Detailed information for compound 666490

Basic information

Technical information
  • TDR Targets ID: 666490
  • Name: 3-[(4-fluorophenyl)methyl]-1,3-thiazolidine-2 ,4-dione
  • MW: 225.239 | Formula: C10H8FNO2S
  • H donors: 0 H acceptors: 2 LogP: 1.85 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc(cc1)CN1C(=O)CSC1=O
  • InChi: 1S/C10H8FNO2S/c11-8-3-1-7(2-4-8)5-12-9(13)6-15-10(12)14/h1-4H,5-6H2
  • InChiKey: GTAZAXSMXJLHEP-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 3-[(4-fluorophenyl)methyl]thiazolidine-2,4-dione
  • 3-(4-fluorobenzyl)thiazolidine-2,4-quinone
  • ZINC02994197

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) glucose-6-phosphate dehydrogenase 0.0093 0.4065 0.7479
Plasmodium falciparum phd finger protein, putative 0.0029 0.0882 0.1969
Brugia malayi jmjC domain containing protein 0.0035 0.1186 0.2841
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.0093 0.4065 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Echinococcus multilocularis Chromo domain 0.0011 0.00000000020295 0.00000000048596
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.2424 0.4459
Trichomonas vaginalis chromobox protein, putative 0.0069 0.2894 0.6464
Onchocerca volvulus Alhambra homolog 0.0029 0.0882 0.2137
Brugia malayi Bloom's syndrome protein homolog 0.0024 0.0626 0.1499
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Echinococcus granulosus citrate lyase subunit beta protein 0.0024 0.065 0.1557
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.1186 0.2841
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.00000000020295 0.00000000049196
Echinococcus granulosus bloom syndrome protein 0.0024 0.0626 0.1499
Brugia malayi CHD4 protein 0.0011 0.00000000020295 0.00000000048596
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0882 0.2111
Trichomonas vaginalis chromobox protein, putative 0.0042 0.1521 0.3396
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0021 0.0481 0.1075
Echinococcus multilocularis chromobox protein 1 0.0069 0.2894 0.693
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.4125 0.4084
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Brugia malayi Type III restriction enzyme, res subunit family protein 0.0011 0.00000000020295 0.00000000048596
Trichomonas vaginalis 6-phosphogluconolactonase, putative 0.0101 0.4478 1
Echinococcus granulosus peregrin 0.0029 0.0882 0.2111
Schistosoma mansoni hypothetical protein 0.0011 0.00000000020295 0.00000000049196
Trichomonas vaginalis chromobox protein, putative 0.0042 0.1521 0.3396
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0093 0.4065 0.4023
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0882 0.1969
Schistosoma mansoni glucose-6-phosphate 1-dehydrogenase 0.0093 0.4065 0.9854
Echinococcus granulosus jumonji domain containing protein 0.004 0.1449 0.3469
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.1186 0.2876
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0882 0.1622
Schistosoma mansoni hypothetical protein 0.0029 0.0882 0.2137
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0882 0.1969
Loa Loa (eye worm) hypothetical protein 0.012 0.5435 1
Schistosoma mansoni jumonji domain containing protein 0.0075 0.3202 0.7761
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.0101 0.4478 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Brugia malayi jmjC domain containing protein 0.0095 0.4176 1
Trichomonas vaginalis DNA helicase recq, putative 0.0024 0.0626 0.1398
Onchocerca volvulus 0.003 0.0954 0.2313
Plasmodium vivax hypothetical protein, conserved 0.0011 0.00000000020295 0.00000000045326
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0094 0.4125 0.9878
Plasmodium vivax glucose-6-phosphate 1-dehydrogenase, putative 0.0101 0.4478 1
Echinococcus granulosus lysine specific demethylase 5A 0.0035 0.1186 0.2841
Brugia malayi chromobox protein homolog 3 0.0039 0.1373 0.3289
Schistosoma mansoni kinase 0.0048 0.1818 0.4407
Echinococcus granulosus glucose 6 phosphate 1 dehydrogenase 0.0093 0.4065 0.9734
Trypanosoma brucei polo-like protein kinase 0.0094 0.4125 0.4084
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4125 0.9213
Trichomonas vaginalis DNA helicase recq, putative 0.0013 0.0071 0.0158
Schistosoma mansoni chromobox protein 0.0069 0.2894 0.7015
Echinococcus granulosus chromobox protein 1 0.0069 0.2894 0.693
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0807 0.1802
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4125 0.9213
Loa Loa (eye worm) hypothetical protein 0.0011 0.00000000020295 0.00000000037338
Loa Loa (eye worm) CHromoDomain protein family member 0.0011 0.00000000020295 0.00000000037338
Echinococcus multilocularis jumonji domain containing protein 0.004 0.1449 0.3469
Echinococcus granulosus chromobox protein 1 0.0069 0.2894 0.693
Mycobacterium tuberculosis Probable glucose-6-phosphate 1-dehydrogenase Zwf2 (G6PD) 0.0032 0.104 1
Echinococcus multilocularis peregrin 0.0029 0.0882 0.2111
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4125 0.9213
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0101 0.4478 1
Schistosoma mansoni serine/threonine protein kinase 0.0094 0.4125 1
Echinococcus multilocularis chromobox protein 1 0.0069 0.2894 0.693
Echinococcus granulosus chromodomain helicase DNA binding protein 4 0.0011 0.00000000020295 0.00000000048596
Schistosoma mansoni chromobox protein 0.0069 0.2894 0.7015
Brugia malayi PHD-finger family protein 0.0029 0.0882 0.2111
Toxoplasma gondii glucose-6-phosphate 1-dehydrogenase 0.006 0.2459 0.5491
Trypanosoma brucei hypothetical protein, conserved 0.0211 1 1
Echinococcus multilocularis bloom syndrome protein 0.0024 0.0626 0.1499
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Entamoeba histolytica hypothetical protein 0.0011 0.00000000020295 0.00000000049196
