Detailed information for compound 664489

Basic information

Technical information
  • TDR Targets ID: 664489
  • Name: N-ethyl-4-methoxy-N-(3-methylphenyl)-3-nitrob enzenesulfonamide
  • MW: 350.39 | Formula: C16H18N2O5S
  • H donors: 0 H acceptors: 4 LogP: 3.16 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCN(S(=O)(=O)c1ccc(c(c1)[N+](=O)[O-])OC)c1cccc(c1)C
  • InChi: 1S/C16H18N2O5S/c1-4-17(13-7-5-6-12(2)10-13)24(21,22)14-8-9-16(23-3)15(11-14)18(19)20/h5-11H,4H2,1-3H3
  • InChiKey: IGZYAPOKLQVVTJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-ethyl-4-methoxy-N-(3-methylphenyl)-3-nitro-benzenesulfonamide
  • STK238410
  • ZINC04993478
  • MLS000621550
  • SMR000299711

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens glucosidase, alpha Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Loa Loa (eye worm) glycosyl hydrolase family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus multilocularis lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum ko:K01187 alpha-glucosidase [EC3.2.1.20], putative Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans closely related to C. albicans GCA1 cell wall mannoprotein glycosyl hydrolase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma japonicum Lysosomal alpha-glucosidase precursor, putative Get druggable targets OG5_127055 All targets in OG5_127055
Onchocerca volvulus Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans hypothetical protein Get druggable targets OG5_127055 All targets in OG5_127055
Candida albicans cell wall mannoprotein glycosyl hydrolase whose expression increases in presence of galatose Get druggable targets OG5_127055 All targets in OG5_127055
Echinococcus granulosus lysosomal alpha glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Schistosoma mansoni alpha-glucosidase Get druggable targets OG5_127055 All targets in OG5_127055
Brugia malayi Glycosyl hydrolases family 31 protein Get druggable targets OG5_127055 All targets in OG5_127055
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Protein patched homolog 1 0.0041 0.016 0.015
Echinococcus granulosus ankyrin repeat and death domain containing protein 0.0031 0.0094 0.0082
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0018 0.0014 0.0007
Loa Loa (eye worm) apoptosis regulator protein 0.0081 0.0413 0.0422
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Brugia malayi nuclear receptor RXR 0.0027 0.0069 0.0071
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0168
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0037 0.0062
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.005 0.0214 0.0362
Echinococcus multilocularis RUN 0.0019 0.0019 0.0006
Brugia malayi orphan nuclear receptor NR2E1 0.0024 0.0051 0.0052
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0721 0.0724
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.005 0.0214 0.0219
Onchocerca volvulus 0.0048 0.0205 0.0712
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0116 0.0634 0.1072
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.115 0.1138
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.172 0.5979
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0084 0.0086
Brugia malayi hypothetical protein 0.0025 0.0054 0.0055
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0027 0.0069 0.0055
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0051 0.0223 0.0228
Echinococcus granulosus histone deacetylase 6 0.0042 0.0165 0.0155
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0721 0.0724
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0051 0.0223 0.0228
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0045 0.0076
Echinococcus multilocularis tar DNA binding protein 0.0129 0.0721 0.0708
Brugia malayi Histone deacetylase family protein 0.0042 0.0165 0.0168
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0051 0.0223 0.0228
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0069 0.0071
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0044 0.0258
Loa Loa (eye worm) hypothetical protein 0.0059 0.0272 0.0278
Brugia malayi RNA binding protein 0.0129 0.0721 0.0737
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0051 0.0223 0.021
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0079 0.0134
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0022 0.0037 0.0023
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.0787 0.0804
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0175 0.1015
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0204 0.1195 0.1223
Echinococcus granulosus sterol regulatory element binding protein 0.0041 0.016 0.015
Entamoeba histolytica acyl-coA synthetase, putative 0.0023 0.0044 0.0258
Schistosoma mansoni netrin receptor unc5 0.0031 0.0094 0.0082
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0044 0.0038
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0944 0.5915 1
Mycobacterium tuberculosis Hypothetical protein 0.0116 0.0634 0.0647
Echinococcus granulosus thyroid hormone receptor alpha 0.0024 0.0051 0.0038
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0064 0.0307 0.0301
Loa Loa (eye worm) hypothetical protein 0.0051 0.0223 0.0228
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0175 0.0607
Brugia malayi hypothetical protein 0.0024 0.0051 0.0052
Echinococcus granulosus tar DNA binding protein 0.0129 0.0721 0.0724
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0071
