Detailed information for compound 666653

Basic information

Technical information
  • TDR Targets ID: 666653
  • Name: N-(3,4-dimethylphenyl)-2-[(5E)-5-[(3-nitrophe nyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3- yl]acetamide
  • MW: 411.431 | Formula: C20H17N3O5S
  • H donors: 1 H acceptors: 5 LogP: 3.84 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(CN1C(=O)S/C(=C/c2cccc(c2)[N+](=O)[O-])/C1=O)Nc1ccc(c(c1)C)C
  • InChi: 1S/C20H17N3O5S/c1-12-6-7-15(8-13(12)2)21-18(24)11-22-19(25)17(29-20(22)26)10-14-4-3-5-16(9-14)23(27)28/h3-10H,11H2,1-2H3,(H,21,24)/b17-10+
  • InChiKey: QEIYDFODCBCSAI-LICLKQGHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(3,4-dimethylphenyl)-2-[(5E)-5-[(3-nitrophenyl)methylene]-2,4-dioxo-thiazolidin-3-yl]acetamide
  • N-(3,4-dimethylphenyl)-2-[(5E)-5-[(3-nitrophenyl)methylene]-2,4-dioxo-3-thiazolidinyl]acetamide
  • 2-[(5E)-2,4-diketo-5-(3-nitrobenzylidene)thiazolidin-3-yl]-N-(3,4-dimethylphenyl)acetamide
  • N-(3,4-dimethylphenyl)-2-[(5E)-5-[(3-nitrophenyl)methylidene]-2,4-dioxo-1,3-thiazolidin-3-yl]ethanamide
  • ZINC04694628
  • STK152024

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.1131
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.0008
Echinococcus multilocularis TRP (transient receptor potential) channel 0.0037 0.017 0.0161
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0084 0.0456 0.1209
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.0008
Brugia malayi F/Y-rich N-terminus family protein 0.0019 0.0057 0.0424
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0224 0.1316 0.3597
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.1131
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0061 0.2739
Loa Loa (eye worm) hypothetical protein 0.01 0.0553 0.4135
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0158 0.038
Echinococcus multilocularis cpg binding protein 0.006 0.0312 0.0303
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0013 0.0021 0.0012
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0321 0.0654
Schistosoma mansoni hypothetical protein 0.0011 0.0009 0.0019
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0267 0.0526
Echinococcus granulosus histone lysine methyltransferase setb 0.0032 0.0138 0.0264
Brugia malayi Ets-domain containing protein 0.0011 0.0009 0.0066
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0228 0.0219
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0022 0.0008
Schistosoma mansoni transient receptor potential channel 0.0066 0.0347 0.0706
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0138 0.0282
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0228 0.0219
Schistosoma mansoni elf1 0.0011 0.0009 0.0019
Brugia malayi mbt repeat family protein 0.0046 0.0228 0.1716
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0158 0.1189
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0398 0.0794
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0061 0.2739
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0084 0.0456 0.1209
Schistosoma mansoni hypothetical protein 0.0011 0.0009 0.0019
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.033
Echinococcus granulosus tar DNA binding protein 0.0062 0.0321 0.0636
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0158 0.0321
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0124 0.0234
Schistosoma mansoni hypothetical protein 0.0286 0.1697 0.3455
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0321 0.2421
Loa Loa (eye worm) hypothetical protein 0.0032 0.0138 0.0982
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0122 0.069 0.1405
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0321 0.0654
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0158 0.038
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0093 0.0514 0.1368
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0061 0.0112
Echinococcus granulosus transient receptor potential ion channel A 0.0096 0.0533 0.1068
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.033
Toxoplasma gondii pantoate-beta-alanine ligase 0.06 0.362 1
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0267 0.2013
Loa Loa (eye worm) hypothetical protein 0.0064 0.0332 0.2456
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0228 0.0464
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0053 0.2146
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.0008
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0138 0.0282
Schistosoma mansoni gabp alpha 0.0074 0.0398 0.0811
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.0071
Schistosoma mansoni polyomavirus enhancer activator 3 pea3 0.0011 0.0009 0.0019
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0158 0.931
Schistosoma mansoni cpg binding protein 0.006 0.0312 0.0635
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0093 0.0514 0.1368
Brugia malayi Pre-SET motif family protein 0.0215 0.1259 0.9501
