Detailed information for compound 663563

Basic information

Technical information
  • TDR Targets ID: 663563
  • Name: N-(2-methoxyphenyl)-4-methyl-N-[2-(4-methylpi peridin-1-yl)-2-oxoethyl]benzenesulfonamide
  • MW: 416.534 | Formula: C22H28N2O4S
  • H donors: 0 H acceptors: 3 LogP: 3.77 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N(S(=O)(=O)c1ccc(cc1)C)CC(=O)N1CCC(CC1)C
  • InChi: 1S/C22H28N2O4S/c1-17-8-10-19(11-9-17)29(26,27)24(20-6-4-5-7-21(20)28-3)16-22(25)23-14-12-18(2)13-15-23/h4-11,18H,12-16H2,1-3H3
  • InChiKey: FLMWGXRDCVBGMZ-UHFFFAOYSA-N  

Network

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Synonyms

  • N-(2-methoxyphenyl)-4-methyl-N-[2-(4-methyl-1-piperidyl)-2-oxo-ethyl]benzenesulfonamide
  • N-(2-methoxyphenyl)-4-methyl-N-[2-(4-methyl-1-piperidinyl)-2-oxoethyl]benzenesulfonamide
  • N-[2-keto-2-(4-methyl-1-piperidyl)ethyl]-N-(2-methoxyphenyl)-4-methyl-benzenesulfonamide
  • N-(2-methoxyphenyl)-4-methyl-N-[2-(4-methylpiperidin-1-yl)-2-oxo-ethyl]benzenesulfonamide
  • BAS 03560215
  • Oprea1_292265
  • EU-0045614
  • Oprea1_769151
  • NCGC00099543-01

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0013 0.0034 0.5
Loa Loa (eye worm) hypothetical protein 0.0069 0.0638 0.0546
Loa Loa (eye worm) hypothetical protein 0.0234 0.241 0.2336
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0875 0.0875
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0538 0.0538
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0034 0.0034
Onchocerca volvulus 0.0057 0.051 0.1302
Plasmodium vivax glutathione reductase, putative 0.0037 0.0296 0.6835
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0433 0.0433
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0104 0.1009 0.1009
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.1009 0.1009
Toxoplasma gondii aminopeptidase n, putative 0.005 0.0433 0.4043
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0261 0.2702 0.5919
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0276 0.0276
Onchocerca volvulus 0.005 0.0433 0.095
Onchocerca volvulus 0.0234 0.2413 1
Mycobacterium ulcerans aminopeptidase N PepN 0.005 0.0433 0.1475
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.1009 0.1009
Brugia malayi Inositol-1 0.0074 0.069 0.1455
Leishmania major trypanothione reductase 0.0037 0.0296 0.3986
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.0225 0.0225
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0024 0.0158 0.0061
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.1209 0.1209
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0277 0.0896
Echinococcus granulosus aminopeptidase N 0.005 0.0433 0.0433
Echinococcus multilocularis neuropeptide receptor A26 0.0451 0.4748 0.4748
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0013 0.0034 0.0797
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3072 1
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0158 0.1885
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0538 0.1864
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.0225 0.2101
Brugia malayi Latrophilin receptor protein 2 0.0083 0.0784 0.1663
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.006 0.006
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0277 0.639
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0035 0.0114
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0069 0.0638 0.2077
Echinococcus multilocularis aminopeptidase N 0.005 0.0433 0.0433
Echinococcus granulosus neuropeptide s receptor 0.0451 0.4748 0.4748
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0097 0.0097
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0261 0.2702 0.263
Brugia malayi latrophilin 2 splice variant baaae 0.0178 0.1814 0.3949
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0083 0.0784 0.0784
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.01 0.0326
Giardia lamblia NADH oxidase lateral transfer candidate 0.0013 0.0034 0.0112
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0296 0.6835
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.01 0.2317
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0409 0.0831
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3072 1
Trypanosoma cruzi importin beta-1 subunit, putative 0.0027 0.0185 0.2292
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.0225 0.0225
Mycobacterium tuberculosis Probable reductase 0.0085 0.0808 0.3374
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.005 0.0433 0.0433
Plasmodium falciparum glutathione reductase 0.0037 0.0296 0.6835
Entamoeba histolytica hypothetical protein 0.0027 0.0185 0.0602
Brugia malayi hypothetical protein 0.005 0.0433 0.0884
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0035 0.0114
Trypanosoma cruzi aminopeptidase, putative 0.005 0.0433 0.6075
Mycobacterium tuberculosis Conserved protein 0.0035 0.0277 0.1056
Onchocerca volvulus 0.0048 0.0409 0.084
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0638 0.0638
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.069 0.2246
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0035 0.0114
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0035 0.0114
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.005 0.0433 0.1409
Schistosoma mansoni hypothetical protein 0.0083 0.0784 0.0784
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0085 0.0808 0.454
