Detailed information for compound 66385

Basic information

Technical information
  • TDR Targets ID: 66385
  • Name: 9-(2-nitrophenyl)sulfanyl-3H-purine-6-thione
  • MW: 305.336 | Formula: C11H7N5O2S2
  • H donors: 0 H acceptors: 5 LogP: 2.46 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: [O-][N+](=O)c1ccccc1Sn1cnc2c1ncnc2S
  • InChi: 1S/C11H7N5O2S2/c17-16(18)7-3-1-2-4-8(7)20-15-6-14-9-10(15)12-5-13-11(9)19/h1-6H,(H,12,13,19)
  • InChiKey: NKYQMJOSFUUYAF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 9-[(2-nitrophenyl)thio]-3H-purine-6-thione
  • AIDS108368
  • 9-(2-Nitrophenylthio)hydropurine-6-thione
  • AIDS-108368

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni glutamate receptor NMDA 0.0047 0.0052 0.004
Echinococcus multilocularis neuropeptides capa receptor 0.0679 0.1624 0.2281
Entamoeba histolytica cyclin family protein 0.0065 0.0097 0.0626
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0679 0.1624 0.2281
Brugia malayi Calcitonin receptor-like protein seb-1 0.1012 0.2453 0.3286
Echinococcus multilocularis Tubulin beta 2C chain 0.0565 0.1341 0.188
Echinococcus granulosus Tubulin beta 2C chain 0.0565 0.1341 0.188
Schistosoma mansoni neuropeptide F-like receptor 0.0679 0.1624 0.1614
Schistosoma mansoni tubulin subunit beta 0.0565 0.1341 0.133
Brugia malayi Serotonin receptor 0.0679 0.1624 0.217
Trypanosoma brucei beta tubulin 0.0565 0.1341 0.7016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0679 0.1624 0.1614
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0679 0.1624 0.217
Echinococcus granulosus fmrfamide receptor 0.0679 0.1624 0.2281
Loa Loa (eye worm) hypothetical protein 0.0692 0.1656 0.2213
Echinococcus multilocularis rhodopsin orphan GPCR 0.0679 0.1624 0.2281
Echinococcus granulosus neuropeptide receptor A26 0.0679 0.1624 0.2281
Echinococcus multilocularis G-protein coupled receptor, putative 0.0679 0.1624 0.2281
Toxoplasma gondii aspartyl protease ASP3 0.0513 0.1212 0.3497
Schistosoma mansoni opsin-like receptor 0.0679 0.1624 0.1614
Loa Loa (eye worm) TYRA-2 protein 0.0679 0.1624 0.217
Echinococcus multilocularis 0.0232 0.0512 0.0707
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0357 0.0993
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Onchocerca volvulus 0.0679 0.1624 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0679 0.1624 0.217
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0679 0.1624 0.2281
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0679 0.1624 0.2281
Brugia malayi neuropeptide F receptor 0.0679 0.1624 0.217
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0353 0.0812 0.0801
Loa Loa (eye worm) tubulin beta chain 0.0565 0.1341 0.1789
Trichomonas vaginalis tubulin epsilon chain, putative 0.0565 0.1341 0.3845
Echinococcus granulosus cyclin b3 0.0065 0.0097 0.012
Plasmodium vivax calcium-dependent protein kinase 1, putative 0.0064 0.0093 0.0229
Echinococcus multilocularis cyclins 0.0065 0.0097 0.012
Plasmodium falciparum plasmepsin VI 0.1418 0.3465 1
Echinococcus multilocularis allatostatin A receptor 0.0679 0.1624 0.2281
Onchocerca volvulus 0.0353 0.0812 0.4927
Brugia malayi endoprotease bli-4 precursor 0.0288 0.0651 0.086
Brugia malayi putative neuropeptide receptor 0.0679 0.1624 0.217
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0679 0.1624 0.1614
Onchocerca volvulus 0.0679 0.1624 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0679 0.1624 0.1614
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0578 0.1635
Plasmodium vivax calcium-dependent protein kinase 3, putative 0.0064 0.0093 0.0229
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0357 0.0993
Entamoeba histolytica tubulin family protein 0.0565 0.1341 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0679 0.1624 0.2281
Echinococcus granulosus 7TM GPCR rhodopsin 0.0679 0.1624 0.2281
Brugia malayi hypothetical protein 0.0679 0.1624 0.217
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0679 0.1624 0.2281
Loa Loa (eye worm) hypothetical protein 0.1418 0.3465 0.4648
Plasmodium vivax cysteine repeat modular protein 1, putative 0.0036 0.0024 0.003
Entamoeba histolytica protein kinase, putative 0.0064 0.0093 0.0595
Leishmania major cyclin 0.013 0.0259 0.1843
Schistosoma mansoni memapsin-2 (A01 family) 0.0353 0.0812 0.0801
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.038 0.1059
Echinococcus granulosus cyclins 0.0065 0.0097 0.012
Schistosoma mansoni hypothetical protein 0.032 0.0731 0.072
Echinococcus multilocularis neuropeptides capa receptor 0.0679 0.1624 0.2281
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0104 0.026
Trypanosoma cruzi cyclin 6, putative 0.013 0.0259 0.1843
Trypanosoma brucei cdc2-related kinase 1 0.0093 0.0165 0.0799
Toxoplasma gondii calcium-dependent protein kinase CDPK3 0.0064 0.0093 0.0268
Toxoplasma gondii aspartyl protease ASP1 0.1418 0.3465 1
Brugia malayi Endoplasmin precursor 0.0032 0.0014 0.0002
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.051 0.1205 0.1688
Brugia malayi ORL1-like opioid receptor 0.0679 0.1624 0.217
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0104 0.026
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0175 0.037 0.0506
Brugia malayi Cyclin, N-terminal domain containing protein 0.013 0.0259 0.0332
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0357 0.0993
Echinococcus multilocularis g protein coupled receptor 0.0679 0.1624 0.2281
Echinococcus granulosus rhodopsin orphan GPCR 0.0679 0.1624 0.2281
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0357 0.0993
Toxoplasma gondii melibiase subfamily protein 0.0107 0.0202 0.0582
