Detailed information for compound 663069

Basic information

Technical information
  • TDR Targets ID: 663069
  • Name: 1-[4-[5-(4-ethylpiperazin-1-yl)-4-fluoro-2-ni trophenyl]piperazin-1-yl]-2,2-dimethylpropan- 1-one
  • MW: 421.509 | Formula: C21H32FN5O3
  • H donors: 0 H acceptors: 3 LogP: 2.95 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN1CCN(CC1)c1cc(N2CCN(CC2)C(=O)C(C)(C)C)c(cc1F)[N+](=O)[O-]
  • InChi: 1S/C21H32FN5O3/c1-5-23-6-8-24(9-7-23)17-15-18(19(27(29)30)14-16(17)22)25-10-12-26(13-11-25)20(28)21(2,3)4/h14-15H,5-13H2,1-4H3
  • InChiKey: QSRFSRLSXFVGIL-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[4-[5-(4-ethylpiperazin-1-yl)-4-fluoro-2-nitro-phenyl]piperazin-1-yl]-2,2-dimethyl-propan-1-one
  • 1-[4-[5-(4-ethyl-1-piperazinyl)-4-fluoro-2-nitrophenyl]-1-piperazinyl]-2,2-dimethylpropan-1-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0024 0.0301 0.0265
Brugia malayi Intermediate filament tail domain containing protein 0.0055 0.145 0.165
Brugia malayi MH2 domain containing protein 0.0125 0.4012 0.4595
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0301 0.1062
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0097 0.2992 0.3423
Echinococcus multilocularis musashi 0.0055 0.145 0.1968
Brugia malayi AMP-binding enzyme family protein 0.0055 0.1434 0.1631
Loa Loa (eye worm) hypothetical protein 0.0029 0.0458 0.0447
Brugia malayi Muscleblind-like protein 0.018 0.6083 0.6976
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0301 0.1212
Schistosoma mansoni retinoic acid receptor RXR 0.002 0.0151 0.0081
Echinococcus multilocularis glutamate receptor NMDA 0.0072 0.2051 0.2841
Treponema pallidum 4'-phosphopantetheinyl transferase 0.0028 0.0441 0.5
Schistosoma mansoni glutamate receptor kainate 0.0051 0.1289 0.1733
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.002 0.0151 0.0081
Onchocerca volvulus 0.0055 0.145 0.145
Loa Loa (eye worm) hypothetical protein 0.0024 0.0301 0.0265
Schistosoma mansoni glutamate receptor kainate 0.0051 0.1289 0.1733
Schistosoma mansoni steroid hormone receptor ad4bp 0.002 0.0151 0.0081
Echinococcus granulosus lamin dm0 0.0055 0.145 0.1968
Mycobacterium ulcerans polyketide synthase 0.0051 0.1292 0.5653
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0301 0.1062
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0731 0.0923
Brugia malayi Nuclear hormone receptor-like 1 0.002 0.0151 0.0157
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0028 0.0441 0.1711
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0072 0.0168
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0054 0.141 0.5747
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0055 0.1434 0.1576
Echinococcus granulosus L aminoadipate semialdehyde 0.01 0.3117 0.4388
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0051 0.1292 0.5726
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0141 0.4639 0.6599
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0652 0.0733
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0061 0.1648 0.2255
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.1234 0.1402
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.002 0.0151 0.0092
Brugia malayi nuclear receptor NHR-88 0.002 0.0151 0.0157
Brugia malayi nuclear hormone receptor 0.002 0.0151 0.0157
Brugia malayi Nuclear hormone receptor family member nhr-40 0.002 0.0151 0.0157
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0028 0.0441 0.048
Echinococcus multilocularis geminin 0.0205 0.6981 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.002 0.0151 0.0081
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0034 0.0649 0.2675
Brugia malayi photoreceptor-specific nuclear receptor 0.002 0.0151 0.0157
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.002 0.0151 0.0092
Echinococcus multilocularis nmda type glutamate receptor 0.0081 0.2411 0.3362
Echinococcus multilocularis glutamate receptor 2 0.0042 0.0947 0.1237
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0151 0.0081
Mycobacterium leprae Polyketide synthase Pks13 0.0077 0.2231 1
Echinococcus multilocularis glutamate receptor 2 0.0051 0.1289 0.1733
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0036 0.0731 0.0923
Onchocerca volvulus Fatty acid synthase homolog 0.0092 0.2816 0.2816
Echinococcus granulosus glutamate NMDA receptor subunit 0.0141 0.4639 0.6599
Echinococcus granulosus FTZ F1 alpha 0.002 0.0151 0.0081
Brugia malayi Nuclear hormone receptor family member nhr-49 0.002 0.0151 0.0157
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0301 0.1062
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0061 0.1648 0.2255