Leishmania major hypothetical protein, conserved 0.0035 0.0277 0.3692
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.005 0.0433 0.6075
Schistosoma mansoni ran 0.0024 0.0158 0.0158
Loa Loa (eye worm) inositol-1 0.0074 0.069 0.0598
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0095 0.0134
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.005 0.0433 0.0433
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0074 0.069 0.2246
Echinococcus granulosus snurportin 1 0.0354 0.3699 0.3699
Loa Loa (eye worm) glutaminase 2 0.0264 0.2734 0.2663
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.01 0.1004
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.051 0.0416
Echinococcus granulosus neuropeptide receptor A26 0.0451 0.4748 0.4748
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3072 1
Leishmania major GTP-binding protein, putative 0.0024 0.0158 0.1885
Treponema pallidum fructose-bisphosphate aldolase 0.0295 0.3072 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0035 0.0114
Plasmodium vivax importin-beta 2, putative 0.0033 0.0252 0.5826
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0035 0.0114
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0276 0.0276
Trichomonas vaginalis set domain proteins, putative 0.0234 0.2413 0.7856
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.01 0.1004
Echinococcus granulosus importin subunit beta 1 0.0033 0.0252 0.0252
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0035 0.0114
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.006 0.006
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0074 0.069 0.2428
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0277 0.1056
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.0225 0.0225
Onchocerca volvulus 0.0035 0.0277 0.0236
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.0538 0.7677
Echinococcus granulosus geminin 0.0171 0.1737 0.1737
Loa Loa (eye worm) hypothetical protein 0.0035 0.0277 0.0181
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0035 0.0114
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0091 0.0875 0.0875
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0433 0.0433
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.005 0.0433 0.0433
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0074 0.069 0.2246
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0277 0.0896
Plasmodium falciparum thioredoxin reductase 0.0037 0.0296 0.6835
Echinococcus multilocularis survival motor neuron protein 1 0.0234 0.241 0.241
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0066 0.0607 0.2821
Schistosoma mansoni ran 0.0024 0.0158 0.0158
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.01 0.01
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0277 0.1056
Entamoeba histolytica hypothetical protein 0.0035 0.0276 0.0899
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0085 0.0808 0.3374
Loa Loa (eye worm) hypothetical protein 0.0035 0.0277 0.0181
Schistosoma mansoni cpg binding protein 0.006 0.0545 0.0545
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0802 0.8518 0.8518
Brugia malayi beta-lactamase family protein 0.0035 0.0277 0.0537
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0069 0.0638 0.0638
Toxoplasma gondii aminopeptidase N, putative 0.005 0.0433 0.4043
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.0538 0.2195
Echinococcus granulosus GPCR family 2 0.0083 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.005 0.0433 0.0339
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.0538 0.0538
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0091 0.0875 0.1865
Trichomonas vaginalis ran, putative 0.0024 0.0158 0.0515
Schistosoma mansoni ap endonuclease 0.0019 0.01 0.01
Loa Loa (eye worm) beta-lactamase 0.0035 0.0277 0.0181
Onchocerca volvulus 0.0035 0.0277 0.0236
Trichomonas vaginalis importin beta-1, putative 0.0027 0.0185 0.0602
Schistosoma mansoni inositol monophosphatase 0.0074 0.069 0.069
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.094 1 1
Schistosoma mansoni inositol monophosphatase 0.0074 0.069 0.069
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.2109 0.2032
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.01 0.0326
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.0225 0.0225
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0433 0.0433
Schistosoma mansoni hypothetical protein 0.0171 0.1737 0.1737
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0277 0.0181
Trichomonas vaginalis inositol monophosphatase, putative 0.0074 0.069 0.2246
Brugia malayi Importin beta-1 subunit 0.0033 0.0252 0.0483
Trypanosoma brucei aminopeptidase, putative 0.005 0.0433 0.6075
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0277 0.09
Onchocerca volvulus 0.005 0.0433 0.095
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.1009 0.1009
Schistosoma mansoni cpg binding protein 0.0057 0.051 0.051
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0277 0.09
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0097 0.0097
Loa Loa (eye worm) hypothetical protein 0.005 0.0433 0.0339
Brugia malayi hypothetical protein 0.005 0.0433 0.0884
Echinococcus granulosus inositol monophosphatase 1 0.0074 0.069 0.069
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.107 1
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0035 0.0114
