Detailed information for compound 663075

Basic information

Technical information
  • TDR Targets ID: 663075
  • Name: 1-(4-methoxy-3-methylphenyl)sulfonylazepane
  • MW: 283.386 | Formula: C14H21NO3S
  • H donors: 0 H acceptors: 2 LogP: 2.61 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1C)S(=O)(=O)N1CCCCCC1
  • InChi: 1S/C14H21NO3S/c1-12-11-13(7-8-14(12)18-2)19(16,17)15-9-5-3-4-6-10-15/h7-8,11H,3-6,9-10H2,1-2H3
  • InChiKey: KSWUKBMPRAMAMS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 1-(4-methoxy-3-methyl-phenyl)sulfonylazepane
  • ZINC00617878
  • ST066554
  • BAS 06704918
  • 1-(4-Methoxy-3-methyl-benzenesulfonyl)-azepane

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.2073 0.7344
Loa Loa (eye worm) hypothetical protein 0.0095 0.1137 0.4028
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0085 0.0228
Echinococcus granulosus zinc finger protein 0.0025 0.0105 0.0105
Schistosoma mansoni protein phosphatase 2C 0.0025 0.0098 0.0098
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0272 0.3755 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0115 0.0306
Echinococcus granulosus chromobox protein 1 0.0065 0.0693 0.0693
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0881 0.0896
Plasmodium falciparum thioredoxin reductase 0.0038 0.0289 0.244
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.4227 1
Schistosoma mansoni cpg binding protein 0.0063 0.0666 0.0666
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0253 0.0675
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0159 0.0159
Onchocerca volvulus 0.0058 0.0591 0.1464
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0085 0.0228
Brugia malayi chromobox protein homolog 3 0.0036 0.0272 0.0963
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0037 0.0282 0.0666
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.0098 0.0098
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0016 0.0016
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0253 0.0253
Giardia lamblia Fructose-bisphosphate aldolase 0.0272 0.3755 1
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0253 0.06
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0272 0.3755 1
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.0098 0.0098
Echinococcus multilocularis transient receptor potential ion channel A 0.0092 0.109 0.109
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0147 0.1905 0.1905
Brugia malayi jmjC domain containing protein 0.0097 0.1173 0.4156
Trichomonas vaginalis chromobox protein, putative 0.0039 0.0313 0.0832
Plasmodium falciparum glutathione reductase 0.0038 0.0289 0.244
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0641 0.0725
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0124 0.1568 0.1568
Treponema pallidum exodeoxyribonuclease (exoA) 0.0037 0.0282 0.0419
Schistosoma mansoni microtubule-associated protein tau 0.0696 1 1
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0086 0.1 0.1131
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0282 0.075
Schistosoma mansoni alpha-glucosidase 0.0136 0.1747 0.1747
Schistosoma mansoni jumonji domain containing protein 0.013 0.1656 0.1656
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0045 0.0396 0.034
Schistosoma mansoni transient receptor potential channel 0.0063 0.0662 0.0662
Loa Loa (eye worm) PHD-finger family protein 0.0027 0.0136 0.048
Onchocerca volvulus 0.0092 0.1087 0.3058
Brugia malayi Bromodomain containing protein 0.0077 0.0867 0.3072
Loa Loa (eye worm) hypothetical protein 0.0035 0.0256 0.0908
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.0136 0.0043
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1069 0.1069
Trichomonas vaginalis chromobox protein, putative 0.0065 0.0693 0.1845
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0037 0.0282 0.0666
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0881 1
Loa Loa (eye worm) hypothetical protein 0.0062 0.0656 0.2325
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0085 0.0228
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0282 0.2343
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0881 0.5
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0311 0.0828
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0098 0.0348
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0115 0.0306
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0641 0.0621
Schistosoma mansoni hypothetical protein 0.0027 0.0136 0.0136
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0297 0.0297
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0086 0.1 0.1131
Schistosoma mansoni hypothetical protein 0.0414 0.5842 0.5842
Loa Loa (eye worm) CXXC zinc finger family protein 0.0058 0.0591 0.2094
Loa Loa (eye worm) jmjC domain-containing protein 0.0056 0.0563 0.1993
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0085 0.0228
Plasmodium vivax glutathione reductase, putative 0.0038 0.0289 0.244
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0098 0.0348
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0194 0.0194
Loa Loa (eye worm) hypothetical protein 0.0029 0.0156 0.0551
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0304 0.4227 1
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0147 0.1905 0.1905
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0881 0.2073
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0095 0.1141 0.1161
Brugia malayi acetyltransferase, GNAT family protein 0.0147 0.1905 0.6748
Loa Loa (eye worm) jmjC domain-containing protein 0.0097 0.1173 0.4156
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0037 0.0282 0.075
Trypanosoma brucei glucosidase, putative 0.0035 0.0253 0.06
Loa Loa (eye worm) hypothetical protein 0.0036 0.0272 0.0963
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0881 0.0881
