Detailed information for compound 666847

Basic information

Technical information
  • TDR Targets ID: 666847
  • Name: N-(2-fluorophenyl)-2-[(4-methyl-1,2,4-triazol -3-yl)sulfanyl]acetamide
  • MW: 266.295 | Formula: C11H11FN4OS
  • H donors: 1 H acceptors: 3 LogP: 1.27 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1F)CSc1nncn1C
  • InChi: 1S/C11H11FN4OS/c1-16-7-13-15-11(16)18-6-10(17)14-9-5-3-2-4-8(9)12/h2-5,7H,6H2,1H3,(H,14,17)
  • InChiKey: MYZFWUIDLAUZPJ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • N-(2-fluorophenyl)-2-[(4-methyl-1,2,4-triazol-3-yl)thio]acetamide
  • N-(2-fluorophenyl)-2-[(4-methyl-1,2,4-triazol-3-yl)sulfanyl]ethanamide
  • AG-205/13322016
  • MLS000685093
  • N-(2-fluorophenyl)-2-[(4-methyl-4H-1,2,4-triazol-3-yl)thio]acetamide
  • SMR000291772
  • A2144/0090031
  • ZINC00082346

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3D Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0329 1
Mycobacterium ulcerans hypothetical protein 0.0024 0.0097 0.0299
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0047 0.0047
Onchocerca volvulus 0.0182 0.1091 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.0118 0.0354
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0047 0.0047
Echinococcus granulosus smad 0.0016 0.0049 0.1486
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0012 0.0025
Schistosoma mansoni ap endonuclease 0.0038 0.0184 0.5609
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0171
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.001 0.0012 0.0025
Brugia malayi ecdysteroid receptor 0.001 0.0012 0.0025
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0012 0.0012
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0012 0.0012
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0012 0.0025
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0012 0.0368
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0025
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.027 0.0833
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0049 0.0139
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0012 0.0012
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0184 0.0557
Schistosoma mansoni smad1 5 8 and 0.0016 0.0049 0.1486
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0097 0.0299
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0072
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.027 0.0833
Echinococcus granulosus FTZ F1 alpha 0.001 0.0012 0.0368
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0329 0.1014
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0047 0.0047
Echinococcus granulosus mitogen activated protein kinase 0.0051 0.027 0.8212
Brugia malayi MH1 domain containing protein 0.0016 0.0049 0.0139
Brugia malayi intermediate filament protein 0.0027 0.0118 0.0354
Echinococcus granulosus lamin dm0 0.0027 0.0118 0.3606
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0051 0.027 0.0827
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.1424 0.4386
Toxoplasma gondii Branched-chain-amino-acid aminotransferase 0.0526 0.3241 1
Schistosoma mansoni ap endonuclease 0.0038 0.0184 0.5609
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.001 0.0012 0.0025
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0012 0.0025
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0047 0.0508
Echinococcus multilocularis lamin 0.0027 0.0118 0.0118
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0047 0.0146
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0184 0.5609
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0039 0.011
Toxoplasma gondii hypothetical protein 0.0151 0.0893 0.2649
Echinococcus multilocularis smad 0.0016 0.0049 0.0049
Schistosoma mansoni nuclear hormone receptor 0.001 0.0012 0.0368
Schistosoma mansoni thyroid hormone receptor 0.001 0.0012 0.0368
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0184 1
Brugia malayi isocitrate dehydrogenase 0.0016 0.0047 0.0134
Mycobacterium tuberculosis Probable amino acid aminotransferase 0.0151 0.0893 0.2757
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.027 0.0833
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0184 0.162
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0025
Leishmania major hypothetical protein, conserved 0.0151 0.0893 0.2752
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0184 0.0569
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.001 0.0012 0.0025
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0097 0.0293
Brugia malayi steroid hormone receptor 0.001 0.0012 0.0025
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0012 0.0012
Brugia malayi MH2 domain containing protein 0.0236 0.1424 0.4386
Brugia malayi MH1 domain containing protein 0.0016 0.0049 0.0139
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0012 0.0025
Schistosoma mansoni smad1 5 8 and 0.0016 0.0049 0.1486
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0012 0.0025
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0184 0.0429
Loa Loa (eye worm) hypothetical protein 0.0013 0.0027 0.0072
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0329 0.1014
Trypanosoma cruzi Aminotransferase class IV, putative 0.0151 0.0893 1
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0047 0.0047
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0012 0.0025
Echinococcus multilocularis mitogen activated protein kinase 0.0051 0.027 0.027
Mycobacterium leprae PROBABLE BRANCHED-CHAIN AMINO ACID TRANSAMINASE ILVE 0.0526 0.3241 1
Brugia malayi MH2 domain containing protein 0.0016 0.0049 0.0139
Echinococcus granulosus intermediate filament protein 0.0027 0.0118 0.3606