Trichomonas vaginalis tubulin beta chain, putative 0.0565 0.1341 0.3845
Echinococcus multilocularis tissue type plasminogen activator 0.0036 0.0024 0.0017
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Leishmania major beta tubulin 0.0565 0.1341 1
Trichomonas vaginalis CMGC family protein kinase 0.0093 0.0165 0.0438
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.0202 0.019
Leishmania major beta tubulin 0.0565 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Echinococcus granulosus cyclin dependent kinase 5 0.0093 0.0165 0.0217
Echinococcus multilocularis neuroendocrine convertase 2 0.0181 0.0385 0.0527
Brugia malayi proprotein convertase 2 0.0181 0.0385 0.0501
Brugia malayi G-protein coupled receptor 0.0679 0.1624 0.217
Trichomonas vaginalis cyclins, putative 0.0065 0.0097 0.0241
Trypanosoma brucei beta tubulin 0.0565 0.1341 0.7016
Echinococcus multilocularis tubulin beta 1 chain 0.0565 0.1341 0.188
Echinococcus multilocularis cyclins 0.0065 0.0097 0.012
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Schistosoma mansoni matrix metallopeptidase-9 (M10 family) 0.0034 0.0019 0.0007
Echinococcus granulosus tubulin beta 1 chain 0.0565 0.1341 0.188
Schistosoma mansoni neuropeptide F-like receptor 0.0679 0.1624 0.1614
Onchocerca volvulus 0.0679 0.1624 1
Giardia lamblia Kinase, CMGC CDK 0.0093 0.0165 0.114
Plasmodium falciparum protein kinase 5 0.0093 0.0165 0.0438
Echinococcus granulosus neuropeptide receptor 0.2871 0.7079 1
Toxoplasma gondii heat shock protein HSP90 0.0032 0.0014 0.004
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.032 0.0731 0.1018
Echinococcus granulosus rhodopsin orphan GPCR 0.0679 0.1624 0.2281
Entamoeba histolytica cyclin, putative 0.013 0.0259 0.1843
Brugia malayi Eukaryotic aspartyl protease family protein 0.0353 0.0812 0.1077
Brugia malayi hypothetical protein 0.0679 0.1624 0.217
Schistosoma mansoni tubulin subunit beta 0.0565 0.1341 0.133
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0093 0.0165 0.0206
Brugia malayi hypothetical protein 0.0353 0.0812 0.1077
Trichomonas vaginalis cyclin B, putative 0.013 0.0259 0.0709
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.1418 0.3465 0.4886
Trypanosoma cruzi cyclin, putative 0.013 0.0259 0.1843
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0107 0.0202 0.0268
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0104 0.026
Trichomonas vaginalis cyclin B, putative 0.013 0.0259 0.0709
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0679 0.1624 0.217
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.0093 0.0165 0.114
Plasmodium vivax protein kinase Crk2 0.0093 0.0165 0.0438
Onchocerca volvulus Neuropeptide F receptor homolog 0.0679 0.1624 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0353 0.0812 0.0801
Echinococcus granulosus cyclins 0.0065 0.0097 0.012
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0093 0.0114
Brugia malayi Kringle domain containing protein 0.0036 0.0024 0.0016
Echinococcus granulosus glutamate receptor 2 0.0047 0.0052 0.0056
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Plasmodium vivax calcium-dependent protein kinase 4, putative 0.0064 0.0093 0.0229
Schistosoma mansoni protein kinase 0.051 0.1205 0.1194
Schistosoma mansoni opsin-like receptor 0.0679 0.1624 0.1614
Onchocerca volvulus 0.0679 0.1624 1
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Leishmania major CYC2-like cyclin, putative,cyclin 6, putative 0.013 0.0259 0.1843
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0357 0.0993
Schistosoma mansoni hypothetical protein 0.0679 0.1624 0.1614
Brugia malayi aspartic protease BmAsp-2, identical 0.0353 0.0812 0.1077
Toxoplasma gondii kringle domain-containing protein 0.0036 0.0024 0.007
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0024 0.0077
Onchocerca volvulus 0.0679 0.1624 1
Loa Loa (eye worm) hypothetical protein 0.013 0.0259 0.0332
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0073 0.0171
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0107 0.0202 0.0268
Onchocerca volvulus 0.0679 0.1624 1
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Trichomonas vaginalis cyclins, putative 0.013 0.0259 0.0709
Brugia malayi neuropeptide F receptor 0.0679 0.1624 0.217
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0259 0.0578 0.0762
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0107 0.0202 0.0268
Schistosoma mansoni hypothetical protein 0.0036 0.0024 0.0012
Echinococcus granulosus neuropeptide FF receptor 2 0.0679 0.1624 0.2281
Brugia malayi Tubulin beta-1 chain 0.0565 0.1341 0.1789
Echinococcus granulosus GPCR family 2 0.032 0.0731 0.1018
Schistosoma mansoni hypothetical protein 0.0692 0.1656 0.1646
Schistosoma mansoni protein kinase 0.051 0.1205 0.1194
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0679 0.1624 0.2281
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0679 0.1624 0.1614
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0679 0.1624 0.2281
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0447 0.1047 0.1393
Trypanosoma cruzi cdc2-related kinase 1 0.0093 0.0165 0.114
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.3016 0.744 1
Leishmania major protein kinase, putative 0.0064 0.0093 0.0595
Echinococcus granulosus cyclins 0.0065 0.0097 0.012
Trichomonas vaginalis CMGC family protein kinase 0.0093 0.0165 0.0438
Echinococcus multilocularis cyclin dependent kinase 0.0093 0.0165 0.0217
Brugia malayi Calcium/calmodulin-dependent protein kinase type II alpha chain 0.0064 0.0093 0.0109
Echinococcus granulosus tissue type plasminogen activator 0.0036 0.0024 0.0017