Echinococcus multilocularis neutral alpha glucosidase AB 0.0044 0.0175 0.0161
Loa Loa (eye worm) dihydrofolate reductase 0.1551 0.9778 1
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0052
Loa Loa (eye worm) hypothetical protein 0.0051 0.0223 0.0228
Schistosoma mansoni hypothetical protein 0.0064 0.0307 0.0301
Echinococcus multilocularis thymidylate synthase 0.0243 0.1446 0.1435
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0175 0.0607
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.0258 0.025
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0721 0.0724
Schistosoma mansoni hypothetical protein 0.004 0.0151 0.014
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0272 0.0265
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0031 0.0017
Schistosoma mansoni rab6-interacting 0.0019 0.0019 0.0006
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0084 0.0119
Brugia malayi Nuclear hormone receptor-like 1 0.0051 0.0223 0.0228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0051 0.0223 0.0228
Echinococcus multilocularis dna polymerase kappa 0.0022 0.0037 0.0023
Onchocerca volvulus 0.0147 0.0836 0.2906
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0037 0.0062
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0123 0.0112
Schistosoma mansoni hypothetical protein 0.0359 0.2182 0.2221
Onchocerca volvulus 0.0019 0.0019 0.0067
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0051 0.0223 0.0228
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.172 0.5979
Echinococcus granulosus Niemann Pick C1 protein 0.0096 0.0511 0.0509
Brugia malayi MAP kinase sur-1 0.005 0.0214 0.0219
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0051 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0051 0.0223 0.0228
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0516 0.0514
Schistosoma mansoni rab6-interacting 0.0019 0.0019 0.0006
Brugia malayi tailless protein 0.0024 0.0051 0.0052
Schistosoma mansoni jumonji domain containing protein 0.0077 0.0384 0.0379
Loa Loa (eye worm) hypothetical protein 0.0031 0.0094 0.0097
Brugia malayi hypothetical protein 0.0147 0.0836 0.0855
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0084 0.0119
Onchocerca volvulus 0.0047 0.0197 0.0686
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0051 0.0223 0.0228
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0051 0.0223 0.0228
Echinococcus multilocularis geminin 0.0359 0.2182 0.2171
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0084 0.013
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.005 0.0214 0.0362
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0052
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0052
Loa Loa (eye worm) hypothetical protein 0.0096 0.0511 0.0522
Giardia lamblia DINP protein human, muc B family 0.0022 0.0037 0.0134
Echinococcus multilocularis ecdysone induced protein 78C 0.0051 0.0223 0.021
Brugia malayi nuclear hormone receptor family member nhr-6 0.0024 0.0051 0.0052
Echinococcus granulosus nuclear factor of activated T cells 5 0.0303 0.1826 0.1856
Onchocerca volvulus Protein ultraspiracle homolog 0.0051 0.0223 0.0776
Schistosoma mansoni histone deacetylase 4 5 0.0042 0.0165 0.0155
Trichomonas vaginalis maltase-glucoamylase, putative 0.0044 0.0175 0.0607
Schistosoma mansoni hypothetical protein 0.0064 0.0307 0.0301
Echinococcus multilocularis mitogen activated protein kinase 0.005 0.0214 0.0201
Plasmodium falciparum histone deacetylase, putative 0.0042 0.0165 0.0267
Loa Loa (eye worm) hypothetical protein 0.0051 0.0223 0.0228
Chlamydia trachomatis dihydrofolate reductase 0.1551 0.9778 1
Echinococcus multilocularis Niemann Pick C1 protein 0.0096 0.0511 0.0498
Echinococcus granulosus mitogen activated protein kinase 3 0.005 0.0214 0.0205
Schistosoma mansoni patched 1 0.0041 0.016 0.015
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0022 0.0037 0.0037
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0027 0.0069 0.0057
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0019 0.0006
Loa Loa (eye worm) histone deacetylase 0.0042 0.0165 0.0168
Echinococcus granulosus mitogen activated protein kinase 0.005 0.0214 0.0205
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0516 0.0514
Echinococcus multilocularis expressed conserved protein 0.0091 0.0473 0.046
Brugia malayi conserved hypotetical protein 0.0024 0.0051 0.0052
Brugia malayi hypothetical protein 0.0024 0.0051 0.0052
Schistosoma mansoni hypothetical protein 0.0307 0.1851 0.1881
Echinococcus multilocularis histone deacetylase 7 0.0042 0.0165 0.0151
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0214 0.0745
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0123 0.0126
Brugia malayi hypothetical protein 0.0116 0.0634 0.0648
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0024 0.0051 0.0052
Loa Loa (eye worm) nuclear hormone receptor 0.0024 0.0051 0.0052
Echinococcus granulosus histone lysine methyltransferase setb 0.0059 0.0272 0.0265
Plasmodium vivax SET domain protein, putative 0.0059 0.0272 0.0449
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0411 0.2515 0.2573
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0023 0.0044 0.0038
Echinococcus multilocularis nuclear receptor nhr 48 0.0024 0.0051 0.0037
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.0787 0.0799
