Detailed information for compound 664616

Basic information

Technical information
  • TDR Targets ID: 664616
  • Name: 2-[(2-cyanophenyl)sulfonylamino]benzoic acid
  • MW: 302.305 | Formula: C14H10N2O4S
  • H donors: 2 H acceptors: 5 LogP: 2.24 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: N#Cc1ccccc1S(=O)(=O)Nc1ccccc1C(=O)O
  • InChi: 1S/C14H10N2O4S/c15-9-10-5-1-4-8-13(10)21(19,20)16-12-7-3-2-6-11(12)14(17)18/h1-8,16H,(H,17,18)
  • InChiKey: FIUXWMJFUHPINA-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0017 0.001 0.0012
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0211 0.0276
Loa Loa (eye worm) jmjC domain-containing protein 0.013 0.3155 0.8466
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0063 0.1282 0.2812
Brugia malayi Thioredoxin reductase 0.005 0.0928 0.1755
Echinococcus multilocularis CREB binding protein 0.0087 0.1941 0.3672
Plasmodium vivax endoplasmin, putative 0.0099 0.2288 0.2287
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0025 0.0211 0.0399
Trypanosoma cruzi trypanothione reductase, putative 0.0017 0.001 0.0012
Trichomonas vaginalis DNA helicase recq1, putative 0.0026 0.0237 0.031
Schistosoma mansoni endoplasmin 0.0099 0.2288 0.5019
Toxoplasma gondii Hsp90 domain-containing protein 0.0375 1 1
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0211 0.0211
Trichomonas vaginalis CAMK family protein kinase 0.01 0.233 0.3056
Loa Loa (eye worm) RecQ helicase 0.0026 0.0237 0.0633
Echinococcus granulosus geminin 0.018 0.4557 0.8625
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0211 0.0276
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1405 0.3082
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0017 0.001 0.001
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.0012
Trichomonas vaginalis DNA helicase recq, putative 0.0026 0.0237 0.031
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0211 0.0276
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.002 0.0091 0.0198
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0017 0.0001 0.0001
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.01 0.233 0.3056
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.001 0.0012
Schistosoma mansoni phosphatidylserine receptor 0.002 0.0091 0.0198
Echinococcus granulosus chromobox protein 2 0.0025 0.0211 0.0399
Echinococcus granulosus heat shock protein 90 0.0085 0.1888 0.3573
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0211 0.0276
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Loa Loa (eye worm) heat shock protein 90 0.0099 0.2288 0.6138
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Schistosoma mansoni CREB-binding protein 1 (SmCBP1) 0.0087 0.1941 0.4258
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1405 0.3082
Trichomonas vaginalis conserved hypothetical protein 0.029 0.762 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0211 0.0565
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0211 0.0276
Echinococcus multilocularis heat shock protein 90 0.0099 0.2288 0.4329
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0025 0.0211 0.0211
Plasmodium falciparum glutathione reductase 0.005 0.0928 0.0927
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0017 0.001 0.0012
Echinococcus granulosus lysine specific demethylase 6a 0.002 0.0091 0.0171
Trichomonas vaginalis heat shock protein, putative 0.0085 0.1888 0.2477
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.1282 0.1282
Brugia malayi hypothetical protein 0.0025 0.0211 0.0399
Plasmodium falciparum thioredoxin reductase 0.005 0.0928 0.0927
Schistosoma mansoni chromobox protein 0.015 0.3727 0.8177
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0026 0.0251 0.0329
Trichomonas vaginalis heat shock protein, putative 0.0099 0.2288 0.3002
Echinococcus granulosus citrate lyase subunit beta protein 0.0026 0.0251 0.0474
Schistosoma mansoni hypothetical protein 0.018 0.4557 1
Echinococcus multilocularis bloom syndrome protein 0.0026 0.0237 0.0446
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.188 0.2466
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0017 0.001 0.0012
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0211 0.0276
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.1652 0.3625