Loa Loa (eye worm) hypothetical protein 0.0026 0.0349 0.0321
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0054 0.141 0.6199
Schistosoma mansoni glutamate receptor AMPA 0.0051 0.1289 0.1733
Loa Loa (eye worm) hypothetical protein 0.0055 0.145 0.1595
Echinococcus multilocularis FTZ F1 alpha 0.002 0.0151 0.0081
Loa Loa (eye worm) hypothetical protein 0.01 0.3117 0.3524
Echinococcus granulosus ecdysone induced protein 78C 0.002 0.0151 0.0081
Schistosoma mansoni hypothetical protein 0.0205 0.6981 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0051 0.1292 0.5726
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0054 0.141 0.6263
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0054 0.141 0.5747
Brugia malayi Pre-SET motif family protein 0.0036 0.0731 0.0823
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0301 0.1062
Loa Loa (eye worm) hypothetical protein 0.0126 0.405 0.4603
Onchocerca volvulus 0.0055 0.145 0.145
Brugia malayi Nuclear hormone receptor family member nhr-14 0.002 0.0151 0.0157
Schistosoma mansoni Tr4/Tr2 (homologue) 0.002 0.0151 0.0081
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0055 0.1434 0.637
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0051 0.1292 0.1469
Onchocerca volvulus 0.0096 0.2964 0.2964
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0061 0.1648 0.2255
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0055 0.145 0.1595
Echinococcus granulosus glutamate receptor 2 0.0061 0.1648 0.2255
Echinococcus multilocularis muscleblind protein 1 0.018 0.6083 0.8695
Mycobacterium tuberculosis Probable thioesterase TesA 0.0043 0.0976 0.4285
Echinococcus granulosus retinoic acid receptor rxr beta a 0.002 0.0151 0.0081
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0042 0.0947 0.4151
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.002 0.0151 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.002 0.0151 0.0092
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.002 0.0151 0.0092
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0301 0.1062
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.002 0.0151 0.0081
Loa Loa (eye worm) hypothetical protein 0.0054 0.1413 0.1552
Loa Loa (eye worm) hypothetical protein 0.0027 0.0387 0.0364
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0036 0.0731 0.0923
Schistosoma mansoni lamin 0.0055 0.145 0.1968
Echinococcus granulosus nmda type glutamate receptor 0.0091 0.2752 0.3859
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0092
Loa Loa (eye worm) hypothetical protein 0.0036 0.0731 0.0763
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0061 0.1648 0.2255
Schistosoma mansoni RAR-like nuclear receptor 0.002 0.0151 0.0081
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0151 0.0081
Mycobacterium ulcerans thioesterase 0.0043 0.0976 0.4187
Trichomonas vaginalis set domain proteins, putative 0.0286 1 0.5
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0151 0.0157
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.002 0.0151 0.0081
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0036 0.0731 0.3221
Loa Loa (eye worm) hypothetical protein 0.0034 0.0652 0.0672
Schistosoma mansoni thyroid hormone receptor 0.002 0.0151 0.0081
Onchocerca volvulus Huntingtin homolog 0.0126 0.405 0.405
Echinococcus granulosus nmda type glutamate receptor 0.0081 0.2411 0.3362
Schistosoma mansoni thyroid hormone receptor 0.002 0.0151 0.0081
Onchocerca volvulus Bile acid receptor homolog 0.002 0.0151 0.0151
Mycobacterium leprae Probable polyketide synthase Pks1 0.0054 0.141 0.5747
Leishmania major phosphopantetheinyl transferase-like protein 0.0028 0.0441 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0301 0.0265
Brugia malayi cytoplasmic intermediate filament protein 0.003 0.0496 0.0553
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0077 0.2231 1
Loa Loa (eye worm) glutamate receptor 1 0.0051 0.1289 0.1408
Brugia malayi steroid hormone receptor 0.002 0.0151 0.0157
Onchocerca volvulus 0.01 0.3117 0.3117
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.002 0.0151 0.0092
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0027 0.0387 0.0423
Loa Loa (eye worm) intermediate filament protein 0.0055 0.145 0.1595
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.002 0.0151 0.0081
Onchocerca volvulus Huntingtin homolog 0.0126 0.405 0.405
Schistosoma mansoni ATP-binding cassette transporter 0.0051 0.1289 0.1733
Mycobacterium ulcerans hypothetical protein 0.0024 0.0301 0.1062
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.002 0.0151 0.0081
Trypanosoma brucei hypothetical protein, conserved 0.0028 0.0441 0.5
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0092