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Brugia malayi heat shock protein 90 0.0032 0.0014 0.0002
Echinococcus multilocularis thyroid hormone receptor alpha 0.0155 0.032 0.0436
Schistosoma mansoni hypothetical protein 0.0679 0.1624 0.1614
Loa Loa (eye worm) pigment dispersing factor receptor c 0.1012 0.2453 0.3286
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0353 0.0812 0.0801
Echinococcus multilocularis g protein coupled receptor 0.0679 0.1624 0.2281
Plasmodium falciparum cyclin 0.0065 0.0097 0.0241
Brugia malayi Cyclin, N-terminal domain containing protein 0.013 0.0259 0.0332
Brugia malayi GnHR receptor homolog 0.0679 0.1624 0.217
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Echinococcus multilocularis neuropeptide Y receptor 0.0679 0.1624 0.2281
Plasmodium falciparum plasmepsin VII 0.0353 0.0812 0.2314
Loa Loa (eye worm) hypothetical protein 0.0072 0.0113 0.0135
Plasmodium vivax tubulin beta chain, putative 0.0565 0.1341 0.3845
Giardia lamblia High cysteine membrane protein Group 2 0.0107 0.0201 0.1407
Echinococcus multilocularis neuropeptide receptor A26 0.0679 0.1624 0.2281
Trichomonas vaginalis CAMK family protein kinase 0.0064 0.0093 0.0229
Echinococcus granulosus hypothetical protein 0.0679 0.1624 0.2281
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0679 0.1624 0.2281
Loa Loa (eye worm) hypothetical protein 0.3016 0.744 1
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0056 0.0073 0.0171
Toxoplasma gondii beta-tubulin, putative 0.0565 0.1341 0.387
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Leishmania major beta tubulin 0.0565 0.1341 1
Brugia malayi hypothetical protein 0.0679 0.1624 0.217
Plasmodium falciparum calcium-dependent protein kinase 4 0.0064 0.0093 0.0229
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0072 0.0113 0.0101
Trypanosoma brucei cdc2-related kinase 3 0.0093 0.0165 0.0799
Brugia malayi hypothetical protein 0.0679 0.1624 0.217
Loa Loa (eye worm) cyclin domain-containing protein 0.0065 0.0097 0.0114
Schistosoma mansoni heat shock protein 0.0032 0.0014 0.0002
Loa Loa (eye worm) hypothetical protein 0.0065 0.0096 0.0113
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Loa Loa (eye worm) endoplasmin 0.0032 0.0014 0.0002
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0104 0.026
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0165 0.0153
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Schistosoma mansoni tubulin subunit beta 0.0565 0.1341 0.133
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0073 0.0171
Onchocerca volvulus 0.0679 0.1624 1
Brugia malayi Melibiase family protein 0.0072 0.0113 0.0135
Plasmodium falciparum tubulin beta chain 0.0565 0.1341 0.3845
Echinococcus granulosus rhodopsin orphan GPCR 0.0679 0.1624 0.2281
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0578 0.1635
Plasmodium falciparum plasmepsin I 0.1418 0.3465 1
Echinococcus multilocularis serotonin receptor 0.0679 0.1624 0.2281
Trypanosoma brucei RNA helicase, putative 0.0792 0.1905 1
Schistosoma mansoni serine/threonine protein kinase 0.0064 0.0093 0.0081
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Loa Loa (eye worm) CAMK/CAMK2 protein kinase 0.0064 0.0093 0.0109
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Brugia malayi Dopamine receptor 0.0679 0.1624 0.217
Schistosoma mansoni thyroid hormone receptor 0.0155 0.032 0.0309
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Echinococcus granulosus tubulin beta 4A class IVa 0.0565 0.1341 0.188
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.0093 0.0165 0.114
Schistosoma mansoni neuropeptide receptor 0.0679 0.1624 0.1614
Trichomonas vaginalis cyclin D, putative 0.0065 0.0097 0.0241
Trichomonas vaginalis cyclin D, putative 0.0065 0.0097 0.0241
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0093 0.0114
Echinococcus multilocularis rhodopsin orphan GPCR 0.0679 0.1624 0.2281
Trichomonas vaginalis tubulin, putative 0.0565 0.1341 0.3845
Brugia malayi hypothetical protein 0.0679 0.1624 0.217
Echinococcus multilocularis g-protein coupled receptor 0.0679 0.1624 0.2281
Echinococcus granulosus tm gpcr rhodopsin 0.0679 0.1624 0.2281
Schistosoma mansoni hypothetical protein 0.032 0.0731 0.072
Plasmodium falciparum calcium-dependent protein kinase 5 0.0064 0.0093 0.0229
Brugia malayi RE15519p 0.0679 0.1624 0.217
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0679 0.1624 0.2281
Echinococcus granulosus Tubulin beta 2C chain 0.0565 0.1341 0.188
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0056 0.0073 0.0171
Brugia malayi beta-tubulin, identical 0.0565 0.1341 0.1789
Brugia malayi G protein-coupled receptor F59B2.13 0.0679 0.1624 0.217
Echinococcus granulosus rhodopsin orphan GPCR 0.0679 0.1624 0.2281
Loa Loa (eye worm) tubulin beta-1 chain 0.0565 0.1341 0.1789
Brugia malayi Cam kinase protein 1 0.0064 0.0093 0.0109
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0679 0.1624 0.2281
Echinococcus granulosus myosin light chain kinase smooth muscle 0.0249 0.0554 0.0767
Echinococcus multilocularis g protein coupled receptor 0.0679 0.1624 0.2281
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0052 0.0056
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0353 0.0812 0.0801
Schistosoma mansoni biogenic amine receptor 0.0679 0.1624 0.1614
Leishmania major beta tubulin 0.0565 0.1341 1
Trichomonas vaginalis cyclin B, putative 0.0065 0.0097 0.0241
Loa Loa (eye worm) tubulin beta-4 chain 0.0565 0.1341 0.1789
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Leishmania major beta tubulin 0.0565 0.1341 1
