TDR Targets

Basic information

Technical information

TDR Targets ID: 66544
Name: 3-butoxy-N-(2,6-difluorophenyl)-4-methoxybenz amide
MW: 335.345 | Formula: C18H19F2NO3
H donors: 1 H acceptors: 1 LogP: 4.15 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: CCCCOc1cc(ccc1OC)C(=O)Nc1c(F)cccc1F
InChi: 1S/C18H19F2NO3/c1-3-4-10-24-16-11-12(8-9-15(16)23-2)18(22)21-17-13(19)6-5-7-14(17)20/h5-9,11H,3-4,10H2,1-2H3,(H,21,22)
InChiKey: NWOCLFCVJFXTGO-UHFFFAOYSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

3-butoxy-N-(2,6-difluorophenyl)-4-methoxy-benzamide

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Sus scrofa	Phosphodiesterase 4A	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	Get druggable targets OG5_128242	All targets in OG5_128242
Neospora caninum	cAMP-specific phosphodiesterase, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4C, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium parvum	membrane associated HD superfamily cyclic nucleotide phosphodiesterase domain containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	IPR002073,3'5'-cyclic nucleotide phosphodiesterase,domain-containing	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	Get druggable targets OG5_128242	All targets in OG5_128242
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase, isoform F, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242
Schistosoma japonicum	cAMP-specific 3',5'-cyclic phosphodiesterase 4D, putative	Get druggable targets OG5_128242	All targets in OG5_128242
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Cryptosporidium hominis	hypothetical protein	Get druggable targets OG5_128242	All targets in OG5_128242
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	Get druggable targets OG5_128242	All targets in OG5_128242

