161 | 1 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.2391 | 1 |
Plasmodium falciparum | dihydroorotate dehydrogenase | 0.0161 | 1 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0063 | 0.3229 | 1 |
Leishmania major | dihydroorotate dehydrogenase | 0.0161 | 1 | 1 |
Trypanosoma brucei | dihydroorotate dehydrogenase (fumarate) | 0.0161 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0063 | 0.3229 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.1283 | 0.5368 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0047 | 0.0047 |
Schistosoma mansoni | dihydroorotate dehydrogenase | 0.0161 | 1 | 1 |
Plasmodium vivax | dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0161 | 1 | 1 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0682 | 0.0682 |
Brugia malayi | Dihydroorotate dehydrogenase, mitochondrial precursor, putative | 0.0161 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydroorotate dehydrogenase 2 | 0.0161 | 1 | 0.5 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0161 | 1 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0161 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0026 | 0.0682 | 0.0682 |
Leishmania major | hypothetical protein, conserved | 0.0026 | 0.0682 | 0.0682 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.3229 | 0.5 |
Toxoplasma gondii | dihydroorotate dehydrogenase reveal, putative | 0.0161 | 1 | 1 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.3229 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.1283 | 0.1283 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.3229 | 0.5 |
Mycobacterium ulcerans | dihydroorotate dehydrogenase 2 | 0.0161 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.2391 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.2391 | 0.2391 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0682 | 0.0682 |
Brugia malayi | Zinc finger, C2H2 type family protein | 0.0063 | 0.3229 | 0.3229 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0026 | 0.0682 | 0.0682 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0026 | 0.0682 | 0.0682 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.3229 | 0.5 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0026 | 0.0682 | 0.0682 |
Trypanosoma cruzi | dihydroorotate dehydrogenase (fumarate), putative | 0.0161 | 1 | 1 |
Echinococcus granulosus | dihydropyrimidine dehydrogenase NADP | 0.0063 | 0.3229 | 1 |
Echinococcus multilocularis | dihydropyrimidine dehydrogenase (NADP+) | 0.0063 | 0.3229 | 1 |
Trypanosoma cruzi | dihydroorotate dehydrogenase, putative | 0.0063 | 0.3229 | 0.3229 |
Trichomonas vaginalis | dihydropyrimidine dehydrogenase, putative | 0.0063 | 0.3229 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0682 | 0.2852 |
Entamoeba histolytica | dihydropyrimidine dehydrogenase, putative | 0.0063 | 0.3229 | 0.5 |
Trichomonas vaginalis | dihydroorotate dehydrogenase, putative | 0.0063 | 0.3229 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.2391 | 0.2391 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.