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0133 0.1698 0.1801
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0025 0.0098 0.0348
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0253 0.0675
Mycobacterium tuberculosis Probable oxidoreductase 0.0095 0.1141 0.1291
Brugia malayi jmjC domain containing protein 0.0148 0.1926 0.6823
Brugia malayi PHD-finger family protein 0.0027 0.0136 0.048
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0272 0.3755 1
Echinococcus granulosus histone acetyltransferase KAT2B 0.0045 0.0396 0.0396
Plasmodium falciparum phd finger protein, putative 0.0027 0.0136 0.0477
Loa Loa (eye worm) MH2 domain-containing protein 0.0123 0.1544 0.5469
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0194 0.0194
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0641 0.0641
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0662 0.0662
Toxoplasma gondii pantoate-beta-alanine ligase 0.0617 0.884 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0272 0.3755 1
Leishmania major mitochondrial DNA polymerase beta 0.0304 0.4227 1
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0148 0.1926 0.1926
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0486 0.055
Trypanosoma brucei trypanothione reductase 0.0038 0.0289 0.0684
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.0289 0.0684
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.0098 0.0098
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0037 0.0282 0.0666
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.0289 0.0327
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.0289 0.1024
Schistosoma mansoni hypothetical protein 0.0169 0.2234 0.2234
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0253 0.0675
Loa Loa (eye worm) hypothetical protein 0.0047 0.0422 0.1496
Brugia malayi Pre-SET motif family protein 0.0031 0.0194 0.0686
Loa Loa (eye worm) hypothetical protein 0.0032 0.0209 0.0742
Brugia malayi CXXC zinc finger family protein 0.0058 0.0591 0.2094
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.0098 0.0232
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1069 0.1069
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0253 0.06
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0037 0.0282 0.0319
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0133 0.1698 0.1921
Echinococcus multilocularis jumonji domain containing protein 0.0038 0.0293 0.0293
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0272 0.3755 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0881 0.0997
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0253 0.0898
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0024 0.0095 0.0095
Echinococcus granulosus chromobox protein 1 0.0065 0.0693 0.0693
Leishmania major hypothetical protein, conserved 0.0025 0.0098 0.0232
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0272 0.0724
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.2073 0.2073
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0144 0.1861 0.4402
Loa Loa (eye worm) hypothetical protein 0.0036 0.0262 0.0929
Schistosoma mansoni chromobox protein 0.0065 0.0693 0.0693
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0093 0.0093
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0881 0.0896
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.003 0.0173 0.0173
Schistosoma mansoni zinc finger protein 0.0025 0.0105 0.0105
Trichomonas vaginalis conserved hypothetical protein 0.0036 0.0272 0.0724
Brugia malayi jmjC domain containing protein 0.0025 0.0098 0.0348
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0486 0.0486
Loa Loa (eye worm) hypothetical protein 0.0042 0.0347 0.123
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.2073 0.2073
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0062 0.0657 0.0657
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0253 0.0675
Echinococcus granulosus cpg binding protein 0.0063 0.0666 0.0666
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0037 0.0282 0.0666
Loa Loa (eye worm) transcription factor SMAD2 0.0123 0.1544 0.5469
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.0098 0.0098
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0253 0.0675
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0297 0.0297
Loa Loa (eye worm) hypothetical protein 0.0066 0.0707 0.2505
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0641 0.1517
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0098 0.0232
Schistosoma mansoni hypothetical protein 0.0019 0.0018 0.0018
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0016 0.0056
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.0098 0.0348
Schistosoma mansoni transient receptor potential channel 0.0095 0.1137 0.1137
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.009 0.1069 0.1069
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0881 0.0881
Brugia malayi Transient-receptor-potential like protein 0.0035 0.0256 0.0908
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0027 0.013 0.0401
Brugia malayi MH2 domain containing protein 0.0123 0.1544 0.5469
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0037 0.0282 0.0998
Giardia lamblia Histone acetyltransferase GCN5 0.0039 0.0311 0.0828
Schistosoma mansoni transient receptor potential channel 4 0.0095 0.1137 0.1137
Echinococcus multilocularis dnaJ subfamily B 0.0414 0.5842 0.5842
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1069 0.1069
Loa Loa (eye worm) PHD-finger family protein 0.0019 0.0018 0.0065
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0253 0.0253
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0052 0.0504 0.1193
Schistosoma mansoni alpha-glucosidase 0.0136 0.1747 0.1747
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0037 0.0282 0.2343
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0033 0.0229 0.0229