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0017 0.001 0.0012
Echinococcus granulosus PHD finger protein rhinoceros 0.0063 0.1282 0.2426
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0066 0.136 0.2573
Brugia malayi PHD-finger family protein 0.0021 0.0098 0.0185
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0211 0.0276
Loa Loa (eye worm) hypothetical protein 0.0025 0.0211 0.0565
Trichomonas vaginalis heat shock protein, putative 0.0093 0.2118 0.2779
Loa Loa (eye worm) jmjC domain-containing protein 0.0076 0.1652 0.4433
Brugia malayi TAZ zinc finger family protein 0.0087 0.1941 0.3672
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0211 0.0276
Trichomonas vaginalis conserved hypothetical protein 0.0084 0.188 0.2466
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0017 0.001 0.0018
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0066 0.136 0.5422
Loa Loa (eye worm) TAR-binding protein 0.0067 0.1405 0.377
Schistosoma mansoni phd/f-box containing protein 0.002 0.0091 0.0198
Brugia malayi AF-10 protein 0.0021 0.0098 0.0185
Trypanosoma brucei heat shock protein, putative 0.0099 0.2288 0.3002
Brugia malayi jmjC domain containing protein 0.002 0.0091 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.006 0.1192 0.1563
Trichomonas vaginalis CAMK family protein kinase 0.01 0.233 0.3056
Giardia lamblia Grp94/Hsp90 0.0093 0.2118 0.9091
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1405 0.3082
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.0012
Trichomonas vaginalis chromobox protein, putative 0.015 0.3727 0.489
Echinococcus granulosus chromobox protein 1 0.015 0.3727 0.7052
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.0211 0.0211
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0251 0.0329
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.002 0.0091 0.0119
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0021 0.0098 0.0098
Mycobacterium ulcerans lysophospholipase 0.029 0.762 1
Trypanosoma cruzi monoglyceride lipase, putative 0.029 0.762 1
Leishmania major hypothetical protein, conserved 0.002 0.0091 0.0119
Trypanosoma cruzi heat shock protein 90, putative 0.0085 0.1888 0.2477
Loa Loa (eye worm) hypothetical protein 0.0053 0.1004 0.2694
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0127 0.3085 0.4048
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Trichomonas vaginalis CAMK family protein kinase 0.01 0.233 0.3056
Trichomonas vaginalis chromobox protein, putative 0.0091 0.2058 0.2701
Toxoplasma gondii hypothetical protein 0.0017 0.0001 0.0001
Trichomonas vaginalis heat shock protein, putative 0.0058 0.113 0.1483
Schistosoma mansoni hypothetical protein 0.0063 0.1282 0.2812
Echinococcus granulosus thioredoxin glutathione reductase 0.005 0.0928 0.1755
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.0012
Echinococcus multilocularis chromobox protein 1 0.015 0.3727 0.7052
Onchocerca volvulus Serine\/threonine kinase homolog 0.01 0.233 1
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.029 0.762 1
Toxoplasma gondii 'chromo' (CHRromatin Organization MOdifier) domain-containing protein 0.0025 0.0211 0.0211
Mycobacterium tuberculosis Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase) 0.0026 0.0251 0.0329
Schistosoma mansoni hypothetical protein 0.0036 0.0536 0.1174
Echinococcus multilocularis geminin 0.018 0.4557 0.8625
Schistosoma mansoni chromobox protein 0.0025 0.0211 0.0462
Plasmodium falciparum heat shock protein 90 0.0099 0.2288 0.2287
Loa Loa (eye worm) CHromoDomain protein family member 0.0025 0.0211 0.0565
Mycobacterium tuberculosis Conserved protein 0.0026 0.0251 0.0329
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0211 0.0462
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0211 0.0276
Loa Loa (eye worm) helicase 0.0025 0.0211 0.0565
Mycobacterium tuberculosis Probable reductase 0.0115 0.2728 0.3579
Loa Loa (eye worm) hypothetical protein 0.0128 0.3113 0.8354
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0017 0.001 0.001
Trichomonas vaginalis heat shock protein, putative 0.0093 0.2118 0.2779
Echinococcus granulosus heat shock protein 90 0.0099 0.2288 0.4329
Schistosoma mansoni heat shock protein 0.0099 0.2288 0.5019