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0509 0.05
Leishmania major hypothetical protein, conserved 0.0035 0.0158 0.931
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0267 0.0258
Brugia malayi Transient-receptor-potential like protein 0.0037 0.017 0.1281
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0092 0.0509 0.05
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.009 0.0191
Mycobacterium leprae Probable pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.06 0.362 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.009 1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0022 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0158 0.0965
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.0008
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.033
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0015 0.0037 0.0028
Trichomonas vaginalis helicase, putative 0.0013 0.0022 0.0008
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0158 0.038
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0158 0.0965
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0321 0.0654
Mycobacterium tuberculosis Conserved protein 0.0035 0.0158 0.038
Mycobacterium tuberculosis Probable oxidoreductase 0.0093 0.0514 0.1368
Schistosoma mansoni transient receptor potential channel 0.0066 0.0347 0.0706
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.0138 0.0282
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0061 0.0052
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.033
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.0008
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0061 0.2739
Loa Loa (eye worm) fli-1 protein 0.0226 0.1325 1
Brugia malayi Ets-domain containing protein 0.0074 0.0398 0.3004
Loa Loa (eye worm) glutathione reductase 0.0037 0.0168 0.1208
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0061 0.0397
Brugia malayi glutathione reductase 0.0037 0.0168 0.1266
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0228 0.0446
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0321 0.0654
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0093 0.0514 0.1201
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0321 0.237
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0084 0.0456 0.1038
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0015 0.0037 0.0028
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0013 0.0021 0.0156
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0158 0.038
Brugia malayi RNA binding protein 0.0062 0.0321 0.2421
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0187 0.1089 0.2202
Plasmodium vivax SET domain protein, putative 0.0032 0.0138 0.7981
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.009 0.0191
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0013 0.0021 0.0024
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0321 0.237
Echinococcus granulosus cpg binding protein 0.006 0.0312 0.0617
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0347 0.0688
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.009 0.0191
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.0071
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0158 0.931
Brugia malayi CXXC zinc finger family protein 0.0057 0.0292 0.2201
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.0008
Schistosoma mansoni hypothetical protein 0.0174 0.1008 0.2053
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0228 0.0446
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0032 0.0138 0.0129
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0053 0.2146
Onchocerca volvulus 0.0035 0.0158 0.0506
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0061 0.2739
Mycobacterium tuberculosis Conserved protein 0.0035 0.0158 0.038
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0398 0.2957
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0019 0.0058 0.0049
Onchocerca volvulus 0.0035 0.0158 0.0506
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0092 0.0509 0.3795
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.0138 0.0129
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.009 0.0191
Onchocerca volvulus 0.0046 0.0228 0.1023
Schistosoma mansoni transient receptor potential channel 0.01 0.0553 0.1126
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0509 0.1019
Brugia malayi DNA-binding protein D-ETS-3 0.0011 0.0009 0.0066
Schistosoma mansoni ets 0.0011 0.0009 0.0019
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0061 0.046
Brugia malayi AMP-binding enzyme family protein 0.0024 0.009 0.0674
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0158 0.0321
Loa Loa (eye worm) CXXC zinc finger family protein 0.0057 0.0292 0.2149
Mycobacterium ulcerans hypothetical protein 0.0035 0.0158 0.038
Brugia malayi AMP-binding enzyme family protein 0.0024 0.009 0.0674