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.001 0.0012 0.0025
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0038 0.0184 0.0569
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0012 0.0368
Loa Loa (eye worm) hypothetical protein 0.0024 0.0097 0.0287
Plasmodium vivax aminodeoxychorismate lyase, putative 0.0151 0.0893 1
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0012 0.0368
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0012 0.0368
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0097 0.0293
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0012 0.0025
Trypanosoma brucei Aminotransferase class IV, putative 0.0151 0.0893 0.2649
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0097 0.0299
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0013 0.003 0.0082
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0012 0.0368
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0053 0.0164
Echinococcus multilocularis mitogen activated protein kinase 3 0.0051 0.027 0.027
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0012 0.0025
Brugia malayi hypothetical protein 0.0182 0.1091 0.3358
Onchocerca volvulus 0.0024 0.0097 0.0785
Echinococcus granulosus TGF beta signal transducer SmadC 0.0016 0.0049 0.1486
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0051 0.027 0.0827
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0012 0.0025
Loa Loa (eye worm) Smad1 0.0016 0.0049 0.0139
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0097 0.0287
Echinococcus multilocularis mothers against decapentaplegic 5 0.0016 0.0049 0.0049
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0012 0.0012
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0061 0.0329 0.1014
Leishmania major 4-coumarate:coa ligase-like protein 0.0024 0.0097 0.0293
Loa Loa (eye worm) hypothetical protein 0.0024 0.0097 0.0287
Giardia lamblia Hypothetical protein 0.0151 0.0893 0.232
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0053 0.0164
Trichomonas vaginalis CMGC family protein kinase 0.0051 0.027 0.0833
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0012 0.0025
Leishmania major branched-chain amino acid aminotransferase, putative 0.0526 0.3241 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0012 0.0025
Mycobacterium ulcerans branched-chain amino acid aminotransferase 0.0526 0.3241 1
Loa Loa (eye worm) steroid hormone receptor 0.001 0.0012 0.0025
Schistosoma mansoni serine/threonine protein kinase 0.0051 0.027 0.8212
Entamoeba histolytica branched-chain amino acid aminotransferase, putative 0.0526 0.3241 1
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0047 0.0134
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.001 0.0012 0.0025
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0184 0.0569
Plasmodium falciparum acyl-CoA synthetase 0.0018 0.0059 0.0142
Echinococcus multilocularis Smad4 0.0016 0.0049 0.0049
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0053 0.0164
Mycobacterium tuberculosis Branched-chain amino acid transaminase IlvE 0.0526 0.3241 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0012 0.0368
Brugia malayi nuclear hormone receptor 0.001 0.0012 0.0025
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0018 0.0059 0.0183
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0184 0.0557
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0049 0.1486
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0047 0.1439
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0047 0.0134
Plasmodium falciparum aminodeoxychorismate lyase 0.0151 0.0893 1
Schistosoma mansoni intermediate filament proteins 0.0027 0.0118 0.3606
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0012 0.0368
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0118 0.0354
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0012 0.0368
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0171
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0049 0.0139
Trichomonas vaginalis branched-chain amino acid aminotransferase, putative 0.0526 0.3241 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0061 0.0329 1
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0051 0.027 0.0822
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0047 0.014
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0051 0.027 0.3005
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0184 0.0569
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.001 0.0012 0.0025
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0184 0.162
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0097 0.0299
Schistosoma mansoni smad 0.0016 0.0049 0.1486
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0171
Brugia malayi Smad1 0.0016 0.0049 0.0139
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0118 0.0354
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0097 0.0287
Loa Loa (eye worm) hypothetical protein 0.0027 0.0115 0.0344
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.027 0.3005
Brugia malayi MH2 domain containing protein 0.0016 0.0049 0.0139
Trypanosoma brucei branched-chain amino acid aminotransferase, putative 0.0526 0.3241 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0012 0.0012
Trypanosoma brucei branched-chain amino acid aminotransferase, putative 0.0526 0.3241 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0061 0.0329 0.1008
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0012 0.0025
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0025
Schistosoma mansoni aldehyde dehydrogenase 0.0061 0.0329 1
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0025
Giardia lamblia Kinase, CMGC MAPK 0.0051 0.027 0.028