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.0012
Trypanosoma cruzi heat shock protein 85, putative 0.0099 0.2288 0.3002
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0025 0.0211 0.0211
Trypanosoma brucei heat shock protein, putative 0.0099 0.2288 0.3002
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.0012
Loa Loa (eye worm) hypothetical protein 0.0025 0.0211 0.0565
Trypanosoma brucei heat shock protein, putative 0.0099 0.2288 0.3002
Echinococcus multilocularis lysine specific demethylase 5A 0.0076 0.1652 0.3126
Plasmodium vivax heat shock protein 90, putative 0.0066 0.136 0.1359
Toxoplasma gondii phospholipase/carboxylesterase 0.0017 0.0001 0.0001
Brugia malayi latrophilin 2 splice variant baaae 0.0036 0.0536 0.1013
Toxoplasma gondii protein c14orf29, putative 0.0017 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0211 0.0565
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0211 0.0276
Loa Loa (eye worm) thioredoxin reductase 0.005 0.0928 0.2489
Brugia malayi CHD4 protein 0.0025 0.0211 0.0399
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0913 0.1197
Toxoplasma gondii heat shock protein 90, putative 0.0099 0.2288 0.2288
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0093 0.2118 0.2779
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0091 0.0243
Echinococcus multilocularis endoplasmin 0.0093 0.2118 0.4007
Toxoplasma gondii esterase/lipase/thioesterase domain-containing protein 0.0017 0.0001 0.0001
Schistosoma mansoni hypothetical protein 0.018 0.4557 1
Schistosoma mansoni hypothetical protein 0.0025 0.0211 0.0462
Trypanosoma brucei heat shock protein, putative 0.0099 0.2288 0.3002
Echinococcus granulosus CREB binding protein 0.0087 0.1941 0.3672
Trypanosoma cruzi trypanothione reductase, putative 0.005 0.0928 0.1217
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0115 0.2728 0.3579
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0211 0.0276
Loa Loa (eye worm) hypothetical protein 0.0066 0.1371 0.3676
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0017 0.001 1
Loa Loa (eye worm) RNA binding protein 0.0067 0.1405 0.377
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0093 0.2118 0.2779
Plasmodium vivax heat shock protein 86, putative 0.0099 0.2288 0.2287
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0127 0.3085 0.1758
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.0012
Echinococcus granulosus CREB binding protein 0.0087 0.1941 0.3672
Toxoplasma gondii NADPH-glutathione reductase 0.0017 0.001 0.001
Trichomonas vaginalis endoplasmin, putative 0.0072 0.153 0.2007
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0211 0.0276
Echinococcus granulosus chromobox protein 1 0.015 0.3727 0.7052
Echinococcus granulosus bloom syndrome protein 0.0026 0.0237 0.0446
Toxoplasma gondii thioredoxin reductase 0.005 0.0928 0.0928
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1405 0.3082
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0017 0.001 0.0018
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.01 0.233 0.6251
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.002 0.0091 0.0091
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.1405 0.2659
Plasmodium vivax hypothetical protein, conserved 0.0063 0.1282 0.1282
Giardia lamblia Heat shock protein HSP 90-alpha 0.0099 0.2288 0.982
Brugia malayi TAR-binding protein 0.0067 0.1405 0.2659
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0211 0.0276
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0251 0.0329
Plasmodium falciparum heterochromatin protein 1 0.0025 0.0211 0.0211
Echinococcus granulosus jumonji domain containing 1A 0.002 0.0091 0.0171
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0091 0.2058 0.872
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0211 0.0276
Trypanosoma brucei hypothetical protein, conserved 0.0226 0.5843 0.7668
Loa Loa (eye worm) heat shock protein 75 0.0066 0.136 0.3648
Schistosoma mansoni hypothetical protein 0.0021 0.0098 0.0214
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.0012
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.0098 0.0128
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.233 0.3056
