Detailed information for compound 667204

Basic information

Technical information
  • TDR Targets ID: 667204
  • Name: 2-(4-bromo-2-methylphenoxy)-1-[4-(2-methoxyph enyl)piperazin-1-yl]ethanone
  • MW: 419.312 | Formula: C20H23BrN2O3
  • H donors: 0 H acceptors: 1 LogP: 4.04 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1CCN(CC1)C(=O)COc1ccc(cc1C)Br
  • InChi: 1S/C20H23BrN2O3/c1-15-13-16(21)7-8-18(15)26-14-20(24)23-11-9-22(10-12-23)17-5-3-4-6-19(17)25-2/h3-8,13H,9-12,14H2,1-2H3
  • InChiKey: WEVUVEYQHBIHGY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 2-(4-bromo-2-methyl-phenoxy)-1-[4-(2-methoxyphenyl)piperazin-1-yl]ethanone
  • 2-(4-bromo-2-methylphenoxy)-1-[4-(2-methoxyphenyl)-1-piperazinyl]ethanone
  • ZINC01160088
  • STK203858

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear receptor nhr-48 0.0019 0.0035 0.0035
Onchocerca volvulus 0.0187 0.1015 0.2455
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0025 0.007 0.007
Onchocerca volvulus Bile acid receptor homolog 0.004 0.0157 0.0306
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0157 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0146 0.1217
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0148 0.0789 0.2021
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0016 0.0021 0.0021
Brugia malayi nuclear receptor RXR 0.0021 0.0048 0.0124
Schistosoma mansoni hypothetical protein 0.0025 0.007 0.007
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0038 0.0146 0.5583
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Loa Loa (eye worm) hypothetical protein 0.0021 0.0048 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0157 0.0403
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.009 0.0748
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0038 0.0146 0.0146
Loa Loa (eye worm) DR-78 0.0019 0.0035 0.009
Loa Loa (eye worm) transcription factor SMAD2 0.0187 0.1017 0.2606
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0048 0.0124
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0029 0.0131
Loa Loa (eye worm) hypothetical protein 0.0021 0.0048 0.0124
Leishmania major DNA polymerase eta, putative 0.0016 0.0021 0.079
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0025 0.0072 0.0517
Brugia malayi steroid hormone receptor 0.004 0.0157 0.0403
Echinococcus multilocularis microtubule associated protein 2 0.1728 1 1
Brugia malayi hypothetical protein 0.0021 0.0048 0.0124
Echinococcus multilocularis Smad4 0.0013 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0028 0.0087 0.0223
Mycobacterium ulcerans phosphotyrosine protein phosphatase PtpA 0.0187 0.1015 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.009 0.0748
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0045 0.0375
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0072 0.2755
Brugia malayi hypothetical protein 0.0019 0.0035 0.009
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0148 0.0789 0.2021
Toxoplasma gondii target of rapamycin (TOR), putative 0.0028 0.009 0.0557
Brugia malayi Nuclear hormone receptor family member nhr-1 0.004 0.0157 0.0403
Schistosoma mansoni hypothetical protein 0.0029 0.0093 0.0093
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0035 0.0035
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0157 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0045 0.0375
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Brugia malayi Steroid receptor seven-up type 2 0.004 0.0157 0.0403
Loa Loa (eye worm) Smad1 0.0013 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0157 0.0157
Giardia lamblia GTOR 0.0038 0.0146 0.1262
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0021 0.079
Schistosoma mansoni retinoid-x-receptor (RXR) 0.004 0.0157 0.0157
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0035 0.009
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0021 0.079
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.0789 0.0789
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0146 0.1217
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.0789 0.0789
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.004 0.0157 0.0157
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0072 0.0185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0056 0.0469
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.079
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0019 0.0035 0.0035
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.0789 0.0789
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0038 0.0146 0.1262
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.004 0.0157 0.0403
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0019 0.0035 0.0035
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0038 0.0146 0.0146
Loa Loa (eye worm) hypothetical protein 0.004 0.0157 0.0403
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.004 0.0157 0.0157
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0019 0.0035 0.009
Loa Loa (eye worm) hypothetical protein 0.004 0.0157 0.0403
Brugia malayi nuclear receptor RXR 0.0019 0.0035 0.009
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0029 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.009 0.0748