Brugia malayi Dopamine receptor protein 2 0.0679 0.1624 0.217
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0679 0.1624 0.217
Onchocerca volvulus 0.0679 0.1624 1
Echinococcus multilocularis nmda type glutamate receptor 0.0111 0.0211 0.0282
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.1418 0.3465 0.3457
Brugia malayi follicle stimulating hormone receptor 0.0679 0.1624 0.217
Loa Loa (eye worm) aspartyl protease 6 0.0353 0.0812 0.1077
Leishmania major beta tubulin 0.0565 0.1341 1
Leishmania major beta tubulin 0.0565 0.1341 1
Schistosoma mansoni cyclins 0.0065 0.0097 0.0085
Giardia lamblia Beta tubulin 0.0565 0.1341 1
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0047 0.0052 0.0056
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0132 0.0263 0.0355
Loa Loa (eye worm) heat shock protein 90 0.0032 0.0014 0.0002
Echinococcus granulosus neuropeptide Y receptor 0.0679 0.1624 0.2281
Echinococcus multilocularis glutamate receptor 2 0.0047 0.0052 0.0056
Echinococcus multilocularis rhodopsin orphan GPCR 0.0679 0.1624 0.2281
Schistosoma mansoni hypothetical protein 0.032 0.0731 0.072
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.2324 0.5718 0.8075
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0679 0.1624 0.2281
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0093 0.0114
Echinococcus multilocularis tubulin subunit beta 0.0565 0.1341 0.188
Echinococcus granulosus G2:mitotic specific cyclin B3 0.0065 0.0097 0.012
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0175 0.037 0.1031
Trypanosoma cruzi CYC2-like cyclin, putative 0.013 0.0259 0.1843
Echinococcus multilocularis cyclins 0.0065 0.0097 0.012
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Brugia malayi hypothetical protein 0.0679 0.1624 0.217
Plasmodium falciparum plasmepsin X 0.0513 0.1212 0.3471
Schistosoma mansoni hypothetical protein 0.0132 0.0263 0.0251
Leishmania major beta tubulin 0.0565 0.1341 1
Brugia malayi hypothetical protein 0.0679 0.1624 0.217
Trypanosoma brucei mitotic cyclin 6 0.013 0.0259 0.1293
Echinococcus multilocularis rhodopsin orphan GPCR 0.0679 0.1624 0.2281
Echinococcus multilocularis orexin receptor type 2 0.0679 0.1624 0.2281
Toxoplasma gondii heat shock protein 90, putative 0.0032 0.0014 0.004
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Echinococcus granulosus Furin 1 0.0068 0.0104 0.0129
Plasmodium falciparum plasmepsin VIII, putative 0.0353 0.0812 0.2314
Echinococcus granulosus beta tubulin 0.0565 0.1341 0.188
Trichomonas vaginalis cyclin B3, putative 0.0065 0.0097 0.0241
Echinococcus granulosus glutamate NMDA receptor subunit 0.0263 0.0589 0.0816
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0679 0.1624 0.217
Echinococcus granulosus somatostatin receptor 0.0679 0.1624 0.2281
Trichomonas vaginalis tubulin gamma chain, putative 0.0565 0.1341 0.3845
Echinococcus multilocularis rhodopsin orphan GPCR 0.0679 0.1624 0.2281
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0073 0.0171
Loa Loa (eye worm) hypothetical protein 0.0353 0.0812 0.1077
Echinococcus multilocularis cyclins 0.0065 0.0097 0.012
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0263 0.0589 0.0816
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Trichomonas vaginalis cyclins, putative 0.013 0.0259 0.0709
Trichomonas vaginalis CMGC family protein kinase 0.0093 0.0165 0.0438
Trypanosoma cruzi cdc2-related kinase 1 0.0093 0.0165 0.114
Echinococcus multilocularis heat shock protein 0.0032 0.0014 0.0003
Echinococcus granulosus furin 0.0288 0.0651 0.0903
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0052 0.0056
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0679 0.1624 0.1614
Brugia malayi G protein-coupled receptor 0.0679 0.1624 0.217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0679 0.1624 0.1614
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0679 0.1624 0.1614
Leishmania major beta tubulin 0.0565 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Schistosoma mansoni neuropeptide f receptor 76f 0.0679 0.1624 0.1614
Echinococcus granulosus sex peptide receptor 0.0679 0.1624 0.2281
Echinococcus granulosus biogenic amine 5HT receptor 0.0679 0.1624 0.2281
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0679 0.1624 1
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.032 0.0731 0.1018
Trypanosoma cruzi beta tubulin, putative 0.0565 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Trypanosoma cruzi cyclin, putative 0.013 0.0259 0.1843
Loa Loa (eye worm) BEN-1 protein 0.0565 0.1341 0.1789
Echinococcus multilocularis cyclin dependent kinase 5 0.0093 0.0165 0.0217
Trichomonas vaginalis tubulin alpha chain, putative 0.0565 0.1341 0.3845
Onchocerca volvulus 0.0679 0.1624 1
Onchocerca volvulus 0.0679 0.1624 1
Echinococcus multilocularis neuropeptide receptor 0.2871 0.7079 1
Schistosoma mansoni serine/threonine protein kinase 0.0093 0.0165 0.0153
Leishmania major beta tubulin 0.0565 0.1341 1
Schistosoma mansoni hypothetical protein 0.0056 0.0073 0.0061
Echinococcus granulosus tm gpcr rhodopsin 0.0679 0.1624 0.2281
Schistosoma mansoni hypothetical protein 0.0679 0.1624 0.1614
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0679 0.1624 0.1614
Echinococcus granulosus alpha 1A adrenergic receptor 0.0679 0.1624 0.2281
Schistosoma mansoni biogenic amine receptor 0.0679 0.1624 0.1614
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0679 0.1624 0.2281
Echinococcus multilocularis cyclins 0.0065 0.0097 0.012
Echinococcus multilocularis GPCR, family 2 0.032 0.0731 0.1018
Brugia malayi hypothetical protein 0.0679 0.1624 0.217
Chlamydia trachomatis glutamine binding protein 0.008 0.0134 0.5
