Detailed information for compound 664828

Basic information

Technical information
  • TDR Targets ID: 664828
  • Name: N-(5-chloro-2-hydroxyphenyl)-2-(4-methoxyphen yl)acetamide
  • MW: 291.73 | Formula: C15H14ClNO3
  • H donors: 2 H acceptors: 2 LogP: 2.94 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccc(cc1)CC(=O)Nc1cc(Cl)ccc1O
  • InChi: 1S/C15H14ClNO3/c1-20-12-5-2-10(3-6-12)8-15(19)17-13-9-11(16)4-7-14(13)18/h2-7,9,18H,8H2,1H3,(H,17,19)
  • InChiKey: MVLSKDWUTDAVET-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(5-chloro-2-hydroxy-phenyl)-2-(4-methoxyphenyl)acetamide
  • N-(5-chloro-2-hydroxy-phenyl)-2-(4-methoxyphenyl)ethanamide
  • AO-548/40923593
  • ZINC00470336
  • STK223940
  • MLS000048304
  • SMR000073666

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens l(3)mbt-like 1 (Drosophila) Starlite/ChEMBL No references
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL No references
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL No references
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL No references
Homo sapiens SMAD family member 2 Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus granulosus endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma mansoni hypothetical protein Get druggable targets OG5_130415 All targets in OG5_130415
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus multilocularis endonuclease exonuclease phosphatase Get druggable targets OG5_130415 All targets in OG5_130415
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Schistosoma japonicum Lethal(3)malignant brain tumor-like 4 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
Schistosoma japonicum Lethal(3)malignant brain tumor-like 3 protein, putative Get druggable targets OG5_130415 All targets in OG5_130415
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Mycobacterium tuberculosis Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0161 0.0665 0.0665
Echinococcus granulosus histone acetyltransferase MYST2 0.0066 0.0143 0.0143
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1238 0.6574 1
Echinococcus granulosus lysine specific demethylase 6a 0.0094 0.03 0.03
Plasmodium falciparum phd finger protein, putative 0.0244 0.1121 1
Brugia malayi jmjC domain containing protein 0.0353 0.1721 0.2707
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0049 0.0052 0.0052
Loa Loa (eye worm) MH2 domain-containing protein 0.0144 0.0574 0.0574
Trichomonas vaginalis chromobox protein, putative 0.0221 0.0993 0.1511
Schistosoma mansoni hypothetical protein 0.0049 0.0052 0.0052
Brugia malayi Latrophilin receptor protein 2 0.0049 0.0052 0.0082
Loa Loa (eye worm) hypothetical protein 0.0287 0.1356 0.1356
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0031 0.0099
Echinococcus granulosus geminin 0.0695 0.3597 0.3597
Brugia malayi Peptidase family M1 containing protein 0.0099 0.0326 0.0512
Toxoplasma gondii aminopeptidase N, putative 0.0099 0.0326 0.2904
Toxoplasma gondii PHD-finger domain-containing protein 0.0244 0.1121 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0099 0.0326 0.0326
Trichomonas vaginalis DNA polymerase eta, putative 0.0045 0.0031 0.0046
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0227 0.1028 0.1028
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0099 0.0326 1
Trypanosoma cruzi Aminopeptidase M1, putative 0.0099 0.0326 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0054 0.0054
Schistosoma mansoni jumonji domain containing protein 0.0094 0.03 0.03
Brugia malayi Pre-SET motif family protein 0.0125 0.0467 0.0734
Schistosoma mansoni chromobox protein 0.0221 0.0993 0.0993
Trypanosoma cruzi aminopeptidase, putative 0.0099 0.0326 1
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.008 0.022 0.1964
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0605 0.31 1
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0031 0.0938
Brugia malayi MH2 domain containing protein 0.0144 0.0574 0.0902
Echinococcus granulosus expressed protein 0.0373 0.1828 0.1828
Brugia malayi mbt repeat family protein 0.0058 0.0099 0.0155
Mycobacterium ulcerans aminopeptidase N PepN 0.0099 0.0326 0.105
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0031 0.0938
Onchocerca volvulus 0.0099 0.0326 0.0625
Loa Loa (eye worm) hypothetical protein 0.0099 0.0326 0.0326
Echinococcus granulosus jumonji domain containing protein 0.0339 0.1645 0.1645
Echinococcus multilocularis phd:f box containing protein 0.0094 0.03 0.03
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1238 0.6574 1
Onchocerca volvulus 0.0989 0.5209 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0269 0.126 0.126
