Detailed information for compound 664850

Basic information

Technical information
  • TDR Targets ID: 664850
  • Name: N-(4-bromo-2-fluorophenyl)-2-[[4-methyl-5-(ph enylmethyl)-1,2,4-triazol-3-yl]sulfanyl]aceta mide
  • MW: 435.313 | Formula: C18H16BrFN4OS
  • H donors: 1 H acceptors: 3 LogP: 3.92 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccc(cc1F)Br)CSc1nnc(n1C)Cc1ccccc1
  • InChi: 1S/C18H16BrFN4OS/c1-24-16(9-12-5-3-2-4-6-12)22-23-18(24)26-11-17(25)21-15-8-7-13(19)10-14(15)20/h2-8,10H,9,11H2,1H3,(H,21,25)
  • InChiKey: QWGSUJHTSNFMRT-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-bromo-2-fluoro-phenyl)-2-[[4-methyl-5-(phenylmethyl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
  • N-(4-bromo-2-fluorophenyl)-2-[[4-methyl-5-(phenylmethyl)-1,2,4-triazol-3-yl]thio]acetamide
  • 2-[[5-(benzyl)-4-methyl-1,2,4-triazol-3-yl]thio]-N-(4-bromo-2-fluoro-phenyl)acetamide
  • N-(4-bromo-2-fluoro-phenyl)-2-[[4-methyl-5-(phenylmethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanamide
  • ZINC00664106
  • AH-487/41732298

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi Latrophilin receptor protein 2 0.0015 0.0044 0.0056
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.002 0.0106 0.1843
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.006 0.0611 0.0813
Echinococcus granulosus L aminoadipate semialdehyde 0.0081 0.0872 0.1576
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0242 0.2915 0.527
Echinococcus multilocularis L aminoadipate semialdehyde 0.0081 0.0872 0.0872
Echinococcus multilocularis lysine specific demethylase 5A 0.0125 0.1438 0.1438
Brugia malayi Ets-domain containing protein 0.007 0.074 0.0982
Echinococcus multilocularis GPCR, family 2 0.0015 0.0044 0.0044
Echinococcus granulosus GA binding protein alpha chain 0.007 0.074 0.1338
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0274 1
Brugia malayi Ets-domain containing protein 0.007 0.074 0.0982
Echinococcus granulosus neuropeptide receptor A26 0.0448 0.5531 1
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.026 0.0301
Onchocerca volvulus Chorion peroxidase homolog 0.0026 0.0175 0.0202
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.026 0.0301
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0002 0.0002
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0232
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0002 0.0002
Plasmodium falciparum JmjC domain-containing protein, putative 0.0033 0.0274 0.4827
Leishmania major pyruvate kinase 0.0032 0.026 0.9498
Echinococcus multilocularis GA binding protein alpha chain 0.007 0.074 0.074
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0225 0.2699 0.2699
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.0957 0.196
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0566 0.7018 0.8181
Loa Loa (eye worm) hypothetical protein 0.0112 0.1269 0.1688
Brugia malayi jmjC domain containing protein 0.0033 0.0274 0.0362
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0175 0.023
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.0463 0.0613
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0002 0.0003
Trypanosoma brucei hypothetical protein, conserved 0.0023 0.0138 0.4995
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0018 0.0084 0.3027
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0232
Onchocerca volvulus Peroxidase homolog 0.0026 0.0175 0.0202
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0269 0.0356
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0232
Leishmania major phosphopantetheinyl transferase-like protein 0.0023 0.0138 0.4995
Schistosoma mansoni protein phosphatase 2C 0.0033 0.0274 0.0558
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0002 0.0003
Echinococcus multilocularis neuropeptide s receptor 0.0448 0.5531 0.5531
Brugia malayi Fli-1 protein 0.0213 0.2551 0.3391
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0002 0.0003
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0087
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0232
Brugia malayi CXXC zinc finger family protein 0.0028 0.0203 0.0268
