Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1904 | 0.1904 |
Echinococcus granulosus | GPCR family 2 | 0.0047 | 0.1904 | 0.1904 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.5563 | 0.6383 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.1904 | 0.1904 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1788 | 0.1788 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1788 | 0.1788 |
Toxoplasma gondii | exonuclease III APE | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0101 | 0.5563 | 0.5563 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1788 | 0.1788 |
Onchocerca volvulus | Bile acid receptor homolog | 0.013 | 0.7467 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1904 | 0.1904 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0148 | 0.8715 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0167 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.7467 | 0.8567 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0019 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0148 | 0.8715 | 1 |
Brugia malayi | ecdysteroid receptor | 0.013 | 0.7467 | 0.8567 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0148 | 0.8715 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0148 | 0.8715 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1904 | 0.1904 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.1788 | 0.1788 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0101 | 0.5563 | 0.6383 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1788 | 0.1788 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.1788 | 0.2052 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0019 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0019 | 0 | 0.5 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0047 | 0.1904 | 0.2185 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | GPCR, family 2 | 0.0047 | 0.1904 | 0.1904 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0047 | 0.1904 | 0.2185 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0047 | 0.1904 | 0.1904 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.1788 | 0.1788 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1904 | 0.2185 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.1904 | 0.1904 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.1788 | 0.1788 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0047 | 0.1904 | 0.1904 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0019 | 0 | 0.5 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.1788 | 0.2052 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0047 | 0.1904 | 0.2185 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0167 | 1 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0047 | 0.1904 | 0.1904 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 83.4 uM | Antiproliferative activity against estrogen receptor positive human MCF7 cells after 72 hrs by MTT assay | ChEMBL. | 18666770 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.