Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ATP-dependent DNA helicase Q1 | 0.0021 | 0.285 | 1 |
Loa Loa (eye worm) | ATP-dependent DNA helicase | 0.0021 | 0.285 | 0.2772 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0011 | 0.0108 | 0.0381 |
Plasmodium vivax | ADP-dependent DNA helicase RecQ, putative | 0.0011 | 0.0108 | 0.0434 |
Loa Loa (eye worm) | hypothetical protein | 0.0021 | 0.285 | 0.2772 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.2497 | 1 |
Giardia lamblia | Sgs1 DNA helicase, putative | 0.0021 | 0.285 | 1 |
Loa Loa (eye worm) | RecQ helicase | 0.0021 | 0.285 | 0.2772 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.285 | 0.047 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.002 | 0.2497 | 0.5 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.2497 | 0.2497 |
Leishmania major | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.285 | 1 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0021 | 0.285 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.2497 | 0.8762 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.2497 | 0.5 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 1 | 1 |
Echinococcus multilocularis | ATP dependent DNA helicase Q1 | 0.0021 | 0.285 | 0.047 |
Echinococcus granulosus | ATP dependent DNA helicase Q5 | 0.0021 | 0.285 | 0.047 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.285 | 1 |
Schistosoma mansoni | DNA helicase recq1 | 0.0021 | 0.285 | 0.285 |
Brugia malayi | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.285 | 0.047 |
Brugia malayi | Bloom's syndrome protein homolog | 0.0021 | 0.285 | 0.047 |
Schistosoma mansoni | blooms syndrome DNA helicase | 0.0011 | 0.0108 | 0.0108 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0.2497 | 0.8762 |
Entamoeba histolytica | recQ family DNA helicase | 0.0011 | 0.0108 | 0.0381 |
Echinococcus multilocularis | ATP dependent DNA helicase Q5 | 0.0021 | 0.285 | 0.047 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.2497 | 0.8713 |
Trichomonas vaginalis | DNA helicase recq1, putative | 0.0021 | 0.285 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.2497 | 0.2497 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.2497 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 1 | 1 |
Echinococcus granulosus | bloom syndrome protein | 0.0021 | 0.285 | 0.047 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 1 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.2497 | 1 |
Trypanosoma brucei | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.285 | 1 |
Entamoeba histolytica | recQ family helicase, putative | 0.0021 | 0.285 | 1 |
Schistosoma mansoni | DNA helicase recq5 | 0.0021 | 0.285 | 0.285 |
Echinococcus multilocularis | bloom syndrome protein | 0.0021 | 0.285 | 0.047 |
Toxoplasma gondii | ATP-dependent DNA helicase, RecQ family protein | 0.0021 | 0.285 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.2497 | 0.2415 |
Plasmodium falciparum | ADP-dependent DNA helicase RecQ | 0.0021 | 0.285 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0108 | 0.0000000023309 |
Trichomonas vaginalis | DNA helicase recq, putative | 0.0021 | 0.285 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.2497 | 0.8713 |
Trypanosoma cruzi | ATP-dependent DEAD/H DNA helicase recQ, putative | 0.0021 | 0.285 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 1 | 1 |
Echinococcus granulosus | ATP dependent DNA helicase Q1 | 0.0021 | 0.285 | 0.047 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.