Echinococcus granulosus pyruvate kinase 0.0032 0.026 0.047
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0643 0.0856
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0232
Loa Loa (eye worm) hypothetical protein 0.0033 0.0274 0.0364
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0012 0.0002 0.0002
Onchocerca volvulus 0.0087 0.0957 0.1114
Brugia malayi AF-10 protein 0.0018 0.0084 0.011
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0035 0.0294 0.0532
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0023 0.0138 0.1423
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0087
Onchocerca volvulus 0.0689 0.8578 1
Schistosoma mansoni hypothetical protein 0.0397 0.4875 1
Toxoplasma gondii PHD-finger domain-containing protein 0.0056 0.0565 0.5901
Brugia malayi Pyruvate kinase, M2 isozyme 0.0032 0.026 0.0344
Onchocerca volvulus Pyruvate kinase homolog 0.0032 0.026 0.0301
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0023 0.0138 0.0406
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.0957 0.196
Onchocerca volvulus Dual oxidase homolog 0.0026 0.0175 0.0202
Entamoeba histolytica hypothetical protein 0.0023 0.0138 0.0194
Schistosoma mansoni phosphatidylserine receptor 0.0033 0.0274 0.0558
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0643 0.1316
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0015 0.0044 0.0044
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0033 0.0274 0.0558
Brugia malayi jmjC domain containing protein 0.0127 0.1459 0.1938
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0212 0.0432
Echinococcus multilocularis peroxidasin 0.0026 0.0175 0.0175
Plasmodium vivax hypothetical protein, conserved 0.0056 0.0565 0.5901
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0276 0.3352 1
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0232
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0087 0.0957 0.0957
Schistosoma mansoni peroxidasin 0.0026 0.0175 0.0355
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0032 0.026 0.0381
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0087
Loa Loa (eye worm) jmjC domain-containing protein 0.0127 0.1459 0.194
Entamoeba histolytica pyruvate kinase, putative 0.0023 0.0136 0.0192
Echinococcus granulosus aminopeptidase N 0.0012 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0056 0.0565 0.0752
Trypanosoma brucei pyruvate kinase 1 0.0032 0.026 0.9498
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0087 0.0957 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0232
Onchocerca volvulus 0.0081 0.0872 0.1014
Schistosoma mansoni cpg binding protein 0.0029 0.0223 0.0455
Echinococcus multilocularis dnaJ subfamily B 0.0397 0.4875 0.4875
Echinococcus multilocularis jumonji domain containing protein 0.0079 0.0846 0.0846
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0242 0.2915 0.2915
Toxoplasma gondii pyruvate kinase PyK1 0.0032 0.026 0.2706
Schistosoma mansoni gabp alpha 0.007 0.074 0.1515
Leishmania major pyruvate kinase 0.0032 0.026 0.9498
Echinococcus granulosus cpg binding protein 0.0029 0.0223 0.0404
Treponema pallidum fructose-bisphosphate aldolase 0.0566 0.7018 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0566 0.7018 0.8181
Plasmodium vivax JmjC domain containing protein 0.0033 0.0274 0.2849
Loa Loa (eye worm) hypothetical protein 0.0048 0.0463 0.0616
Echinococcus multilocularis pyruvate kinase 0.0017 0.0061 0.0061
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.1317 0.1752
Plasmodium falciparum pyruvate kinase 2 0.0017 0.0061 0.1046
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0175 0.023
Echinococcus multilocularis cpg binding protein 0.0029 0.0223 0.0223
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0015 0.0044 0.008
Echinococcus granulosus PHD finger protein rhinoceros 0.0056 0.0565 0.1022
Toxoplasma gondii pyruvate kinase PyKII 0.0017 0.0061 0.0617
Brugia malayi Pre-SET motif family protein 0.0087 0.0957 0.1271
Giardia lamblia Pyruvate kinase 0.0032 0.026 0.0287
Brugia malayi Bromodomain containing protein 0.0056 0.0565 0.075
