Detailed information for compound 663147

Basic information

Technical information
  • TDR Targets ID: 663147
  • Name: 2-[[4-methyl-5-[1-(phenoxy)ethyl]-1,2,4-triaz ol-3-yl]sulfanyl]-N-(4-propan-2-ylphenyl)acet amide
  • MW: 410.532 | Formula: C22H26N4O2S
  • H donors: 1 H acceptors: 3 LogP: 4.2 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(c1nnc(n1C)SCC(=O)Nc1ccc(cc1)C(C)C)Oc1ccccc1
  • InChi: 1S/C22H26N4O2S/c1-15(2)17-10-12-18(13-11-17)23-20(27)14-29-22-25-24-21(26(22)4)16(3)28-19-8-6-5-7-9-19/h5-13,15-16H,14H2,1-4H3,(H,23,27)
  • InChiKey: SDQTWNLBUIJYIZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-isopropylphenyl)-2-[[4-methyl-5-[1-(phenoxy)ethyl]-1,2,4-triazol-3-yl]sulfanyl]acetamide
  • N-(4-isopropylphenyl)-2-[[4-methyl-5-[1-(phenoxy)ethyl]-1,2,4-triazol-3-yl]thio]acetamide
  • 2-[[4-methyl-5-[1-(phenoxy)ethyl]-1,2,4-triazol-3-yl]sulfanyl]-N-(4-propan-2-ylphenyl)ethanamide
  • STK118184

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis dro:myosuppressin receptor 0.0032 0.0891 0.0878
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0891 0.0878
Brugia malayi Serotonin receptor 0.0032 0.0891 0.1324
Onchocerca volvulus 0.0032 0.0891 0.1324
Onchocerca volvulus 0.0032 0.0891 0.1324
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.2063 0.2052
Loa Loa (eye worm) hypothetical protein 0.0044 0.1631 0.244
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0032 0.0887 0.2533
Loa Loa (eye worm) hypothetical protein 0.0023 0.035 0.0507
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0124 0.6489 0.6484
Brugia malayi Carboxylesterase family protein 0.0103 0.5189 0.7812
Schistosoma mansoni amine GPCR 0.0032 0.0891 0.0878
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0032 0.0891 0.0878
Loa Loa (eye worm) phosphatidylinositol 3 0.002 0.0163 0.0225
Brugia malayi ORL1-like opioid receptor 0.0032 0.0891 0.1324
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Toxoplasma gondii target of rapamycin (TOR), putative 0.0024 0.0423 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0891 0.0878
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0024 0.0397 0.1273
Echinococcus multilocularis neuropeptide receptor A26 0.0032 0.0891 0.0878
Echinococcus multilocularis g-protein coupled receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0891 0.1324
Echinococcus granulosus acetylcholinesterase 0.0103 0.5189 0.5182
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0517 0.1673
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0047 0.1785 0.5893
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.2063 0.2052
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Brugia malayi putative neuropeptide receptor 0.0032 0.0891 0.1324
Echinococcus granulosus tachykinin peptides receptor 99D 0.0032 0.0891 0.0878
Onchocerca volvulus 0.0032 0.0891 0.1324
Schistosoma mansoni opsin-like receptor 0.0032 0.0891 0.0878
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0891 0.0878
Echinococcus granulosus acetylcholinesterase 0.0103 0.5189 0.5182
Brugia malayi G-protein coupled receptor 0.0032 0.0891 0.1324
Schistosoma mansoni hypothetical protein 0.0032 0.0891 0.0878
Entamoeba histolytica hypothetical protein 0.004 0.1401 0.383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0291 0.0923
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0124 0.6489 0.6484
Brugia malayi Latrophilin receptor protein 2 0.0035 0.1059 0.1577
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Schistosoma mansoni neuropeptide receptor 0.0032 0.0891 0.0878
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Onchocerca volvulus 0.0032 0.0891 0.1324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0131
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0891 0.0878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0423 0.1362
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0887 0.2904
Schistosoma mansoni neuropeptide receptor 0.0032 0.0891 0.0878
Onchocerca volvulus 0.0127 0.6638 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Brugia malayi neuropeptide F receptor 0.0032 0.0891 0.1324
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.1401 0.1389
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0024 0.0397 0.1273
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0051 0.2063 0.2052
Brugia malayi follicle stimulating hormone receptor 0.0032 0.0891 0.1324
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Brugia malayi hypothetical protein 0.0032 0.0891 0.1324
Schistosoma mansoni hypothetical protein 0.0075 0.3492 0.3483
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0159 0.0482
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0026 0.0518 0.3235
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0032 0.0891 0.0878
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0032 0.0891 0.0878
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.2063 0.2052
Brugia malayi hypothetical protein 0.0032 0.0891 0.1324