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0059 0.0272 0.0259
Onchocerca volvulus 0.0024 0.0051 0.0176
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0944 0.5915 1
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0944 0.5915 1
Onchocerca volvulus 0.0051 0.0223 0.0776
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0051 0.0223 0.0228
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.1551 0.9778 1
Loa Loa (eye worm) hypothetical protein 0.0147 0.0836 0.0855
Echinococcus granulosus thymidylate synthase 0.0243 0.1446 0.1467
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0037 0.0062
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0051 0.0223 0.0215
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0044 0.0175 0.0179
Giardia lamblia PHD finger protein 15 0.0029 0.0084 0.0411
Plasmodium falciparum phd finger protein, putative 0.0029 0.0084 0.013
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0014 0.0048
Brugia malayi RNA recognition motif domain containing protein 0.0129 0.0721 0.0737
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0051 0.0223 0.0215
Onchocerca volvulus 0.0023 0.0044 0.0154
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0044 0.0045
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0051 0.0223 0.0215
Schistosoma mansoni dihydrofolate reductase 0.1551 0.9778 1
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0157 0.0147
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0044 0.0075
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0037 0.0037
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.0054 0.0091
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0223 0.0228
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0019 0.0006
Loa Loa (eye worm) hypothetical protein 0.0081 0.0413 0.0422
Echinococcus multilocularis Niemann Pick C1 protein 0.0138 0.0774 0.0762
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0175 0.0607
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0204 0.1195 0.1223
Echinococcus granulosus Niemann Pick C1 protein 0.0138 0.0774 0.0779
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0051 0.0223 0.0215
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0052
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0052
Plasmodium falciparum histone deacetylase 2 0.0042 0.0165 0.0267
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0051 0.0223 0.0215
Trypanosoma brucei glucosidase, putative 0.0044 0.0175 0.0295
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0031 0.0102
Loa Loa (eye worm) hypothetical protein 0.0031 0.0094 0.0096
Echinococcus multilocularis lysosomal alpha glucosidase 0.0197 0.115 0.1138
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0084 0.0072
Brugia malayi hypothetical protein 0.0027 0.0069 0.0071
Schistosoma mansoni DNA polymerase eta 0.0022 0.0037 0.0023
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.1551 0.9778 1
Schistosoma mansoni hypothetical protein 0.0081 0.0413 0.0409
Echinococcus granulosus dna polymerase eta 0.0022 0.0037 0.0023
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0024 0.0051 0.0052
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0175 0.0607
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0044 0.0045
Schistosoma mansoni hypothetical protein 0.0139 0.0784 0.0789
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0243 0.1446 0.1467
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0051 0.0223 0.0215
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0014 0.0023
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0081 0.0413 0.04
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0516 0.0503
Schistosoma mansoni ran 0.0021 0.0031 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0051 0.0223 0.0228
Brugia malayi hypothetical protein 0.0019 0.0019 0.002
Echinococcus granulosus FTZ F1 alpha 0.0051 0.0223 0.0215
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0096 0.051 0.0509
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0052
Trichomonas vaginalis sucrase-isomaltase, putative 0.0044 0.0175 0.0607
Loa Loa (eye worm) RNA binding protein 0.0129 0.0721 0.0737
Echinococcus granulosus lysosomal alpha glucosidase 0.0197 0.115 0.1164
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0084 0.007
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.172 0.5979
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0031 0.0053
Echinococcus granulosus netrin receptor unc 5 0.0031 0.0094 0.0082
Schistosoma mansoni microtubule-associated protein tau 0.0676 0.4202 0.429
Brugia malayi latrophilin 2 splice variant baaae 0.0139 0.0784 0.0802
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.0121 0.0107
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0022 0.0037 0.0062
Echinococcus granulosus death domain containing protein 0.0031 0.0094 0.0082
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0024 0.0051 0.0038
Leishmania major DNA polymerase kappa, putative 0.0022 0.0037 0.0062
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.0019 0.0006
Brugia malayi Bromodomain containing protein 0.0029 0.0084 0.0086
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0052
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0054 0.0091
Echinococcus granulosus dihydrofolate reductase 0.1551 0.9778 1
Onchocerca volvulus 0.0024 0.0051 0.0176
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0051 0.0223 0.0215
