Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0052 | 0.0121 | 0.0358 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0143 | 0.1307 | 0.3871 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0102 | 0.0773 | 0.5 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0303 | 0.3378 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0159 | 0.1518 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0102 | 0.0773 | 0.5 |
Echinococcus granulosus | tumor protein p63 | 0.0347 | 0.3956 | 0.8073 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0143 | 0.1307 | 0.3871 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.051 | 0.6051 |
Echinococcus multilocularis | tumor protein p63 | 0.0347 | 0.3956 | 0.3449 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0773 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0102 | 0.0773 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0159 | 0.1518 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0406 | 0.4715 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0.0081 | 0.5 |
Onchocerca volvulus | 0.0051 | 0.0107 | 0.5 | |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0303 | 0.3378 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0303 | 0.3378 | 1 |
Leishmania major | mitochondrial DNA polymerase beta | 0.0303 | 0.3378 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.