Echinococcus multilocularis GPCR, family 2 0.0049 0.0052 0.0052
Schistosoma mansoni survival motor neuron protein 0.0048 0.0044 0.0044
Brugia malayi Calcitonin receptor-like protein seb-1 0.0155 0.0633 0.0996
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0094 0.03 0.03
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0099 0.0326 0.0326
Brugia malayi hypothetical protein 0.0099 0.0326 0.0512
Treponema pallidum fructose-bisphosphate aldolase 0.1238 0.6574 0.5
Loa Loa (eye worm) hypothetical protein 0.0097 0.0315 0.0315
Trichomonas vaginalis chromobox protein, putative 0.0133 0.0513 0.078
Echinococcus multilocularis polycomb protein SCMH1 0.0058 0.0099 0.0099
Echinococcus granulosus aminopeptidase N 0.0099 0.0326 0.0326
Echinococcus multilocularis JmjC domain containing protein 4 0.0094 0.03 0.03
Schistosoma mansoni jumonji/arid domain-containing protein 0.0353 0.1721 0.1721
Loa Loa (eye worm) hypothetical protein 0.0106 0.0364 0.0364
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0054 0.0054
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0084 0.0245 0.0245
Loa Loa (eye worm) hypothetical protein 0.0269 0.126 0.126
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0857 0.4485 0.4485
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0049 0.0054 0.0085
Loa Loa (eye worm) peptidase family M1 containing protein 0.0099 0.0326 0.0326
Giardia lamblia Fructose-bisphosphate aldolase 0.1238 0.6574 1
Echinococcus multilocularis survival motor neuron protein 1 0.0233 0.1062 0.1062
Loa Loa (eye worm) hypothetical protein 0.0094 0.03 0.03
Brugia malayi jmjC domain containing protein 0.0094 0.03 0.0471
Onchocerca volvulus Alhambra homolog 0.0244 0.1121 0.2152
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0099 0.0326 0.0326
Loa Loa (eye worm) mbt repeat family protein 0.0058 0.0099 0.0099
Loa Loa (eye worm) heterochromatin protein 1 0.0221 0.0993 0.0993
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0099 0.0326 1
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0605 0.31 1
Brugia malayi chromobox protein homolog 3 0.0124 0.0461 0.0725
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0094 0.03 0.9204
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0049 0.0054 0.0054
Brugia malayi jmjC domain containing protein 0.0857 0.4485 0.7053
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0326 0.0326
Echinococcus granulosus GPCR family 2 0.0049 0.0052 0.0052
Toxoplasma gondii PHD-finger domain-containing protein 0.008 0.022 0.1964
Brugia malayi Bromodomain containing protein 0.0244 0.1121 0.1763
Schistosoma mansoni hypothetical protein 0.0244 0.1121 0.1121
Trypanosoma brucei DNA polymerase IV, putative 0.0045 0.0031 0.0938
Brugia malayi Peptidase family M1 containing protein 0.0099 0.0326 0.0512
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0326 0.0326
Schistosoma mansoni hypothetical protein 0.0049 0.0052 0.0052
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0467 0.0467
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0031 0.0938
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0094 0.03 0.2672
Echinococcus granulosus SAM and MBT domain containing protein 0.0058 0.0099 0.0099
Trichomonas vaginalis set domain proteins, putative 0.0989 0.5209 0.7924
Echinococcus multilocularis lysine specific demethylase 6a 0.0094 0.03 0.03
Echinococcus granulosus dna polymerase kappa 0.0045 0.0031 0.0031
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0099 0.0326 0.0495
Schistosoma mansoni hypothetical protein 0.0695 0.3597 0.3597
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0467 0.0467
Schistosoma mansoni hypothetical protein 0.0106 0.0364 0.0364
Echinococcus multilocularis SAM and MBT domain containing protein 0.0058 0.0099 0.0099
Loa Loa (eye worm) hypothetical protein 0.1198 0.6358 0.6358
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.012 0.0441 0.0441
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0054 0.0054
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0094 0.03 0.03
Echinococcus multilocularis leukotriene A 4 hydrolase 0.1862 1 1
Brugia malayi mbt repeat family protein 0.0058 0.0099 0.0155
Loa Loa (eye worm) hypothetical protein 0.0058 0.0099 0.0099
Echinococcus multilocularis dna polymerase kappa 0.0045 0.0031 0.0031
Mycobacterium ulcerans aminopeptidase N PepN 0.0099 0.0326 0.105
Brugia malayi TATA binding protein associated factor 0.0099 0.0326 0.0512
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0031 0.0938
Brugia malayi jmjC domain containing protein 0.0094 0.03 0.0471
Echinococcus granulosus histone lysine methyltransferase setb 0.0125 0.0467 0.0467
