Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.4117 | 1 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.3387 | 1 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0031 | 0.0049 | 0.0075 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0098 | 0.2513 | 0.3855 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0049 | 0.0119 |
Echinococcus granulosus | GPCR family 2 | 0.0031 | 0.0049 | 0.0144 |
Brugia malayi | MH2 domain containing protein | 0.0116 | 0.3155 | 0.4841 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0302 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0159 | 0.4751 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0031 | 0.0049 | 0.0075 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0302 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0049 | 0.0119 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0067 | 0.1372 | 0.2105 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0116 | 0.3155 | 0.4841 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0098 | 0.2513 | 0.3855 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0049 | 0.0119 |
Schistosoma mansoni | thyroid hormone receptor | 0.0142 | 0.4117 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0049 | 0.0144 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0116 | 0.3155 | 0.4841 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0031 | 0.0049 | 0.0144 |
Onchocerca volvulus | 0.0236 | 0.757 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0049 | 0.0119 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0031 | 0.0049 | 0.0075 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0.0697 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.3387 | 0.8225 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0159 | 0.4751 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0049 | 0.0075 |
Schistosoma mansoni | hypothetical protein | 0.0031 | 0.0049 | 0.0119 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.3387 | 0.8225 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0207 | 0.6518 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0098 | 0.2513 | 0.3855 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.1372 | 0.3333 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0143 | 0.4158 | 0.3871 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0031 | 0.0049 | 0.0119 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0052 | 0.0809 | 0.0358 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.2513 | 0.3855 |
Plasmodium vivax | SET domain protein, putative | 0.003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.1372 | 0.2105 |
Trichomonas vaginalis | set domain proteins, putative | 0.0236 | 0.757 | 0.5 |
Brugia malayi | Pre-SET motif family protein | 0.0207 | 0.6518 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0143 | 0.4158 | 0.3871 |
Echinococcus multilocularis | GPCR, family 2 | 0.0031 | 0.0049 | 0.0119 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0302 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0142 | 0.4117 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.