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.01 0.0287
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.006 0.006
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0144 0.1447 0.6162
Schistosoma mansoni importin beta-1 0.0033 0.0252 0.0252
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0277 0.0277
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.006 0.006
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.01 0.1004
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.01 0.0326
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0034 0.0034
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0083 0.0784 0.0784
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0277 0.1056
Echinococcus multilocularis cpg binding protein 0.006 0.0545 0.0545
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0013 0.0034 0.0322
Echinococcus multilocularis leukotriene A 4 hydrolase 0.094 1 1
Loa Loa (eye worm) TATA binding protein associated factor 0.005 0.0433 0.0339
Schistosoma mansoni hypothetical protein 0.0171 0.1737 0.1737
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0538 0.1864
Schistosoma mansoni hypothetical protein 0.0083 0.0784 0.0784
Mycobacterium ulcerans aminopeptidase N PepN 0.005 0.0433 0.1475
Schistosoma mansoni hypothetical protein 0.0083 0.0784 0.0784
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0035 0.0114
Entamoeba histolytica hypothetical protein 0.0035 0.0276 0.0899
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.005 0.0433 0.6075
Brugia malayi Calcitonin receptor-like protein seb-1 0.0261 0.2702 0.5919
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0094 0.091 0.3818
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0433 0.0433
Mycobacterium ulcerans beta-lactamase 0.0035 0.0277 0.0896
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0296 0.3986
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0085 0.0808 0.3374
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0277 0.0277
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0024 0.0158 0.1885
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.005 0.0433 0.6075
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0085 0.0808 0.3374
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.0538 0.0538
Loa Loa (eye worm) hypothetical protein 0.0035 0.0277 0.0181
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0252 0.332
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0144 0.1447 1
Schistosoma mansoni hypothetical protein 0.0178 0.1814 0.1814
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0277 0.1056
Trichomonas vaginalis glutaminase, putative 0.0264 0.2734 0.8901
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0875 0.0875
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0277 0.3692
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0013 0.0034 0.0797
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.005 0.0433 0.6075
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0015 0.0053 0.0053
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0277 0.1056
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0035 0.0114
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0035 0.0114
Brugia malayi Pre-SET motif family protein 0.0206 0.2109 0.4604
Brugia malayi Peptidase family M1 containing protein 0.005 0.0433 0.0884
Echinococcus multilocularis thioredoxin glutathione reductase 0.0038 0.0301 0.0301
Mycobacterium ulcerans glutaminase 0.0264 0.2734 1
Brugia malayi TATA binding protein associated factor 0.005 0.0433 0.0884
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.005 0.0433 0.1409
Mycobacterium ulcerans lipase LipD 0.0035 0.0277 0.0896
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.3072 1
Plasmodium falciparum importin beta, putative 0.0033 0.0252 0.5826
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0276 0.0276
Echinococcus granulosus thioredoxin glutathione reductase 0.0038 0.0301 0.0301
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0035 0.0114
Echinococcus multilocularis GPCR, family 2 0.0083 0.0784 0.0784
Loa Loa (eye worm) hypothetical protein 0.005 0.0433 0.0339
Onchocerca volvulus 0.0035 0.0277 0.0236
Echinococcus multilocularis geminin 0.0171 0.1737 0.1737
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0185 0.0602
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0085 0.0808 0.3374
Brugia malayi Peptidase family M1 containing protein 0.005 0.0433 0.0884
Entamoeba histolytica aminopeptidase, putative 0.005 0.0433 0.1409
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0354 0.3699 0.3637
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.01 0.0244
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3072 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0277 0.0277
Leishmania major importin beta-1 subunit, putative 0.0027 0.0185 0.2292
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0433 0.0433
Loa Loa (eye worm) hypothetical protein 0.0261 0.2702 0.263
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0104 0.1009 0.1009
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.005 0.0433 0.0433
Trypanosoma brucei Aminopeptidase M1, putative 0.005 0.0433 0.6075
Entamoeba histolytica hypothetical protein 0.0035 0.0276 0.0899
Giardia lamblia Fructose-bisphosphate aldolase 0.0295 0.3072 1
