Detailed information for compound 667370

Basic information

Technical information
  • TDR Targets ID: 667370
  • Name: 1-[2-(4-methyl-2-nitrophenoxy)ethyl]piperidin e
  • MW: 264.32 | Formula: C14H20N2O3
  • H donors: 0 H acceptors: 2 LogP: 2.97 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1ccc(c(c1)[N+](=O)[O-])OCCN1CCCCC1
  • InChi: 1S/C14H20N2O3/c1-12-5-6-14(13(11-12)16(17)18)19-10-9-15-7-3-2-4-8-15/h5-6,11H,2-4,7-10H2,1H3
  • InChiKey: OECPZHSNPGJSFA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[2-(4-methyl-2-nitro-phenoxy)ethyl]piperidine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii ABC1 family protein 0.0036 0.025 0.3728
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.3363 1
Brugia malayi nuclear receptor RXR 0.002 0.0045 0.014
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0042 0.0323 0.0791
Leishmania major hypothetical protein, conserved 0.0036 0.025 0.3728
Echinococcus granulosus nuclear receptor nhr 48 0.002 0.0045 0.0111
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0323 0.0999
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.002 0.0045 0.0045
Leishmania major GTP-binding protein, putative 0.0021 0.0066 0.0401
Echinococcus granulosus nuclear receptor 2DBD gamma 0.002 0.0045 0.0111
Loa Loa (eye worm) hypothetical protein 0.005 0.0425 0.0832
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0163 0.4746
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0138 0.1539 0.2311
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.025 0.0318
Schistosoma mansoni nuclear receptor 0.002 0.0045 0.0122
Plasmodium vivax importin-beta 2, putative 0.0029 0.0163 0.0184
Trypanosoma cruzi trypanothione reductase, putative 0.004 0.0294 1
Schistosoma mansoni lamin 0.0027 0.0141 0.0382
Loa Loa (eye worm) hypothetical protein 0.0027 0.0141 0.0277
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0088
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0269 0.0677
Schistosoma mansoni inositol monophosphatase 0.0038 0.0269 0.0725
Trichomonas vaginalis glutaminase, putative 0.0273 0.3236 0.9619
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.025 0.0619
Echinococcus multilocularis tumor protein p63 0.0341 0.4089 0.4089
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0042 0.0323 0.0633
Echinococcus multilocularis geminin 0.0172 0.1963 0.1963
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.3363 1
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0534 0.6511 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.025 0.0619
Schistosoma mansoni nuclear receptor nhr-48 0.002 0.0045 0.0122
Brugia malayi hypothetical protein 0.0022 0.0075 0.0232
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.025 0.0674
Brugia malayi hypothetical protein 0.0017 0.0011 0.0034
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0141 0.0277
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.009 0.0932 0.5402
Echinococcus multilocularis FTZ F1 alpha 0.0042 0.0323 0.0323
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0323 0.0999
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0017 0.0007 0.0018
Schistosoma mansoni hypothetical protein 0.0172 0.1963 0.5295
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0128 0.3364
Toxoplasma gondii thioredoxin reductase 0.004 0.0294 0.4538
Brugia malayi hypothetical protein 0.0026 0.0128 0.0397
Echinococcus granulosus snurportin 1 0.0311 0.3707 0.9066
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.01 0.1059 0.1569
Loa Loa (eye worm) nuclear receptor nhr-7B 0.002 0.0045 0.0088
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0042 0.0323 0.0872
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0022 0.0075 0.0147
Loa Loa (eye worm) hypothetical protein 0.0035 0.0236 0.0462
Brugia malayi Steroid receptor seven-up type 2 0.0042 0.0323 0.0999
Entamoeba histolytica fatty acid elongase, putative 0.0069 0.0669 0.1882
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.002 0.0045 0.014
Schistosoma mansoni cellular tumor antigen P53 0.005 0.0425 0.1146
Entamoeba histolytica fatty acid elongase, putative 0.0069 0.0669 0.1882
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0066 0.0883
Mycobacterium ulcerans beta-lactamase 0.0036 0.025 0.0318
Echinococcus granulosus FTZ F1 alpha 0.0042 0.0323 0.0791
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0147
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0022 0.0075 0.0075
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0044 0.0137
Schistosoma mansoni nuclear hormone receptor 0.002 0.0045 0.0122
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0066 0.013
Plasmodium vivax hypothetical protein, conserved 0.0036 0.025 0.0318
Brugia malayi MH2 domain containing protein 0.0017 0.0007 0.002
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.002 0.0045 0.0111
Trichomonas vaginalis esterase, putative 0.0036 0.025 0.0619
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0042 0.0323 0.0999
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0042 0.0323 0.0633
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0088
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0236 0.0729
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0323 0.0323
