Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0072 | 1 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.8682 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.8682 | 0.8682 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0072 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.001 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.8682 | 0.8682 |
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.8682 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.8254 | 0.8254 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.8254 | 0.8254 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.8254 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.8682 | 0.8682 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.8254 | 0.5 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.8254 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 1 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.8682 | 0.8682 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.8682 | 0.8682 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.001 | 0 | 0.5 |
Onchocerca volvulus | 0.001 | 0 | 0.5 | |
Brugia malayi | RNA binding protein | 0.0063 | 0.8682 | 0.8682 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.8682 | 0.8682 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.8254 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0072 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.001 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 1 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.8682 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0072 | 1 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.8682 | 0.8682 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0072 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.8254 | 0.8254 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.8682 | 0.8682 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.8254 | 0.8254 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.8682 | 0.8682 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0072 | 1 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.8254 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.8254 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.