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0721 0.0724
Echinococcus granulosus expressed conserved protein 0.0091 0.0473 0.0471
Brugia malayi Pre-SET motif family protein 0.0411 0.2515 0.2573
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0037 0.0062
Loa Loa (eye worm) steroid hormone receptor 0.0051 0.0223 0.0228
Schistosoma mansoni alpha-glucosidase 0.0169 0.0976 0.0985
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0027 0.0069 0.0057
Trypanosoma brucei histone deacetylase 3 0.0042 0.0165 0.0278
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0037 0.003
Brugia malayi hypothetical protein 0.0035 0.0121 0.0124
Echinococcus granulosus dna polymerase kappa 0.0022 0.0037 0.0023
Schistosoma mansoni importin beta-1 0.0029 0.0079 0.0067
Leishmania major GTP-binding protein, putative 0.0021 0.0031 0.0053
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0051 0.0223 0.0228
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0071
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0027 0.0069 0.0071
Entamoeba histolytica deoxycytidyl transferase, putative 0.0022 0.0037 0.0213
Brugia malayi Doublecortin family protein 0.0019 0.0019 0.002
Trypanosoma cruzi histone deacetylase, putative 0.0042 0.0165 0.0278
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0037 0.0062
Loa Loa (eye worm) hypothetical protein 0.0051 0.0223 0.0228
Echinococcus granulosus GPCR family 2 0.0064 0.0307 0.0301
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0096 0.0511 0.2969
Giardia lamblia Kinase, CMGC MAPK 0.005 0.0214 0.1176
Onchocerca volvulus Alhambra homolog 0.0029 0.0084 0.0291
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0024 0.0051 0.0038
Brugia malayi steroid hormone receptor 0.0051 0.0223 0.0228
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0031 0.0053
Brugia malayi ImpB/MucB/SamB family protein 0.0022 0.0037 0.0037
Brugia malayi Calcitonin receptor-like protein seb-1 0.0204 0.1195 0.1223
Schistosoma mansoni hypothetical protein 0.004 0.0151 0.014
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0129 0.0721 0.0737
Schistosoma mansoni alpha-glucosidase 0.0169 0.0976 0.0985
Trypanosoma brucei DNA polymerase eta, putative 0.0022 0.0037 0.0062
Entamoeba histolytica hypothetical protein 0.0023 0.0045 0.0261
Leishmania major histone deacetylase, putative 0.0042 0.0165 0.0278
Entamoeba histolytica hypothetical protein 0.0035 0.0121 0.0703
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0051 0.0176
Mycobacterium tuberculosis Conserved hypothetical protein 0.0022 0.0037 0.0037
Brugia malayi jmjC domain containing protein 0.0096 0.051 0.0522
Echinococcus multilocularis sterol regulatory element binding protein 0.0041 0.016 0.0146
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0079 0.0111
Echinococcus multilocularis histone deacetylase 6 0.0042 0.0165 0.0151
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0044 0.0075
Echinococcus multilocularis netrin receptor unc 5 0.0031 0.0094 0.008
Entamoeba histolytica hypothetical protein 0.0035 0.0121 0.0703
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.172 0.5979
Loa Loa (eye worm) doublecortin family protein 0.0019 0.0019 0.002
Brugia malayi photoreceptor-specific nuclear receptor 0.0051 0.0223 0.0228
Treponema pallidum fructose-bisphosphate aldolase 0.0286 0.172 1
Brugia malayi ecdysteroid receptor 0.0051 0.0223 0.0228
Plasmodium vivax histone deacetylase 2, putative 0.0042 0.0165 0.0267
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0024 0.0051 0.0038
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0023 0.0044 0.0038
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0014 0.0023
Echinococcus multilocularis mitogen activated protein kinase 3 0.005 0.0214 0.0201
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0037 0.0062
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0205 0.0196
Echinococcus multilocularis Ankyrin 0.0031 0.0094 0.0081
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0031 0.0032
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0022 0.0037 0.0127
Brugia malayi CHE-14 protein 0.0041 0.016 0.0164
Loa Loa (eye worm) hypothetical protein 0.0051 0.0223 0.0228
Entamoeba histolytica hypothetical protein 0.0035 0.0121 0.0703
Echinococcus multilocularis histone deacetylase 6 0.0042 0.0165 0.0151
Brugia malayi TAR-binding protein 0.0129 0.0721 0.0737
Trypanosoma brucei protein kinase, putative 0.005 0.0214 0.0362
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0071
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0071
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0031 0.0053
Giardia lamblia Fructose-bisphosphate aldolase 0.0286 0.172 1
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0223 0.021
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0944 0.5915 1
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0045
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0054 0.0079
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0014 0.008
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0097 0.0516 0.0503
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0017 0.0007 0.0006
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0214 0.0745
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0059 0.0272 0.0259
Brugia malayi Glycosyl hydrolases family 31 protein 0.0197 0.115 0.1176
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0944 0.5915 1