Loa Loa (eye worm) hypothetical protein 0.0033 0.0274 0.0364
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0175 0.023
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0276 0.3352 1
Loa Loa (eye worm) pyruvate kinase 0.0032 0.026 0.0346
Echinococcus granulosus pyruvate kinase 0.0017 0.0061 0.011
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0084 0.0909 0.1643
Brugia malayi RNA binding protein 0.0063 0.0643 0.0853
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0643 0.0853
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Loa Loa (eye worm) fli-1 protein 0.0213 0.2551 0.3393
Brugia malayi jmjC domain containing protein 0.0033 0.0274 0.0362
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0232
Echinococcus granulosus lysine specific demethylase 5A 0.0127 0.1459 0.2637
Loa Loa (eye worm) hypothetical protein 0.0012 0.0002 0.0002
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0643 0.0643
Echinococcus granulosus jumonji domain containing 1A 0.0033 0.0274 0.0495
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0023 0.0138 0.1423
Loa Loa (eye worm) hypothetical protein 0.002 0.0104 0.0139
Echinococcus granulosus pyruvate kinase 0.0017 0.0061 0.011
Loa Loa (eye worm) aminopeptidase N 0.0012 0.0002 0.0002
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.026 0.0301
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0566 0.7018 0.8181
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0018 0.0084 0.3027
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0175 0.0232
Echinococcus multilocularis jumonji domain containing 1A 0.0033 0.0274 0.0274
Echinococcus multilocularis pyruvate kinase 0.0017 0.0061 0.0061
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0087 0.0957 0.0957
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0056 0.0565 0.1157
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0175 0.0232
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0276 0.3352 1
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0023 0.0138 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0566 0.7018 0.8181
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0643 0.1316
Echinococcus granulosus leukotriene A 4 hydrolase 0.0225 0.2699 0.488
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0566 0.7018 0.8181
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0023 0.0138 0.0406
Plasmodium vivax pyruvate kinase, putative 0.0032 0.026 0.2706
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0087 0.0957 0.196
Loa Loa (eye worm) hypothetical protein 0.0015 0.0044 0.0059
Plasmodium vivax hypothetical protein, conserved 0.002 0.0106 0.1087
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0012 0.0002 0.0002
Schistosoma mansoni hypothetical protein 0.0015 0.0044 0.0087
Loa Loa (eye worm) pyruvate kinase 0.0032 0.026 0.0346
Brugia malayi TAR-binding protein 0.0063 0.0643 0.0853
Toxoplasma gondii PHD-finger domain-containing protein 0.0018 0.0084 0.0862
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0175 0.0232
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0175 0.023
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0566 0.7018 1
Echinococcus granulosus neuropeptide s receptor 0.0448 0.5531 1
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0232
Loa Loa (eye worm) hypothetical protein 0.0081 0.0872 0.1159
Schistosoma mansoni cpg binding protein 0.0029 0.0223 0.0455
Toxoplasma gondii PHD-finger domain-containing protein 0.0056 0.0565 0.5901
Loa Loa (eye worm) hypothetical protein 0.0033 0.0269 0.0358
Onchocerca volvulus 0.0028 0.0203 0.0235
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.026 0.9498
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0559 0.5836
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.0463 0.0616
Schistosoma mansoni jumonji domain containing protein 0.0033 0.0274 0.0558
Loa Loa (eye worm) peptidase family M1 containing protein 0.0012 0.0002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0087 0.0957 0.196
Loa Loa (eye worm) pyruvate kinase 0.0032 0.026 0.0346
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0138 0.2411