Brugia malayi Pre-SET motif family protein 0.0028 0.0087 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.009 0.0748
Onchocerca volvulus 0.0028 0.0087 0.013
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.004 0.0157 0.0157
Brugia malayi MH2 domain containing protein 0.0013 0.0001 0.0001
Entamoeba histolytica hypothetical protein 0.0029 0.0093 0.0726
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0021 0.079
Plasmodium vivax SET domain protein, putative 0.0028 0.0087 0.5001
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0703 0.4027 1
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0038 0.0146 0.1262
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0157 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0101 0.0842
Loa Loa (eye worm) hypothetical protein 0.0025 0.0072 0.0185
Echinococcus granulosus ecdysone induced protein 78C 0.004 0.0157 0.0157
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0187 0.1015 0.8447
Brugia malayi Pre-SET motif family protein 0.0192 0.1047 0.2682
Loa Loa (eye worm) phosphotyrosine protein phosphatase 0.0187 0.1015 0.26
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0101 0.0842
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0072 0.0517
Echinococcus granulosus FTZ F1 alpha 0.004 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.0664 0.3796 0.9721
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0072 0.2755
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0038 0.0146 0.5583
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0025 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0053 0.0238 0.0609
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0072 0.0517
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0187 0.1015 0.8447
Echinococcus granulosus nuclear receptor nhr 48 0.0019 0.0035 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Brugia malayi Nuclear hormone receptor family member nhr-25 0.004 0.0157 0.0403
Brugia malayi Nuclear hormone receptor family member nhr-19 0.004 0.0157 0.0403
Brugia malayi Nuclear hormone receptor family member nhr-3 0.004 0.0157 0.0403
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0029 0.0131
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0036 0.0139 0.0139
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0101 0.0842
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Echinococcus granulosus smad 0.0013 0.0001 0.0001
Schistosoma mansoni family C48 unassigned peptidase (C48 family) 0.0036 0.0139 0.0139
Echinococcus granulosus retinoic acid receptor rxr beta a 0.004 0.0157 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.009 0.0748
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0018 0.003 0.1156
Loa Loa (eye worm) hypothetical protein 0.004 0.0157 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.009 0.0748
Brugia malayi MH1 domain containing protein 0.0013 0.0001 0.0001
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0019 0.0035 0.0146
Schistosoma mansoni transcription factor LCR-F1 0.0029 0.0093 0.0093
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0045 0.0375
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.004 0.0157 0.0157
Loa Loa (eye worm) nuclear receptor NHR-67 0.0019 0.0035 0.009
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0148 0.0789 0.0789
Schistosoma mansoni hypothetical protein 0.0025 0.007 0.007
Loa Loa (eye worm) hypothetical protein 0.0078 0.0382 0.0978
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0021 0.0048 0.0048
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0038 0.0146 0.5583
Loa Loa (eye worm) MH1 domain-containing protein 0.0013 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.0025 0.0072 0.0185
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0021 0.0048 0.0124
Brugia malayi Ulp1 protease family, C-terminal catalytic domain containing protein 0.0036 0.0139 0.0355
Leishmania major DNA polymerase kappa, putative 0.0016 0.0021 0.079
Schistosoma mansoni RAR-like nuclear receptor 0.004 0.0157 0.0157
Brugia malayi nuclear receptor NHR-88 0.004 0.0157 0.0403
Brugia malayi ecdysteroid receptor 0.004 0.0157 0.0403
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Echinococcus granulosus TGF beta signal transducer SmadC 0.0013 0.0001 0.0001
Leishmania major hypothetical protein, conserved 0.0058 0.0262 1
Schistosoma mansoni nuclear hormone receptor 0.004 0.0157 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0045 0.0373
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.004 0.0157 0.0403
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0025 0.007 0.007
Brugia malayi nuclear hormone receptor 0.0682 0.3905 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0058 0.048
Brugia malayi Smad1 0.0013 0.0001 0.0001
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.004 0.0157 0.0403
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0035 0.0035
Brugia malayi Nuclear hormone receptor E75 0.0019 0.0035 0.009
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0029 0.0131
Brugia malayi latrophilin 2 splice variant baaae 0.0053 0.0238 0.0609