Schistosoma mansoni phd/f-box containing protein 0.0094 0.03 0.03
Echinococcus multilocularis serotonin receptor 0.0269 0.126 0.126
Brugia malayi jmjC domain containing protein 0.0094 0.03 0.0471
Brugia malayi Peptidase family M1 containing protein 0.0099 0.0326 0.0512
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1238 0.6574 1
Echinococcus granulosus survival motor neuron protein 1 0.0233 0.1062 0.1062
Brugia malayi AF-10 protein 0.008 0.022 0.0346
Loa Loa (eye worm) jmjC domain-containing protein 0.0094 0.03 0.03
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1238 0.6574 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1238 0.6574 1
Brugia malayi hypothetical protein 0.0856 0.448 0.7046
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0094 0.03 0.03
Loa Loa (eye worm) hypothetical protein 0.0233 0.1062 0.1062
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0099 0.0326 0.2904
Brugia malayi PHD-finger family protein 0.008 0.022 0.0346
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0099 0.0326 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0869 0.455 0.455
Schistosoma mansoni hypothetical protein 0.0049 0.0052 0.0052
Schistosoma mansoni aminopeptidase A (M01 family) 0.0099 0.0326 0.0326
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0099 0.0326 0.1169
Mycobacterium ulcerans DNA polymerase IV 0.0045 0.0031 0.0099
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0155 0.0633 0.0996
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.0461 0.0702
Loa Loa (eye worm) transcription factor SMAD2 0.0144 0.0574 0.0574
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0099 0.0326 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0326 0.0326
Schistosoma mansoni hypothetical protein 0.0695 0.3597 0.3597
Echinococcus granulosus chromobox protein 1 0.0221 0.0993 0.0993
Brugia malayi Heterochromatin protein 1 0.0221 0.0993 0.1562
Echinococcus granulosus PHD finger protein rhinoceros 0.0244 0.1121 0.1121
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0049 0.0052 0.0052
Schistosoma mansoni hypothetical protein 0.0048 0.0044 0.0044
Loa Loa (eye worm) TATA binding protein associated factor 0.0099 0.0326 0.0326
Onchocerca volvulus 0.0048 0.0044 0.0084
Echinococcus granulosus chromobox protein 1 0.0221 0.0993 0.0993
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0099 0.0099
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.008 0.022 0.6764
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0125 0.0467 0.4161
Schistosoma mansoni jumonji domain containing protein 0.0693 0.3584 0.3584
Trypanosoma cruzi aminopeptidase, putative 0.0099 0.0326 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0605 0.31 1
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0099 0.0326 1
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.1862 1 1
Echinococcus multilocularis aminopeptidase N 0.0099 0.0326 0.0326
Trypanosoma brucei aminopeptidase, putative 0.0099 0.0326 1
Toxoplasma gondii aminopeptidase n, putative 0.0099 0.0326 0.2904
Loa Loa (eye worm) PHD-finger family protein 0.0244 0.1121 0.1121
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0155 0.0633 0.0633
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0099 0.0326 0.0326
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0031 0.0938
Loa Loa (eye worm) aminopeptidase N 0.0099 0.0326 0.0326
Onchocerca volvulus 0.0099 0.0326 0.0625
Leishmania major hypothetical protein, conserved 0.0094 0.03 0.9204
Loa Loa (eye worm) jmjC domain-containing protein 0.0353 0.1721 0.1721
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1238 0.6574 1
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0044 0.0069
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0049 0.0054 0.0054
Loa Loa (eye worm) hypothetical protein 0.0066 0.0143 0.0143
Schistosoma mansoni sex comb on midleg homolog 0.0058 0.0099 0.0099
Plasmodium vivax hypothetical protein, conserved 0.008 0.022 0.1964
Schistosoma mansoni jumonji/arid domain-containing protein 0.0353 0.1721 0.1721
Echinococcus granulosus peregrin 0.0244 0.1121 0.1121
Brugia malayi hypothetical protein 0.0233 0.1062 0.1671
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0133 0.0513 0.0984
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0031 0.0938
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0094 0.03 0.9204
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0099 0.0326 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0031 0.0938
Onchocerca volvulus 0.0097 0.0315 0.0604
Schistosoma mansoni protein phosphatase 2C 0.0094 0.03 0.03