Mycobacterium tuberculosis Carboxylesterase LipT 0.0017 0.0014 0.5
Brugia malayi hypothetical protein 0.0032 0.0891 0.1324
Brugia malayi hypothetical protein 0.0032 0.0891 0.1324
Plasmodium vivax ataxin-2 like protein, putative 0.0023 0.0342 0.5
Onchocerca volvulus 0.0032 0.0891 0.1324
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0032 0.0891 0.1324
Entamoeba histolytica hypothetical protein 0.004 0.1401 0.383
Echinococcus granulosus hypothetical protein 0.0032 0.0891 0.0878
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0891 0.0878
Echinococcus granulosus GPCR family 2 0.0035 0.1059 0.1046
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0342 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0032 0.0891 0.1324
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0032 0.0891 0.1324
Echinococcus granulosus 7tm_1 domain containing protein 0.0032 0.0891 0.0878
Onchocerca volvulus 0.0032 0.0891 0.1324
Schistosoma mansoni adenoreceptor 0.0032 0.0891 0.0878
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0891 0.0878
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0024 0.0397 0.1003
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0891 0.0878
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0054 0.2214 0.6931
Schistosoma mansoni biogenic amine receptor 0.0032 0.0891 0.0878
Schistosoma mansoni opsin-like receptor 0.0032 0.0891 0.0878
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0067 0.3019 1
Brugia malayi hypothetical protein 0.0032 0.0891 0.1324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0887 0.2904
Echinococcus granulosus neuropeptides capa receptor 0.0032 0.0891 0.0878
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0148 0.0447
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0032 0.0891 0.0878
Brugia malayi Calcitonin receptor-like protein seb-1 0.0109 0.5589 0.8416
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0891 0.0878
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0891 0.0878
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0047 0.1785 0.5893
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0891 0.0878
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0891 0.0878
Brugia malayi hypothetical protein 0.0127 0.6638 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0035 0.1059 0.1046
Schistosoma mansoni growth hormone secretagogue receptor 0.0032 0.0891 0.0878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0131
Echinococcus multilocularis acetylcholinesterase 0.0103 0.5189 0.5182
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0891 0.0878
Onchocerca volvulus 0.0032 0.0891 0.1324
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0109 0.5589 0.8416
Loa Loa (eye worm) hypothetical protein 0.0075 0.3492 0.5251
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0891 0.0878
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0035 0.1059 0.1577
Onchocerca volvulus 0.0032 0.0891 0.1324
Brugia malayi RE15519p 0.0032 0.0891 0.1324
Onchocerca volvulus 0.0032 0.0891 0.1324
Onchocerca volvulus 0.0032 0.0891 0.1324
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Giardia lamblia GTOR 0.0032 0.0887 0.9047
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Brugia malayi putative neuropeptide receptor NPR1 0.0032 0.0891 0.1324
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0032 0.0887 0.2533
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Schistosoma mansoni transcription factor LCR-F1 0.004 0.1401 0.1389
Onchocerca volvulus Neuropeptide F receptor homolog 0.0032 0.0891 0.1324
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0032 0.0891 0.1324
Loa Loa (eye worm) melatonin receptor type 1A 0.0032 0.0891 0.1324
Echinococcus multilocularis sex peptide receptor 0.0032 0.0891 0.0878
Echinococcus granulosus neuropeptide FF receptor 2 0.0032 0.0891 0.0878
Brugia malayi latrophilin 2 splice variant baaae 0.0075 0.3492 0.5251
Echinococcus granulosus 7TM GPCR rhodopsin 0.0032 0.0891 0.0878
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0032 0.0891 0.0878
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0067 0.3019 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0067 0.3019 1
Echinococcus granulosus neuropeptide receptor 0.0032 0.0891 0.0878
Brugia malayi G protein-coupled receptor F59B2.13 0.0032 0.0891 0.1324
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0033 0.098 1
Echinococcus granulosus g-protein coupled receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0055 0.0136
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0032 0.0891 0.0878
Echinococcus multilocularis geminin 0.0182 1 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0423 0.1362
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0891 0.0878
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0035 0.1059 0.1046
Echinococcus multilocularis allatostatin A receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0159 0.0482