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Schistosoma mansoni serine-type protease inhibitor 0.3057 0.7544 0.7541
Echinococcus multilocularis beta tubulin 0.0565 0.1341 0.188
Loa Loa (eye worm) hypothetical protein 0.013 0.0259 0.0332
Giardia lamblia G2/mitotic-specific cyclin B 0.013 0.0259 0.1843
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Trichomonas vaginalis cyclin A, putative 0.013 0.0259 0.0709
Echinococcus granulosus orexin receptor type 2 0.0679 0.1624 0.2281
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0353 0.0812 0.0801
Plasmodium falciparum calcium-dependent protein kinase 1 0.0064 0.0093 0.0229
Brugia malayi hypothetical protein 0.0353 0.0812 0.1077
Brugia malayi Protein kinase domain containing protein 0.0093 0.0165 0.0206
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Brugia malayi Angiotensin-converting enzyme family protein 0.0606 0.1442 0.1925
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Echinococcus granulosus neuropeptides capa receptor 0.0679 0.1624 0.2281
Echinococcus multilocularis G protein coupled receptor 139 0.2871 0.7079 1
Loa Loa (eye worm) G-protein coupled receptor 0.0679 0.1624 0.217
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.2324 0.5718 0.8075
Mycobacterium ulcerans 3-dehydroquinate dehydratase 0.2458 0.6052 1
Schistosoma mansoni heat shock protein 0.0032 0.0014 0.0002
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0175 0.037 0.0506
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0679 0.1624 0.2281
Echinococcus multilocularis neuropeptide receptor 0.0679 0.1624 0.2281
Trichomonas vaginalis cyclin B, putative 0.013 0.0259 0.0709
Plasmodium vivax aspartyl proteinase, putative 0.1418 0.3465 1
Schistosoma mansoni furin-1 (S08 family) 0.0125 0.0246 0.0234
Echinococcus multilocularis neuropeptide FF receptor 2 0.0679 0.1624 0.2281
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0073 0.0171
Onchocerca volvulus 0.0679 0.1624 1
Trichomonas vaginalis glucosylceramidase, putative 0.0179 0.038 0.1059
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0259 0.0578 0.0762
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0073 0.0171
Echinococcus granulosus neuropeptide Y receptor 0.0679 0.1624 0.2281
Leishmania major beta tubulin 0.0565 0.1341 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0679 0.1624 0.1614
Echinococcus granulosus calcium dependent protein kinase 0.0061 0.0086 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0073 0.0171
Entamoeba histolytica tubulin family protein 0.0565 0.1341 1
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0578 0.1635
Schistosoma mansoni cyclin B 0.013 0.0259 0.0247
Schistosoma mansoni hypothetical protein 0.0792 0.1905 0.1895
Echinococcus granulosus g protein coupled receptor 0.0679 0.1624 0.2281
Plasmodium vivax calcium-dependent protein kinase, putative 0.0064 0.0093 0.0229
Echinococcus multilocularis serotonin receptor 0.0679 0.1624 0.2281
Loa Loa (eye worm) BEN-1 protein 0.0565 0.1341 0.1789
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0679 0.1624 0.1614
Echinococcus multilocularis cyclin b3 0.0065 0.0097 0.012
Plasmodium falciparum plasmepsin III 0.0353 0.0812 0.2314
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Schistosoma mansoni cathepsin D (A01 family) 0.4044 1 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0679 0.1624 0.2281
Schistosoma mansoni growth hormone secretagogue receptor 0.0679 0.1624 0.1614
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0072 0.0113 0.0101
Giardia lamblia Beta tubulin 0.0565 0.1341 1
Schistosoma mansoni amine GPCR 0.0679 0.1624 0.1614
Loa Loa (eye worm) tubulin beta-2A chain 0.0565 0.1341 0.1789
Echinococcus multilocularis neuropeptide s receptor 0.0679 0.1624 0.2281
Loa Loa (eye worm) angiotensin-converting enzyme family protein 0.0606 0.1442 0.1925
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Toxoplasma gondii beta-1 tubulin, putative 0.0565 0.1341 0.387
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Echinococcus granulosus cyclin B 0.013 0.0259 0.0349
Brugia malayi latrophilin 2 splice variant baaae 0.0692 0.1656 0.2213
Trichomonas vaginalis cyclins, putative 0.0081 0.0135 0.0351
Echinococcus granulosus rhodopsin orphan GPCR 0.0679 0.1624 0.2281
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0052 0.0056
Plasmodium falciparum plasmepsin IV 0.1418 0.3465 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0679 0.1624 0.1614
Plasmodium vivax aspartyl proteinase, putative 0.0353 0.0812 0.2314
Trichomonas vaginalis cyclins, putative 0.013 0.0259 0.0709
Onchocerca volvulus 0.013 0.0259 0.1464
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Brugia malayi hypothetical protein 0.0679 0.1624 0.217
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0679 0.1624 0.217
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0679 0.1624 0.1614
Plasmodium vivax aspartyl protease, putative 0.0353 0.0812 0.2314
Plasmodium vivax aspartyl protease, putative 0.0513 0.1212 0.3471
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0047 0.0052 0.0056
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0679 0.1624 0.2281
Brugia malayi neuroendocrine convertase 1 precursor 0.0181 0.0385 0.0501
Brugia malayi Cyclin, N-terminal domain containing protein 0.0065 0.0097 0.0114
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0679 0.1624 0.2281
Schistosoma mansoni thyroid hormone receptor 0.0155 0.032 0.0309
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Echinococcus granulosus g protein coupled receptor 0.0679 0.1624 0.2281