Mycobacterium ulcerans hypothetical protein 0.0024 0.009 0.0191
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0158 0.1131
Loa Loa (eye worm) hypothetical protein 0.0018 0.0053 0.033
Echinococcus multilocularis geminin 0.0174 0.1008 0.1
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0022 0.0008
Loa Loa (eye worm) hypothetical protein 0.0037 0.017 0.1223
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0061 0.0112
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.0008
Echinococcus granulosus dnaJ subfamily B 0.0811 0.4912 1
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0061 0.0284
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.1131
Brugia malayi Ets-domain containing protein 0.0074 0.0398 0.3004
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.1131
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.009 0.4666
Schistosoma mansoni ets-related 0.0011 0.0009 0.0019
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0022 0.0008
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.0071
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0013 0.0021 0.0043
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0509 0.1035
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0084 0.0456 0.1209
Loa Loa (eye worm) thioredoxin reductase 0.0037 0.0168 0.1208
Schistosoma mansoni cpg binding protein 0.0057 0.0292 0.0594
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0228 0.1023
Echinococcus granulosus TRP transient receptor potential channel 0.0037 0.017 0.0328
Toxoplasma gondii histone lysine methyltransferase SET1 0.0109 0.0611 0.1639
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0398 0.039
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0092 0.0509 0.1019
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.009 0.0191
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.1131
Brugia malayi Fli-1 protein 0.0226 0.1325 1
Mycobacterium ulcerans lipase LipD 0.0035 0.0158 0.038
Loa Loa (eye worm) hypothetical protein 0.0063 0.0326 0.241
Loa Loa (eye worm) hypothetical protein 0.0035 0.0158 0.1131
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0084 0.0456 0.1209
Brugia malayi AMP-binding enzyme family protein 0.0024 0.009 0.0674
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0022 0.0008
Loa Loa (eye worm) RNA binding protein 0.0062 0.0321 0.237
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0158 0.931
Brugia malayi TAR-binding protein 0.0062 0.0321 0.2421
Mycobacterium tuberculosis Conserved protein 0.0035 0.0158 0.038
Mycobacterium ulcerans pantoate--beta-alanine ligase 0.06 0.362 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0158 0.038
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0061 0.0106
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.009 0.4666
Onchocerca volvulus 0.0032 0.0138 0.0361
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0092 0.0509 0.3836
Plasmodium falciparum thioredoxin reductase 0.0037 0.0168 1
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0158 0.038
Leishmania major trypanothione reductase 0.0037 0.0168 1
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0321 0.0654
Schistosoma mansoni transient receptor potential channel 4 0.01 0.0553 0.1126
Mycobacterium tuberculosis Probable reductase 0.0084 0.0456 0.1209
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0158 0.931
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0509 0.1035
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0015 0.0037 0.0075
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0015 0.0037 0.0056
Echinococcus granulosus transient receptor potential gamma protein 0.01 0.0553 0.111
Schistosoma mansoni hypothetical protein 0.0174 0.1008 0.2053
Brugia malayi mbt repeat family protein 0.0046 0.0228 0.1716
Schistosoma mansoni cpg binding protein 0.006 0.0312 0.0635
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0158 0.0965
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.009 0.0191
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0158 0.0149
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.0008
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0158 0.0965
Toxoplasma gondii thioredoxin reductase 0.0037 0.0168 0.0408
Plasmodium vivax glutathione reductase, putative 0.0037 0.0168 1
Trypanosoma brucei trypanothione reductase 0.0037 0.0168 1
Mycobacterium ulcerans beta-lactamase 0.0035 0.0158 0.038
Brugia malayi beta-lactamase 0.0035 0.0158 0.1189
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0053 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0092 0.0509 0.1035
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.0138 0.0326
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0019 0.0058 0.01
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0061 0.0284
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0267 0.0258
Schistosoma mansoni ap endonuclease 0.0019 0.0061 0.0125
