Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0159 | 0.0657 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.067 | 0.276 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0037 | 0.0199 | 0.0311 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0063 | 0.1005 | 0.1573 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0037 | 0.0199 | 0.0199 |
Plasmodium vivax | hypothetical protein, conserved | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0356 | 1 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.1194 | 0.1194 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0658 | 0.1029 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.1194 | 0.1867 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0675 | 0.1055 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0199 | 0.0311 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0069 | 0.1194 | 0.4914 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0069 | 0.1194 | 0.1867 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0052 | 0.0658 | 0.1029 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.067 | 0.1049 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0101 | 0.2148 | 0.2148 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.067 | 0.1049 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0037 | 0.0199 | 0.0311 |
Echinococcus granulosus | jumonji domain containing protein | 0.0043 | 0.037 | 0.037 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0043 | 0.037 | 0.037 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0159 | 0.0249 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0 | 0.5 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0238 | 0.6393 | 0.6393 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0224 | 0.5946 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0224 | 0.5946 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0224 | 0.5946 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0224 | 0.5946 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0037 | 0.0199 | 0.0818 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0238 | 0.6393 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0159 | 0.0249 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0069 | 0.1194 | 0.1194 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0037 | 0.0199 | 0.0199 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0238 | 0.6393 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.0031 | 0 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.004 | 0.0293 | 0.0293 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0101 | 0.2148 | 0.2148 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0031 | 0 | 0.5 |
Plasmodium falciparum | phd finger protein, putative | 0.0031 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.067 | 0.276 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0238 | 0.6393 | 0.6393 |
Brugia malayi | hypothetical protein | 0.011 | 0.2429 | 1 |
Onchocerca volvulus | 0.0052 | 0.0658 | 1 | |
Schistosoma mansoni | jumonji domain containing protein | 0.008 | 0.1513 | 0.2366 |
Brugia malayi | jmjC domain containing protein | 0.0101 | 0.2148 | 0.8844 |
Echinococcus granulosus | transcription factor Dp 1 | 0.004 | 0.0293 | 0.0293 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0069 | 0.1194 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.