Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | conserved hypothetical protein | 0.0041 | 0.1382 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1382 | 0.2652 |
Mycobacterium ulcerans | beta-lactamase | 0.0041 | 0.1382 | 0.2555 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0139 | 0.5177 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.1382 | 0.1313 |
Echinococcus granulosus | bloom syndrome protein | 0.0027 | 0.0817 | 0.102 |
Schistosoma mansoni | DNA helicase recq1 | 0.0011 | 0.0209 | 0.018 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0335 | 0.1964 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0011 | 0.0209 | 0.0265 |
Loa Loa (eye worm) | RecQ helicase | 0.0027 | 0.0817 | 0.1502 |
Entamoeba histolytica | recQ family helicase, putative | 0.0014 | 0.0335 | 1 |
Wolbachia endosymbiont of Brugia malayi | bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase | 0.0008 | 0.0079 | 0.5 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0011 | 0.0209 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.1382 | 1 |
Toxoplasma gondii | methylmalonate-semialdehyde dehydrogenase [acylating], putative | 0.0008 | 0.0079 | 0.0153 |
Onchocerca volvulus | 0.0041 | 0.1382 | 1 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0139 | 0.5177 | 0.705 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0139 | 0.5177 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0139 | 0.5177 | 1 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0139 | 0.5177 | 0.705 |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.7309 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 0.2596 | 0.5126 |
Entamoeba histolytica | aldehyde-alcohol dehydrogenase 2, putative | 0.0008 | 0.0079 | 0.2363 |
Loa Loa (eye worm) | beta-lactamase | 0.0041 | 0.1382 | 0.2652 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0041 | 0.1382 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase (NAD) family protein | 0.0008 | 0.0079 | 0.0153 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0011 | 0.0209 | 0.018 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0014 | 0.0335 | 0.1964 |
Toxoplasma gondii | NADP-dependent succinate-semialdehyde dehydrogenase | 0.0008 | 0.0079 | 0.0153 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0011 | 0.0209 | 0.018 |
Schistosoma mansoni | DNA helicase recq5 | 0.0011 | 0.0209 | 0.018 |
Entamoeba histolytica | aldehyde-alcohol dehydrogenase 2, putative | 0.0008 | 0.0079 | 0.2363 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0027 | 0.0817 | 0.5664 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0209 | 0.0517 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0209 | 0.0265 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.2596 | 0.3481 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.1382 | 1 |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.0041 | 0.1382 | 0.1313 |
Treponema pallidum | gamma-glutamyl phosphate reductase | 0.0008 | 0.0079 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0041 | 0.1382 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0041 | 0.1382 | 0.2555 |
Onchocerca volvulus | 0.0041 | 0.1382 | 1 | |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 0.2596 | 1 |
Echinococcus multilocularis | geminin | 0.0194 | 0.7309 | 1 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.0041 | 0.1382 | 0.1313 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0027 | 0.0817 | 0.5664 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 0.2596 | 0.5126 |
Entamoeba histolytica | aldehyde dehydrogenase 1, putative | 0.0008 | 0.0079 | 0.2363 |
Plasmodium vivax | hypothetical protein, conserved | 0.0041 | 0.1382 | 1 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.0041 | 0.1382 | 0.1801 |
Brugia malayi | RNA binding protein | 0.0072 | 0.2596 | 1 |
Brugia malayi | TAR-binding protein | 0.0072 | 0.2596 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.0041 | 0.1382 | 0.5175 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1382 | 0.2652 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.1382 | 0.1801 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0209 | 0.0517 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.1382 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0018 | 0.0474 | 0.0915 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.0041 | 0.1382 | 0.1801 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0335 | 0.0502 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.2596 | 0.3481 |
Echinococcus granulosus | geminin | 0.0194 | 0.7309 | 1 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0209 | 0.0404 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0139 | 0.5177 | 0.705 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.0041 | 0.1382 | 0.1313 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0139 | 0.5177 | 1 |
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 0.2596 | 0.3481 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0139 | 0.5177 | 0.5138 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.2596 | 0.3481 |
Leishmania major | hypothetical protein, conserved | 0.0041 | 0.1382 | 0.2555 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0027 | 0.0817 | 0.2931 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0041 | 0.1382 | 0.2555 |
Toxoplasma gondii | gamma-glutamyl phosphate reductase, putative | 0.0008 | 0.0079 | 0.0153 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.1382 | 0.5175 |
Onchocerca volvulus | 0.0041 | 0.1382 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0194 | 0.7309 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0011 | 0.0209 | 0.018 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1382 | 0.2652 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1382 | 0.2652 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.1382 | 0.1313 |
Entamoeba histolytica | aldehyde-alcohol dehydrogenase 2, putative | 0.0008 | 0.0079 | 0.2363 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1382 | 0.2652 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.1382 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0139 | 0.5177 | 1 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0023 | 0.0691 | 1 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0041 | 0.1382 | 0.2555 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 0.2596 | 0.3481 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0139 | 0.5177 | 0.705 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.1382 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0041 | 0.1382 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0011 | 0.0209 | 0.018 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0041 | 0.1382 | 0.2652 |
Mycobacterium tuberculosis | Probable hydrolase | 0.0041 | 0.1382 | 0.1313 |
Mycobacterium tuberculosis | Conserved protein | 0.0041 | 0.1382 | 0.1313 |
Brugia malayi | beta-lactamase family protein | 0.0041 | 0.1382 | 0.5175 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 0.2596 | 0.5126 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.0041 | 0.1382 | 0.1313 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0014 | 0.0335 | 0.1964 |
Loa Loa (eye worm) | hypothetical protein | 0.0134 | 0.499 | 1 |
Toxoplasma gondii | ABC1 family protein | 0.0041 | 0.1382 | 0.2669 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0209 | 0.0404 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.0041 | 0.1382 | 0.1313 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.2596 | 0.3481 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0021 | 0.0599 | 0.0719 |
Mycobacterium ulcerans | lipase LipD | 0.0041 | 0.1382 | 0.2555 |
Mycobacterium leprae | Probable lipase LipE | 0.0041 | 0.1382 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.1382 | 0.2652 |
Echinococcus multilocularis | bloom syndrome protein | 0.0027 | 0.0817 | 0.102 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.2596 | 0.3481 |
Trichomonas vaginalis | esterase, putative | 0.0041 | 0.1382 | 1 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.0041 | 0.1382 | 0.1801 |
Brugia malayi | beta-lactamase | 0.0041 | 0.1382 | 0.5175 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.0041 | 0.1382 | 0.1313 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.