Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA binding protein | 0.0063 | 0.2513 | 0.2513 |
Echinococcus granulosus | cytochrome B | 0.0203 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0019 | 0.0149 | 0.0149 |
Wolbachia endosymbiont of Brugia malayi | cytochrome b subunit of the bc complex | 0.0203 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2513 | 0.2513 |
Toxoplasma gondii | cytochrome b | 0.0203 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0149 | 0.0149 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0019 | 0.0149 | 0.0149 |
Trypanosoma brucei | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 0.0989 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0.0149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.1916 | 0.1916 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0019 | 0.0149 | 0.0593 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0149 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.1916 | 0.1916 |
Brugia malayi | RNA binding protein | 0.0063 | 0.2513 | 0.2513 |
Plasmodium falciparum | cytochrome b | 0.0203 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0019 | 0.0149 | 0.0149 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.1029 | 0.1029 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2513 | 0.2513 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.1029 | 0.1029 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2513 | 0.2513 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 0.0989 | 1 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0.0149 | 0.5 |
Schistosoma mansoni | cytochrome b | 0.0203 | 1 | 1 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0035 | 0.0989 | 0.0989 |
Echinococcus granulosus | tar DNA binding protein | 0.0063 | 0.2513 | 0.2513 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0019 | 0.0149 | 0.0149 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0.0149 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.1029 | 0.1029 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0.0149 | 0.5 |
Toxoplasma gondii | apocytochrome b, putative | 0.0203 | 1 | 1 |
Echinococcus multilocularis | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.0989 | 0.3933 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0063 | 0.2513 | 0.2513 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0035 | 0.0989 | 0.0852 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2513 | 0.2513 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0.0989 | 1 |
Trypanosoma cruzi | ERV/ALR sulfhydryl oxidase domain-containing protein | 0.0035 | 0.0989 | 1 |
Toxoplasma gondii | Erv1 / Alr family protein | 0.0035 | 0.0989 | 0.0852 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.1916 | 0.1916 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.1916 | 0.1916 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0063 | 0.2513 | 0.2513 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0035 | 0.0989 | 0.0852 |
Schistosoma mansoni | cytochrome b | 0.0203 | 1 | 1 |
Loa Loa (eye worm) | TAR-binding protein | 0.0063 | 0.2513 | 0.2513 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0.0149 | 0.5 |
Brugia malayi | Augmenter of liver regeneration | 0.0035 | 0.0989 | 0.0989 |
Plasmodium vivax | cytochrome b | 0.0203 | 1 | 1 |
Loa Loa (eye worm) | cytochrome b | 0.0203 | 1 | 1 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0.0149 | 0.5 |
Echinococcus granulosus | FAD linked sulfhydryl oxidase ALR | 0.0035 | 0.0989 | 0.0989 |
Echinococcus multilocularis | tar DNA binding protein | 0.0063 | 0.2513 | 1 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0035 | 0.0989 | 0.0852 |
Schistosoma mansoni | tar DNA-binding protein | 0.0063 | 0.2513 | 0.2513 |
Brugia malayi | TAR-binding protein | 0.0063 | 0.2513 | 0.2513 |
Trypanosoma cruzi | Present in the outer mitochondrial membrane proteome 4 | 0.0035 | 0.0989 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.