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0016 0.0021 0.079
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.079
Loa Loa (eye worm) hypothetical protein 0.004 0.0157 0.0403
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.0789 0.0789
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0045 0.0373
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0187 0.1015 0.8447
Brugia malayi nuclear receptor NHR-88 0.0019 0.0035 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.079
Trypanosoma brucei DNA polymerase eta, putative 0.0016 0.0021 0.079
Entamoeba histolytica hypothetical protein 0.0029 0.0093 0.0726
Brugia malayi hypothetical protein 0.0019 0.0035 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.079
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0262 1
Onchocerca volvulus 0.004 0.0157 0.0306
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0025 0.0072 0.0517
Onchocerca volvulus 0.0042 0.0168 0.0334
Schistosoma mansoni hypothetical protein 0.0025 0.007 0.007
Echinococcus multilocularis dna polymerase eta 0.0016 0.0021 0.0021
Trypanosoma brucei target of rapamycin kinase 3, putative 0.003 0.0101 0.3871
Loa Loa (eye worm) hypothetical protein 0.004 0.0157 0.0403
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.079
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0021 0.0048 0.0048
Echinococcus granulosus histone lysine methyltransferase setb 0.0028 0.0087 0.0087
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.004 0.0157 0.0157
Onchocerca volvulus 0.0219 0.1202 0.2923
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.004 0.0157 0.0403
Leishmania major 4-coumarate:coa ligase-like protein 0.0025 0.0072 0.2755
Giardia lamblia Low molecular weight protein-tyrosine-phosphatase 0.0187 0.1015 1
Echinococcus multilocularis tumor protein p63 0.0284 0.158 0.158
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Schistosoma mansoni steroid hormone receptor ad4bp 0.004 0.0157 0.0157
Schistosoma mansoni hypothetical protein 0.0053 0.0238 0.0238
Plasmodium falciparum sentrin-specific protease 1 0.0036 0.0139 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0029 0.0093 0.0093
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0021 0.079
Loa Loa (eye worm) hypothetical protein 0.0025 0.0072 0.0185
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.004 0.0157 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.009 0.0748
Brugia malayi Low molecular weight phosphotyrosine protein phosphatase containing protein 0.0187 0.1015 0.26
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0146 0.1217
Schistosoma mansoni Smad4 0.0013 0.0001 0.0001
Entamoeba histolytica Ulp1 protease family, C-terminal catalytic domain containing protein 0.0036 0.0139 0.1186
Brugia malayi Nuclear hormone receptor-like 1 0.0021 0.0048 0.0124
Schistosoma mansoni smad1 5 8 and 0.0013 0.0001 0.0001
Echinococcus granulosus nuclear receptor 2DBD gamma 0.004 0.0157 0.0157
Brugia malayi nuclear hormone receptor family member odr-7 0.0019 0.0035 0.009
Schistosoma mansoni hypothetical protein 0.0025 0.007 0.007
Entamoeba histolytica hypothetical protein 0.0029 0.0093 0.0726
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0025 0.0072 0.0781
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0101 0.0842
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0028 0.0087 0.0087
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0078 0.0382 0.0978
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0021 0.0053
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0013 0.0001 0.0001
Brugia malayi photoreceptor-specific nuclear receptor 0.004 0.0157 0.0403
Trypanosoma brucei low molecular weight protein tyrosine phosphatase, putative 0.0058 0.0262 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0025 0.007 0.007
Onchocerca volvulus Protein ultraspiracle homolog 0.004 0.0157 0.0306
Echinococcus granulosus GPCR family 2 0.0025 0.007 0.007
Schistosoma mansoni terminal deoxycytidyl transferase 0.0016 0.0021 0.0021
Echinococcus granulosus dna polymerase kappa 0.0016 0.0021 0.0021
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0148 0.0789 0.0789
Brugia malayi Nuclear hormone receptor-like 1 0.004 0.0157 0.0403
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Brugia malayi Nuclear hormone receptor family member nhr-14 0.004 0.0157 0.0403
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0058 0.048
Brugia malayi conserved hypotetical protein 0.0019 0.0035 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.079
Echinococcus granulosus thyroid hormone receptor alpha 0.0019 0.0035 0.0035
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.004 0.0157 0.0157
Loa Loa (eye worm) hypothetical protein 0.004 0.0157 0.0403
Schistosoma mansoni nuclear receptor 0.0019 0.0035 0.0035
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.079
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0016 0.0018 0.0672
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0025 0.0072 0.0517
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.004 0.0157 0.0403
