Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0156 | 0.141 | 0.4311 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.3107 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0086 | 0.0089 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0041 | 0.0086 | 0.0089 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0304 | 0.3107 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0041 | 0.0086 | 0.011 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0041 | 0.0086 | 0.0089 |
Brugia malayi | nuclear hormone receptor | 0.0881 | 0.9751 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0041 | 0.0086 | 0.0089 |
Brugia malayi | steroid hormone receptor | 0.0041 | 0.0086 | 0.0089 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0148 | 0.1321 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0041 | 0.0086 | 0.011 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0178 | 0.0183 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0156 | 0.141 | 0.4311 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0041 | 0.0086 | 0.0089 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0041 | 0.0086 | 0.011 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0156 | 0.141 | 0.5 |
Brugia malayi | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | 0.0156 | 0.141 | 0.1446 |
Schistosoma mansoni | coup transcription factor | 0.0041 | 0.0086 | 0.011 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0041 | 0.0086 | 0.0089 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0041 | 0.0086 | 0.0054 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0041 | 0.0086 | 0.0054 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0041 | 0.0086 | 0.0089 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0041 | 0.0086 | 0.011 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0041 | 0.0086 | 0.011 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0041 | 0.0081 | 0.0121 |
Brugia malayi | hypothetical protein | 0.0037 | 0.0045 | 0.0046 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0041 | 0.0086 | 0.011 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0041 | 0.0086 | 0.0089 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0041 | 0.0086 | 0.0054 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0146 | 0.1298 | 0.1604 |
Trichomonas vaginalis | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0156 | 0.141 | 0.4311 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0041 | 0.0086 | 0.011 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.3107 | 1 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0717 | 0.7861 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.3107 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0717 | 0.7861 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.3107 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0086 | 0.0089 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0041 | 0.0086 | 0.011 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0151 | 0.1347 | 0.1666 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0037 | 0.0045 | 0.0057 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0041 | 0.0086 | 0.0089 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0041 | 0.0086 | 0.0089 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0041 | 0.0086 | 0.0089 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0041 | 0.0086 | 0.0054 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0041 | 0.0086 | 0.0089 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0041 | 0.0086 | 0.0089 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0041 | 0.0086 | 0.0089 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0041 | 0.0086 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0086 | 0.0089 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0086 | 0.0089 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.3107 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0041 | 0.0086 | 0.0054 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0148 | 0.1321 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 0.0045 | 0.0057 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0041 | 0.0086 | 0.0089 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0041 | 0.0086 | 0.0089 |
Mycobacterium ulcerans | hypothetical protein | 0.0156 | 0.141 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0041 | 0.0086 | 0.0054 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0041 | 0.0086 | 0.0054 |
Trypanosoma brucei | 3-oxo-5-alpha-steroid 4-dehydrogenase-like, putative | 0.0156 | 0.141 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0041 | 0.0086 | 0.0089 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0086 | 0.0089 |
Trypanosoma cruzi | 3-oxo-5-alpha-steroid 4-dehydrogenase, putative | 0.0156 | 0.141 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0041 | 0.0086 | 0.0054 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0041 | 0.0081 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0086 | 0.0089 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0041 | 0.0086 | 0.0054 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0304 | 0.3107 | 1 |
Entamoeba histolytica | steroid 5-alpha reductase, putative | 0.0156 | 0.141 | 0.4458 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0178 | 0.0183 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0086 | 0.0089 |
Brugia malayi | nuclear hormone receptor | 0.0041 | 0.0086 | 0.0089 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0044 | 0.0124 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0041 | 0.0086 | 0.011 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0041 | 0.0086 | 0.0054 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0041 | 0.0086 | 0.0089 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0151 | 0.1347 | 0.1381 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0304 | 0.3107 | 0.5 |
Loa Loa (eye worm) | acetyltransferase | 0.0151 | 0.1347 | 0.1381 |
Toxoplasma gondii | 3-oxo-5-alpha-steroid 4-dehydrogenase | 0.0156 | 0.141 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0041 | 0.0086 | 0.0054 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0717 | 0.7861 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0041 | 0.0086 | 0.0089 |
Brugia malayi | ecdysteroid receptor | 0.0041 | 0.0086 | 0.0089 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0178 | 0.0183 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0041 | 0.0086 | 0.011 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0041 | 0.0086 | 0.0054 |
Brugia malayi | nuclear receptor NHR-88 | 0.0041 | 0.0086 | 0.0089 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0178 | 0.0183 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0041 | 0.0086 | 0.0054 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0041 | 0.0086 | 0.0089 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0041 | 0.0086 | 0.011 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0041 | 0.0086 | 0.0089 |
Echinococcus granulosus | FTZ F1 alpha | 0.0041 | 0.0086 | 0.0054 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0881 | 0.9751 | 1 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0304 | 0.3107 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0041 | 0.0086 | 0.011 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0086 | 0.0089 |
Leishmania major | 3-oxo-5-alpha-steroid 4-dehydrogenase-like protein | 0.0156 | 0.141 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.3107 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0041 | 0.0086 | 0.0089 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.3107 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0862 | 0.9528 | 0.9772 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0041 | 0.0086 | 0.0089 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.141 | 0.1446 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0041 | 0.0086 | 0.0054 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0304 | 0.3107 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0041 | 0.0086 | 0.0054 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0151 | 0.1347 | 0.1713 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0041 | 0.0086 | 0.0054 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0041 | 0.0086 | 0.0089 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0044 | 0.0124 | 0.0102 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0041 | 0.0086 | 0.0089 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 48 uM | Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils | ChEMBL. | 2415706 |
IC50 (functional) | > 48 uM | Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils | ChEMBL. | 2415706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.