Brugia malayi Endoplasmin precursor 0.0099 0.2288 0.4329
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.029 0.762 1
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Schistosoma mansoni blooms syndrome DNA helicase 0.002 0.0087 0.0188
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0115 0.2728 0.3579
Toxoplasma gondii hypothetical protein 0.0017 0.0001 0.0001
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.002 0.0091 0.0171
Trypanosoma cruzi heat shock protein 90, putative 0.0041 0.0681 0.0893
Schistosoma mansoni CREB-binding protein 2 0.0087 0.1941 0.4258
Toxoplasma gondii hydrolase, alpha/beta fold family protein 0.0017 0.0001 0.0001
Brugia malayi Bromodomain containing protein 0.0063 0.1282 0.2426
Loa Loa (eye worm) hypothetical protein 0.0108 0.2539 0.6812
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0017 0.001 0.0012
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0091 0.0243
Echinococcus multilocularis PHD finger protein rhinoceros 0.0063 0.1282 0.2426
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0091 0.0119
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0025 0.0211 0.0399
Trypanosoma brucei Heat shock protein 83, putative 0.0099 0.2288 0.3002
Loa Loa (eye worm) heterochromatin protein 1 0.015 0.3727 1
Echinococcus multilocularis heat shock protein 90 0.0085 0.1888 0.3573
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.001 0.0012
Brugia malayi jmjC domain containing protein 0.0076 0.1652 0.3126
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0211 0.0276
Entamoeba histolytica hypothetical protein 0.0025 0.0211 0.0276
Plasmodium falciparum JmjC domain-containing protein, putative 0.002 0.0091 0.009
Trypanosoma brucei heat shock protein 90, putative 0.0099 0.2288 0.3002
Trypanosoma brucei monoglyceride lipase, putative 0.029 0.762 1
Toxoplasma gondii hypothetical protein 0.0017 0.0001 0.0001
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0026 0.0251 0.0329
Plasmodium vivax thioredoxin reductase, putative 0.005 0.0928 0.0927
Trypanosoma cruzi heat shock protein, putative 0.0066 0.136 0.1784
Mycobacterium ulcerans heat shock protein 90 0.0093 0.2118 0.2779
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0066 0.136 0.1784
Mycobacterium tuberculosis Probable oxidoreductase 0.0127 0.3085 0.4048
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Toxoplasma gondii heat shock protein 75, putative 0.0066 0.136 0.136
Trichomonas vaginalis CAMK family protein kinase 0.01 0.233 0.3056
Echinococcus multilocularis JmjC domain containing protein 4 0.002 0.0091 0.0171
Trichomonas vaginalis CAMK family protein kinase 0.01 0.233 0.3056
Trichomonas vaginalis Heterochromatin protein, putative 0.0025 0.0211 0.0276
Trypanosoma brucei heat shock protein 84, putative 0.0066 0.136 0.1784
Trichomonas vaginalis chromobox protein, putative 0.015 0.3727 0.489
Loa Loa (eye worm) CBP-B 0.0087 0.1941 0.5207
Entamoeba histolytica hypothetical protein 0.0025 0.0211 0.0276
Mycobacterium ulcerans citrate (pro-3S)-lyase subunit beta 0.0026 0.0251 0.0329
Mycobacterium ulcerans hypothetical protein 0.0026 0.0251 0.0329
Giardia lamblia NADH oxidase lateral transfer candidate 0.0017 0.001 0.0041
Trypanosoma cruzi hypothetical protein, conserved 0.0226 0.5843 0.7668
Plasmodium falciparum thioredoxin reductase 0.0017 0.001 0.001
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0211 0.0276
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Schistosoma mansoni chromobox protein 0.015 0.3727 0.8177
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0206 0.5284 1
Brugia malayi Hsp90 protein 0.0066 0.136 0.2573
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0211 0.0276
Echinococcus granulosus phd:f box containing protein 0.002 0.0091 0.0171
Toxoplasma gondii histone lysine demethylase JMJD6a 0.002 0.0091 0.0091
Schistosoma mansoni heat shock protein 0.0099 0.2288 0.5019
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.005 0.0928 0.1217
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0085 0.1888 0.3573
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.1405 0.377
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0053 0.1004 0.2694