Echinococcus multilocularis dro:myosuppressin receptor 0.0679 0.1624 0.2281
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0679 0.1624 0.1614
Entamoeba histolytica cyclin, putative 0.0065 0.0097 0.0626
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0679 0.1624 0.1614
Echinococcus granulosus heat shock protein 90 0.0032 0.0014 0.0003
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0052 0.0056
Plasmodium falciparum plasmepsin II 0.1418 0.3465 1
Echinococcus multilocularis heat shock protein 90 0.0032 0.0014 0.0003
Echinococcus granulosus Tubulin beta 2C chain 0.0565 0.1341 0.188
Echinococcus granulosus g-protein coupled receptor 0.0679 0.1624 0.2281
Giardia lamblia Kinase, CMGC CDK 0.0093 0.0165 0.114
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.008 0.0134 0.5
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0679 0.1624 0.217
Plasmodium vivax plasmepsin V, putative 0.0353 0.0812 0.2314
Echinococcus multilocularis cyclins 0.0065 0.0097 0.012
Onchocerca volvulus 0.0679 0.1624 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0104 0.026
Trypanosoma brucei beta tubulin 0.0565 0.1341 0.7016
Schistosoma mansoni neuropeptide receptor 0.0679 0.1624 0.1614
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase ID 0.0064 0.0093 0.0109
Brugia malayi Serotonin receptor 0.0679 0.1624 0.217
Onchocerca volvulus 0.0679 0.1624 1
Onchocerca volvulus 0.0679 0.1624 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0679 0.1624 0.2281
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0073 0.0171
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Schistosoma mansoni neuropeptide receptor 0.2871 0.7079 0.7075
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0578 0.1635
Loa Loa (eye worm) hypothetical protein 0.0064 0.0093 0.0109
Toxoplasma gondii calcium-dependent protein kinase CDPK2A 0.0064 0.0093 0.0268
Brugia malayi Dopamine receptor protein 1 0.0679 0.1624 0.217
Brugia malayi putative neuropeptide receptor NPR1 0.0679 0.1624 0.217
Brugia malayi celfurPC protein 0.0232 0.0512 0.0673
Echinococcus granulosus neuropeptide s receptor 0.0679 0.1624 0.2281
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.032 0.0731 0.0968
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Echinococcus multilocularis rhodopsin orphan GPCR 0.0679 0.1624 0.2281
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0073 0.0171
Toxoplasma gondii calcium-dependent protein kinase CDPK2B 0.0064 0.0093 0.0268
Loa Loa (eye worm) aspartic protease BmAsp-2 0.1418 0.3465 0.4648
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0357 0.0993
Echinococcus granulosus allatostatin A receptor 0.0679 0.1624 0.2281
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.051 0.1205 0.1688
Trichomonas vaginalis cyclins, putative 0.013 0.0259 0.0709
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.0202 0.019
Loa Loa (eye worm) melatonin receptor type 1A 0.0679 0.1624 0.217
Echinococcus multilocularis Tubulin beta 2C chain 0.0565 0.1341 0.188
Schistosoma mansoni biogenic amine receptor 0.0679 0.1624 0.1614
Echinococcus granulosus 7tm_1 domain containing protein 0.0679 0.1624 0.2281
Leishmania major hypothetical protein, conserved 0.0036 0.0024 0.0077
Brugia malayi aspartic protease BmAsp-1, identical 0.0353 0.0812 0.1077
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.008 0.0134 0.5
Echinococcus multilocularis fmrfamide receptor 0.0679 0.1624 0.2281
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0679 0.1624 0.1614
Onchocerca volvulus 0.0679 0.1624 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0679 0.1624 0.1614
Schistosoma mansoni hypothetical protein 0.032 0.0731 0.072
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.0202 0.019
Echinococcus granulosus biogenic amine 5HT receptor 0.0679 0.1624 0.2281
Leishmania major beta tubulin 0.0565 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.0113 0.0215 0.0274
Plasmodium falciparum calcium-dependent protein kinase 2 0.0064 0.0093 0.0229
Trichomonas vaginalis tubulin epsilon chain, putative 0.0565 0.1341 0.3845
Schistosoma mansoni adenoreceptor 0.0679 0.1624 0.1614
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0679 0.1624 0.217
Echinococcus multilocularis calcium:calmodulin dependent protein kinase type 0.0064 0.0093 0.0114
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0679 0.1624 0.217
Loa Loa (eye worm) hypothetical protein 0.032 0.0731 0.0968
Loa Loa (eye worm) endoprotease bli-4 0.0288 0.0651 0.086
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Schistosoma mansoni protein kinase 0.051 0.1205 0.1194
Echinococcus granulosus tm gpcr rhodopsin 0.0679 0.1624 0.2281
Brugia malayi AKH receptor 0.0679 0.1624 0.217
Echinococcus granulosus dro:myosuppressin receptor 0.0679 0.1624 0.2281
Schistosoma mansoni endoplasmin 0.0032 0.0014 0.0002
Schistosoma mansoni opsin-like receptor 0.0679 0.1624 0.1614
Brugia malayi hypothetical protein 0.0679 0.1624 0.217
Trichomonas vaginalis conserved hypothetical protein 0.0065 0.0097 0.0241
Schistosoma mansoni neuropeptide receptor 0.0679 0.1624 0.1614
Echinococcus multilocularis myosin light chain kinase, smooth muscle 0.0249 0.0554 0.0767
Trypanosoma cruzi cdc2-related kinase 3 0.0093 0.0165 0.114
Loa Loa (eye worm) beta-tubulin 0.0565 0.1341 0.1789
Plasmodium falciparum plasmepsin V 0.0353 0.0812 0.2314
Echinococcus multilocularis rhodopsin orphan GPCR 0.0679 0.1624 0.2281
Entamoeba histolytica protein kinase, putative 0.0064 0.0093 0.0595
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 0.0064 0.0093 0.0114
Leishmania major beta tubulin 0.0565 0.1341 1