Toxoplasma gondii Ulp1 protease family, C-terminal catalytic domain-containing protein 0.0036 0.0139 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Echinococcus granulosus dna polymerase eta 0.0016 0.0021 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0023 0.0058 0.048
Echinococcus granulosus mothers against decapentaplegic 5 0.0013 0.0001 0.0001
Onchocerca volvulus 0.0025 0.0072 0.0093
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.004 0.0157 0.0403
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0038 0.0146 0.5583
Loa Loa (eye worm) hypothetical protein 0.0021 0.0048 0.0124
Echinococcus multilocularis smad 0.0013 0.0001 0.0001
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0038 0.0146 0.0146
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0019 0.0035 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0021 0.0053
Loa Loa (eye worm) MH2 domain-containing protein 0.0013 0.0001 0.0001
Brugia malayi Latrophilin receptor protein 2 0.0025 0.007 0.018
Trichomonas vaginalis low molecular weight protein-tyrosine-phosphatase, putative 0.0187 0.1015 0.8447
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0682 0.3905 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0078 0.0382 0.0978
Mycobacterium ulcerans hypothetical protein 0.0025 0.0072 0.0517
Trypanosoma cruzi target of rapamycin kinase 3 0.003 0.0101 0.3871
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0192 0.1047 0.2682
Trichomonas vaginalis PIKK family atypical protein kinase 0.0025 0.0074 0.0614
Echinococcus granulosus sentrin specific protease 1 0.0036 0.0139 0.0139
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0038 0.0146 0.0375
Brugia malayi tailless protein 0.0019 0.0035 0.009
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.004 0.0157 0.0403
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0035 0.0035
Loa Loa (eye worm) MH2 domain-containing protein 0.0187 0.1017 0.2606
Echinococcus multilocularis nuclear receptor nhr 48 0.0019 0.0035 0.0035
Brugia malayi hypothetical protein 0.0029 0.0093 0.0238
Brugia malayi Calcitonin receptor-like protein seb-1 0.0078 0.0382 0.0978
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0101 0.0842
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0021 0.0048 0.0048
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Schistosoma mansoni coup transcription factor 0.004 0.0157 0.0157
Brugia malayi nuclear hormone receptor 0.004 0.0157 0.0403
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.004 0.0157 0.0403
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0016 0.0021 0.0172
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.004 0.0157 0.0157
Trichomonas vaginalis PIKK family atypical protein kinase 0.0022 0.0056 0.0469
Trypanosoma cruzi DNA polymerase eta, putative 0.0016 0.0021 0.079
Trypanosoma brucei DNA polymerase IV, putative 0.0016 0.0021 0.079
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0187 0.1015 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0072 0.0517
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.004 0.0157 0.0157
Trypanosoma brucei unspecified product 0.0016 0.0021 0.079
Loa Loa (eye worm) hypothetical protein 0.0021 0.0048 0.0124
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0072 0.0185
Loa Loa (eye worm) hypothetical protein 0.0042 0.0168 0.0431
Loa Loa (eye worm) hypothetical protein 0.0036 0.0139 0.0355
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0016 0.0021 0.0021
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0019 0.0035 0.0035
Entamoeba histolytica hypothetical protein 0.0029 0.0093 0.0726
Brugia malayi orphan nuclear receptor NR2E1 0.0019 0.0035 0.009
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.079
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0045 0.0373
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0148 0.0789 0.0789
Schistosoma mansoni DNA polymerase eta 0.0016 0.0021 0.0021
Loa Loa (eye worm) latrophilin receptor protein 2 0.0025 0.007 0.018
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0027 0.0081 0.0081
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0038 0.0146 0.5583
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0018 0.0029 0.0131
Echinococcus multilocularis FTZ F1 alpha 0.004 0.0157 0.0157
Brugia malayi AMP-binding enzyme family protein 0.0025 0.0072 0.0185
Loa Loa (eye worm) hypothetical protein 0.004 0.0157 0.0403
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0072 0.5
Brugia malayi Nuclear hormone receptor family member nhr-49 0.004 0.0157 0.0403
Echinococcus multilocularis mothers against decapentaplegic 5 0.0013 0.0001 0.0001
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0019 0.0035 0.0035
Schistosoma mansoni thyroid hormone receptor 0.004 0.0157 0.0157
Echinococcus multilocularis dna polymerase kappa 0.0016 0.0021 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-31 0.004 0.0157 0.0403
Loa Loa (eye worm) hypothetical protein 0.0021 0.0048 0.0124
Loa Loa (eye worm) phosphatidylinositol 3 0.0038 0.0146 0.0375
Schistosoma mansoni retinoic acid receptor RXR 0.004 0.0157 0.0157
Brugia malayi nuclear hormone receptor family member nhr-6 0.0019 0.0035 0.009