Schistosoma mansoni aminopeptidase A (M01 family) 0.005 0.0433 0.0433
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0277 0.1056
Brugia malayi Melibiase family protein 0.0069 0.0638 0.1339
Toxoplasma gondii melibiase subfamily protein 0.0104 0.1009 0.9425
Mycobacterium tuberculosis Conserved protein 0.0035 0.0277 0.1056
Loa Loa (eye worm) hypothetical protein 0.0035 0.0277 0.0181
Brugia malayi hypothetical protein 0.0234 0.241 0.5272
Mycobacterium ulcerans hypothetical protein 0.0035 0.0277 0.0896
Echinococcus multilocularis importin subunit beta 1 0.0033 0.0252 0.0252
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.005 0.0433 0.1409
Brugia malayi glutaminase DH11.1 0.0264 0.2734 0.599
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0277 0.0537
Schistosoma mansoni hypothetical protein 0.0048 0.0409 0.0409
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.069 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.069 1
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.005 0.0433 0.6075
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3072 1
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.005 0.0433 0.6075
Trichomonas vaginalis mercuric reductase, putative 0.0013 0.0034 0.0112
Plasmodium falciparum thioredoxin reductase 0.0013 0.0034 0.0797
Trichomonas vaginalis helicase, putative 0.0013 0.0035 0.0114
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.005 0.0433 0.6075
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.2327 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3072 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0144 0.1447 0.5233
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0875 0.0875
Brugia malayi beta-lactamase family protein 0.0035 0.0277 0.0537
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0277 0.09
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0091 0.0875 0.0875
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0035 0.0114
Echinococcus granulosus GTP binding nuclear protein Ran 0.0024 0.0158 0.0158
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.005 0.0433 0.0433
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0035 0.0114
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.006 0.006
Schistosoma mansoni hypothetical protein 0.0083 0.0784 0.0784
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0024 0.0158 0.3653
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0024 0.0158 0.0274
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0035 0.0114
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.005 0.0433 0.6075
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0277 0.3692
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0277 0.1056
Trypanosoma brucei trypanothione reductase 0.0037 0.0296 0.3986
Onchocerca volvulus 0.005 0.0433 0.095
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0277 0.0277
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0225 0.0225
Loa Loa (eye worm) hypothetical protein 0.0035 0.0277 0.0181
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.005 0.0433 0.0433
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.0538 0.5024
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.005 0.0433 0.0433
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0875 0.0875
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0296 0.114
Trypanosoma cruzi Aminopeptidase M1, putative 0.005 0.0433 0.6075
Brugia malayi Thioredoxin reductase 0.0037 0.0296 0.058
Plasmodium falciparum glutathione reductase 0.0013 0.0034 0.0797
Schistosoma mansoni hypothetical protein 0.0813 0.8638 0.8638
Loa Loa (eye worm) hypothetical protein 0.0031 0.0225 0.0129
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0024 0.0158 0.0515
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0024 0.0158 0.1477
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0091 0.0875 0.0785
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.069 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0013 0.0034 0.0797
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.005 0.0433 0.6075
Loa Loa (eye worm) glutathione reductase 0.0037 0.0296 0.02
Mycobacterium tuberculosis Probable dehydrogenase 0.0085 0.0808 0.3374
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0066 0.0607 0.2496
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.005 0.0433 0.6075
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0091 0.0875 0.0875
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0083 0.0784 0.1663
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0074 0.069 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.01 0.0326
Toxoplasma gondii ABC1 family protein 0.0035 0.0277 0.2583
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.005 0.0433 1
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.005 0.0433 0.0433
Brugia malayi RNA, U transporter 1 0.0094 0.0909 0.194
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.01 0.1004
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0225 0.0225
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.0538 0.1864
Echinococcus multilocularis neuropeptide s receptor 0.0451 0.4748 0.4748
Brugia malayi Peptidase family M1 containing protein 0.005 0.0433 0.0884
Toxoplasma gondii exonuclease III APE 0.0019 0.01 0.0937
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0074 0.069 0.6447