Echinococcus multilocularis Tubulin beta 2C chain 0.0565 0.1341 0.188
Onchocerca volvulus 0.0679 0.1624 1
Trichomonas vaginalis hypothetical protein 0.0056 0.0073 0.0171
Echinococcus granulosus neuroendocrine convertase 2 0.0181 0.0385 0.0527
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0578 0.1635
Schistosoma mansoni tubulin subunit beta 0.0565 0.1341 0.133
Echinococcus multilocularis fmrfamide receptor 0.0679 0.1624 0.2281
Mycobacterium tuberculosis 3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase) 0.2458 0.6052 1
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.0093 0.0165 0.0477
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.1418 0.3465 0.4886
Schistosoma mansoni amine GPCR 0.0679 0.1624 0.1614
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0679 0.1624 0.1614
Echinococcus granulosus calcium:calmodulin dependent protein kinase type 1 0.0064 0.0093 0.0114
Echinococcus multilocularis neuropeptide Y receptor 0.0679 0.1624 0.2281
Loa Loa (eye worm) hypothetical protein 0.0288 0.0651 0.086
Echinococcus granulosus cyclins 0.0065 0.0097 0.012
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0679 0.1624 0.2281
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0047 0.0052 0.0056
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0107 0.0202 0.019
Loa Loa (eye worm) neuropeptide F receptor 0.0679 0.1624 0.217
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.1418 0.3465 1
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0056 0.0073 0.0171
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Entamoeba histolytica cyclin family protein 0.0065 0.0097 0.0626
Toxoplasma gondii aspartyl protease 0.0353 0.0812 0.2345
Echinococcus multilocularis calcium dependent protein kinase 0.0061 0.0086 0.0104
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0073 0.0171
Schistosoma mansoni amine GPCR 0.0679 0.1624 0.1614
Brugia malayi Pepsin A precursor 0.0353 0.0812 0.1077
Brugia malayi G-protein coupled receptor 0.0679 0.1624 0.217
Echinococcus granulosus Tubulin beta 2C chain 0.0565 0.1341 0.188
Leishmania major beta tubulin 0.0565 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0024 0.0016
Giardia lamblia Beta tubulin 0.0565 0.1341 1
Brugia malayi sulfakinin receptor protein 0.0679 0.1624 0.217
Echinococcus multilocularis cyclin dependent kinase 1 0.0093 0.0165 0.0217
Leishmania major beta tubulin 0.0565 0.1341 1
Echinococcus multilocularis Furin 1 0.0068 0.0104 0.0129
Loa Loa (eye worm) proprotein convertase 2 0.0068 0.0104 0.0123
Brugia malayi Melatonin receptor type 1A 0.0679 0.1624 0.217
Schistosoma mansoni amine GPCR 0.0679 0.1624 0.1614
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0111 0.0211 0.0282
Plasmodium falciparum calcium-dependent protein kinase 3 0.0064 0.0093 0.0229
Echinococcus multilocularis cyclin B 0.013 0.0259 0.0349
Toxoplasma gondii beta tubulin 0.0565 0.1341 0.387
Echinococcus granulosus rhodopsin orphan GPCR 0.0679 0.1624 0.2281
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Schistosoma mansoni cyclin B3 0.0065 0.0097 0.0085
Brugia malayi Tachykinin-like peptides receptor 99D 0.0679 0.1624 0.217
Echinococcus granulosus neuropeptides capa receptor 0.0679 0.1624 0.2281
Leishmania major beta tubulin 0.0565 0.1341 1
Echinococcus granulosus beta tubulin 0.0565 0.1341 0.188
Echinococcus granulosus nmda type glutamate receptor 0.0111 0.0211 0.0282
Echinococcus multilocularis Tubulin beta 2C chain 0.0565 0.1341 0.188
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0353 0.0812 0.1077
Schistosoma mansoni tubulin subunit beta 0.0565 0.1341 0.133
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0679 0.1624 0.2281
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0068 0.0104 0.026
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0132 0.0263 0.0355
Schistosoma mansoni tubulin subunit beta 0.0565 0.1341 0.133
Echinococcus multilocularis Tubulin beta 2C chain 0.0565 0.1341 0.188
Echinococcus granulosus cyclin dependent kinase 0.0093 0.0165 0.0217
Schistosoma mansoni biogenic amine (5HT) receptor 0.0679 0.1624 0.1614
Brugia malayi cell division control protein 2 homolog 0.0093 0.0165 0.0206
Schistosoma mansoni hypothetical protein 0.0679 0.1624 0.1614
Leishmania major beta tubulin 0.0565 0.1341 1
Loa Loa (eye worm) hypothetical protein 0.009 0.0158 0.0196
Echinococcus granulosus G protein coupled receptor 139 0.0679 0.1624 0.2281
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0047 0.0052 0.0056
Echinococcus granulosus cyclin B3 1 0.0065 0.0097 0.012
Loa Loa (eye worm) G-protein coupled receptor 0.0679 0.1624 0.217
Onchocerca volvulus Glucosylceramidase homolog 0.017 0.0357 0.2079
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0679 0.1624 0.1614
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0353 0.0812 0.2345
Onchocerca volvulus 0.0679 0.1624 1
Echinococcus granulosus neuropeptide receptor 0.0679 0.1624 0.2281
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0679 0.1624 0.2281
Echinococcus multilocularis cyclin dependent kinase 1 0.0093 0.0165 0.0217
Leishmania major beta tubulin 0.0565 0.1341 1
Giardia lamblia Hypothetical protein 0.0065 0.0097 0.0626
Loa Loa (eye worm) hypothetical protein 0.0353 0.0812 0.1077
Brugia malayi Protein kinase domain containing protein 0.0036 0.0024 0.0016
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.0093 0.0165 0.0206
Schistosoma mansoni myosin xvIII 0.0679 0.1624 0.1614
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0353 0.0812 0.0801
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.0093 0.0165 0.0217
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0068 0.0104 0.0092
