Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.3397 | 0.39 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.1315 | 1 |
Plasmodium vivax | replication factor C subunit 1, putative | 0.001 | 0.0286 | 0.2682 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0023 | 0.1315 | 1 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0007 | 0.0072 | 0.0546 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0041 | 0.2691 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0286 | 0.0251 |
Loa Loa (eye worm) | abnormal chemotaxis protein 14 | 0.0041 | 0.2691 | 0.3073 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0286 | 0.0251 |
Trypanosoma cruzi | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.001 | 0.0286 | 1 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1315 | 0.1458 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1315 | 0.1458 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0798 | 0.6071 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0118 | 0.8597 | 1 |
Echinococcus multilocularis | sterol regulatory element binding protein | 0.0041 | 0.2691 | 0.2639 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1315 | 0.1458 |
Entamoeba histolytica | Activator 1 140 kDa subunit, putative | 0.001 | 0.0286 | 0.0315 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0286 | 0.0251 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0007 | 0.0072 | 0.0546 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.2956 | 0.3383 |
Echinococcus granulosus | nibrin | 0.001 | 0.0286 | 0.0216 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2956 | 0.4177 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0.0286 | 0.0817 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0007 | 0.0072 | 0.0546 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.2226 | 0.217 |
Schistosoma mansoni | smad | 0.0008 | 0.0171 | 0.0144 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.4258 | 0.491 |
Echinococcus granulosus | smad | 0.0008 | 0.0171 | 0.01 |
Plasmodium falciparum | replication factor C subunit 1, putative | 0.001 | 0.0286 | 0.2682 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0798 | 0.6071 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.4258 | 0.491 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0286 | 0.0817 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.2226 | 0.3171 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.2226 | 0.217 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2956 | 0.2905 |
Onchocerca volvulus | 0.001 | 0.0286 | 0.1722 | |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0171 | 0.0117 |
Schistosoma mansoni | DNA ligase IV | 0.001 | 0.0286 | 0.031 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0017 | 0.087 | 0.6617 |
Schistosoma mansoni | topbp1 | 0.001 | 0.0286 | 0.031 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.1315 | 0.183 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0286 | 0.0817 |
Brugia malayi | RNA binding protein | 0.0061 | 0.4258 | 0.491 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0286 | 0.0817 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0072 | 0.0546 |
Echinococcus multilocularis | replication factor c subunit 1 | 0.001 | 0.0286 | 0.0216 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2956 | 0.2905 |
Trypanosoma cruzi | FHA domain containing protein, putative | 0.001 | 0.0286 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.087 | 0.0936 |
Trichomonas vaginalis | RNA polymerase II ctd phosphatase, putative | 0.001 | 0.0286 | 0.0817 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2578 | 0.363 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.2226 | 0.3171 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0.0286 | 0.0817 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0017 | 0.087 | 1 |
Brugia malayi | hypothetical protein | 0.001 | 0.0286 | 0.0251 |
Echinococcus granulosus | sterol regulatory element binding protein | 0.0041 | 0.2691 | 0.2639 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0072 | 0.0546 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0171 | 0.0144 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0072 | 0.0546 |
Brugia malayi | hypothetical protein | 0.0035 | 0.2226 | 0.2527 |
Toxoplasma gondii | ATPase, AAA family protein | 0.001 | 0.0286 | 1 |
Entamoeba histolytica | Niemann-Pick C1 protein, putative | 0.0095 | 0.6864 | 1 |
Trichomonas vaginalis | chromosome transmission fidelity factor, putative | 0.001 | 0.0286 | 0.0817 |
Echinococcus granulosus | Smad4 | 0.0008 | 0.0171 | 0.01 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0008 | 0.0171 | 0.01 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.001 | 0.0286 | 1 |
Schistosoma mansoni | chromosome transmission fidelity factor | 0.001 | 0.0286 | 0.031 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0286 | 0.0251 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0798 | 0.6071 |
Mycobacterium ulcerans | NAD-dependent DNA ligase LigA | 0.001 | 0.0286 | 0.1722 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.087 | 0.0936 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.087 | 0.0936 |
Brugia malayi | ATP dependent DNA ligase C terminal region family protein | 0.001 | 0.0286 | 0.0251 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0007 | 0.0072 | 0.0546 |
Brugia malayi | topoisomerase | 0.001 | 0.0286 | 0.0251 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.1315 | 1 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0008 | 0.0171 | 0.0117 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.4258 | 0.4216 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0007 | 0.0072 | 0.0546 |
Mycobacterium ulcerans | hypothetical protein | 0.0023 | 0.1315 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.4258 | 0.4216 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0286 | 0.0817 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2578 | 0.363 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2956 | 0.4177 |
Schistosoma mansoni | Smad4 | 0.0008 | 0.0171 | 0.0144 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1315 | 0.1458 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.1315 | 0.1458 |
Treponema pallidum | DNA ligase (lig) | 0.001 | 0.0286 | 0.5 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0136 | 1 | 1 |