Brugia malayi jmjC domain containing protein 0.0242 0.2915 0.3875
Onchocerca volvulus Alhambra homolog 0.0056 0.0565 0.0657
Trypanosoma brucei pyruvate kinase 1, putative 0.0032 0.026 0.9498
Brugia malayi PHD-finger family protein 0.002 0.0104 0.0136
Onchocerca volvulus 0.0026 0.0175 0.0202
Loa Loa (eye worm) TATA binding protein associated factor 0.0012 0.0002 0.0002
Echinococcus multilocularis pyruvate kinase 0.0017 0.0061 0.0061
Echinococcus granulosus pyruvate kinase 0.0032 0.026 0.047
Chlamydia trachomatis pyruvate kinase 0.0032 0.026 1
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0023 0.0138 0.1423
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0232
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0643 0.1316
Loa Loa (eye worm) animal heme peroxidase 0.0026 0.0175 0.0232
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0015 0.0044 0.0044
Schistosoma mansoni jumonji/arid domain-containing protein 0.0127 0.1459 0.2989
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0566 0.7018 0.8181
Schistosoma mansoni pyruvate kinase 0.0032 0.026 0.053
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0232
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.0463 0.0613
Mycobacterium ulcerans pyruvate kinase 0.0032 0.026 0.0771
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0002 0.0003
Loa Loa (eye worm) hypothetical protein 0.0087 0.0957 0.1273
Echinococcus multilocularis PHD finger protein rhinoceros 0.0056 0.0565 0.0565
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0643 0.0856
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0566 0.7018 0.8181
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0566 0.7018 1
Echinococcus granulosus pyruvate kinase 0.0017 0.0061 0.011
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0033 0.0274 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0087 0.0957 0.173
Brugia malayi jmjC domain containing protein 0.0033 0.0274 0.0362
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0605 0.7519 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0274 0.0364
Onchocerca volvulus 0.0026 0.0175 0.0202
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.0639 0.1308
Giardia lamblia PHD finger protein 15 0.0056 0.0565 0.0725
Plasmodium falciparum pyruvate kinase 0.0032 0.026 0.4585
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0232
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0274 0.0364
Brugia malayi Animal haem peroxidase family protein 0.0026 0.0175 0.023
Brugia malayi Peroxidasin 0.0026 0.0175 0.023
Echinococcus multilocularis phd:f box containing protein 0.0033 0.0274 0.0274
Schistosoma mansoni hypothetical protein 0.0056 0.0565 0.1157
Trichomonas vaginalis set domain proteins, putative 0.0689 0.8578 1
Echinococcus granulosus peregrin 0.0056 0.0565 0.1022
Echinococcus granulosus tar DNA binding protein 0.0063 0.0643 0.1163
Echinococcus granulosus dnaJ subfamily B 0.0397 0.4875 0.8814
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0015 0.0044 0.0056
Brugia malayi Pyruvate kinase, muscle isozyme 0.0032 0.026 0.0344
Echinococcus multilocularis pyruvate kinase 0.0026 0.0174 0.0174
Giardia lamblia Fructose-bisphosphate aldolase 0.0566 0.7018 1
Schistosoma mansoni hypothetical protein 0.0329 0.4014 0.8234
Echinococcus granulosus lysine specific demethylase 6a 0.0033 0.0274 0.0495
Echinococcus granulosus peroxidasin 0.0026 0.0175 0.0316
Onchocerca volvulus 0.0026 0.0175 0.0202
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0175 0.0202
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.1317 0.1752
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0232
Trypanosoma cruzi pyruvate kinase 2, putative 0.0032 0.026 0.9498
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0015 0.0044 0.008
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0081 0.0872 0.1157
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0225 0.2699 0.5535
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0566 0.7018 0.8181
Onchocerca volvulus Peroxidase homolog 0.0026 0.0175 0.0202