Echinococcus granulosus lamin 0.0055 0.145 0.1968
Brugia malayi Steroid receptor seven-up type 2 0.002 0.0151 0.0157
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0054 0.141 0.6263
Schistosoma mansoni hypothetical protein 0.0034 0.0652 0.0809
Loa Loa (eye worm) hypothetical protein 0.0087 0.262 0.2949
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0041 0.0922 0.3935
Mycobacterium leprae conserved hypothetical protein 0.0028 0.0441 0.0727
Onchocerca volvulus 0.0055 0.1434 0.1434
Echinococcus granulosus geminin 0.0205 0.6981 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.002 0.0151 0.0081
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0021 0.0162 0.0578
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0441 0.5606
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0301 0.0329
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0061 0.1648 0.2255
Chlamydia trachomatis holo [acyl-carrier protein] synthase 0.0028 0.0441 1
Echinococcus multilocularis lamin dm0 0.0055 0.145 0.1968
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0151 0.0081
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.002 0.0151 0.0092
Loa Loa (eye worm) hypothetical protein 0.018 0.6083 0.6956
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.003 0.0496 0.0491
Echinococcus multilocularis nmda type glutamate receptor 0.0091 0.2752 0.3859
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0731 0.0923
Echinococcus granulosus intermediate filament protein 0.0055 0.145 0.1968
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0033 0.0626 0.2224
Loa Loa (eye worm) transcription factor SMAD2 0.0125 0.4012 0.456
Echinococcus multilocularis glutamate receptor 2 0.0061 0.1648 0.2255
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0077 0.2231 1
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0061 0.1648 0.2255
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0041 0.0922 0.3935
Mycobacterium ulcerans polyketide synthase 0.0054 0.141 0.6199
Mycobacterium ulcerans Type I modular polyketide synthase 0.0051 0.1292 0.5653
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0041 0.0922 0.3215
Schistosoma mansoni nuclear hormone receptor 0.002 0.0151 0.0081
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0092
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0035 0.0682 0.0852
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0151 0.0157
Schistosoma mansoni glutamate receptor kainate 0.0051 0.1289 0.1733
Onchocerca volvulus Protein ultraspiracle homolog 0.002 0.0151 0.0151
Echinococcus multilocularis ecdysone induced protein 78C 0.002 0.0151 0.0081
Echinococcus granulosus glutamate receptor NMDA 0.0072 0.2051 0.2841
Mycobacterium tuberculosis holo-[acyl-carrier protein] synthase AcpS (holo-ACP synthase) (CoA:APO-[ACP]pantetheinephosphotransferase) (CoA:APO-[acyl-carrie 0.0028 0.0441 0.1851
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.002 0.0151 0.0081
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0301 0.1212
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.002 0.0151 0.0151
Echinococcus multilocularis thyroid hormone receptor alpha 0.002 0.0151 0.0081
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0051 0.1292 0.5136
Loa Loa (eye worm) hypothetical protein 0.005 0.1234 0.1345
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.005 0.1234 0.5461
Toxoplasma gondii type I fatty acid synthase, putative 0.0036 0.0745 0.3358
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0151 0.0081
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.0034 0.0649 0.1805
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.002 0.0151 0.0081
Entamoeba histolytica hypothetical protein 0.0028 0.0441 0.7317
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0043 0.0976 0.3497
Loa Loa (eye worm) hypothetical protein 0.0126 0.405 0.4603
Mycobacterium ulcerans Type I modular polyketide synthase 0.0051 0.1292 0.5653
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0054 0.141 0.6199
Onchocerca volvulus 0.0036 0.0731 0.0731
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.01 0.3117 0.4388
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-19 0.002 0.0151 0.0157
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.01 0.3117 0.3566
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0027 0.0387 0.0423
Echinococcus granulosus glutamate receptor 2 0.0042 0.0947 0.1237
Echinococcus multilocularis lamin 0.0055 0.145 0.1968
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0036 0.0731 0.0923
Mycobacterium ulcerans polyketide synthase Pks13 0.0077 0.2231 1
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0061 0.1648 0.2255