Schistosoma mansoni cellular tumor antigen P53 0.0042 0.0168 0.0168
Loa Loa (eye worm) steroid hormone receptor 0.004 0.0157 0.0403
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0028 0.0087 0.0087
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0021 0.0048 0.0048
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0025 0.0072 0.0781
Schistosoma mansoni smad 0.0013 0.0001 0.0001
Echinococcus multilocularis thyroid hormone receptor alpha 0.004 0.0157 0.0157
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.004 0.0157 0.0157
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.004 0.0157 0.0157
Entamoeba histolytica acyl-coA synthetase, putative 0.0025 0.0072 0.0517
Trypanosoma cruzi hypothetical protein, conserved 0.0058 0.0262 1
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0016 0.0021 0.0053
Brugia malayi MH2 domain containing protein 0.0013 0.0001 0.0001
Trichomonas vaginalis set domain proteins, putative 0.0219 0.1202 1
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0058 0.0262 0.2179
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0019 0.0035 0.0035
Loa Loa (eye worm) nuclear hormone receptor 0.0019 0.0035 0.009
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0025 0.0072 0.0517
Schistosoma mansoni nuclear hormone receptor 0.0019 0.0035 0.0035
Brugia malayi Nuclear hormone receptor family member nhr-41 0.004 0.0157 0.0403
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.079
Echinococcus granulosus tumor protein p63 0.0284 0.158 0.158
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.003 0.0101 0.3871
Echinococcus multilocularis sentrin specific protease 1 0.0036 0.0139 0.0139
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0021 0.079
Plasmodium vivax sentrin-specific protease 1, putative 0.0036 0.0139 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0019 0.0035 0.0221
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0087 0.0087
Echinococcus granulosus Nuclear hormone receptor HR96 0.0019 0.0035 0.0035
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0028 0.0087 0.0087
Brugia malayi ecdysone receptor 0.0019 0.0035 0.009
Trichomonas vaginalis DNA polymerase eta, putative 0.0016 0.0021 0.0172
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0069 0.0574
Entamoeba histolytica protein tyrosine phosphatase, putative 0.0187 0.1015 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0016 0.0021 0.079
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0013 0.0001 0.0001
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0025 0.0072 0.5
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0019 0.0035 0.0035
Brugia malayi nuclear receptor NHR-67 0.0019 0.0035 0.009
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0114 0.0949
Trichomonas vaginalis PIKK family atypical protein kinase 0.002 0.0045 0.0375
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0016 0.0021 0.0021
Entamoeba histolytica acyl-CoA synthetase, putative 0.0025 0.0072 0.0517
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0187 0.1015 0.8447
Loa Loa (eye worm) hypothetical protein 0.0025 0.007 0.018
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0038 0.0146 0.5583
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0187 0.1015 0.8447
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0019 0.0035 0.0035
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.004 0.0157 0.0157
Echinococcus multilocularis ecdysone induced protein 78C 0.004 0.0157 0.0157
Schistosoma mansoni nuclear receptor 0.0019 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0019 0.0035 0.009
Mycobacterium tuberculosis Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) 0.0129 0.068 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.004 0.0157 0.0157
Trypanosoma cruzi DNA polymerase kappa, putative 0.0016 0.0021 0.079
Brugia malayi MH1 domain containing protein 0.0013 0.0001 0.0001
Schistosoma mansoni smad1 5 8 and 0.0013 0.0001 0.0001
Schistosoma mansoni thyroid hormone receptor 0.004 0.0157 0.0157
Echinococcus multilocularis GPCR, family 2 0.0025 0.007 0.007
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0025 0.007 0.018
Schistosoma mansoni microtubule-associated protein tau 0.1728 1 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.004 0.0157 0.0403
Trichomonas vaginalis low molecular weight protein tyrosine phosphatase, putative 0.0058 0.0262 0.2179
Echinococcus granulosus Smad4 0.0013 0.0001 0.0001
Loa Loa (eye worm) hypothetical protein 0.004 0.0157 0.0403
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0028 0.0087 0.0087
Mycobacterium ulcerans acyl-CoA synthetase 0.0025 0.0072 0.0517
Trichomonas vaginalis Clan CE, family C48, Ulp1-like cysteine peptidase 0.0036 0.0139 0.1154
Schistosoma mansoni zinc finger protein 0.0019 0.0035 0.0035
Brugia malayi ImpB/MucB/SamB family protein 0.0016 0.0021 0.0053
Schistosoma mansoni Tr4/Tr2 (homologue) 0.004 0.0157 0.0157
Brugia malayi hypothetical protein 0.0021 0.0048 0.0124
Brugia malayi MH2 domain containing protein 0.0187 0.1017 0.2606
Schistosoma mansoni smad1 5 8 and 0.0013 0.0001 0.0001

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.