Brugia malayi Tachykinin-like peptides receptor 99D 0.0032 0.0891 0.1324
Onchocerca volvulus 0.0032 0.0891 0.1324
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0032 0.0891 0.1324
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0891 0.0878
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0067 0.3019 1
Brugia malayi G-protein coupled receptor 0.0032 0.0891 0.1324
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0891 0.0878
Echinococcus granulosus orexin receptor type 2 0.0032 0.0891 0.0878
Plasmodium falciparum ataxin-2 like protein, putative 0.0023 0.0342 0.5
Loa Loa (eye worm) hypothetical protein 0.0103 0.5189 0.7812
Brugia malayi hypothetical protein 0.0032 0.0891 0.1324
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Loa Loa (eye worm) TYRA-2 protein 0.0032 0.0891 0.1324
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0891 0.0878
Schistosoma mansoni hypothetical protein 0.0035 0.1059 0.1046
Trichomonas vaginalis PIKK family atypical protein kinase 0.0021 0.0252 0.0793
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0423 0.1362
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.1401 0.1389
Brugia malayi neuropeptide F receptor 0.0032 0.0891 0.1324
Schistosoma mansoni amine GPCR 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Echinococcus granulosus somatostatin receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Schistosoma mansoni myosin xvIII 0.0032 0.0891 0.0878
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0891 0.0878
Schistosoma mansoni amine GPCR 0.0032 0.0891 0.0878
Brugia malayi Melatonin receptor type 1A 0.0032 0.0891 0.1324
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0891 0.0878
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0067 0.3019 1
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Echinococcus granulosus carboxylesterase 5A 0.0103 0.5189 0.5182
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0891 0.0878
Brugia malayi Dopamine receptor protein 2 0.0032 0.0891 0.1324
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0159 0.0482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0423 0.1362
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0017 0.0014 0.5
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Schistosoma mansoni hypothetical protein 0.0182 1 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0032 0.0891 0.0878
Echinococcus multilocularis fmrfamide receptor 0.0032 0.0891 0.0878
Schistosoma mansoni amine GPCR 0.0032 0.0891 0.0878
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0032 0.0891 0.0878
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0032 0.0891 0.0878
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0891 0.0878
Brugia malayi Carboxylesterase family protein 0.0103 0.5189 0.7812
Brugia malayi sulfakinin receptor protein 0.0032 0.0891 0.1324
Echinococcus multilocularis orexin receptor type 2 0.0032 0.0891 0.0878
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0891 0.1324
Echinococcus granulosus peptide allatostatin:somatostatin 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Schistosoma mansoni neuropeptide receptor 0.0032 0.0891 0.0878
Brugia malayi larval opioid receptor 0.0032 0.0891 0.1324
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0032 0.0891 0.0878
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0891 0.0878
Entamoeba histolytica hypothetical protein 0.004 0.1401 0.383
Schistosoma mansoni hypothetical protein 0.0182 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0887 0.2904
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0891 0.0878
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0024 0.0397 0.1273
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0055 0.0136
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0024 0.0397 0.0578
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0024 0.0397 0.0817
Loa Loa (eye worm) acetylcholinesterase 1 0.0103 0.5189 0.7812
Schistosoma mansoni amine GPCR 0.0032 0.0891 0.0878
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0035 0.1059 0.1046
Echinococcus granulosus g protein coupled receptor 0.0032 0.0891 0.0878
Echinococcus granulosus allatostatin A receptor 0.0032 0.0891 0.0878
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0032 0.0891 0.0878
Echinococcus multilocularis serotonin receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0423 0.1362
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0035 0.1059 0.1046
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0051 0.2063 0.3093
Mycobacterium tuberculosis POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) 0.0017 0.0014 0.5
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0055 0.0136
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0891 0.0878
Echinococcus granulosus sex peptide receptor 0.0032 0.0891 0.0878
Brugia malayi hypothetical protein 0.0032 0.0891 0.1324
Mycobacterium ulcerans carboxylesterase, LipT 0.0017 0.0014 0.5