Schistosoma mansoni hypothetical protein 0.0354 0.3699 0.3699
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0027 0.0185 0.0602
Toxoplasma gondii NADPH-glutathione reductase 0.0013 0.0034 0.0322
Loa Loa (eye worm) glutaminase 0.0264 0.2734 0.2663
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0024 0.0158 0.0158
Loa Loa (eye worm) leukotriene A4 hydrolase 0.094 1 1
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0013 0.0034 0.0797
Brugia malayi glutathione reductase 0.0037 0.0296 0.058
Echinococcus multilocularis snurportin 1 0.0354 0.3699 0.3699
Plasmodium falciparum M1-family alanyl aminopeptidase 0.005 0.0433 1
Brugia malayi Pre-SET motif family protein 0.0031 0.0225 0.0422
Echinococcus granulosus puromycin sensitive aminopeptidase 0.005 0.0433 0.0433
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0028 0.02 0.02
Brugia malayi beta-lactamase 0.0035 0.0277 0.0537
Schistosoma mansoni hypothetical protein 0.0035 0.0276 0.0276
Loa Loa (eye worm) latrophilin receptor protein 2 0.0083 0.0784 0.0693
Loa Loa (eye worm) hypothetical protein 0.0178 0.1814 0.1734
Brugia malayi hypothetical protein 0.0432 0.4541 1
Loa Loa (eye worm) aminopeptidase N 0.005 0.0433 0.0339
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0024 0.0158 0.3653
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.0225 0.0225
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0104 0.1009 0.1009
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.005 0.0433 0.0433
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.01 0.2317
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.01 0.1004
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.01 0.0217
Schistosoma mansoni ap endonuclease 0.0019 0.01 0.01
Echinococcus multilocularis dnaJ subfamily B 0.0813 0.8638 0.8638
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0035 0.0114
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0034 0.0034
Trypanosoma brucei Aminopeptidase M1, putative 0.005 0.0433 0.6075
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.0538 0.0538
Toxoplasma gondii Alpha-galactosidase 0.0015 0.0053 0.0499
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0094 0.091 0.5409
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3072 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0083 0.0784 0.0784
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0024 0.0158 0.1885
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0094 0.091 0.3818
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0296 0.02
Entamoeba histolytica hypothetical protein 0.0035 0.0276 0.0899
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0295 0.3072 1
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0277 0.09
Plasmodium vivax SET domain protein, putative 0.0031 0.0225 0.5197
Brugia malayi CXXC zinc finger family protein 0.0057 0.051 0.1054
Toxoplasma gondii aminopeptidase N protein 0.005 0.0433 0.4043
Trypanosoma brucei importin beta-1 subunit, putative 0.0033 0.0252 0.332
Loa Loa (eye worm) peptidase family M1 containing protein 0.005 0.0433 0.0339
Loa Loa (eye worm) hypothetical protein 0.0033 0.0252 0.0156
Echinococcus granulosus dnaJ subfamily B 0.0813 0.8638 0.8638
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0074 0.069 1
Mycobacterium tuberculosis Probable oxidoreductase 0.0094 0.091 0.3818
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0277 0.3692
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0104 0.1009 0.1009
Trichomonas vaginalis esterase, putative 0.0035 0.0277 0.09
Echinococcus granulosus survival motor neuron protein 1 0.0234 0.241 0.241
Entamoeba histolytica Ran family GTPase 0.0024 0.0158 0.0515
Trypanosoma cruzi aminopeptidase, putative 0.005 0.0433 0.6075
Mycobacterium tuberculosis Conserved protein 0.0035 0.0277 0.1056
Schistosoma mansoni survival motor neuron protein 0.0048 0.0409 0.0409
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.01 0.0146
Loa Loa (eye worm) hypothetical protein 0.0035 0.0277 0.0181
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.005 0.0433 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0295 0.3072 1
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.01 0.0003
Toxoplasma gondii thioredoxin reductase 0.0037 0.0296 0.2763
Echinococcus multilocularis inositol monophosphatase 1 0.0074 0.069 0.069
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.01 0.01
Schistosoma mansoni cpg binding protein 0.006 0.0545 0.0545
Echinococcus granulosus cpg binding protein 0.006 0.0545 0.0545
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0277 0.09
Toxoplasma gondii HEAT repeat-containing protein 0.0033 0.0252 0.2355
Loa Loa (eye worm) hypothetical protein 0.0083 0.0784 0.0693
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.005 0.0433 1
Schistosoma mansoni glutaminase 0.0264 0.2734 0.2734
Brugia malayi hypothetical protein 0.0035 0.0276 0.0536
Trichomonas vaginalis glutathione reductase, putative 0.0013 0.0034 0.0112
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0083 0.0784 0.0784

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 35.4813 um PUBCHEM_BIOASSAY: qHTS Assay for Identifying the Cell-Membrane Permeable IMPase Inhibitors. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 39.8107 uM PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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