Giardia lamblia Kinase, PLK 0.01 0.233 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0211 0.0276
Echinococcus granulosus heat shock protein 0.0099 0.2288 0.4329
Leishmania major monoglyceride lipase, putative 0.029 0.762 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.0211 0.0565
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0115 0.2728 0.3579
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0025 0.0211 0.0211
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0127 0.3085 0.4048
Brugia malayi Associated with TFs and helicases family protein 0.0025 0.0211 0.0399
Brugia malayi jmjC domain containing protein 0.002 0.0091 0.0171
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.002 0.0091 0.0119
Schistosoma mansoni protein phosphatase 2C 0.002 0.0091 0.0198
Plasmodium falciparum lysophospholipase, putative 0.029 0.762 0.762
Leishmania major heat shock protein, putative 0.0066 0.136 0.1784
Trypanosoma brucei heat shock protein, putative 0.0099 0.2288 0.3002
Toxoplasma gondii phospholipase 0.0017 0.0001 0.0001
Schistosoma mansoni jumonji/arid domain-containing protein 0.0076 0.1652 0.3625
Plasmodium vivax glutathione reductase, putative 0.005 0.0928 0.0927
Brugia malayi SET domain containing protein 0.0025 0.0211 0.0399
Leishmania major hypothetical protein, conserved 0.0226 0.5843 0.7668
Trichomonas vaginalis valacyclovir hydrolase, putative 0.029 0.762 1
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0211 0.0276
Brugia malayi Heterochromatin protein 1 0.015 0.3727 0.7052
Plasmodium vivax heterochromatin protein 1, putative 0.0025 0.0211 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0211 0.0276
Toxoplasma gondii peptidase S15, putative 0.0017 0.0001 0.0001
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0211 0.0276
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0022 0.015 0.0149
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0017 0.001 0.0021
Trichomonas vaginalis hypothetical protein 0.0025 0.0211 0.0276
Schistosoma mansoni chromobox protein-related (chromobox 1) (heterochromatin 1) 0.0025 0.0211 0.0462
Trichomonas vaginalis CAMK family protein kinase 0.005 0.0913 0.1197
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0017 0.001 0.0012
Giardia lamblia Heat shock protein HSP 90-alpha 0.0085 0.1888 0.8106
Trypanosoma brucei heat shock protein, putative 0.0099 0.2288 0.3002
Mycobacterium tuberculosis Probable dehydrogenase 0.0115 0.2728 0.3579
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.029 0.762 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.01 0.233 0.3056
Echinococcus multilocularis chromobox protein 2 0.0025 0.0211 0.0399
Brugia malayi jmjC domain containing protein 0.0206 0.5284 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.005 0.0928 0.1755
Plasmodium falciparum lysophospholipase, putative 0.029 0.762 0.762
Loa Loa (eye worm) hypothetical protein 0.0025 0.0211 0.0565
Loa Loa (eye worm) hypothetical protein 0.0036 0.0536 0.1436
Plasmodium falciparum phd finger protein, putative 0.0063 0.1282 0.1282
Echinococcus multilocularis phd:f box containing protein 0.002 0.0091 0.0171
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.029 0.762 1
Echinococcus multilocularis Chromo domain 0.0025 0.0211 0.0399
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0206 0.5284 1
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.1282 0.344
Echinococcus multilocularis jumonji domain containing protein 0.0088 0.1971 0.373
Echinococcus granulosus Chromobox protein 3 0.0025 0.0211 0.0399
Echinococcus multilocularis lysine specific demethylase 6a 0.002 0.0091 0.0171
Mycobacterium ulcerans hypothetical protein 0.0026 0.0251 0.0329
Trypanosoma cruzi heat shock protein 85, putative 0.0099 0.2288 0.3002
Brugia malayi Valyl-tRNA synthetase 0.0025 0.0211 0.0399
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0084 0.188 0.7875
Echinococcus granulosus jumonji domain containing protein 0.0088 0.1971 0.373
Plasmodium vivax heat shock protein, putative 0.0375 1 1
Trichomonas vaginalis glutathione reductase, putative 0.0017 0.001 0.0012
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.0098 0.0128
Brugia malayi heat shock protein 90 0.0099 0.2288 0.4329
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0211 0.0276