Onchocerca volvulus 0.0032 0.0891 0.1324
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0032 0.0891 0.1324
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0032 0.0887 0.0874
Schistosoma mansoni alpha-1 adrenergic receptor 0.0032 0.0891 0.0878
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0342 0.0626
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0032 0.0887 0.1869
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0148 0.0447
Echinococcus multilocularis acetylcholinesterase 0.0103 0.5189 0.5182
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0891 0.0878
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0891 0.0878
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0891 0.0878
Schistosoma mansoni hypothetical protein 0.0035 0.1059 0.1046
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0063 0.2785 0.911
Echinococcus granulosus neuropeptide receptor 0.0032 0.0891 0.0878
Brugia malayi Serotonin receptor 0.0032 0.0891 0.1324
Loa Loa (eye worm) phosphatidylinositol 3 0.0032 0.0887 0.1317
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Brugia malayi hypothetical protein 0.0032 0.0891 0.1324
Loa Loa (eye worm) carboxylesterase 0.0103 0.5189 0.7812
Echinococcus multilocularis neuropeptide FF receptor 2 0.0032 0.0891 0.0878
Echinococcus multilocularis serotonin receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0109 0.5589 0.8416
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0032 0.0891 0.1324
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0032 0.0887 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0051 0.2063 0.3093
Loa Loa (eye worm) phosphatidylinositol 3 0.0111 0.5684 0.856
Trypanosoma cruzi target of rapamycin kinase 3 0.0026 0.0518 0.1243
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0517 0.1673
Schistosoma mansoni hypothetical protein 0.0035 0.1059 0.1046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.2063 0.2052
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0891 0.0878
Echinococcus multilocularis GPCR, family 2 0.0035 0.1059 0.1046
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Loa Loa (eye worm) hypothetical protein 0.0023 0.0342 0.0495
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0032 0.0891 0.0878
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0032 0.0891 0.0878
Brugia malayi hypothetical protein 0.0032 0.0891 0.1324
Echinococcus granulosus dro:myosuppressin receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Brugia malayi AKH receptor 0.0032 0.0891 0.1324
Echinococcus multilocularis g protein coupled receptor 0.0032 0.0891 0.0878
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0891 0.0878
Echinococcus granulosus g protein coupled receptor 0.0032 0.0891 0.0878
Onchocerca volvulus 0.0032 0.0891 0.1324
Onchocerca volvulus 0.0032 0.0891 0.1324
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0891 0.0878
Echinococcus granulosus phosphatidylinositol 45 bisphosphate 3 kinase 0.0124 0.6489 0.6484
Echinococcus multilocularis somatostatin receptor 0.0032 0.0891 0.0878
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0891 0.0878
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0032 0.0891 0.0878
Schistosoma mansoni biogenic amine (5HT) receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0517 0.1673
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Brugia malayi Dopamine receptor protein 1 0.0032 0.0891 0.1324
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0032 0.0891 0.1324
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0423 0.1362
Schistosoma mansoni neuropeptide f receptor 76f 0.0032 0.0891 0.0878
Loa Loa (eye worm) G-protein coupled receptor 0.0032 0.0891 0.1324
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0032 0.0887 0.1869
Echinococcus multilocularis G-protein coupled receptor, putative 0.0032 0.0891 0.0878
Loa Loa (eye worm) neuropeptide F receptor 0.0032 0.0891 0.1324
Brugia malayi hypothetical protein 0.004 0.1401 0.2094
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0044 0.1631 0.244
Brugia malayi Dopamine receptor 0.0032 0.0891 0.1324
Schistosoma mansoni hypothetical protein 0.0035 0.1059 0.1046
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Echinococcus granulosus biogenic amine 5HT receptor 0.0032 0.0891 0.0878
Onchocerca volvulus 0.0032 0.0891 0.1324
Echinococcus granulosus fmrfamide receptor 0.0032 0.0891 0.0878
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0044 0.1631 0.1619
Schistosoma mansoni biogenic amine receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0031 0.0826 0.1637
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0055 0.0136
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0032 0.0891 0.0878
Echinococcus multilocularis carboxylesterase 5A 0.0103 0.5189 0.5182
Echinococcus multilocularis G protein coupled receptor 139 0.0032 0.0891 0.0878
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0891 0.0878