Echinococcus multilocularis | expressed conserved protein | 0.009 | 0.642 | 0.6395 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.4258 | 0.491 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.001 | 0.0286 | 1 |
Entamoeba histolytica | hypothetical protein | 0.001 | 0.0286 | 0.0315 |
Echinococcus granulosus | replication factor c subunit 1 | 0.001 | 0.0286 | 0.0216 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.1315 | 1 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0171 | 0.0144 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4258 | 0.6062 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.087 | 0.0936 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.2956 | 0.2905 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0023 | 0.1315 | 1 |
Echinococcus multilocularis | Niemann Pick C1 protein | 0.0095 | 0.6864 | 0.6841 |
Brugia malayi | MH2 domain containing protein | 0.0118 | 0.8597 | 1 |
Echinococcus multilocularis | smad | 0.0008 | 0.0171 | 0.01 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0017 | 0.087 | 0.6421 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.2956 | 0.3383 |
Trichomonas vaginalis | conserved hypothetical protein | 0.001 | 0.0286 | 0.0817 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.2226 | 0.312 |
Schistosoma mansoni | patched 1 | 0.0041 | 0.2691 | 0.3794 |
Schistosoma mansoni | niemann-pick C1 (NPC1) | 0.0097 | 0.6977 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0008 | 0.0171 | 0.0117 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.2226 | 0.312 |
Brugia malayi | CHE-14 protein | 0.0041 | 0.2691 | 0.3073 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.2226 | 0.3171 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0171 | 0.0117 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4258 | 0.6062 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.1315 | 1 |
Toxoplasma gondii | poly(ADP-ribose) polymerase catalytic domain-containing protein | 0.001 | 0.0286 | 1 |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0008 | 0.0171 | 0.01 |
Echinococcus multilocularis | protein patched | 0.0041 | 0.2691 | 0.2639 |
Echinococcus multilocularis | Smad4 | 0.0008 | 0.0171 | 0.01 |
Loa Loa (eye worm) | Smad1 | 0.0008 | 0.0171 | 0.0117 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0017 | 0.087 | 1 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0007 | 0.0072 | 0.0546 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2578 | 0.363 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.1315 | 0.1458 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.2578 | 0.363 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.087 | 0.0936 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0023 | 0.1315 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.2956 | 0.2905 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.4258 | 0.491 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.2226 | 0.3171 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0023 | 0.1315 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0286 | 0.0251 |
Echinococcus multilocularis | protein dispatched 1 | 0.0047 | 0.3135 | 0.3085 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.2691 | 0.3073 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0023 | 0.1315 | 1 |
Brugia malayi | Smad1 | 0.0008 | 0.0171 | 0.0117 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0007 | 0.0072 | 0.0546 |
Brugia malayi | MH2 domain containing protein | 0.0008 | 0.0171 | 0.0117 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.1315 | 1 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0007 | 0.0072 | 0.0546 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0017 | 0.087 | 1 |
Echinococcus granulosus | expressed conserved protein | 0.009 | 0.642 | 0.6395 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0023 | 0.1315 | 0.183 |
Schistosoma mansoni | smad1 5 8 and | 0.0008 | 0.0171 | 0.0144 |
Brugia malayi | Pax transcription activation domain interacting protein | 0.001 | 0.0286 | 0.0251 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0023 | 0.1315 | 1 |
Onchocerca volvulus | 0.0023 | 0.1315 | 1 | |
Mycobacterium leprae | PROBABLE DNA LIGASE [NAD DEPENDENT] LIGA (POLYDEOXYRIBONUCLEOTIDE SYNTHASE [NAD+]) | 0.001 | 0.0286 | 0.1722 |
Schistosoma mansoni | topbp1 | 0.001 | 0.0286 | 0.031 |
Echinococcus multilocularis | nibrin | 0.001 | 0.0286 | 0.0216 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.4258 | 0.491 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0016 | 0.0798 | 0.6071 |
Trypanosoma brucei | BRCA1 C Terminus (BRCT) domain containing protein, putative | 0.001 | 0.0286 | 1 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0023 | 0.1315 | 1 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0118 | 0.8597 | 1 |
Brugia malayi | Niemann-Pick C1 protein precursor | 0.0095 | 0.6864 | 0.7966 |
Echinococcus granulosus | Niemann Pick C1 protein | 0.0095 | 0.6864 | 0.6841 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.6864 | 0.7966 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.2956 | 0.4177 |
Brugia malayi | DKFZp564C0469 protein | 0.001 | 0.0286 | 0.0251 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4258 | 0.6062 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0008 | 0.0171 | 0.01 |
Brugia malayi | MH1 domain containing protein | 0.0008 | 0.0171 | 0.0117 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0023 | 0.1315 | 1 |
Wolbachia endosymbiont of Brugia malayi | NAD-dependent DNA ligase, Lig | 0.001 | 0.0286 | 0.5 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0008 | 0.0171 | 0.0144 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0023 | 0.1315 | 1 |
Trichomonas vaginalis | replication factor C large subunit, putative | 0.001 | 0.0286 | 0.0817 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0008 | 0.0171 | 0.01 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0023 | 0.1315 | 0.183 |
Loa Loa (eye worm) | hypothetical protein | 0.001 | 0.0286 | 0.0251 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4258 | 0.6062 |
Giardia lamblia | Replication factor C, subunit 1 | 0.001 | 0.0286 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.4258 | 0.6062 |
Echinococcus granulosus | Protein patched homolog 1 | 0.0041 | 0.2691 | 0.2639 |
Brugia malayi | hypothetical protein | 0.001 | 0.0286 | 0.0251 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.