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0099 0.0326 0.0326
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0099 0.0326 0.0326
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1238 0.6574 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.0633 0.0633
Trichomonas vaginalis chromobox protein, putative 0.0221 0.0993 0.1511
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0031 0.0938
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0049 0.0052 0.0052
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0124 0.0461 0.0885
Plasmodium vivax SET domain protein, putative 0.0125 0.0467 0.4161
Brugia malayi F/Y-rich N-terminus family protein 0.0084 0.0245 0.0386
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0326 0.0326
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0125 0.0467 0.0467
Echinococcus granulosus jumonji domain containing 1A 0.0094 0.03 0.03
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0099 0.0326 0.0326
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0099 0.0326 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0253 0.1171 0.3776
Echinococcus multilocularis serotonin receptor 0.0269 0.126 0.126
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0227 0.1028 0.1028
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0031 0.0938
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0099 0.0326 0.1169
Echinococcus granulosus JmjC domain containing protein 4 0.0094 0.03 0.03
Onchocerca volvulus 0.0161 0.0665 0.1276
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0244 0.1121 0.1121
Loa Loa (eye worm) hypothetical protein 0.008 0.022 0.022
Loa Loa (eye worm) leukotriene A4 hydrolase 0.1862 1 1
Schistosoma mansoni chromobox protein 0.0221 0.0993 0.0993
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.1198 0.6358 0.6358
Echinococcus granulosus polycomb protein SCMH1 0.0058 0.0099 0.0099
Plasmodium falciparum JmjC domain-containing protein, putative 0.0094 0.03 0.0881
Brugia malayi hypothetical protein 0.0099 0.0326 0.0512
Loa Loa (eye worm) hypothetical protein 0.0094 0.03 0.03
Echinococcus multilocularis peregrin 0.0244 0.1121 0.1121
Schistosoma mansoni hypothetical protein 0.035 0.1704 0.1704
Echinococcus granulosus phd:f box containing protein 0.0094 0.03 0.03
Schistosoma mansoni hypothetical protein 0.008 0.022 0.022
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0099 0.0326 0.0326
Schistosoma mansoni hypothetical protein 0.0049 0.0052 0.0052
Loa Loa (eye worm) latrophilin receptor protein 2 0.0049 0.0052 0.0052
Brugia malayi Pre-SET motif family protein 0.0869 0.455 0.7156
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0066 0.0143 0.0224
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0031 0.0938
Loa Loa (eye worm) hypothetical protein 0.0244 0.1121 0.1121
Loa Loa (eye worm) hypothetical protein 0.0434 0.2162 0.2162
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0099 0.0326 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1238 0.6574 1
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0094 0.03 0.2672
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0125 0.0467 0.0467
Trypanosoma brucei Aminopeptidase M1, putative 0.0099 0.0326 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0031 0.0938
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0979 0.5156 0.5156
Brugia malayi SET domain containing protein 0.0041 0.0006 0.0009
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0031 0.0938
Loa Loa (eye worm) MBCTL1 0.0066 0.0143 0.0143
Trichomonas vaginalis chromobox protein, putative 0.0133 0.0513 0.078
Echinococcus multilocularis chromobox protein 1 0.0221 0.0993 0.0993
Toxoplasma gondii PHD-finger domain-containing protein 0.0244 0.1121 1
Echinococcus multilocularis PHD finger protein rhinoceros 0.0244 0.1121 0.1121
Brugia malayi jmjC domain containing protein 0.0094 0.03 0.0471
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0058 0.0099 0.0099
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0099 0.0326 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0099 0.0326 0.0495
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0099 0.0326 0.0495
Loa Loa (eye worm) hypothetical protein 0.0124 0.0461 0.0461
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0094 0.03 0.9204
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0066 0.0143 0.0143
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0049 0.0052 0.0082
Echinococcus multilocularis expressed protein 0.0373 0.1828 0.1828
Loa Loa (eye worm) hypothetical protein 0.0099 0.0326 0.0326
Toxoplasma gondii aminopeptidase N protein 0.0099 0.0326 0.2904
