Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0065 | 0.0177 |
Echinococcus multilocularis | dihydrofolate reductase | 0.1284 | 1 | 1 |
Schistosoma mansoni | dihydrofolate reductase | 0.1284 | 1 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.1284 | 1 | 1 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0065 | 0.5 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0036 | 0.0065 | 0.0177 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.1284 | 1 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0036 | 0.0065 | 0.0065 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0491 | 0.3686 | 1 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0491 | 0.3686 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0491 | 0.3686 | 1 |
Brugia malayi | Dihydrofolate reductase | 0.1284 | 1 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0491 | 0.3686 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.1284 | 1 | 1 |
Echinococcus granulosus | dihydrofolate reductase | 0.1284 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0036 | 0.0065 | 0.5 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0036 | 0.0065 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.1284 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0491 | 0.3686 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0036 | 0.0065 | 0.5 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0491 | 0.3686 | 1 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0036 | 0.0065 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.1284 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 2.5 uM | Antiproliferative activity against human breast MDA-MB-435 cell line | ChEMBL. | 12699385 |
GI50 (functional) | = 2.5 uM | Antiproliferative activity against human breast MDA-MB-435 cell line | ChEMBL. | 12699385 |
GI50 (functional) | = 6.7 uM | Antiproliferative activity against human ovarian OVCAR-3 cell line | ChEMBL. | 12699385 |
GI50 (functional) | = 6.7 uM | Antiproliferative activity against human ovarian OVCAR-3 cell line | ChEMBL. | 12699385 |
GI50 (functional) | = 12 uM | Antiproliferative activity against human colon HCT-116 cell line | ChEMBL. | 12699385 |
GI50 (functional) | = 12 uM | Antiproliferative activity against human colon HCT-116 cell line | ChEMBL. | 12699385 |
GI50 (functional) | = 24.4 uM | Antiproliferative activity against human melanoma UACC-62 cell line | ChEMBL. | 12699385 |
GI50 (functional) | = 24.4 uM | Antiproliferative activity against human melanoma UACC-62 cell line | ChEMBL. | 12699385 |
GI50 (functional) | > 100 uM | Antiproliferative activity against human lung HOP-62 cell line | ChEMBL. | 12699385 |
GI50 (functional) | > 100 uM | Antiproliferative activity against human CNS SF-539 cell line | ChEMBL. | 12699385 |
GI50 (functional) | > 100 uM | Antiproliferative activity against human renal SN12C cell line | ChEMBL. | 12699385 |
GI50 (functional) | > 100 uM | Antiproliferative activity against human prostate DU-145 cell line | ChEMBL. | 12699385 |
GI50 (functional) | > 100 uM | Antiproliferative activity against human lung HOP-62 cell line | ChEMBL. | 12699385 |
GI50 (functional) | > 100 uM | Antiproliferative activity against human CNS SF-539 cell line | ChEMBL. | 12699385 |
GI50 (functional) | > 100 uM | Antiproliferative activity against human renal SN12C cell line | ChEMBL. | 12699385 |
GI50 (functional) | > 100 uM | Antiproliferative activity against human prostate DU-145 cell line | ChEMBL. | 12699385 |
IC50 (functional) | > 40 uM | Inhibition of tubulin polymerization was determined at 1.2 mg/mL concentration | ChEMBL. | 12699385 |
IC50 (functional) | > 40 uM | Inhibition of tubulin polymerization was determined at 1.2 mg/mL concentration | ChEMBL. | 12699385 |
MGM (functional) | = 40.7 | Mean graph midpoint for growth inhibition of all human cancer cells was determined | ChEMBL. | 12699385 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.