Loa Loa (eye worm) acetyltransferase 0.0147 0.1905 0.6748
Echinococcus multilocularis chromobox protein 1 0.0065 0.0693 0.0693
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0037 0.0282 0.0282
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0047 0.0428 0.0428
Onchocerca volvulus 0.0238 0.3247 1
Brugia malayi F/Y-rich N-terminus family protein 0.0029 0.017 0.0601
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0428 0.0428
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0037 0.0282 0.0282
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0086 0.1 0.0999
Onchocerca volvulus 0.0029 0.0156 0.0065
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0641 0.0725
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0253 0.0675
Brugia malayi Bromodomain containing protein 0.0039 0.0314 0.1111
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0881 0.0881
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0272 0.3755 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0062 0.0657 0.0657
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0024 0.0085 0.0228
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0037 0.0282 0.0319
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1861 0.4402
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0641 0.0641
Loa Loa (eye worm) hypothetical protein 0.0047 0.0428 0.1517
Toxoplasma gondii hypothetical protein 0.0027 0.013 0.0036
Brugia malayi PHD-finger family protein 0.003 0.0178 0.0632
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0133 0.1698 0.1921
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0272 0.3755 1
Echinococcus granulosus dnaJ subfamily B 0.0414 0.5842 0.5842
Schistosoma mansoni cpg binding protein 0.0058 0.0591 0.0591
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0085 0.0228
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.009 0.1069 0.1069
Loa Loa (eye worm) hypothetical protein 0.0078 0.0881 0.3121
Brugia malayi Thioredoxin reductase 0.0038 0.0289 0.1024
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0253 0.06
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0641 0.0725
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0253 0.0675
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.2073 0.2073
Mycobacterium tuberculosis Probable reductase 0.0086 0.1 0.1131
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.0098 0.0098
Mycobacterium tuberculosis Conserved hypothetical protein 0.016 0.2101 0.2377
Toxoplasma gondii exonuclease III APE 0.0037 0.0282 0.021
Echinococcus granulosus histone lysine methyltransferase setb 0.0047 0.0428 0.0428
Toxoplasma gondii PHD-finger domain-containing protein 0.0027 0.0136 0.0043
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0253 0.0675
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0093 0.0093
Schistosoma mansoni jumonji/arid domain-containing protein 0.0097 0.1173 0.1173
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0045 0.0396 0.034
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0366 0.0866
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0641 0.0725
Echinococcus multilocularis lysine specific demethylase 5A 0.0092 0.1098 0.1098
Echinococcus multilocularis peregrin 0.0033 0.022 0.022
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0085 0.0228
Loa Loa (eye worm) heterochromatin protein 1 0.0065 0.0693 0.2454
Echinococcus multilocularis geminin 0.0169 0.2234 0.2234
Loa Loa (eye worm) hypothetical protein 0.0027 0.0136 0.048
Brugia malayi jmjC domain containing protein 0.0025 0.0098 0.0348
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0144 0.1861 0.4402
Schistosoma mansoni ap endonuclease 0.0037 0.0282 0.0282
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.0617 0.884 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0253 0.0178
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.009 0.1069 0.3788
Brugia malayi jmjC domain containing protein 0.0025 0.0098 0.0348
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0033 0.0229 0.0229
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.009 0.1069 0.3788
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0086 0.1 0.1131
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0194 0.0109
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0148 0.1926 0.1926
Schistosoma mansoni jumonji/arid domain-containing protein 0.0097 0.1173 0.1173
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0086 0.1 0.1131
Echinococcus multilocularis transient receptor potential gamma protein 0.0095 0.1137 0.1137
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0043 0.0366 0.0866
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0045 0.0396 0.3801
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0024 0.0085 0.0228
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0617 0.884 1
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0045 0.0396 0.1054
Echinococcus multilocularis short transient receptor potential channel 6 0.0063 0.0662 0.0662
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0311 0.2716
Giardia lamblia PHD finger protein 15 0.0027 0.0136 0.0361
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0047 0.0428 0.0428
Onchocerca volvulus 0.0042 0.035 0.0691
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0043 0.0366 0.0866
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0662 0.0662
Echinococcus multilocularis PHD finger protein rhinoceros 0.0027 0.0136 0.0136
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1069 0.1069
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.003 0.0173 0.0173
Toxoplasma gondii histone lysine methyltransferase SET1 0.0117 0.1459 0.1556
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.009 0.1069 0.1069
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0209 0.2823 1
