Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0042 | 0.0273 | 0.0282 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0042 | 0.0273 | 0.1535 |
Brugia malayi | ecdysteroid receptor | 0.0042 | 0.0273 | 0.0282 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0042 | 0.0273 | 0.0282 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0042 | 0.0273 | 0.1535 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0042 | 0.0273 | 0.1854 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0273 | 0.0282 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0042 | 0.0273 | 0.0282 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0151 | 0.1778 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0042 | 0.0273 | 0.0282 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0042 | 0.0273 | 0.1854 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0273 | 0.0282 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0042 | 0.0273 | 0.0282 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0042 | 0.0273 | 0.1535 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0042 | 0.0273 | 0.1535 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0273 | 0.0282 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0042 | 0.0273 | 0.0282 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0042 | 0.0273 | 0.0282 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0042 | 0.0273 | 0.1535 |
Brugia malayi | nuclear hormone receptor | 0.0042 | 0.0273 | 0.0282 |
Brugia malayi | steroid hormone receptor | 0.0042 | 0.0273 | 0.0282 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0042 | 0.0273 | 0.0282 |
Brugia malayi | nuclear hormone receptor | 0.0723 | 0.9694 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0042 | 0.0273 | 0.1535 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0042 | 0.0273 | 0.1535 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0042 | 0.0273 | 0.1535 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0042 | 0.0273 | 0.0282 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0042 | 0.0273 | 0.1854 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0042 | 0.0273 | 0.0282 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0042 | 0.0273 | 0.1854 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0042 | 0.0273 | 0.1854 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0273 | 0.0282 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0042 | 0.0273 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0273 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0273 | 0.0282 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0723 | 0.9694 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0042 | 0.0273 | 0.1535 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0042 | 0.0273 | 0.0282 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0042 | 0.0273 | 0.0282 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0042 | 0.0273 | 0.0282 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0129 | 0.1473 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0042 | 0.0273 | 0.0282 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0042 | 0.0273 | 0.1535 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0042 | 0.0273 | 0.0282 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0042 | 0.0273 | 0.1535 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0273 | 0.0282 |
Echinococcus granulosus | FTZ F1 alpha | 0.0042 | 0.0273 | 0.1535 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0042 | 0.0273 | 0.1535 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0151 | 0.1778 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0042 | 0.0273 | 0.0282 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0042 | 0.0273 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.0273 | 0.0282 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0042 | 0.0273 | 0.1854 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0042 | 0.0273 | 0.1854 |
Schistosoma mansoni | thyroid hormone receptor | 0.0042 | 0.0273 | 0.1535 |
Schistosoma mansoni | thyroid hormone receptor | 0.0042 | 0.0273 | 0.1535 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0042 | 0.0273 | 0.0282 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0042 | 0.0273 | 0.1854 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0042 | 0.0273 | 0.0282 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0042 | 0.0273 | 0.0282 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0042 | 0.0273 | 0.1854 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0042 | 0.0273 | 0.1535 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0042 | 0.0273 | 0.0282 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0042 | 0.0273 | 0.0282 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0042 | 0.0273 | 0.1535 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0042 | 0.0273 | 0.1535 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0042 | 0.0273 | 0.1535 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0042 | 0.0273 | 0.0282 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0042 | 0.0273 | 0.0282 |
Loa Loa (eye worm) | hypothetical protein | 0.0703 | 0.9421 | 0.9718 |
Schistosoma mansoni | nuclear hormone receptor | 0.0042 | 0.0273 | 0.1535 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 48 uM | Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils | ChEMBL. | 2415706 |
IC50 (functional) | > 48 uM | Inhibitory activity against histamine release from antigen-challenged, sensitized human basophils | ChEMBL. | 2415706 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.