Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0104 | 0.3161 | 0.7163 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0331 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0331 | 0.075 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0331 | 0.075 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0331 | 0.075 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0331 | 0.5 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.018 | 0.6558 | 0.644 |
Plasmodium vivax | glutathione reductase, putative | 0.0079 | 0.2053 | 1 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0331 | 0.075 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0079 | 0.2053 | 0.4653 |
Loa Loa (eye worm) | TAR-binding protein | 0.0132 | 0.4413 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.018 | 0.6558 | 0.644 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.02 | 0.7453 | 0.7366 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.018 | 0.6558 | 0.644 |
Mycobacterium tuberculosis | Probable reductase | 0.018 | 0.6558 | 0.644 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.018 | 0.6558 | 0.8743 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0331 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0331 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.4413 | 0.4504 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0104 | 0.3161 | 0.7163 |
Brugia malayi | TAR-binding protein | 0.0132 | 0.4413 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.4413 | 0.4504 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0331 | 0.0338 |
Brugia malayi | beta-lactamase | 0.004 | 0.0331 | 0.075 |
Echinococcus multilocularis | tar DNA binding protein | 0.0132 | 0.4413 | 0.7521 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0331 | 0.5 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.02 | 0.7453 | 0.7366 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0331 | 0.075 |
Loa Loa (eye worm) | glutathione reductase | 0.0079 | 0.2053 | 0.4653 |
Brugia malayi | Thioredoxin reductase | 0.0079 | 0.2053 | 0.4653 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0079 | 0.2053 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0132 | 0.4413 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.4413 | 0.4504 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0331 | 0.075 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0331 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0132 | 0.4413 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5867 | 0.5989 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0331 | 0.075 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.5867 | 0.5989 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.02 | 0.7453 | 0.7366 |
Brugia malayi | RNA binding protein | 0.0132 | 0.4413 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.018 | 0.6558 | 0.644 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.008 | 0.21 | 0.3579 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0331 | 0.075 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0079 | 0.2053 | 0.1781 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0079 | 0.2053 | 1 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0331 | 0.5 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.018 | 0.6558 | 0.644 |
Plasmodium falciparum | thioredoxin reductase | 0.0079 | 0.2053 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0331 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0331 | 0.5 |
Toxoplasma gondii | thioredoxin reductase | 0.0079 | 0.2053 | 1 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0331 | 0.0564 |
Brugia malayi | glutathione reductase | 0.0079 | 0.2053 | 0.4653 |
Onchocerca volvulus | 0.004 | 0.0331 | 0.5 | |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.02 | 0.7453 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0079 | 0.2053 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0071 | 0.1698 | 0.3848 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0331 | 0.075 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.008 | 0.21 | 0.3579 |
Echinococcus granulosus | geminin | 0.0165 | 0.5867 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.3161 | 0.7163 |
Echinococcus granulosus | tar DNA binding protein | 0.0132 | 0.4413 | 0.7521 |
Schistosoma mansoni | hypothetical protein | 0.0071 | 0.1698 | 0.1733 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.4413 | 0.4504 |
Onchocerca volvulus | 0.004 | 0.0331 | 0.5 | |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0331 | 0.075 |
Leishmania major | trypanothione reductase | 0.0079 | 0.2053 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0331 | 0.075 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0104 | 0.3161 | 0.7163 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0331 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0331 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0132 | 0.4413 | 0.4504 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0331 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0071 | 0.1698 | 0.3848 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0331 | 0.0338 |
Echinococcus multilocularis | geminin | 0.0165 | 0.5867 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0132 | 0.4413 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0079 | 0.2053 | 1 |
Onchocerca volvulus | 0.004 | 0.0331 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.