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus	SH3 domain-binding glutamic acid-rich protein homolog	Phosphodiesterase 4A	118 aa	112 aa	28.6 %
Candida albicans	similar to a group of Candida orfs that show weak similarity to Leucine-rich repeat viral proteins	Phosphodiesterase 4A	118 aa	97 aa	26.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	cyclic AMP specific phosphodiesterase PDE4D5A	0.0196	0.0676	0.7684
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.0147	0.2155
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.0196	0.0676	0.7684
Echinococcus granulosus	FTZ F1 alpha	0.003	0.0006	0.0052
Loa Loa (eye worm)	hypothetical protein	0.003	0.0006	0.0052
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0215	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0147	0.0109
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0038	1
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0147	0.0109
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0038	0.042
Echinococcus granulosus	Mitotic checkpoint protein PRCC C terminal	0.0134	0.0425	0.4829
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0038	0.042
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.005	0.0089	0.1004
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0038	0.042
Echinococcus multilocularis	peptidase Clp (S14 family)	0.0053	0.0102	0.1149
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0006	0.0052
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.003	0.0006	0.0052
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0006	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0196	0.0676	0.7684
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.003	0.0006	0.0068
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.0053	0.0102	0.0064
Brugia malayi	TAR-binding protein	0.0066	0.0153	0.1726
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.003	0.0006	0.0052
Onchocerca volvulus		0.0038	0.0038	0.3859
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.003	0.0006	0.0052
Toxoplasma gondii	ATP-citrate lyase, putative	0.0142	0.0457	0.6765
Loa Loa (eye worm)	hypothetical protein	0.003	0.0006	0.0052
Echinococcus granulosus	peptidase Clp S14 family	0.0053	0.0102	0.1149
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.003	0.0006	0.0052
Brugia malayi	RNA binding protein	0.0066	0.0153	0.1726
Schistosoma mansoni	ATP-citrate synthase	0.0124	0.0387	0.5723
Toxoplasma gondii	hypothetical protein	0.0028	0.0001	0.0018
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.003	0.0006	0.0068
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0038	1
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0215	1
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.003	0.0006	0.0052
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0038	0.5
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0153	0.2247
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0196	0.0676	0.7684
Loa Loa (eye worm)	hypothetical protein	0.003	0.0006	0.0052
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0038	1
Loa Loa (eye worm)	steroid hormone receptor	0.003	0.0006	0.0052
Brugia malayi	hypothetical protein	0.0247	0.0879	1
Brugia malayi	beta-lactamase	0.0038	0.0038	0.042
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.0196	0.0676	1
Echinococcus multilocularis	ecdysone induced protein 78C	0.003	0.0006	0.0052
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0006	0.0052
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0153	0.2247
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0006	0.0052
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0038	0.042
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.003	0.0006	0.0052
Loa Loa (eye worm)	TAR-binding protein	0.0066	0.0153	0.1726
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0038	0.5
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0082	0.0215	0.3182
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0196	0.0676	0.7684
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.024	0.0852	0.0817
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0153	0.2247
Echinococcus multilocularis	survival motor neuron protein 1	0.0247	0.0879	1
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.003	0.0006	0.0052
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0038	0.042
Brugia malayi	steroid hormone receptor	0.003	0.0006	0.0052
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0006	0.0052
Mycobacterium ulcerans	3-dehydroquinate dehydratase	0.2514	1	1
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.003	0.0006	0.0052
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0038	0.5
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.003	0.0006	0.0052
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.003	0.0006	0.0068
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0038	0.5
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.003	0.0006	0.0052
Echinococcus multilocularis	FTZ F1 alpha	0.003	0.0006	0.0052
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0196	0.0676	0.7684
Brugia malayi	beta-lactamase family protein	0.0038	0.0038	0.042
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.003	0.0006	0.0052
Onchocerca volvulus		0.0038	0.0038	0.3859
Brugia malayi	nuclear hormone receptor	0.003	0.0006	0.0052
Schistosoma mansoni	RAR-like nuclear receptor	0.003	0.0006	0.0068
Schistosoma mansoni	hypothetical protein	0.0177	0.0598	0.8846
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0038	0.0038
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0038	0.042
Brugia malayi	RNA recognition motif domain containing protein	0.0066	0.0153	0.1726
Mycobacterium tuberculosis	3-dehydroquinate dehydratase AroD (AROQ) (3-dehydroquinase) (type II dhqase)	0.2514	1	1
Brugia malayi	ATP-citrate synthase	0.0142	0.0457	0.5194
Echinococcus granulosus	geminin	0.0177	0.0598	0.6797
Loa Loa (eye worm)	hypothetical protein	0.003	0.0006	0.0052
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0215	0.5
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.0196	0.0676	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0038	0.0546
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.003	0.0006	0.0068
Echinococcus granulosus	tar DNA binding protein	0.0066	0.0153	0.1726
Schistosoma mansoni	nuclear hormone receptor	0.003	0.0006	0.0068
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0215	0.5
Mycobacterium ulcerans	aldehyde dehydrogenase	0.0065	0.0147	0.0109