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.008 0.022 0.6764
Loa Loa (eye worm) jmjC domain-containing protein 0.0504 0.2546 0.2546
Echinococcus multilocularis histone acetyltransferase MYST2 0.0066 0.0143 0.0143
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0099 0.0326 0.0326
Trichomonas vaginalis conserved hypothetical protein 0.0124 0.0461 0.0702
Brugia malayi latrophilin 2 splice variant baaae 0.0106 0.0364 0.0573
Schistosoma mansoni myelin transcription factor 1 myt1 0.0066 0.0143 0.0143
Echinococcus multilocularis jumonji domain containing protein 0.0339 0.1645 0.1645
Loa Loa (eye worm) hypothetical protein 0.0269 0.126 0.126
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0263 0.04
Echinococcus multilocularis chromobox protein 1 0.0221 0.0993 0.0993
Onchocerca volvulus 0.0058 0.0099 0.019
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0099 0.0326 0.0326
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0066 0.0143 0.0143
Loa Loa (eye worm) hypothetical protein 0.0125 0.0467 0.0467
Echinococcus multilocularis jumonji domain containing 1A 0.0094 0.03 0.03
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0857 0.4485 0.4485
Echinococcus multilocularis geminin 0.0695 0.3597 0.3597
Loa Loa (eye worm) jmjC domain-containing protein 0.0094 0.03 0.03
Loa Loa (eye worm) jmjC domain-containing protein 0.0094 0.03 0.03
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0049 0.0054 0.0054
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0049 0.0052 0.0052
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0099 0.0326 0.2904
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0049 0.0054 0.0054
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0099 0.0326 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0326 0.0326
Brugia malayi PHD-finger family protein 0.0244 0.1121 0.1763
Loa Loa (eye worm) hypothetical protein 0.0049 0.0052 0.0052
Trichomonas vaginalis conserved hypothetical protein 0.0088 0.0263 0.04
Schistosoma mansoni phosphatidylserine receptor 0.0094 0.03 0.03
Echinococcus granulosus lysine specific demethylase 5A 0.0353 0.1721 0.1721
Onchocerca volvulus 0.0099 0.0326 0.0625
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1238 0.6574 1
Plasmodium vivax JmjC domain containing protein 0.0094 0.03 0.2672
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1238 0.6574 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.1198 0.6358 1
Plasmodium vivax hypothetical protein, conserved 0.0244 0.1121 1
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0058 0.0099 0.019
Trypanosoma cruzi DNA polymerase kappa, putative 0.0045 0.0031 0.0938
Trypanosoma brucei Aminopeptidase M1, putative 0.0099 0.0326 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0269 0.126 0.126
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0125 0.0467 0.0467
Trypanosoma brucei DNA polymerase kappa, putative 0.0045 0.0031 0.0938
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0099 0.0326 0.0326
Loa Loa (eye worm) hypothetical protein 0.1198 0.6358 0.6358
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0045 0.0031 0.0046
Echinococcus multilocularis lysine specific demethylase 5A 0.0353 0.1721 0.1721

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) = 1.122 um PUBCHEM_BIOASSAY: qHTS Assay for the Inhibitors of L3MBTL1. (Class of assay: confirmatory) [Related pubchem assays: 485292 (Probe Development Summary for Inhibitors of L3MBTL1)] ChEMBL. No reference
Potency (functional) = 5.0119 um PUBCHEM_BIOASSAY: qHTS Assay for Anthrax Lethal Toxin Internalization. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) = 10 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Influenza NS1 Protein Function. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 11.6891 uM PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] ChEMBL. No reference
Potency (functional) 12.5893 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588856, AID588860] ChEMBL. No reference
Potency (functional) 18.3564 uM PUBCHEM_BIOASSAY: qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493107, AID493125] ChEMBL. No reference
Potency (binding) = 28.1838 um PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] ChEMBL. No reference
Potency (functional) 35.4813 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of TGF-b: Cytotox Counterscreen. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588855, AID588860] ChEMBL. No reference
Potency (functional) = 39.8107 um PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 89.1251 uM PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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