Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | bacterioferritin BfrB | 0.001 | 0.0172 | 0.0906 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0065 | 0.3344 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0809 | 0.2507 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0019 | 0.0718 | 0.0655 |
Schistosoma mansoni | ferritin | 0.001 | 0.0172 | 0.0105 |
Brugia malayi | CXXC zinc finger family protein | 0.0034 | 0.1569 | 0.5073 |
Mycobacterium ulcerans | bacterioferritin BfrA | 0.001 | 0.0172 | 0.0906 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0008 | 0.0067 | 0.0085 |
Plasmodium falciparum | glutathione reductase | 0.0019 | 0.0718 | 0.2337 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0008 | 0.0067 | 0.0085 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.1223 | 0.1483 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0809 | 0.2507 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.1223 | 0.3905 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0019 | 0.0718 | 0.2337 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0021 | 0.0809 | 0.1029 |
Plasmodium falciparum | glutathione reductase | 0.0056 | 0.2852 | 1 |
Loa Loa (eye worm) | glutathione reductase | 0.0056 | 0.2852 | 0.9402 |
Mycobacterium ulcerans | hypothetical protein | 0.0028 | 0.1223 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0809 | 0.2507 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0019 | 0.0718 | 0.1986 |
Onchocerca volvulus | 0.0034 | 0.1569 | 1 | |
Loa Loa (eye worm) | thioredoxin reductase | 0.0056 | 0.2852 | 0.9402 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.1223 | 0.4153 |
Trichomonas vaginalis | ferritin, putative | 0.001 | 0.0172 | 0.1995 |
Echinococcus granulosus | mixed lineage leukemia protein mll | 0.0008 | 0.0079 | 0.0043 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0072 | 0.3793 | 0.3751 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0059 | 0.3029 | 1 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0019 | 0.0718 | 0.2337 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0.0718 | 1 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.1223 | 0.1555 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0019 | 0.0718 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0059 | 0.3029 | 1 |
Mycobacterium tuberculosis | Probable bacterioferritin BfrA | 0.001 | 0.0172 | 0.0218 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0019 | 0.0718 | 0.2337 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1939 | 0.6322 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0028 | 0.1223 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0128 | 0.7035 | 0.8943 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0143 | 0.7866 | 1 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0172 | 0.0105 |
Trypanosoma brucei | trypanothione reductase | 0.0056 | 0.2852 | 1 |
Treponema pallidum | NADH oxidase | 0.0019 | 0.0718 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0019 | 0.0718 | 0.2337 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0028 | 0.1223 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0034 | 0.1569 | 0.1513 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0128 | 0.7035 | 0.8943 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0028 | 0.1223 | 0.1483 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0079 | 0.0043 |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.1682 | 0.1627 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0028 | 0.1223 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0056 | 0.2852 | 1 |
Toxoplasma gondii | thioredoxin reductase | 0.0056 | 0.2852 | 0.8498 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0008 | 0.0067 | 0.0085 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0014 | 0.0417 | 0.1183 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0008 | 0.0067 | 0.0085 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1223 | 0.3905 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0019 | 0.0718 | 0.2337 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0172 | 0.0105 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.002 | 0.0743 | 0.0944 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0011 | 0.02 | 0.0477 |
Schistosoma mansoni | ferritin | 0.001 | 0.0172 | 0.0105 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.1223 | 0.4153 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0019 | 0.0718 | 0.2337 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0056 | 0.2852 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0019 | 0.0718 | 0.1986 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0718 | 0.2337 |
Echinococcus multilocularis | cpg binding protein | 0.0036 | 0.1682 | 0.5802 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0056 | 0.2852 | 1 |
Schistosoma mansoni | ferritin | 0.001 | 0.0172 | 0.0105 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.002 | 0.0743 | 0.0944 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0008 | 0.0079 | 0.0012 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0019 | 0.0718 | 0.5 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0128 | 0.7035 | 0.8943 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0028 | 0.1223 | 0.1555 |
Mycobacterium leprae | PROBABLE BACTERIOFERRITIN BFRA | 0.001 | 0.0172 | 0.0134 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0019 | 0.0718 | 0.5627 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0021 | 0.0809 | 0.2667 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0021 | 0.0809 | 0.6421 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0718 | 0.2337 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0019 | 0.0718 | 0.2197 |
Leishmania major | trypanothione reductase | 0.0056 | 0.2852 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0019 | 0.0675 | 0.2055 |
Echinococcus multilocularis | GPCR, family 2 | 0.0019 | 0.0675 | 0.2185 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0718 | 0.2337 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0021 | 0.0809 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0143 | 0.7866 | 1 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0128 | 0.7035 | 0.8943 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0128 | 0.7035 | 0.8943 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0128 | 0.7035 | 0.8943 |
