Detailed information for compound 663649

Basic information

Technical information
  • TDR Targets ID: 663649
  • Name: 2-(4-methoxyphenoxy)-N-methyl-N-phenylacetami de
  • MW: 271.311 | Formula: C16H17NO3
  • H donors: 0 H acceptors: 1 LogP: 2.95 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)OCC(=O)N(c1ccccc1)C
  • InChi: 1S/C16H17NO3/c1-17(13-6-4-3-5-7-13)16(18)12-20-15-10-8-14(19-2)9-11-15/h3-11H,12H2,1-2H3
  • InChiKey: MPZAGIAQCVOIEU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-(4-methoxyphenoxy)-N-methyl-N-phenyl-acetamide
  • 2-(4-methoxyphenoxy)-N-methyl-N-phenyl-ethanamide
  • STK225712
  • ZINC00466788

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Pre-SET motif family protein 0.0031 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0086 0.0086
Loa Loa (eye worm) isocitrate dehydrogenase gamma subunit 0.0167 0.1113 0.1113
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0591 0.4223 1
Echinococcus granulosus isocitrate dehydrogenase NAD subunit 0.0167 0.1113 0.1113
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0289 0.2004 0.1002
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0031 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0027 0.0086 0.0086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0591 0.4223 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0031 0.011 0.011
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0086 0.0086
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0086 0.0086
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0086 0.0086
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.023 0.023
Giardia lamblia Fructose-bisphosphate aldolase 0.0591 0.4223 0.5
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0027 0.0086 0.0086
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1378 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0086 0.0086
Entamoeba histolytica tartrate dehydrogenase, putative 0.0167 0.1113 0.2376
Onchocerca volvulus 0.0027 0.0086 0.0364
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.1378 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.023 0.023
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.023 0.023
Brugia malayi Trypsin family protein 0.0338 0.2364 0.2364
Brugia malayi isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial 0.0167 0.1113 0.1113
Brugia malayi Protein kinase domain containing protein 0.0021 0.0037 0.0037
Echinococcus multilocularis enteropeptidase 0.0027 0.0086 0.0086
Brugia malayi Isocitrate dehydrogenase 0.1378 1 1
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0102 0.0102
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0086 0.0086
Onchocerca volvulus 0.0021 0.0037 0.0155
Leishmania major isocitrate dehydrogenase, putative 0.0167 0.1113 0.1081
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1378 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0086 0.0086
Brugia malayi isocitrate dehydrogenase [NAD] subunit beta, mitochondrial 0.0167 0.1113 0.1113
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.1378 1 1
Loa Loa (eye worm) trypsin family protein 0.0027 0.0086 0.0086
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0027 0.0086 0.0086
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.1378 1 1
Echinococcus granulosus isocitrate dehydrogenase NAD 0.0167 0.1113 0.1113
Loa Loa (eye worm) hypothetical protein 0.0178 0.1188 0.1188
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0214 0.1455 0.1455
Brugia malayi Trypsin family protein 0.0027 0.0086 0.0086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0591 0.4223 1
Mycobacterium ulcerans 3-isopropylmalate dehydrogenase 0.0167 0.1113 0.5357
Onchocerca volvulus 0.0027 0.0086 0.0364
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.023 0.023
Wolbachia endosymbiont of Brugia malayi isocitrate dehydrogenase 0.0167 0.1113 0.5
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0027 0.0086 0.0086
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0086 0.0086
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.023 0.023
Onchocerca volvulus 0.0027 0.0086 0.0364
Echinococcus granulosus transmembrane protease serine 3 0.0027 0.0086 0.0086
Trypanosoma brucei isocitrate dehydrogenase, putative 0.1378 1 0.5
Schistosoma mansoni hypothetical protein 0.0027 0.0086 0.0086
Loa Loa (eye worm) isocitrate dehydrogenase 0.1378 1 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.023 0.023
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0086 0.0086
Toxoplasma gondii isocitrate dehydrogenase 0.1378 1 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.011 0.011
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1378 1 1
Brugia malayi Trypsin family protein 0.0027 0.0086 0.0086
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0338 0.2364 0.2364
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0027 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0027 0.0086 0.0086
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0086 0.0086
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0145 0.0145
Echinococcus multilocularis isocitrate dehydrogenase 0.1378 1 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.1378 1 1
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0086 0.0086
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0145 0.0145