Echinococcus granulosus microtubule associated protein 2 0.0676 0.4202 0.429
Mycobacterium ulcerans DNA polymerase IV 0.0022 0.0037 0.003
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0051 0.0223 0.0215
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.0121 0.011
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0051 0.0052
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0051 0.0038
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0064 0.0307 0.0301
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0307 0.1851 0.1893
Plasmodium vivax importin-beta 2, putative 0.0029 0.0079 0.0123
Schistosoma mansoni alpha glucosidase 0.0044 0.0175 0.0165
Mycobacterium ulcerans thymidylate synthase 0.0243 0.1446 0.1473
Echinococcus granulosus Nuclear hormone receptor HR96 0.0024 0.0051 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0037 0.0062
Brugia malayi AMP-binding enzyme family protein 0.0023 0.0044 0.0045
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Brugia malayi dihydrofolate reductase family protein 0.1551 0.9778 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0084 0.0086
Leishmania major DNA polymerase eta, putative 0.0022 0.0037 0.0062
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.172 0.5979
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0214 0.0362
Loa Loa (eye worm) hypothetical protein 0.0064 0.0307 0.0314
Echinococcus multilocularis ankyrin repeat and death domain containing protein 0.0031 0.0094 0.008
Echinococcus multilocularis nuclear factor of activated T cells 5 0.0303 0.1826 0.1815
Plasmodium falciparum ataxin-2 like protein, putative 0.0025 0.0054 0.0079
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0516 0.0514
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0045 0.0156
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0157 0.0144
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.005 0.0214 0.0362
Schistosoma mansoni zinc finger protein 0.0024 0.0051 0.0038
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0044 0.0038
Loa Loa (eye worm) hypothetical protein 0.0051 0.0219 0.0224
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0064 0.0307 0.0294
Mycobacterium ulcerans hypothetical protein 0.0023 0.0044 0.0038
Schistosoma mansoni nuclear hormone receptor 0.0024 0.0051 0.0038
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0241 0.0227
Echinococcus granulosus importin subunit beta 1 0.0029 0.0079 0.0067
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.005 0.0214 0.0362
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0223 0.021
Brugia malayi nuclear receptor NHR-67 0.0024 0.0051 0.0052
Brugia malayi Nuclear hormone receptor E75 0.0024 0.0051 0.0052
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0064 0.0307 0.0294
Echinococcus multilocularis peregrin 0.0029 0.0084 0.007
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0214 0.0745
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0018 0.0014 0.0013
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0051 0.0223 0.0215
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0014 0.0048
Entamoeba histolytica Ran family GTPase 0.0021 0.0031 0.0181
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0051 0.0223 0.021
Echinococcus granulosus peregrin 0.0029 0.0084 0.0072
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0037 0.0062
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0037 0.0062
Brugia malayi nuclear receptor RXR 0.0024 0.0051 0.0052
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0045
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0023 0.0044 0.0044
Loa Loa (eye worm) thymidylate synthase 0.0243 0.1446 0.1479
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0031 0.0041
Loa Loa (eye worm) nuclear receptor NHR-67 0.0024 0.0051 0.0052
Onchocerca volvulus 0.0468 0.2878 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0022 0.0037 0.0062
Plasmodium falciparum importin beta, putative 0.0029 0.0079 0.0123
Echinococcus multilocularis protein patched 0.0041 0.016 0.0146
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.005 0.0214 0.0362
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0027 0.0069 0.0057
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0023 0.0044 0.0038
Echinococcus granulosus survival motor neuron protein 1 0.0232 0.1372 0.1391
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.0054 0.0068
Echinococcus multilocularis dihydrofolate reductase 0.1551 0.9778 0.9777
Schistosoma mansoni lipoxygenase 0.0054 0.0241 0.0233
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0037 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0037 0.0062
Schistosoma mansoni hypothetical protein 0.0035 0.0121 0.011
Brugia malayi Glycosyl hydrolases family 31 protein 0.0044 0.0175 0.0179
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0243 0.1446 0.1479
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.0019 0.0006
Onchocerca volvulus Netrin receptor homolog 0.0031 0.0094 0.0326
Brugia malayi jmjC domain containing protein 0.0036 0.0123 0.0126
Onchocerca volvulus 0.0019 0.0019 0.0067
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0052
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.005 0.0214 0.0362
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0052
Echinococcus multilocularis histone deacetylase 0.0042 0.0165 0.0151
