Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0039 | 0.035 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.035 | 0.5 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 1 | 1 |
Brugia malayi | Inositol-1 | 0.0039 | 0.035 | 0.035 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.035 | 0.5 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.035 | 0.035 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0039 | 0.035 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 1 | 1 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0039 | 0.035 | 0.035 |
Schistosoma mansoni | inositol monophosphatase | 0.0039 | 0.035 | 0.035 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.035 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 1 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Brugia malayi | TAR-binding protein | 0.0067 | 1 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0039 | 0.035 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0039 | 0.035 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0039 | 0.035 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.035 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0039 | 0.035 | 0.5 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0039 | 0.035 | 0.035 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0039 | 0.035 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.0586 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (functional) | 10 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of binding or entry into cells for Lassa Virus. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID463114, AID540249] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | ||
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.