Echinococcus multilocularis zinc finger protein 0.0025 0.0105 0.0105
Echinococcus multilocularis cpg binding protein 0.0063 0.0666 0.0666
Trichomonas vaginalis chromobox protein, putative 0.0065 0.0693 0.1845
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.2073 0.7344
Schistosoma mansoni hypothetical protein 0.0169 0.2234 0.2234
Schistosoma mansoni chromobox protein 0.0065 0.0693 0.0693
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0037 0.0282 0.075
Brugia malayi Probable ClpP-like protease 0.0078 0.0881 0.3121
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0253 0.0898
Echinococcus granulosus transient receptor potential ion channel A 0.0092 0.109 0.109
Loa Loa (eye worm) bromodomain containing protein 0.002 0.003 0.0106
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0027 0.013 0.0401
Toxoplasma gondii hypothetical protein 0.0049 0.0459 0.0413
Loa Loa (eye worm) hypothetical protein 0.006 0.0616 0.218
Brugia malayi Bromodomain containing protein 0.0033 0.022 0.0781
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0881 0.5
Mycobacterium tuberculosis Probable dehydrogenase 0.0086 0.1 0.1131
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0881 1
Schistosoma mansoni jumonji domain containing protein 0.0025 0.0098 0.0098
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0027 0.0136 0.0136
Schistosoma mansoni phd/f-box containing protein 0.0025 0.0098 0.0098
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0272 0.3755 1
Loa Loa (eye worm) glutathione reductase 0.0038 0.0289 0.1024
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.0098 0.0098
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.0617 0.884 1
Trichomonas vaginalis ap endonuclease, putative 0.0037 0.0282 0.075
Echinococcus granulosus transient receptor potential gamma protein 0.0095 0.1137 0.1137
Echinococcus granulosus jumonji domain containing protein 0.0038 0.0293 0.0293
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0641 0.0641
Echinococcus granulosus histone acetyltransferase KAT2B 0.0141 0.1812 0.1812
Brugia malayi glutathione reductase 0.0038 0.0289 0.1024
Treponema pallidum fructose-bisphosphate aldolase 0.0272 0.3755 1
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0036 0.0272 0.0438
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0486 0.0409
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0486 0.055
Leishmania major trypanothione reductase 0.0038 0.0289 0.0684
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0095 0.1141 0.1291
Brugia malayi Pre-SET motif family protein 0.0209 0.2823 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0304 0.4227 1
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0253 0.0675
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0093 0.0093
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.0289 0.244
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0035 0.0256 0.0256
Brugia malayi Heterochromatin protein 1 0.0065 0.0693 0.2454
Echinococcus multilocularis microtubule associated protein 2 0.0696 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0272 0.3755 1
Echinococcus granulosus TRP transient receptor potential channel 0.0035 0.0256 0.0256
Echinococcus multilocularis phd:f box containing protein 0.0025 0.0098 0.0098
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0881 0.0863
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.0098 0.0098
Trichomonas vaginalis chromobox protein, putative 0.0039 0.0313 0.0832
Schistosoma mansoni transient receptor potential channel 0.0063 0.0662 0.0662
Plasmodium vivax hypothetical protein, conserved 0.0027 0.0136 0.0477
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0641 0.0641
Loa Loa (eye worm) hypothetical protein 0.0025 0.0098 0.0348
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0253 0.0675
Schistosoma mansoni alpha glucosidase 0.0035 0.0253 0.0253
Schistosoma mansoni ap endonuclease 0.0037 0.0282 0.0282
Echinococcus granulosus PHD finger protein rhinoceros 0.0027 0.0136 0.0136
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0016 0.0016
Echinococcus multilocularis chromobox protein 1 0.0065 0.0693 0.0693
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0881 0.0997
Echinococcus granulosus short transient receptor potential channel 6 0.0063 0.0662 0.0662
Echinococcus granulosus geminin 0.0169 0.2234 0.2234
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.0098 0.0098
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0272 0.3755 1
Toxoplasma gondii thioredoxin reductase 0.0038 0.0289 0.0219
Schistosoma mansoni cpg binding protein 0.0063 0.0666 0.0666
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0025 0.0098 0.0232
Echinococcus granulosus lysine specific demethylase 5A 0.0097 0.1173 0.1173
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0095 0.1141 0.1291
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0881 1
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0253 0.0675
Trichomonas vaginalis bromodomain-containing protein, putative 0.0045 0.0396 0.1054
Echinococcus granulosus phd:f box containing protein 0.0025 0.0098 0.0098
Schistosoma mansoni bromodomain containing protein 0.0066 0.0706 0.0706
Mycobacterium ulcerans hypothetical protein 0.016 0.2101 0.2377
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0043 0.0366 0.0866
Brugia malayi jmjC domain containing protein 0.0025 0.0098 0.0348
Brugia malayi exodeoxyribonuclease III family protein 0.0037 0.0282 0.0998
Plasmodium vivax SET domain protein, putative 0.0031 0.0194 0.1218
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0042 0.035 0.035
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.0313 0.0569
Trichomonas vaginalis set domain proteins, putative 0.0238 0.3247 0.8648
Echinococcus granulosus peregrin 0.0033 0.022 0.022

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.