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0051 0.1292 0.5653
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.1234 0.1345
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.0029 0.0473 0.1997
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0028 0.0441 0.5
Schistosoma mansoni intermediate filament proteins 0.0055 0.145 0.1968
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0092
Brugia malayi Nuclear hormone receptor family member nhr-31 0.002 0.0151 0.0157
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.002 0.0151 0.0092
Loa Loa (eye worm) steroid hormone receptor 0.002 0.0151 0.0092
Echinococcus granulosus muscleblind protein 0.018 0.6083 0.8695
Schistosoma mansoni glutamate receptor NMDA 0.0132 0.4305 0.6113
Loa Loa (eye worm) acyl carrier protein 0.0024 0.0267 0.0226
Brugia malayi intermediate filament protein 0.0055 0.145 0.165
Brugia malayi Nuclear hormone receptor family member nhr-3 0.002 0.0151 0.0157
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.1234 0.1402
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0028 0.0441 1
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0037 0.0758 0.3292
Onchocerca volvulus 0.0024 0.0301 0.0301
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0054 0.141 0.6263
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.002 0.0151 0.0081
Schistosoma mansoni coup transcription factor 0.002 0.0151 0.0081
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0061 0.1648 0.2255
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0301 0.1062
Schistosoma mansoni hypothetical protein 0.0205 0.6981 1
Brugia malayi Nuclear hormone receptor family member nhr-41 0.002 0.0151 0.0157
Loa Loa (eye worm) hypothetical protein 0.0026 0.0349 0.0321
Mycobacterium tuberculosis Polyketide synthase Pks2 0.005 0.1234 0.5461
Mycobacterium ulcerans Type I modular polyketide synthase 0.0051 0.1292 0.5653
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0028 0.0441 0.048
Echinococcus multilocularis L aminoadipate semialdehyde 0.01 0.3117 0.4388
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.002 0.0151 0.0081
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0151 0.0157
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0301 0.0329
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0028 0.0441 0.1711
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0092
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0036 0.0731 0.0923
Mycobacterium ulcerans thioesterase TesA 0.0043 0.0976 0.4187
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0251 0.8713 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.002 0.0151 0.0157
Brugia malayi Glutamate receptor 2 precursor 0.0051 0.1289 0.1464
Loa Loa (eye worm) fatty acid synthase 0.0051 0.1267 0.1383
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0301 0.1062
Toxoplasma gondii type I fatty acid synthase, putative 0.0055 0.1447 1
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0051 0.1292 0.5726
Loa Loa (eye worm) glutamate receptor 2 0.0051 0.1289 0.1408
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0018 0.0047 0.0055
Loa Loa (eye worm) hypothetical protein 0.018 0.6083 0.6956
Schistosoma mansoni glutamate receptor NMDA 0.0141 0.4639 0.6599
Plasmodium vivax SET domain protein, putative 0.0036 0.0731 1
Schistosoma mansoni lamin 0.0055 0.145 0.1968
Echinococcus multilocularis muscleblind protein 0.018 0.6083 0.8695
Brugia malayi Nuclear hormone receptor family member nhr-1 0.002 0.0151 0.0157
Loa Loa (eye worm) MH2 domain-containing protein 0.0125 0.4012 0.456
Entamoeba histolytica acyl-CoA synthetase, putative 0.003 0.0493 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0092
Onchocerca volvulus 0.002 0.0151 0.0151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.002 0.0151 0.0157
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.002 0.0151 0.0081
Echinococcus granulosus histone lysine methyltransferase setb 0.0036 0.0731 0.0923
Loa Loa (eye worm) hypothetical protein 0.002 0.0151 0.0092
Brugia malayi ecdysteroid receptor 0.002 0.0151 0.0157
Mycobacterium ulcerans polyketide synthase Pks9 0.0034 0.0649 0.2675
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0051 0.1292 0.5136
Schistosoma mansoni glutamate receptor AMPA 0.0051 0.1289 0.1733
Brugia malayi Glutamate receptor 1 precursor 0.0051 0.1289 0.1464
Brugia malayi Pre-SET motif family protein 0.0251 0.8713 1
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0301 0.0329
Brugia malayi hypothetical protein 0.0126 0.405 0.4639

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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