Toxoplasma gondii exonuclease III APE 0.0019 0.0061 0.0112
Loa Loa (eye worm) MBCTL1 0.0053 0.0267 0.196
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.0138 0.0282
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0022 0.0008
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0158 0.0193
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0053 0.0088
Echinococcus multilocularis transient receptor potential ion channel A 0.0096 0.0533 0.0524
Loa Loa (eye worm) hypothetical protein 0.0046 0.0228 0.1661
Mycobacterium leprae Probable lipase LipE 0.0035 0.0158 0.0193
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0047 0.0071
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0612
Mycobacterium tuberculosis Pantoate--beta-alanine ligase PanC (pantothenate synthetase) (pantoate activating enzyme) 0.06 0.362 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.015 0.1068
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.009 1
Plasmodium falciparum glutathione reductase 0.0037 0.0168 1
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0158 0.0303
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0061 1
Onchocerca volvulus 0.0057 0.0292 0.1499
Schistosoma mansoni ap endonuclease 0.0019 0.0061 0.0125
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.0013 0.0022 0.0008
Mycobacterium tuberculosis Probable dehydrogenase 0.0084 0.0456 0.1209
Plasmodium vivax thioredoxin reductase, putative 0.0037 0.0168 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.009 0.0191
Echinococcus granulosus thioredoxin glutathione reductase 0.0037 0.0171 0.033
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0158 0.038
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0061 1
Echinococcus granulosus mixed lineage leukemia protein mll 0.0015 0.0037 0.0056
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0061 0.2739
Onchocerca volvulus 0.0244 0.144 1
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0187 0.1089 0.108
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.009 0.0191
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0321 0.0312
Brugia malayi Pre-SET motif family protein 0.0032 0.0138 0.1042
Brugia malayi beta-lactamase family protein 0.0035 0.0158 0.1189
Brugia malayi transcription factor E74 isoform 0.0011 0.0009 0.0066
Echinococcus granulosus short transient receptor potential channel 6 0.0066 0.0347 0.0688
Toxoplasma gondii ABC1 family protein 0.0035 0.0158 0.038
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0053 0.0088
Brugia malayi Thioredoxin reductase 0.0037 0.0168 0.1266
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0037 0.0168 0.0408
Echinococcus multilocularis dnaJ subfamily B 0.0811 0.4912 0.4907
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0228 0.0464
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0267 0.0526
Trichomonas vaginalis conserved hypothetical protein 0.0013 0.0022 0.0008
Echinococcus granulosus geminin 0.0174 0.1008 0.2038
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0158 0.038
Trichomonas vaginalis esterase, putative 0.0035 0.0158 0.0965
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0612
Loa Loa (eye worm) histone methyltransferase 0.0019 0.0058 0.0371
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0061 0.2739
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0158 0.0965
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0228 0.1661
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0158 0.038
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0061 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.009 0.0191
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.009 1
Schistosoma mansoni ets-related 0.0226 0.1325 0.2698
Loa Loa (eye worm) hypothetical protein 0.0024 0.009 0.0612
Echinococcus multilocularis transient receptor potential gamma protein 0.01 0.0553 0.0545
Loa Loa (eye worm) hypothetical protein 0.0053 0.0267 0.196
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0215 0.1259 0.9497
Trichomonas vaginalis set domain proteins, putative 0.0244 0.144 1
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.0013 0.0022 0.0008
Onchocerca volvulus 0.0035 0.0158 0.0506
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0347 0.0338
Echinococcus multilocularis short transient receptor potential channel 6 0.0066 0.0347 0.0338
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0168 1
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0228 0.0464
Brugia malayi beta-lactamase family protein 0.0035 0.0158 0.1189
Loa Loa (eye worm) beta-lactamase 0.0035 0.0158 0.1131
Schistosoma mansoni hypothetical protein 0.0811 0.4912 1
Echinococcus multilocularis thioredoxin glutathione reductase 0.0037 0.0171 0.0162
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.009 0.4666
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0267 0.0544

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.