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0042 0.0323 0.0633
Mycobacterium leprae Probable lipase LipE 0.0036 0.025 0.023
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.009 0.0932 0.1373
Trichomonas vaginalis ran, putative 0.0021 0.0066 0.0067
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.025 0.0318
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0269 0.8977
Schistosoma mansoni hypothetical protein 0.0172 0.1963 0.5295
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0042 0.0323 0.0633
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0066 0.0883
Echinococcus granulosus lamin dm0 0.0027 0.0141 0.0346
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.025 0.0318
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1556 0.4197
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0042 0.0323 0.0999
Brugia malayi ecdysone receptor 0.002 0.0045 0.014
Loa Loa (eye worm) hypothetical protein 0.0042 0.0323 0.0633
Brugia malayi MH1 domain containing protein 0.0017 0.0007 0.002
Onchocerca volvulus Bile acid receptor homolog 0.0042 0.0323 0.7326
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0066 0.0162
Brugia malayi nuclear receptor NHR-88 0.002 0.0045 0.014
Schistosoma mansoni ap endonuclease 0.002 0.0044 0.0119
Mycobacterium tuberculosis Conserved protein 0.0036 0.025 0.0318
Loa Loa (eye worm) transcription factor SMAD2 0.0245 0.2876 0.5631
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0088
Loa Loa (eye worm) MH1 domain-containing protein 0.0017 0.0007 0.0013
Loa Loa (eye worm) nuclear hormone receptor 0.002 0.0045 0.0088
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.025 0.0318
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.01 0.1059 0.1569
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0534 0.6511 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0323 0.0791
Loa Loa (eye worm) beta-lactamase 0.0036 0.025 0.0489
Brugia malayi RNA, U transporter 1 0.0083 0.0838 0.259
Echinococcus multilocularis nuclear receptor nhr 48 0.002 0.0045 0.0045
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1556 0.3805
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.025 0.0772
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0042 0.0323 0.0633
Brugia malayi Inositol-1 0.0038 0.0269 0.0831
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.025 0.8214
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0045 0.0111
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.3363 1
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0066 0.0205
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0596 0.1607
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0044 0.0108
Schistosoma mansoni smad1 5 8 and 0.0017 0.0007 0.0018
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0088
Mycobacterium ulcerans hypothetical protein 0.0036 0.025 0.0318
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0045 0.0045
Loa Loa (eye worm) Smad1 0.0017 0.0007 0.0013
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0283 0.3363 1
Brugia malayi conserved hypotetical protein 0.002 0.0045 0.014
Onchocerca volvulus 0.0036 0.025 0.5388
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0323 0.0999
Echinococcus multilocularis musashi 0.0027 0.0141 0.0141
Echinococcus multilocularis lamin dm0 0.0027 0.0141 0.0141
Echinococcus granulosus TGF beta signal transducer SmadC 0.0017 0.0007 0.0016
Onchocerca volvulus 0.0036 0.025 0.5388
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0066 0.0034
Loa Loa (eye worm) hypothetical protein 0.0042 0.0323 0.0633
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0022 0.0075 0.0202
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.3363 1
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0042 0.0323 0.0872
Brugia malayi nuclear hormone receptor 0.0042 0.0323 0.0999
Loa Loa (eye worm) hypothetical protein 0.0036 0.025 0.0489
Echinococcus multilocularis snurportin 1 0.0311 0.3707 0.3707
Mycobacterium tuberculosis Possible penicillin-binding protein 0.023 0.2691 0.4093
Brugia malayi tailless protein 0.002 0.0045 0.014
Entamoeba histolytica fatty acid elongase, putative 0.0069 0.0669 0.1882
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0147
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0022 0.0075 0.0183
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0596 0.0853
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0323 0.0872
Loa Loa (eye worm) DR-78 0.002 0.0045 0.0088
Echinococcus granulosus thyroid hormone receptor alpha 0.002 0.0045 0.0111
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.1556 0.4807
Mycobacterium tuberculosis Conserved protein 0.0036 0.025 0.0318
Entamoeba histolytica fatty acid elongase, putative 0.0069 0.0669 0.1882
Brugia malayi Importin beta-1 subunit 0.0029 0.0163 0.0504
Brugia malayi Smad1 0.0017 0.0007 0.002
Onchocerca volvulus 0.0036 0.025 0.5388
Onchocerca volvulus 0.0027 0.0141 0.2536
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0128 0.013
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1556 0.3805
Loa Loa (eye worm) hypothetical protein 0.0422 0.5108 1
Schistosoma mansoni nuclear receptor 0.002 0.0045 0.0122
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0534 0.6511 0.5