Entamoeba histolytica recQ family helicase, putative 0.0013 0.0071 0.0171
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.065 0.0584
Brugia malayi Heterochromatin protein 1 0.0069 0.2894 0.693
Trypanosoma brucei glucose-6-phosphate 1-dehydrogenase 0.0093 0.4065 0.4023
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4125 0.9213
Brugia malayi Associated with TFs and helicases family protein 0.0011 0.00000000020295 0.00000000048596
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0016 0.024 0.0536
Trypanosoma cruzi hypothetical protein, conserved 0.0211 1 1
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0094 0.4125 0.759
Leishmania major glucose-6-phosphate 1-dehydrogenase, putative 0.0093 0.4065 0.4023
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4125 0.9213
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000020295 0.00000000049196
Trypanosoma cruzi 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.065 0.0584
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Echinococcus granulosus chromodomain helicase DNA binding protein 1 0.0011 0.00000000020295 0.00000000048596
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0016 0.023 0.0514
Trichomonas vaginalis Citrate lyase beta chain, putative 0.0024 0.065 0.1453
Loa Loa (eye worm) hypothetical protein 0.0039 0.1373 0.2527
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1756 0.3922
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0042 0.1521 0.3686
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000020295 0.00000000049196
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Onchocerca volvulus Serine\/threonine kinase homolog 0.0094 0.4125 1
Trichomonas vaginalis conserved hypothetical protein 0.0027 0.0807 0.1802
Brugia malayi Bromodomain containing protein 0.0029 0.0882 0.2111
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.1373 0.3067
Brugia malayi glucose-6-phosphate dehydrogenase 0.0093 0.4065 0.9734
Schistosoma mansoni blooms syndrome DNA helicase 0.0019 0.0375 0.0909
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4125 0.9213
Chlamydia trachomatis glucose-6-phosphate 1-dehydrogenase 0.0093 0.4065 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0211 1 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0039 0.1373 0.3329
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.1373 0.3067
Mycobacterium ulcerans glucose-6-phosphate 1-dehydrogenase 0.006 0.2459 0.5295
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0882 0.2111
Echinococcus multilocularis citrate lyase subunit beta protein 0.0024 0.065 0.1557
Trypanosoma cruzi glucose-6-phosphate 1-dehydrogenase, putative 0.0031 0.0968 0.0904
Leishmania major 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative 0.0024 0.065 0.0584
Echinococcus multilocularis chromodomain helicase DNA binding protein 4 0.0011 0.00000000020295 0.00000000048596
Echinococcus multilocularis glucose 6 phosphate 1 dehydrogenase 0.0093 0.4065 0.9734
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.4176 1
Entamoeba histolytica serine/threonine protein kinase, putative 0.0094 0.4125 1
Giardia lamblia Glucose-6-phosphate 1-dehydrogenase 0.0101 0.4478 1
Treponema pallidum glucose-6-phosphate 1-dehydrogenase 0.0093 0.4065 0.5
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0094 0.4125 0.9878
Echinococcus multilocularis chromodomain helicase DNA binding protein 1 0.0011 0.00000000020295 0.00000000048596
Echinococcus granulosus Chromo domain 0.0011 0.00000000020295 0.00000000048596
Plasmodium falciparum chromodomain-helicase-DNA-binding protein 1 homolog, putative 0.0011 0.00000000020295 0.00000000045326
Schistosoma mansoni chromodomain helicase DNA binding protein 0.0011 0.00000000020295 0.00000000049196
Trypanosoma cruzi polo-like protein kinase, putative 0.0094 0.4125 0.4084
Loa Loa (eye worm) hypothetical protein 0.003 0.0954 0.1756
Trichomonas vaginalis CAMK family protein kinase 0.0046 0.1756 0.3922
Trypanosoma cruzi Glucose-6-phosphate dehydrogenase, putative 0.003 0.0924 0.0859
Toxoplasma gondii chromodomain helicase DNA binding protein CHD1/SWI2/SNF2 0.0011 0.00000000020295 0.00000000045326
Loa Loa (eye worm) hypothetical protein 0.005 0.1916 0.3525
Trichomonas vaginalis DNA helicase recq1, putative 0.0024 0.0626 0.1398
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0882 0.1969
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0882 0.2137
Giardia lamblia Kinase, PLK 0.0094 0.4125 0.902
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Plasmodium falciparum glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase 0.0101 0.4478 1
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0094 0.4125 0.4084
Schistosoma mansoni jumonji/arid domain-containing protein 0.0035 0.1186 0.2876
Loa Loa (eye worm) RecQ helicase 0.0024 0.0626 0.1152
Brugia malayi serine/threonine-protein kinase plk-2 0.0094 0.4125 0.9878
Trichomonas vaginalis CAMK family protein kinase 0.0094 0.4125 0.9213
Loa Loa (eye worm) heterochromatin protein 1 0.0069 0.2894 0.5325
Trichomonas vaginalis chromobox protein, putative 0.0069 0.2894 0.6464
Entamoeba histolytica chromodomain-helicase-DNA-binding protein, putative 0.0011 0.00000000020295 0.00000000049196
Trichomonas vaginalis glucosamine-6-phosphate isomerase, putative 0.0101 0.4478 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.0882 0.1622
Loa Loa (eye worm) jmjC domain-containing protein 0.0035 0.1186 0.2183
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0011 0.00000000020295 0.00000000045326
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.4176 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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