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0353 0.0812 0.0801
Trypanosoma brucei beta tubulin 0.0565 0.1341 0.7016
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0072 0.0113 0.0286
Echinococcus granulosus Tubulin beta 2C chain 0.0565 0.1341 0.188
Brugia malayi Latrophilin receptor protein 2 0.032 0.0731 0.0968
Schistosoma mansoni histamine h1 receptor 0.0679 0.1624 0.1614
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0679 0.1624 0.2281
Entamoeba histolytica cell division protein kinase 2, putative 0.0093 0.0165 0.114
Echinococcus granulosus heat shock protein 0.0032 0.0014 0.0003
Echinococcus multilocularis rhodopsin orphan GPCR 0.0679 0.1624 0.2281
Schistosoma mansoni endoplasmin 0.0032 0.0014 0.0002
Plasmodium vivax plasmepsin IV, putative 0.1418 0.3465 1
Trichomonas vaginalis cyclin B, putative 0.013 0.0259 0.0709
Loa Loa (eye worm) neuropeptide F receptor 0.0679 0.1624 0.217
Echinococcus granulosus g protein coupled receptor 0.0679 0.1624 0.2281
Schistosoma mansoni serine-type protease inhibitor 0.3057 0.7544 0.7541
Trichomonas vaginalis glucosylceramidase, putative 0.0259 0.0578 0.1635
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0288 0.0651 0.0639
Trypanosoma cruzi cdc2-related kinase 3 0.0093 0.0165 0.114
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0353 0.0812 0.0801
Echinococcus multilocularis G2:mitotic specific cyclin B3 0.0065 0.0097 0.012
Entamoeba histolytica cell division protein kinase 2, putative 0.0093 0.0165 0.114
Trichomonas vaginalis glucosylceramidase, putative 0.017 0.0357 0.0993
Plasmodium falciparum plasmepsin IX 0.0513 0.1212 0.3471
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0679 0.1624 0.1614
Echinococcus multilocularis tubulin, beta 4A class IVa 0.0565 0.1341 0.188
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0073 0.0171
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.1418 0.3465 1
Plasmodium vivax aspartyl protease, putative 0.0513 0.1212 0.3471
Toxoplasma gondii hypothetical protein 0.005 0.0058 0.0167
Echinococcus granulosus cyclins 0.0065 0.0097 0.012
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Loa Loa (eye worm) calcium/calmodulin-dependent protein kinase subunit type II alpha 0.0447 0.1047 0.1393
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0679 0.1624 0.1614
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0679 0.1624 0.1614
Plasmodium falciparum cysteine repeat modular protein 1 0.0036 0.0024 0.003
Schistosoma mansoni glutamate receptor NMDA 0.0263 0.0589 0.0578
Echinococcus granulosus serotonin receptor 0.0679 0.1624 0.2281
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0679 0.1624 0.1614
Echinococcus multilocularis cyclins 0.0065 0.0097 0.012
Echinococcus granulosus peptide allatostatin:somatostatin 0.0679 0.1624 0.2281
Echinococcus multilocularis cyclin B3 1 0.0065 0.0097 0.012
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Trypanosoma brucei calcium/calmodulin-dependent protein kinase, putative 0.0064 0.0093 0.0418
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0679 0.1624 0.2281
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0679 0.1624 0.217
Trichomonas vaginalis conserved hypothetical protein 0.0056 0.0073 0.0171
Echinococcus granulosus serine:threonine protein kinase 0.0249 0.0554 0.0767
Brugia malayi larval opioid receptor 0.0679 0.1624 0.217
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0679 0.1624 0.1614
Echinococcus granulosus cyclin dependent kinase 1 0.0093 0.0165 0.0217
Echinococcus multilocularis sex peptide receptor 0.0679 0.1624 0.2281
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.0093 0.0165 0.0206
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.008 0.0134 0.5
Mycobacterium leprae 3-dehydroquinate dehydratase AroD (AroQ) (3-dehydroquinase) (Type II DHQase) 0.2458 0.6052 0.5
Loa Loa (eye worm) latrophilin receptor protein 2 0.032 0.0731 0.0968
Onchocerca volvulus 0.0353 0.0812 0.4927
Echinococcus granulosus tubulin subunit beta 0.0565 0.1341 0.188
Schistosoma mansoni amine GPCR 0.0679 0.1624 0.1614
Giardia lamblia Cyclin A 0.0065 0.0097 0.0626
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0679 0.1624 0.1614
Loa Loa (eye worm) hypothetical protein 0.0679 0.1624 0.217
Echinococcus multilocularis beta tubulin 0.0565 0.1341 0.188
Echinococcus multilocularis serine:threonine protein kinase 0.0249 0.0554 0.0767
Loa Loa (eye worm) TK/ROR protein kinase 0.0039 0.0032 0.0026
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0175 0.037 0.1031
Echinococcus multilocularis somatostatin receptor 0.0679 0.1624 0.2281
Giardia lamblia Furin precursor putative serine protease 0.0056 0.0073 0.0445

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 5 ug ml-1 Cytotoxicity determined in VERO cells at concentrations less than or equal to 62.5 mg/mL or 10 times the MIC against M. tuberculosis H37Rv. ChEMBL. 11425535
Inhibition (functional) = 75 % Percent inhibition against M. avium at the dose of 12.5 microM using Microplate Alamar Blue Assay (MABA) assay ChEMBL. 11425535
MIC (functional) = 0.78 ug ml-1 Antimycobacterial activity against M. tuberculosis H37Rv using Microplate Alamar Blue Assay (MABA) assay ChEMBL. 11425535
MIC (functional) = 0.78 ug ml-1 Antimycobacterial activity against M. tuberculosis H37Rv using Microplate Alamar Blue Assay (MABA) assay ChEMBL. 11425535
Selectivity index (functional) = 6.4 SI Selectivity index (IC50/MIC) of the compound was determined ChEMBL. 11425535

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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