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0323 0.0872
Echinococcus multilocularis Nuclear hormone receptor HR96 0.002 0.0045 0.0045
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0042 0.0323 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0042 0.0323 0.0999
Loa Loa (eye worm) hypothetical protein 0.0036 0.025 0.0489
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0066 0.0067
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0269 0.8977
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0066 0.0401
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0147
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0128 0.1527
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0269 0.0677
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0042 0.0323 0.0999
Loa Loa (eye worm) hypothetical protein 0.0042 0.0323 0.0633
Echinococcus granulosus ecdysone induced protein 78C 0.0042 0.0323 0.0791
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0088
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.025 0.0619
Loa Loa (eye worm) hypothetical protein 0.0042 0.0323 0.0633
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.025 0.025
Schistosoma mansoni RAR-like nuclear receptor 0.0042 0.0323 0.0872
Loa Loa (eye worm) nuclear receptor NHR-67 0.002 0.0045 0.0088
Brugia malayi ecdysteroid receptor 0.0042 0.0323 0.0999
Loa Loa (eye worm) hypothetical protein 0.0029 0.0163 0.0319
Loa Loa (eye worm) hypothetical protein 0.0026 0.0128 0.0251
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0088
Onchocerca volvulus 0.005 0.0425 1
Onchocerca volvulus 0.0042 0.0323 0.7326
Entamoeba histolytica hypothetical protein 0.0024 0.0094 0.0149
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0596 0.0596
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0138 0.1539 0.2311
Plasmodium vivax glutathione reductase, putative 0.004 0.0294 0.0387
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.01 0.1059 0.6362
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.3363 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0042 0.0323 0.0999
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.025 0.0674
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0017 0.0007 0.0007
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0596 0.0853
Brugia malayi beta-lactamase 0.0036 0.025 0.0772
Echinococcus multilocularis thioredoxin glutathione reductase 0.004 0.0301 0.0301
Echinococcus granulosus tumor protein p63 0.0341 0.4089 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.3363 1
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0311 0.3707 0.7256
Entamoeba histolytica Ran family GTPase 0.0021 0.0066 0.0067
Echinococcus granulosus smad 0.0017 0.0007 0.0016
Schistosoma mansoni ran 0.0021 0.0066 0.0179
Schistosoma mansoni inositol monophosphatase 0.0038 0.0269 0.0725
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0042 0.0323 0.0633
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.025 0.0619
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0596 0.0853
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0534 0.6511 1
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.025 0.0318
Loa Loa (eye worm) hypothetical protein 0.0036 0.025 0.0489
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1556 0.1556
Onchocerca volvulus Protein ultraspiracle homolog 0.0042 0.0323 0.7326
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0042 0.0323 0.0791
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0042 0.0323 0.0791
Brugia malayi nuclear hormone receptor 0.002 0.0045 0.014
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0094 0.0149
Schistosoma mansoni intermediate filament proteins 0.0027 0.0141 0.0382
Loa Loa (eye worm) glutathione reductase 0.004 0.0294 0.0576
Loa Loa (eye worm) hypothetical protein 0.0042 0.0323 0.0633
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0042 0.0323 0.7326
Brugia malayi glutaminase DH11.1 0.0273 0.3236 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0245 0.2876 0.5631
Mycobacterium ulcerans lipase LipD 0.0036 0.025 0.0318
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.025 0.0318
Schistosoma mansoni retinoic acid receptor RXR 0.0042 0.0323 0.0872
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0088
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0596 1
Brugia malayi hypothetical protein 0.002 0.0045 0.014
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0128 0.3364
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0042 0.0323 0.0323
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0128 0.3364
Loa Loa (eye worm) hypothetical protein 0.0051 0.0439 0.086
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.009 0.0932 0.1373
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0141 0.0437
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0596 0.0853
Loa Loa (eye worm) glutaminase 0.0273 0.3236 0.6335
Brugia malayi nuclear receptor RXR 0.0022 0.0075 0.0232
Brugia malayi Nuclear hormone receptor E75 0.002 0.0045 0.014
Brugia malayi photoreceptor-specific nuclear receptor 0.0042 0.0323 0.0999
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0042 0.0323 0.0323
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0269 0.0677