Echinococcus multilocularis | expressed protein | 0.001 | 0.0172 | 0.0376 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0056 | 0.2852 | 0.3625 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.1939 | 0.1885 |
Brugia malayi | F/Y-rich N-terminus family protein | 0.001 | 0.0192 | 0.0422 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0008 | 0.0067 | 0.0085 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0028 | 0.1223 | 1 |
Mycobacterium tuberculosis | Bacterioferritin BfrB | 0.001 | 0.0172 | 0.0218 |
Plasmodium vivax | glutathione reductase, putative | 0.0056 | 0.2852 | 1 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0008 | 0.0067 | 0.0085 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0019 | 0.0675 | 0.2055 |
Brugia malayi | Thioredoxin reductase | 0.0056 | 0.2852 | 0.9402 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0718 | 0.2337 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0675 | 0.2185 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.1223 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.1939 | 0.6322 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0028 | 0.1223 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0675 | 0.2185 |
Schistosoma mansoni | apoferritin-2 | 0.001 | 0.0172 | 0.0105 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0718 | 0.2337 |
Plasmodium falciparum | thioredoxin reductase | 0.0019 | 0.0718 | 0.2337 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0718 | 0.2337 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0014 | 0.0417 | 0.1183 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.1223 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0059 | 0.3029 | 1 |
Brugia malayi | glutathione reductase | 0.0056 | 0.2852 | 0.9402 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0809 | 0.2507 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0718 | 0.2337 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.002 | 0.0743 | 0.0944 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0008 | 0.0067 | 0.0085 |
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0034 | 0.1569 | 0.5073 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.0675 | 0.2055 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.1223 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0019 | 0.0675 | 0.2185 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0019 | 0.0718 | 0.2337 |
Echinococcus granulosus | GPCR family 2 | 0.0019 | 0.0675 | 0.2185 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.1223 | 0.3905 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0019 | 0.0718 | 0.2337 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0143 | 0.7866 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1223 | 0.3905 |
Brugia malayi | AMP-binding enzyme family protein | 0.0028 | 0.1223 | 0.3905 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0019 | 0.0718 | 0.2337 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0019 | 0.0718 | 0.2337 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0008 | 0.0079 | 0.0043 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0019 | 0.0718 | 0.2337 |
Schistosoma mansoni | ferritin light chain | 0.001 | 0.0172 | 0.0105 |
Echinococcus multilocularis | ferritin | 0.001 | 0.0172 | 0.0376 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0675 | 0.0613 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0019 | 0.0718 | 0.2337 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0019 | 0.0718 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0675 | 0.0613 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0019 | 0.0675 | 0.2055 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0008 | 0.0067 | 0.0085 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0019 | 0.0718 | 0.5627 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0019 | 0.0718 | 0.0912 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0008 | 0.0067 | 0.0085 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0021 | 0.0809 | 0.2667 |
Echinococcus multilocularis | mixed lineage leukemia protein mll | 0.0008 | 0.0079 | 0.0043 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.3029 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0028 | 0.1223 | 0.4153 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0056 | 0.2852 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0675 | 0.0613 |
Onchocerca volvulus | 0.0028 | 0.1223 | 0.7697 | |
Schistosoma mansoni | cpg binding protein | 0.0036 | 0.1682 | 0.1627 |
Echinococcus granulosus | expressed protein | 0.001 | 0.0172 | 0.0376 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.002 | 0.0743 | 0.0944 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0019 | 0.0675 | 0.2185 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.0809 | 0.2507 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0143 | 0.7866 | 1 |
Loa Loa (eye worm) | histone methyltransferase | 0.0011 | 0.02 | 0.0449 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0008 | 0.0067 | 0.0085 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0019 | 0.0718 | 0.2337 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0056 | 0.2852 | 1 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0011 | 0.02 | 0.0477 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0019 | 0.0718 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0019 | 0.0675 | 0.0613 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.1223 | 0.3905 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0028 | 0.1223 | 1 |
Echinococcus granulosus | ferritin | 0.001 | 0.0172 | 0.0376 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0019 | 0.0718 | 0.5627 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0019 | 0.0718 | 0.2337 |
Echinococcus granulosus | cpg binding protein | 0.0036 | 0.1682 | 0.5802 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0008 | 0.0067 | 0.046 |
Schistosoma mansoni | ferritin | 0.001 | 0.0172 | 0.0105 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0008 | 0.0067 | 0.046 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0028 | 0.1223 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0019 | 0.0718 | 0.2337 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0019 | 0.0718 | 0.2337 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0008 | 0.0067 | 0.0085 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0128 | 0.7035 | 0.8934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.