Echinococcus granulosus g protein coupled receptor 0.0032 0.0891 0.0878
Schistosoma mansoni opsin-like receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0032 0.0891 0.0878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0622 0.2024
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0032 0.0891 0.0878
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0067 0.3019 0.4536
Echinococcus granulosus neuropeptide s receptor 0.0032 0.0891 0.0878
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0032 0.0887 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0032 0.0887 1
Brugia malayi hypothetical protein 0.0032 0.0891 0.1324
Echinococcus multilocularis neuropeptide s receptor 0.0032 0.0891 0.0878
Entamoeba histolytica hypothetical protein 0.004 0.1401 0.383
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0032 0.0891 0.1324
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0891 0.0878
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0032 0.0891 0.0878
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0032 0.0891 0.0878
Echinococcus multilocularis neuropeptides capa receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0109 0.5589 0.8416
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0051 0.2063 0.2052
Onchocerca volvulus 0.0032 0.0891 0.1324
Loa Loa (eye worm) hypothetical protein 0.0127 0.6638 1
Loa Loa (eye worm) hypothetical protein 0.0103 0.5189 0.7812
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0032 0.0887 0.0874
Trypanosoma cruzi PAB1-binding protein , putative 0.0023 0.0342 0.0626
Echinococcus granulosus serotonin receptor 0.0032 0.0891 0.0878
Echinococcus granulosus rhodopsin orphan GPCR 0.0032 0.0891 0.0878
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0044 0.1631 0.1619
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0517 0.1673
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Loa Loa (eye worm) latrophilin receptor protein 2 0.0035 0.1059 0.1577
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0032 0.0887 0.1317
Schistosoma mansoni hypothetical protein 0.0032 0.0891 0.0878
Onchocerca volvulus 0.0032 0.0891 0.1324
Entamoeba histolytica hypothetical protein 0.0054 0.2214 0.6931
Trichomonas vaginalis PIKK family atypical protein kinase 0.0018 0.0053 0.0131
Brugia malayi GnHR receptor homolog 0.0032 0.0891 0.1324
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0891 0.0878
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.0103 0.5189 0.5182
Brugia malayi G protein-coupled receptor 0.0032 0.0891 0.1324
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0032 0.0891 0.0878
Schistosoma mansoni hypothetical protein 0.0032 0.0891 0.0878
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Loa Loa (eye worm) hypothetical protein 0.0035 0.1059 0.1577
Echinococcus granulosus tm gpcr rhodopsin 0.0032 0.0891 0.0878
Schistosoma mansoni histamine h1 receptor 0.0032 0.0891 0.0878
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0032 0.0891 0.1324
Schistosoma mansoni hypothetical protein 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0891 0.0878
Echinococcus multilocularis neuropeptide Y receptor 0.0032 0.0891 0.0878
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0024 0.0397 0.0383
Echinococcus multilocularis rhodopsin orphan GPCR 0.0032 0.0891 0.0878
Schistosoma mansoni hypothetical protein 0.004 0.1401 0.1389
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0891 0.0878
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0032 0.0891 0.0878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0423 0.1362
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0026 0.0518 0.3235
Echinococcus granulosus G protein coupled receptor 139 0.0032 0.0891 0.0878
Echinococcus multilocularis neuropeptide receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0032 0.0887 0.0874
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0032 0.0887 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0057 0.2432 0.3651
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0032 0.0891 0.1324
Echinococcus granulosus neuropeptide receptor A26 0.0032 0.0891 0.0878
Schistosoma mansoni neuropeptide receptor 0.0032 0.0891 0.0878
Echinococcus granulosus neuropeptide Y receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0067 0.3019 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0032 0.0891 0.0878
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0517 0.1673
Schistosoma mansoni biogenic amine receptor 0.0032 0.0891 0.0878
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Schistosoma mansoni neuropeptide F-like receptor 0.0032 0.0891 0.0878
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0051 0.2063 0.2052
Loa Loa (eye worm) hypothetical protein 0.0032 0.0891 0.1324
Brugia malayi hypothetical protein 0.0023 0.0342 0.0495
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0032 0.0891 0.0878

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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