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0025
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0012 0.0368
Echinococcus multilocularis musashi 0.0027 0.0118 0.0118
Brugia malayi Branched-chain amino acid aminotransferase, cytosolic, putative 0.0526 0.3241 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.001 0.0012 0.0025
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0184 0.2045
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0012 0.0012
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0097 0.0299
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0012 0.0368
Mycobacterium ulcerans aldehyde dehydrogenase 0.0061 0.0329 0.1014
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0012 0.0368
Onchocerca volvulus 0.0027 0.0118 0.0986
Schistosoma mansoni Smad4 0.0016 0.0049 0.1486
Schistosoma mansoni smad1 5 8 and 0.0016 0.0049 0.1486
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0012 0.0368
Echinococcus granulosus mothers against decapentaplegic 5 0.0016 0.0049 0.1486
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0012 0.0012
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0097 0.0299
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0012 0.0368
Echinococcus granulosus lamin 0.0027 0.0118 0.3606
Brugia malayi cytoplasmic intermediate filament protein 0.0015 0.0039 0.011
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0047 0.1439
Toxoplasma gondii exonuclease III APE 0.0038 0.0184 0.0429
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0097 0.0299
Loa Loa (eye worm) hypothetical protein 0.0024 0.0097 0.0287
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0171
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0017 0.0053 0.0164
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0018 0.0059 0.0183
Brugia malayi nuclear receptor NHR-88 0.001 0.0012 0.0025
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0012 0.0025
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0051 0.027 0.0697
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0097 0.0299
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.1424 0.4386
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0016 0.0049 0.0049
Echinococcus granulosus mitogen activated protein kinase 3 0.0051 0.027 0.8212
Brugia malayi MAP kinase sur-1 0.0051 0.027 0.0822
Schistosoma mansoni thyroid hormone receptor 0.001 0.0012 0.0368
Echinococcus granulosus Smad4 0.0016 0.0049 0.1486
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0024 0.0097 0.0299
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0012 0.0368
Loa Loa (eye worm) hypothetical protein 0.0182 0.1091 0.3358
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0012 0.0368
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0097 0.0299
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0025
Echinococcus multilocularis lamin dm0 0.0027 0.0118 0.0118
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0047 0.0508
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0012 0.0368
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0013 0.003 0.003
Loa Loa (eye worm) hypothetical protein 0.001 0.0012 0.0025
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0013 0.003 0.0926
Giardia lamblia Branched-chain amino acid aminotransferase lateral transfer candidate 0.0526 0.3241 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0097 0.0299
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0051 0.027 0.3005
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0012 0.0025
Loa Loa (eye worm) hypothetical protein 0.0018 0.0059 0.0171
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0118 0.0354
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0012 0.0012
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0051 0.027 0.0697
Onchocerca volvulus 0.0027 0.0118 0.0986
Schistosoma mansoni lamin 0.0027 0.0118 0.3606
Loa Loa (eye worm) branched-chain amino acid aminotransferase 0.0526 0.3241 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0012 0.0025
Trypanosoma brucei protein kinase, putative 0.0051 0.027 0.0697
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0018 0.0059 0.5
Mycobacterium ulcerans 4-amino-4-deoxychorismate lyase 0.0151 0.0893 0.2757
Trypanosoma brucei branched-chain amino acid aminotransferase, putative 0.0526 0.3241 1
Schistosoma mansoni lamin 0.0027 0.0118 0.3606
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0097 0.0299
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0184 0.0184
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0184 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0061 0.0329 0.0329
Schistosoma mansoni coup transcription factor 0.001 0.0012 0.0368
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0097 0.0287
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0012 0.0025
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0012 0.0368
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0184 0.2045
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0184 0.0278
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0184 0.0563
Plasmodium vivax acyl-CoA synthetase, putative 0.0018 0.0059 0.0142
Trichomonas vaginalis subgroup IIIi aminotransferase, putative 0.0526 0.3241 1
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0051 0.027 0.3005
Toxoplasma gondii aldehyde dehydrogenase 0.0061 0.0329 0.0881

Activities

Activity type Activity value Assay description Source Reference
Potency (functional) 3.5481 uM PUBCHEM_BIOASSAY: qHTS for Inhibitors of Vif-A3F Interactions: qHTS. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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