Trypanosoma brucei unspecified product 0.0022 0.0037 0.0062
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0223 0.0215
Trichomonas vaginalis DNA polymerase eta, putative 0.0022 0.0037 0.0127
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0045 0.0156
Loa Loa (eye worm) hypothetical protein 0.0204 0.1195 0.1223
Echinococcus granulosus histone deacetylase 6 0.0042 0.0165 0.0155
Schistosoma mansoni histone deacetylase 4 5 0.0042 0.0165 0.0155
Entamoeba histolytica acyl-CoA synthetase, putative 0.0023 0.0044 0.0258
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0024 0.0051 0.0037
Onchocerca volvulus Bile acid receptor homolog 0.0051 0.0223 0.0776
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0097 0.0516 0.0527
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0081 0.0413 0.0409
Echinococcus granulosus nuclear receptor nhr 48 0.0024 0.0051 0.0038
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0023 0.0044 0.0044
Brugia malayi nuclear hormone receptor family member odr-7 0.0024 0.0051 0.0052
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0031 0.0029
Schistosoma mansoni serine/threonine protein kinase 0.005 0.0214 0.0205
Loa Loa (eye worm) immunoglobulin I-set domain-containing protein 0.0031 0.0094 0.0096
Echinococcus multilocularis microtubule associated protein 2 0.0676 0.4202 0.4194
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0023 0.0044 0.0038
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0037 0.0062
Schistosoma mansoni hypothetical protein 0.0081 0.0413 0.0409
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0031 0.0041
Brugia malayi ecdysone receptor 0.0024 0.0051 0.0052
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0084 0.0072
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0071
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.0019 0.0006
Schistosoma mansoni nuclear receptor 0.0024 0.0051 0.0038
Schistosoma mansoni RAR-like nuclear receptor 0.0051 0.0223 0.0215
Trichomonas vaginalis set domain proteins, putative 0.0468 0.2877 1
Brugia malayi Steroid receptor seven-up type 2 0.0051 0.0223 0.0228
Leishmania major alpha glucosidase II subunit, putative 0.0044 0.0175 0.0295
Brugia malayi Niemann-Pick C1 protein precursor 0.0096 0.0511 0.0522
Schistosoma mansoni tar DNA-binding protein 0.0129 0.0721 0.0724
Echinococcus multilocularis histone deacetylase 6 0.0042 0.0165 0.0151
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0024 0.0051 0.0037
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0014 0.0014
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0175 0.0607
Brugia malayi nuclear hormone receptor 0.0024 0.0051 0.0052
Loa Loa (eye worm) hypothetical protein 0.0048 0.0205 0.021
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0283 0.029
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.0054 0.0091
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0223 0.0228
Schistosoma mansoni hypothetical protein 0.0029 0.0084 0.0072
Schistosoma mansoni retinoic acid receptor RXR 0.0051 0.0223 0.0215
Echinococcus granulosus RUN 0.0019 0.0019 0.0006
Loa Loa (eye worm) hypothetical protein 0.0017 0.0007 0.0007
Echinococcus granulosus tumor protein p63 0.0331 0.2005 0.2039
Schistosoma mansoni hypothetical protein 0.0019 0.0019 0.0006
Plasmodium vivax histone deacetylase, putative 0.0042 0.0165 0.0267
Brugia malayi PHD-finger family protein 0.0029 0.0084 0.0086
Echinococcus granulosus histone deacetylase 0.0042 0.0165 0.0155
Schistosoma mansoni hypothetical protein 0.0064 0.0307 0.0301
Brugia malayi nuclear receptor NHR-88 0.0051 0.0223 0.0228
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0223 0.0215
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0051 0.0223 0.0228
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0241 0.0233
Loa Loa (eye worm) hypothetical protein 0.0051 0.0223 0.0228
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0051 0.0037
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0052
Schistosoma mansoni ankyrin 23/unc44 0.0031 0.0094 0.0082
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0197 0.115 0.1176
Schistosoma mansoni steroid hormone receptor ad4bp 0.0051 0.0223 0.0215
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0081 0.0413 0.04
Echinococcus granulosus snurportin 1 0.0307 0.1851 0.1881
Schistosoma mansoni apoptosis regulator bax 0.0081 0.0413 0.0409
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.172 0.5979
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0051 0.0223 0.0228
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0097 0.0516 0.0514
Loa Loa (eye worm) hypothetical protein 0.0139 0.0784 0.0802
Schistosoma mansoni hypothetical protein 0.004 0.0151 0.014
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.0121 0.011
Echinococcus granulosus neutral alpha glucosidase AB 0.0044 0.0175 0.0165
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0044 0.0175 0.0273
Trypanosoma cruzi histone deacetylase, putative 0.0042 0.0165 0.0278
Echinococcus multilocularis tumor protein p63 0.0331 0.2005 0.1994
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0123 0.0112
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0031 0.0018
Brugia malayi RNA, U transporter 1 0.0082 0.0417 0.0426
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0081 0.0413 0.0409
Brugia malayi Dihydrofolate reductase 0.1551 0.9778 1