Trypanosoma brucei heat shock protein, putative 0.0099 0.2288 0.3002
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0243
Trypanosoma brucei polo-like protein kinase 0.01 0.233 0.3056
Schistosoma mansoni serine/threonine protein kinase 0.01 0.233 0.5111
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.029 0.762 1
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0026 0.0251 0.0329
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0017 0.001 0.0012
Trichomonas vaginalis CAMK family protein kinase 0.01 0.233 0.3056
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0017 0.001 0.001
Echinococcus multilocularis jumonji domain containing 1A 0.002 0.0091 0.0171
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0017 0.001 0.0012
Echinococcus granulosus endoplasmin 0.0093 0.2118 0.4007
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0211 0.0276
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Brugia malayi RNA binding protein 0.0067 0.1405 0.2659
Schistosoma mansoni chromobox protein 0.0025 0.0211 0.0462
Plasmodium falciparum lysophospholipase, putative 0.029 0.762 0.762
Loa Loa (eye worm) endoplasmin 0.0099 0.2288 0.6138
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0017 0.0006 0.0005
Schistosoma mansoni endoplasmin 0.0099 0.2288 0.5019
Brugia malayi chromobox protein homolog 3 0.0084 0.188 0.3556
Brugia malayi Bloom's syndrome protein homolog 0.0026 0.0237 0.0446
Schistosoma mansoni jumonji domain containing protein 0.002 0.0091 0.0198
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.1282 0.1282
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0025 0.0211 0.0399
Loa Loa (eye worm) jmjC domain-containing protein 0.002 0.0091 0.0243
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0017 0.001 0.0012
Trichomonas vaginalis mercuric reductase, putative 0.0017 0.001 0.0012
Brugia malayi serine/threonine-protein kinase plk-2 0.01 0.233 0.4408
Treponema pallidum heat shock protein 90 0.0093 0.2118 1
Loa Loa (eye worm) glutathione reductase 0.005 0.0928 0.2489
Echinococcus granulosus Chromo domain 0.0025 0.0211 0.0399
Echinococcus granulosus peregrin 0.0063 0.1282 0.2426
Trichomonas vaginalis Clan SC, family S33, methylesterase-like serine peptidase 0.029 0.762 1
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0025 0.0211 0.0399
Mycobacterium ulcerans citrate lyase beta subunit, CitE_2 0.0026 0.0251 0.0329
Echinococcus multilocularis heat shock protein 0.0099 0.2288 0.4329
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0025 0.0211 0.0462
Trypanosoma cruzi hypothetical protein, conserved 0.0226 0.5843 0.7668
Brugia malayi Protein cec-1. 0.0025 0.0211 0.0399
Echinococcus multilocularis citrate lyase subunit beta protein 0.0026 0.0251 0.0474
Mycobacterium leprae POSSIBLE LYSOPHOSPHOLIPASE 0.029 0.762 1
Entamoeba histolytica heat shock protein 90, putative 0.0099 0.2288 0.3002
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0017 0.001 0.0012
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.01 0.233 0.4408
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0017 0.001 0.0018
Trypanosoma cruzi Heat shock protein 83, putative 0.0099 0.2288 0.3002
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0017 0.001 0.0012
Brugia malayi M-phase phosphoprotein, mpp8 0.0025 0.0211 0.0399
Onchocerca volvulus Alhambra homolog 0.0063 0.1282 0.5056
Mycobacterium ulcerans hypothetical protein 0.029 0.762 1
Giardia lamblia PHD finger protein 15 0.0063 0.1282 0.5503
Trypanosoma cruzi heat shock protein 85, putative 0.0099 0.2288 0.3002
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0017 0.001 0.001
Trichomonas vaginalis chromobox protein, putative 0.0091 0.2058 0.2701
Trypanosoma cruzi heat shock protein 90, putative 0.0099 0.2288 0.3002
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0211 0.0276
Toxoplasma gondii heat shock protein HSP90 0.0099 0.2288 0.2288
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0066 0.136 0.2573
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Plasmodium vivax PST-A protein 0.029 0.762 0.762
Loa Loa (eye worm) hypothetical protein 0.002 0.0091 0.0243
Echinococcus granulosus JmjC domain containing protein 4 0.002 0.0091 0.0171