Plasmodium falciparum thioredoxin reductase 0.004 0.0294 0.0387
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0269 0.4074
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0094 0.0149
Loa Loa (eye worm) MH2 domain-containing protein 0.0017 0.0007 0.0013
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0269 0.0677
Schistosoma mansoni smad1 5 8 and 0.0017 0.0007 0.0018
Schistosoma mansoni coup transcription factor 0.0042 0.0323 0.0872
Trypanosoma brucei trypanothione reductase 0.004 0.0294 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0088
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0269 0.0658
Entamoeba histolytica fatty acid elongase, putative 0.0069 0.0669 0.1882
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0534 0.6511 1
Echinococcus multilocularis thyroid hormone receptor alpha 0.0042 0.0323 0.0323
Plasmodium falciparum glutathione reductase 0.004 0.0294 0.0387
Schistosoma mansoni ap endonuclease 0.002 0.0044 0.0119
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0066 0.0034
Echinococcus granulosus intermediate filament protein 0.0027 0.0141 0.0346
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.025 0.0318
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0269 0.0269
Echinococcus multilocularis lamin 0.0027 0.0141 0.0141
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0269 0.0347
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.3363 1
Brugia malayi MH2 domain containing protein 0.0017 0.0007 0.002
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0042 0.0323 0.0999
Brugia malayi Thioredoxin reductase 0.004 0.0294 0.091
Mycobacterium ulcerans glutaminase 0.0273 0.3236 0.4936
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0042 0.0323 0.0872
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0163 0.2154
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0075 0.0232
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.004 0.0294 0.0387
Echinococcus multilocularis ecdysone induced protein 78C 0.0042 0.0323 0.0323
Mycobacterium tuberculosis Probable dehydrogenase 0.009 0.0932 0.1373
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0088
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0075 0.0202
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0596 1
Echinococcus multilocularis mothers against decapentaplegic 5 0.0017 0.0007 0.0007
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0042 0.0323 0.0791
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0042 0.0323 0.0999
Schistosoma mansoni glutaminase 0.0273 0.3236 0.8732
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0042 0.0323 0.0323
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0147
Brugia malayi MH1 domain containing protein 0.0017 0.0007 0.002
Giardia lamblia Fructose-bisphosphate aldolase 0.0283 0.3363 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.025 0.0489
Loa Loa (eye worm) hypothetical protein 0.0036 0.025 0.0489
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.025 0.0611
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.002 0.0045 0.0122
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0094 0.1979
Loa Loa (eye worm) inositol-1 0.0038 0.0269 0.0526
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0066 0.0066
Schistosoma mansoni thyroid hormone receptor 0.0042 0.0323 0.0872
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0042 0.0323 0.0323
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0075 0.0232
Loa Loa (eye worm) hypothetical protein 0.0042 0.0323 0.0633
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0163 0.4746
Brugia malayi hypothetical protein 0.0022 0.0075 0.0232
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0534 0.6511 1
Echinococcus granulosus importin subunit beta 1 0.0029 0.0163 0.0399
Loa Loa (eye worm) hypothetical protein 0.0042 0.0323 0.0633
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.025 0.0619
Schistosoma mansoni hypothetical protein 0.0035 0.0236 0.0636
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0088
Echinococcus granulosus Nuclear hormone receptor HR96 0.002 0.0045 0.0111
Treponema pallidum fructose-bisphosphate aldolase 0.0283 0.3363 1
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0219 0.0271
Schistosoma mansoni ran 0.0021 0.0066 0.0179
Onchocerca volvulus 0.0027 0.0141 0.2536
Mycobacterium tuberculosis Probable oxidoreductase 0.01 0.1059 0.1569
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0534 0.6511 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.3363 1
Echinococcus multilocularis smad 0.0017 0.0007 0.0007
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.002 0.0045 0.0045
Loa Loa (eye worm) hypothetical protein 0.0036 0.025 0.0489
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0042 0.0323 0.0999
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1556 0.4197
Leishmania major importin beta-1 subunit, putative 0.0024 0.0094 0.0898
Echinococcus granulosus thioredoxin glutathione reductase 0.004 0.0301 0.0737
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0042 0.0323 0.0999
Brugia malayi nuclear receptor NHR-67 0.002 0.0045 0.014
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.025 0.8214
Brugia malayi Nuclear hormone receptor E75 0.002 0.0045 0.014