Loa Loa (eye worm)	hypothetical protein	0.003	0.0006	0.0052
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0082	0.0215	0.2436
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0153	0.2247
Echinococcus multilocularis	aldehyde dehydrogenase, mitochondrial	0.0065	0.0147	0.1656
Loa Loa (eye worm)	hypothetical protein	0.003	0.0006	0.0052
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.003	0.0006	0.0052
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0196	0.0676	0.7684
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0082	0.0215	0.0215
Loa Loa (eye worm)	hypothetical protein	0.003	0.0006	0.0052
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.003	0.0006	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0038	0.042
Loa Loa (eye worm)	hypothetical protein	0.003	0.0006	0.0052
Echinococcus multilocularis	geminin	0.0177	0.0598	0.6797
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.003	0.0006	0.0052
Schistosoma mansoni	hypothetical protein	0.0134	0.0425	0.6285
Toxoplasma gondii	aldehyde dehydrogenase	0.0065	0.0147	0.2169
Schistosoma mansoni	aldehyde dehydrogenase	0.0065	0.0147	0.2155
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0215	1
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.003	0.0006	0.0068
Schistosoma mansoni	retinoic acid receptor RXR	0.003	0.0006	0.0068
Plasmodium falciparum	carbonic anhydrase	0.0028	0.0001	0.0055
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0242	0.0859	0.9768
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.003	0.0006	0.0052
Mycobacterium tuberculosis	Probable aldehyde dehydrogenase	0.0065	0.0147	0.0109
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.0053	0.0102	0.0064
Echinococcus granulosus	survival motor neuron protein 1	0.0247	0.0879	1
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.0196	0.0676	0.5
Brugia malayi	photoreceptor-specific nuclear receptor	0.003	0.0006	0.0052
Brugia malayi	Steroid receptor seven-up type 2	0.003	0.0006	0.0052
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0215	0.0178
Leishmania major	hypothetical protein, conserved	0.0038	0.0038	0.2534
Loa Loa (eye worm)	RNA binding protein	0.0066	0.0153	0.1726
Trichomonas vaginalis	esterase, putative	0.0038	0.0038	0.5
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.003	0.0006	0.0052
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0066	0.0153	0.1726
Schistosoma mansoni	hypothetical protein	0.0177	0.0598	0.8846
Brugia malayi	beta-lactamase family protein	0.0038	0.0038	0.042
Schistosoma mansoni	survival motor neuron protein	0.005	0.0089	0.1307
Echinococcus granulosus	ecdysone induced protein 78C	0.003	0.0006	0.0052
Echinococcus granulosus	aldehyde dehydrogenase mitochondrial	0.0065	0.0147	0.1656
Schistosoma mansoni	thyroid hormone receptor	0.0163	0.0544	0.8046
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.003	0.0006	0.0052
Toxoplasma gondii	ABC1 family protein	0.0038	0.0038	0.0563
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0038	0.042
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.003	0.0006	0.0052
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.003	0.0006	0.0052
Schistosoma mansoni	peptidase Clp (S14 family)	0.0082	0.0215	0.317
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0082	0.0215	0.0178
Schistosoma mansoni	hypothetical protein	0.005	0.0089	0.1307
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0038	0.042
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0082	0.0215	0.3182
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.003	0.0006	0.0052
Brugia malayi	Nuclear hormone receptor-like 1	0.003	0.0006	0.0052
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0082	0.0215	1
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0038	0.0038
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.003	0.0006	0.0052
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0082	0.0215	0.2436
Onchocerca volvulus		0.0038	0.0038	0.3859
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.003	0.0006	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0038	0.042
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0038	0.5
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.003	0.0006	0.0052
Brugia malayi	nuclear receptor NHR-88	0.003	0.0006	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0247	0.0879	1
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0038	0.0546
Echinococcus multilocularis	tar DNA binding protein	0.0066	0.0153	0.1726
Schistosoma mansoni	thyroid hormone receptor	0.0163	0.0544	0.8046
Brugia malayi	follicle stimulating hormone receptor	0.0242	0.0859	0.9768
Loa Loa (eye worm)	hypothetical protein	0.0082	0.0215	0.2436
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.003	0.0006	0.0052
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0038	0.042
Brugia malayi	Probable ClpP-like protease	0.0082	0.0215	0.2436
Echinococcus multilocularis	thyroid hormone receptor alpha	0.0163	0.0544	0.6183
Leishmania major	aldehyde dehydrogenase, mitochondrial precursor	0.0065	0.0147	1
Schistosoma mansoni	coup transcription factor	0.003	0.0006	0.0068
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.003	0.0006	0.0052
Loa Loa (eye worm)	ATP-citrate synthase	0.0142	0.0457	0.5194
Brugia malayi	ecdysteroid receptor	0.003	0.0006	0.0052
Echinococcus multilocularis	Mitotic checkpoint protein PRCC, C terminal	0.0134	0.0425	0.4829
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.003	0.0006	0.0068
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.0196	0.0676	0.7684
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.003	0.0006	0.0052
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.0053	0.0102	0.0102
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.003	0.0006	0.0052
Schistosoma mansoni	tar DNA-binding protein	0.0066	0.0153	0.2247
Onchocerca volvulus		0.005	0.0089	1
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.003	0.0006	0.0052
Schistosoma mansoni	steroid hormone receptor ad4bp	0.003	0.0006	0.0068
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.0196	0.0676	0.7684
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0038	0.1768

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.3 uM	Inhibitory potency against pig aortic PDE IV	ChEMBL.	8201604
IC50 (binding)	= 0.3 uM	Inhibitory potency against pig aortic PDE IV	ChEMBL.	8201604

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

PubChem: 10472116

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 66544