Entamoeba histolytica hypothetical protein 0.0035 0.0121 0.0703
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0022 0.0037 0.0023
Loa Loa (eye worm) TAR-binding protein 0.0129 0.0721 0.0737
Trichomonas vaginalis conserved hypothetical protein 0.0041 0.016 0.0556
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0059 0.0272 0.0438
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0272 0.0265
Loa Loa (eye worm) hypothetical protein 0.0023 0.0044 0.0045
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0024 0.0051 0.0037
Toxoplasma gondii histone deacetylase HDAC1 0.0042 0.0165 0.0256
Plasmodium vivax ataxin-2 like protein, putative 0.0025 0.0054 0.0079
Echinococcus multilocularis thyroid hormone receptor alpha 0.0051 0.0223 0.021
Brugia malayi Histone deacetylase family protein 0.0042 0.0165 0.0168
Echinococcus multilocularis GPCR, family 2 0.0064 0.0307 0.0294
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.0787 0.0763
Trichomonas vaginalis conserved hypothetical protein 0.0116 0.0634 0.2203
Echinococcus granulosus Ankyrin 0.0031 0.0094 0.0083
Brugia malayi nuclear hormone receptor 0.0051 0.0223 0.0228
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.172 1
Trichomonas vaginalis CMGC family protein kinase 0.005 0.0214 0.0745
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0051 0.0223 0.0228
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0047 0.0197 0.0202
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0175 0.0295
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.172 0.5979
Loa Loa (eye worm) hypothetical protein 0.0025 0.0054 0.0055
Trypanosoma cruzi DNA polymerase eta, putative 0.0022 0.0037 0.0062
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0037 0.0062
Schistosoma mansoni nuclear receptor 0.0024 0.0051 0.0038
Schistosoma mansoni nuclear receptor nhr-48 0.0024 0.0051 0.0038
Echinococcus multilocularis survival motor neuron protein 1 0.0232 0.1372 0.136
Loa Loa (eye worm) hypothetical protein 0.0029 0.0079 0.0081
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0031 0.0032
Brugia malayi Latrophilin receptor protein 2 0.0064 0.0307 0.0314
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0098 0.052 0.0519
Schistosoma mansoni histone deacetylase hda2 0.0042 0.0165 0.0155
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0052
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.005 0.0214 0.034
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.0019 0.0006
Brugia malayi Death domain containing protein 0.0031 0.0094 0.0096
Brugia malayi hypothetical protein 0.0027 0.0069 0.0071
Loa Loa (eye worm) hypothetical protein 0.0051 0.0223 0.0228
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0064 0.0307 0.0314
Leishmania major importin beta-1 subunit, putative 0.0023 0.0045 0.0076
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0022 0.0037 0.0037
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0051 0.0223 0.0776
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0223 0.0215
Trypanosoma cruzi histone deacetylase, putative 0.0042 0.0165 0.0278
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0052
Brugia malayi Immunoglobulin I-set domain containing protein 0.0031 0.0094 0.0096
Loa Loa (eye worm) hypothetical protein 0.0051 0.0223 0.0228
Loa Loa (eye worm) hypothetical protein 0.0232 0.1372 0.1403
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.0019 0.0021
Trypanosoma brucei histone deacetylase, putative 0.0042 0.0165 0.0278
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0014 0.5
Schistosoma mansoni ran 0.0021 0.0031 0.0018
Brugia malayi nuclear receptor NHR-88 0.0024 0.0051 0.0052
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0024 0.0051 0.0038
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0097 0.0516 0.0527
Leishmania major hypothetical protein, conserved 0.0025 0.0054 0.0091
Loa Loa (eye worm) latrophilin receptor protein 2 0.0064 0.0307 0.0314
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0944 0.5915 1
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0024 0.0051 0.0176
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0286 0.172 0.5979
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0041 0.016 0.0164
Leishmania major histone deacetylase, putative 0.0042 0.0165 0.0278
Schistosoma mansoni loxhd1 0.0019 0.0019 0.0006
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0079 0.0134
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0123 0.0112
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0051 0.0223 0.0228
Leishmania major 4-coumarate:coa ligase-like protein 0.0023 0.0044 0.0075
Echinococcus granulosus geminin 0.0359 0.2182 0.2221
Loa Loa (eye worm) hypothetical protein 0.0041 0.016 0.0164
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0059 0.0272 0.0265
Trichomonas vaginalis alpha-glucosidase, putative 0.0044 0.0175 0.0607
Loa Loa (eye worm) hypothetical protein 0.005 0.0218 0.0223
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0223 0.0228
Brugia malayi hypothetical protein 0.0019 0.0019 0.002
Loa Loa (eye worm) hypothetical protein 0.0042 0.0165 0.0168
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0079 0.0066
Schistosoma mansoni coup transcription factor 0.0051 0.0223 0.0215
Brugia malayi Uncoordinated protein 44 0.0031 0.0094 0.0096
Schistosoma mansoni hypothetical protein 0.0081 0.0413 0.0409
Loa Loa (eye worm) DR-78 0.0024 0.0051 0.0052