Echinococcus multilocularis lysine specific demethylase 6a 0.0033 0.0274 0.0274
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0033 0.0274 1
Plasmodium vivax SET domain protein, putative 0.0087 0.0957 1
Schistosoma mansoni hypothetical protein 0.0033 0.0269 0.0548
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0225 0.2699 0.359
Echinococcus multilocularis aminopeptidase N 0.0012 0.0002 0.0002
Echinococcus granulosus phd:f box containing protein 0.0033 0.0274 0.0495
Echinococcus granulosus jumonji domain containing protein 0.0079 0.0846 0.1529
Schistosoma mansoni pyruvate kinase 0.0032 0.026 0.053
Brugia malayi Pre-SET motif family protein 0.0605 0.7519 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0203 0.027
Loa Loa (eye worm) hypothetical protein 0.0032 0.026 0.0346
Loa Loa (eye worm) blistered cuticle protein 3 0.0026 0.0175 0.0232
Echinococcus multilocularis pyruvate kinase 0.0032 0.026 0.026
Plasmodium vivax pyruvate kinase 2, putative 0.0017 0.0061 0.0617
Echinococcus granulosus GPCR family 2 0.0015 0.0044 0.008
Loa Loa (eye worm) hypothetical protein 0.0023 0.0136 0.0181
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0012 0.0002 0.0003
Onchocerca volvulus Peroxidasin homolog 0.0026 0.0175 0.0202
Schistosoma mansoni phd/f-box containing protein 0.0033 0.0274 0.0558
Loa Loa (eye worm) latrophilin receptor protein 2 0.0015 0.0044 0.0059
Schistosoma mansoni hypothetical protein 0.0329 0.4014 0.8234
Brugia malayi hypothetical protein 0.0103 0.116 0.1541
Echinococcus multilocularis JmjC domain containing protein 4 0.0033 0.0274 0.0274
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0643 0.1316
Loa Loa (eye worm) jmjC domain-containing protein 0.0117 0.1327 0.1765
Schistosoma mansoni jumonji domain containing protein 0.0204 0.2434 0.499
Loa Loa (eye worm) PHD-finger family protein 0.0056 0.0565 0.0752
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0033 0.0274 0.2849
Loa Loa (eye worm) pyruvate kinase-PB 0.0023 0.0136 0.0181
Mycobacterium leprae Probable pyruvate kinase PykA 0.0032 0.026 0.0381
Schistosoma mansoni jumonji/arid domain-containing protein 0.0127 0.1459 0.2989
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0232 0.0307
Loa Loa (eye worm) hypothetical protein 0.0026 0.0175 0.0232
Brugia malayi hypothetical protein 0.0026 0.0175 0.023
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0643 0.1316
Plasmodium falciparum phd finger protein, putative 0.0056 0.0565 1
Brugia malayi PHD-finger family protein 0.0056 0.0565 0.075
Loa Loa (eye worm) jmjC domain-containing protein 0.0033 0.0274 0.0364
Loa Loa (eye worm) RNA binding protein 0.0063 0.0643 0.0856
Brugia malayi Blistered cuticle protein 3 0.0026 0.0175 0.023
Schistosoma mansoni peroxidasin 0.0026 0.0175 0.0355
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0018 0.0084 0.0862
Schistosoma mansoni hypothetical protein 0.0018 0.0084 0.0169
Echinococcus multilocularis geminin 0.0329 0.4014 0.4014
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0033 0.0274 0.2849
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0081 0.0872 0.1785
Trichomonas vaginalis pyruvate kinase, putative 0.0032 0.026 0.0301
Echinococcus granulosus geminin 0.0329 0.4014 0.7258
Brugia malayi MH2 domain containing protein 0.0116 0.1317 0.175
Leishmania major hypothetical protein, conserved 0.0033 0.0274 1
Schistosoma mansoni ets-related 0.0213 0.2551 0.5231
Schistosoma mansoni cpg binding protein 0.0028 0.0203 0.0413
Echinococcus multilocularis pyruvate kinase 0.0032 0.026 0.026
Echinococcus granulosus JmjC domain containing protein 4 0.0033 0.0274 0.0495
Schistosoma mansoni pyruvate kinase 0.0017 0.0061 0.0121
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0035 0.0294 0.0294
Echinococcus multilocularis peregrin 0.0056 0.0565 0.0565
Echinococcus multilocularis neuropeptide receptor A26 0.0448 0.5531 0.5531
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.007 0.074 0.0984
Brugia malayi jmjC domain containing protein 0.0033 0.0274 0.0362

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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