Echinococcus granulosus tar DNA binding protein 0.0067 0.1405 0.2659
Echinococcus granulosus lysine specific demethylase 5A 0.0076 0.1652 0.3126
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0063 0.1282 0.344
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0025 0.0211 0.0462
Brugia malayi F/Y-rich N-terminus family protein 0.0021 0.0098 0.0185
Plasmodium falciparum glutathione reductase 0.0017 0.001 0.001
Echinococcus multilocularis peregrin 0.0063 0.1282 0.2426
Brugia malayi jmjC domain containing protein 0.002 0.0091 0.0171
Trichomonas vaginalis conserved hypothetical protein 0.0025 0.0211 0.0276
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1405 0.3082
Entamoeba histolytica heat shock protein 90, putative 0.0099 0.2288 0.3002
Plasmodium vivax hypothetical protein, conserved 0.0025 0.0211 0.0211
Trichomonas vaginalis conserved hypothetical protein 0.006 0.1192 0.1563
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0025 0.0211 0.0276
Leishmania major heat shock protein 83-1 0.0099 0.2288 0.3002
Trichomonas vaginalis heat shock protein, putative 0.0072 0.153 0.2007
Plasmodium falciparum esterase, putative 0.029 0.762 0.762
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0025 0.0211 0.0276
Trypanosoma cruzi polo-like protein kinase, putative 0.01 0.233 0.3056
Echinococcus multilocularis chromobox protein 1 0.015 0.3727 0.7052
Toxoplasma gondii hypothetical protein 0.0017 0.0001 0.0001
Plasmodium vivax JmjC domain containing protein 0.002 0.0091 0.009
Trypanosoma brucei monoglyceride lipase, putative 0.029 0.762 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.01 0.233 0.4408
Loa Loa (eye worm) hypothetical protein 0.0025 0.0211 0.0565
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0093 0.2118 1
Trypanosoma brucei heat shock protein 90, putative 0.0099 0.2288 0.3002
Leishmania major trypanothione reductase 0.005 0.0928 0.1217
Brugia malayi PHD-finger family protein 0.0063 0.1282 0.2426
Mycobacterium tuberculosis Possible lysophospholipase 0.029 0.762 1
Brugia malayi jmjC domain containing protein 0.002 0.0091 0.0171
Trichomonas vaginalis chromobox protein, putative 0.0025 0.0211 0.0276
Entamoeba histolytica hydrolase, alpha/beta fold family domain containing protein 0.029 0.762 1
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0115 0.2728 0.1108
Trypanosoma cruzi heat shock protein 85, putative 0.0085 0.1888 0.2477
Echinococcus multilocularis tar DNA binding protein 0.0067 0.1405 0.2659
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0115 0.2728 0.3579
Onchocerca volvulus 0.0066 0.1371 0.5472
Schistosoma mansoni jumonji domain containing protein 0.0164 0.41 0.8996
Entamoeba histolytica hypothetical protein 0.0025 0.0211 0.0276
Schistosoma mansoni kinase 0.0051 0.095 0.2082
Trichomonas vaginalis CAMK family protein kinase 0.01 0.233 0.3056
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0053 0.1004 0.19
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0098 0.0098
Echinococcus multilocularis Chromobox protein 3 0.0025 0.0211 0.0399
Brugia malayi Calcitonin receptor-like protein seb-1 0.0053 0.1004 0.19
Plasmodium falciparum endoplasmin, putative 0.0072 0.153 0.1529
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0098 0.0098
Loa Loa (eye worm) hypothetical protein 0.0084 0.188 0.5043
Loa Loa (eye worm) hypothetical protein 0.0021 0.0098 0.0262
Schistosoma mansoni heat shock protein 0.0066 0.136 0.2983
Trichomonas vaginalis conserved hypothetical protein 0.029 0.762 1
Trypanosoma brucei heat shock protein, putative 0.0099 0.2288 0.3002
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0025 0.0211 0.0399
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0021 0.0098 0.0214
Plasmodium falciparum heat shock protein 90, putative 0.0058 0.113 0.113
Brugia malayi glutathione reductase 0.005 0.0928 0.1755
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0017 0.001 0.001
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0025 0.0211 0.0462
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.002 0.0091 0.0171
Trypanosoma brucei trypanothione reductase 0.005 0.0928 0.1217

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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