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0269 0.0347
Schistosoma mansoni hypothetical protein 0.0311 0.3707 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0042 0.0323 0.0791
Brugia malayi nuclear receptor NHR-88 0.0042 0.0323 0.0999
Loa Loa (eye worm) hypothetical protein 0.0036 0.025 0.0489
Brugia malayi glutathione reductase 0.004 0.0294 0.091
Echinococcus granulosus mothers against decapentaplegic 5 0.0017 0.0007 0.0016
Leishmania major hypothetical protein, conserved 0.0026 0.0128 0.1527
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0042 0.0323 0.0872
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.002 0.0045 0.0122
Plasmodium vivax thioredoxin reductase, putative 0.004 0.0294 0.0387
Brugia malayi orphan nuclear receptor NR2E1 0.002 0.0045 0.014
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0128 0.013
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0283 0.3363 1
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0138 0.1539 1
Mycobacterium tuberculosis Conserved protein 0.0036 0.025 0.0318
Brugia malayi nuclear hormone receptor family member odr-7 0.002 0.0045 0.014
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0323 0.0999
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.1556 0.3045
Loa Loa (eye worm) hypothetical protein 0.0027 0.0135 0.0265
Schistosoma mansoni zinc finger protein 0.002 0.0045 0.0122
Mycobacterium leprae conserved hypothetical protein 0.0036 0.025 0.023
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0439 0.1357
Plasmodium falciparum importin beta, putative 0.0029 0.0163 0.0184
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0044 0.0044
Schistosoma mansoni Smad4 0.0017 0.0007 0.0018
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0042 0.0323 0.0999
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.009 0.0932 0.1373
Echinococcus granulosus Smad4 0.0017 0.0007 0.0016
Brugia malayi beta-lactamase family protein 0.0036 0.025 0.0772
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0269 0.4074
Loa Loa (eye worm) hypothetical protein 0.0422 0.5108 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0596 0.1457
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0439 0.1357
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0141 0.0277
Brugia malayi intermediate filament protein 0.0027 0.0141 0.0437
Schistosoma mansoni steroid hormone receptor ad4bp 0.0042 0.0323 0.0872
Mycobacterium tuberculosis Probable reductase 0.009 0.0932 0.1373
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.002 0.0045 0.0045
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1556 0.4197
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0534 0.6511 1
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.025 0.8214
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0042 0.0323 0.0872
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0044 0.0087
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0066 0.0883
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.025 0.0318
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0088
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0088
Loa Loa (eye worm) glutaminase 2 0.0273 0.3236 0.6335
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0042 0.0323 0.0323
Echinococcus multilocularis Smad4 0.0017 0.0007 0.0007
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0094 0.0149
Brugia malayi nuclear hormone receptor family member nhr-6 0.002 0.0045 0.014
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1556 0.1556
Echinococcus granulosus lamin 0.0027 0.0141 0.0346
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0269 0.8977
Brugia malayi steroid hormone receptor 0.0042 0.0323 0.0999
Schistosoma mansoni smad1 5 8 and 0.0017 0.0007 0.0018
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0596 0.1607
Schistosoma mansoni smad 0.0017 0.0007 0.0018
Loa Loa (eye worm) thioredoxin reductase 0.004 0.0294 0.0576
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0128 0.013
Schistosoma mansoni lamin 0.0027 0.0141 0.0382
Mycobacterium tuberculosis Putative ferredoxin reductase 0.009 0.0932 0.1373
Schistosoma mansoni nuclear hormone receptor 0.002 0.0045 0.0122
Leishmania major trypanothione reductase 0.004 0.0294 0.4538
Echinococcus granulosus geminin 0.0172 0.1963 0.4801
Loa Loa (eye worm) hypothetical protein 0.0042 0.0323 0.0633
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0163 0.0163
Loa Loa (eye worm) hypothetical protein 0.002 0.0045 0.0088
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0042 0.0323 0.0791
Loa Loa (eye worm) hypothetical protein 0.0022 0.0075 0.0147
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.025 0.0318
Brugia malayi MH2 domain containing protein 0.0245 0.2876 0.8888
Loa Loa (eye worm) steroid hormone receptor 0.0042 0.0323 0.0633
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0439 0.086
Schistosoma mansoni nuclear hormone receptor 0.0042 0.0323 0.0872
Brugia malayi hypothetical protein 0.002 0.0045 0.014
Schistosoma mansoni importin beta-1 0.0029 0.0163 0.044
Brugia malayi beta-lactamase family protein 0.0036 0.025 0.0772

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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