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0086 0.0086
Loa Loa (eye worm) hypothetical protein 0.0167 0.1113 0.1113
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0086 0.0086
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.023 0.023
Echinococcus multilocularis glycoprotein Antigen 5 0.0027 0.0086 0.0086
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0027 0.0086 0.0086
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0086 0.0086
Onchocerca volvulus 0.0243 0.1672 0.7074
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.023 0.023
Onchocerca volvulus 0.0027 0.0086 0.0364
Echinococcus multilocularis Mastin 0.0027 0.0086 0.0086
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0145 0.0145
Echinococcus granulosus tissue type plasminogen activator 0.0021 0.0037 0.0037
Brugia malayi Trypsin-like protease protein 5 0.0027 0.0086 0.0086
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0031 0.011 0.011
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.011 0.011
Onchocerca volvulus 0.0031 0.011 0.0466
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0031 0.011 0.011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.023 0.023
Echinococcus multilocularis transmembrane protease serine 3 0.0027 0.0086 0.0086
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0591 0.4223 1
Treponema pallidum fructose-bisphosphate aldolase 0.0591 0.4223 0.5
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0289 0.2004 1
Brugia malayi Trypsin family protein 0.0027 0.0086 0.0086
Echinococcus multilocularis tissue type plasminogen activator 0.0021 0.0037 0.0037
Echinococcus granulosus glycoprotein Antigen 5 0.0027 0.0086 0.0086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0591 0.4223 1
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1378 1 0.5
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.1378 1 1
Loa Loa (eye worm) hypothetical protein 0.0021 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0338 0.2364 0.2364
Schistosoma mansoni unc-13 (munc13) 0.0167 0.1113 0.1113
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.011 0.011
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0027 0.0086 0.0086
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0178 0.1188 0.5027
Trichomonas vaginalis set domain proteins, putative 0.0243 0.1672 0.1798
Onchocerca volvulus 0.0027 0.0086 0.0364
Loa Loa (eye worm) TK/ROR protein kinase 0.0021 0.0037 0.0037
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0027 0.0086 0.0086
Toxoplasma gondii isocitrate dehydrogenase 0.1378 1 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.1378 1 1
Echinococcus multilocularis isocitrate dehydrogenase (NAD+) 0.0167 0.1113 0.1113
Brugia malayi Pre-SET motif family protein 0.0214 0.1455 0.1455
Schistosoma mansoni hypothetical protein 0.0035 0.0145 0.0145
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0086 0.0086
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0591 0.4223 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0591 0.4223 1
Echinococcus granulosus Mastin 0.0027 0.0086 0.0086
Echinococcus granulosus enteropeptidase 0.0027 0.0086 0.0086
Plasmodium vivax SET domain protein, putative 0.0031 0.011 0.0074
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0591 0.4223 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0031 0.011 0.011
Toxoplasma gondii kringle domain-containing protein 0.0021 0.0037 0.0037
Loa Loa (eye worm) hypothetical protein 0.0338 0.2364 0.2364
Schistosoma mansoni isocitrate dehydrogenase 0.0167 0.1113 0.1113
Schistosoma mansoni Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial 0.0167 0.1113 0.1113
Schistosoma mansoni hypothetical protein 0.0021 0.0037 0.0037
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0289 0.2004 1
Brugia malayi Kringle domain containing protein 0.0021 0.0037 0.0037
Brugia malayi Probable isocitrate dehydrogenase 0.0167 0.1113 0.1113
Echinococcus multilocularis isocitrate dehydrogenase (NAD) subunit 0.0167 0.1113 0.1113
Schistosoma mansoni cercarial elastase (S01 family) 0.0027 0.0086 0.0086
Brugia malayi N-terminal motif family protein 0.0178 0.1188 0.1188
Brugia malayi hypothetical protein 0.0035 0.0145 0.0145
Onchocerca volvulus 0.0338 0.2364 1
Onchocerca volvulus 0.031 0.2163 0.9149
Loa Loa (eye worm) hypothetical protein 0.0027 0.0086 0.0086
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.1378 1 1
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.1378 1 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0338 0.2364 0.2364
Brugia malayi Isocitrate dehydrogenase subunit gamma, mitochondrial precursor 0.0167 0.1113 0.1113
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0591 0.4223 1
Schistosoma mansoni hypothetical protein 0.0027 0.0086 0.0086
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0798 0.574 0.574
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0031 0.011 0.011
Brugia malayi hypothetical protein 0.0027 0.0086 0.0086
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0591 0.4223 1
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.1378 1 1
Brugia malayi Probable isocitrate dehydrogenase 0.0167 0.1113 0.1113

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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