Schistosoma mansoni hypothetical protein 0.0064 0.0307 0.0301
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0018 0.0014 0.0023
Loa Loa (eye worm) histone deacetylase 7A 0.0042 0.0165 0.0168
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0051 0.0223 0.021
Onchocerca volvulus 0.0114 0.0622 0.216
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0044 0.0175 0.0607
Schistosoma mansoni hypothetical protein 0.004 0.0151 0.014
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0051 0.0223 0.0228
Onchocerca volvulus 0.0243 0.1446 0.5026
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0014 0.0012
Brugia malayi Nuclear hormone receptor-like 1 0.0027 0.0069 0.0071
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0096 0.051 0.0497
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0081 0.0413 0.0422
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0051 0.0223 0.0215
Echinococcus granulosus histone deacetylase 6 0.0042 0.0165 0.0155
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0018 0.0014 0.0012
Brugia malayi Pre-SET motif family protein 0.0059 0.0272 0.0278
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.0019 0.0021
Schistosoma mansoni polycystin 1-related 0.0019 0.0019 0.0006
Schistosoma mansoni hypothetical protein 0.0047 0.0197 0.0188
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0037 0.0062
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0123 0.011
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0024 0.0051 0.0037
Echinococcus granulosus ecdysone induced protein 78C 0.0051 0.0223 0.0215
Echinococcus multilocularis protein dispatched 1 0.0047 0.0197 0.0184
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0051 0.0223 0.0215
Schistosoma mansoni thyroid hormone receptor 0.0051 0.0223 0.0215
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0014 0.0014
Echinococcus multilocularis snurportin 1 0.0307 0.1851 0.184
Loa Loa (eye worm) hypothetical protein 0.0024 0.0051 0.0052
Schistosoma mansoni hypothetical protein 0.0359 0.2182 0.2221
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0051 0.0223 0.021
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0097 0.0516 0.0514
Schistosoma mansoni terminal deoxycytidyl transferase 0.0022 0.0037 0.0023
Schistosoma mansoni retinoblastoma-binding protein 4 (rbbp4) 0.0031 0.0094 0.0083
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0059 0.0272 0.0265
Schistosoma mansoni hypothetical protein 0.0031 0.0094 0.0082
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0243 0.1446 0.1441
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0051 0.0223 0.0228
Trypanosoma brucei DNA polymerase IV, putative 0.0022 0.0037 0.0062
Echinococcus multilocularis dna polymerase eta 0.0022 0.0037 0.0023
Trichomonas vaginalis ran, putative 0.0021 0.0031 0.0108
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0044 0.0175 0.1015
Trypanosoma brucei DNA polymerase kappa, putative 0.0022 0.0037 0.0062
Loa Loa (eye worm) hypothetical protein 0.0019 0.0019 0.002
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0018 0.0014 0.0023
Trypanosoma cruzi hypothetical protein, conserved 0.0044 0.0175 0.0295
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0022 0.0037 0.0023
Brugia malayi Protein kinase domain containing protein 0.0031 0.0097 0.0099
Brugia malayi thymidylate synthase 0.0243 0.1446 0.1479
Echinococcus granulosus histone deacetylase 7 0.0042 0.0165 0.0155
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0286 0.172 1
Onchocerca volvulus 0.0059 0.0272 0.0945
Echinococcus multilocularis FTZ F1 alpha 0.0051 0.0223 0.021
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.1551 0.9778 1
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0045 0.0156
Loa Loa (eye worm) hypothetical protein 0.0022 0.0037 0.0037
Trypanosoma brucei histone deacetylase 4 0.0042 0.0165 0.0278
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0223 0.0215
Brugia malayi Importin beta-1 subunit 0.0029 0.0079 0.0081
Schistosoma mansoni survival motor neuron protein 0.0047 0.0197 0.0188
Brugia malayi hypothetical protein 0.0232 0.1372 0.1403
Mycobacterium ulcerans acyl-CoA synthetase 0.0023 0.0044 0.0038
Schistosoma mansoni lipoxygenase 0.0019 0.0019 0.0006
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0081 0.0413 0.0409

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 6.3096 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 997 ] ChEMBL. No reference
Potency (functional) = 8.9125 um PUBCHEM_BIOASSAY: qHTS Assay for Activators of Human alpha-Glucosidase as a Potential Chaperone Treatment of Pompe Disease. (Class of assay: confirmatory) [Related pubchem assays: 1467, 2100, 2112, 1473, 1466 ] ChEMBL. No reference
Potency (functional) 10.4179 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1). (Class of assay: confirmatory) [Related pubchem assays: 1030 (qHTS Validation Assay for Inhibitors of aldehyde dehydrogenase 1 (ALDH1A1))] ChEMBL. No reference
Potency (functional) = 25.1189 um PUBCHEM_BIOASSAY: qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction. (Class of assay: confirmatory) ChEMBL. No reference
Potency (binding) = 31.6228 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (binding) 39.8107 uM PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 44.6684 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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