Detailed information for compound 667381

Basic information

Technical information
  • TDR Targets ID: 667381
  • Name: N-(3-chlorophenyl)-2-[[4-methyl-5-(phenylmeth yl)-1,2,4-triazol-3-yl]sulfanyl]acetamide
  • MW: 372.872 | Formula: C18H17ClN4OS
  • H donors: 1 H acceptors: 3 LogP: 3.76 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1cccc(c1)Cl)CSc1nnc(n1C)Cc1ccccc1
  • InChi: 1S/C18H17ClN4OS/c1-23-16(10-13-6-3-2-4-7-13)21-22-18(23)25-12-17(24)20-15-9-5-8-14(19)11-15/h2-9,11H,10,12H2,1H3,(H,20,24)
  • InChiKey: UDNCKHZPEBDVCA-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(3-chlorophenyl)-2-[[4-methyl-5-(phenylmethyl)-1,2,4-triazol-3-yl]thio]acetamide
  • 2-[[5-(benzyl)-4-methyl-1,2,4-triazol-3-yl]thio]-N-(3-chlorophenyl)acetamide
  • N-(3-chlorophenyl)-2-[[4-methyl-5-(phenylmethyl)-1,2,4-triazol-3-yl]sulfanyl]ethanamide
  • Oprea1_172674
  • AG-690/40750345
  • ST059028
  • Oprea1_402924
  • BAS 01915948
  • ZINC00976816

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0842 0.6861
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0057 0.056 0.0573
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0078 0.0842 0.1491
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0078 0.0842 0.0861
Loa Loa (eye worm) hypothetical protein 0.0048 0.043 0.0763
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.0842 0.4334
Echinococcus multilocularis microtubule associated protein 2 0.0716 0.9556 0.9773
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3919 0.6148
Loa Loa (eye worm) camk/mapkapk/mnk protein kinase 0.0429 0.5645 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0108 0.088
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0291 0.0305
Echinococcus multilocularis L aminoadipate semialdehyde 0.0086 0.0956 0.0978
Schistosoma mansoni DNA polymerase IV / kappa 0.0024 0.0108 0.0113
Schistosoma mansoni DNA polymerase eta 0.0104 0.1203 0.1259
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0765 0.1027
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0169 0.0061
Loa Loa (eye worm) hypothetical protein 0.0104 0.1203 0.2131
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0842 0.6861
Plasmodium vivax DNA repair protein REV1, putative 0.0024 0.0108 0.1803
Brugia malayi hypothetical protein 0.002 0.0057 0.0101
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0063 0.0638 0.0653
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0373 0.0507
Loa Loa (eye worm) hypothetical protein 0.004 0.0331 0.0587
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.043 0.044
Plasmodium vivax multidomain scavenger receptor, putative 0.002 0.0057 0.0954
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3919 0.6148
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.043 0.044
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0151 0.1841 0.3261
Echinococcus granulosus RUN 0.002 0.0057 0.0058
Echinococcus multilocularis expressed protein 0.0732 0.9777 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0956 0.1693
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0842 0.6861
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.3919 1
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0302 0.0316
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0511 0.4169
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0331 0.0323
Toxoplasma gondii aldehyde dehydrogenase 0.0063 0.0638 1
Brugia malayi regulator of G-protein signaling rgs-7 0.0038 0.0291 0.0516
Echinococcus multilocularis chromobox protein 1 0.0072 0.0765 0.0782
Onchocerca volvulus Heterochromatin protein 1 homolog 0.004 0.0331 0.0439
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0842 0.6861
Leishmania major DNA polymerase eta, putative 0.0104 0.1203 0.9803
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0599 0.9382
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0611 0.064
Loa Loa (eye worm) hypothetical protein 0.0032 0.0212 0.0375
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0108 0.088
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0108 0.088
Schistosoma mansoni blooms syndrome DNA helicase 0.0038 0.0301 0.0315
Echinococcus multilocularis dna polymerase kappa 0.0078 0.0842 0.0861
Loa Loa (eye worm) hypothetical protein 0.002 0.0052 0.0091
Brugia malayi ImpB/MucB/SamB family protein 0.0078 0.0842 0.1491
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0842 0.6861
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0447 0.0511
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0842 0.6861
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0061 0.0611 0.0625
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0419 0.5501 0.9746
Wolbachia endosymbiont of Brugia malayi 4'-phosphopantetheinyl transferase 0.0024 0.0109 0.5
Echinococcus multilocularis Polycystic kidney disease protein 0.002 0.0057 0.0058
Echinococcus granulosus Regulator of G protein signaling 20 0.0038 0.0291 0.0298
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0291 0.0305
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0291 0.0258
Loa Loa (eye worm) RecQ helicase 0.0049 0.0441 0.0781
Trypanosoma brucei polo-like protein kinase 0.0098 0.1123 0.9151
Plasmodium falciparum ADP-dependent DNA helicase RecQ 0.0043 0.036 1
Loa Loa (eye worm) doublecortin family protein 0.002 0.0057 0.0101
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3919 0.6148
Echinococcus granulosus microtubule associated protein 2 0.0716 0.9556 0.9773
Trypanosoma brucei unspecified product 0.0054 0.0511 0.4169
Mycobacterium ulcerans DNA polymerase IV 0.0078 0.0842 0.4334
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0058 0.0568 0.0581
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0373 0.0391
Loa Loa (eye worm) hypothetical protein 0.0038 0.0291 0.0516
Giardia lamblia DNA damage repair protein 0.0024 0.0108 0.0146
Leishmania major phosphopantetheinyl transferase-like protein 0.0024 0.0109 0.0889
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0169 0.0158
Loa Loa (eye worm) hypothetical protein 0.0038 0.0291 0.0516
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1123 0.1608
Loa Loa (eye worm) phosphofructokinase 0.0106 0.1227 0.2173
Schistosoma mansoni z-protein (S1r protein) 0.0038 0.0291 0.0305
Brugia malayi polk-prov protein 0.0024 0.0108 0.0191
Brugia malayi jmjC domain containing protein 0.0061 0.0611 0.1083
Brugia malayi hypothetical protein 0.0038 0.0291 0.0516
Trypanosoma cruzi DNA polymerase eta, putative 0.0051 0.0469 0.3822
Loa Loa (eye worm) hypothetical protein 0.0038 0.0291 0.0516
Echinococcus granulosus Polycystic kidney disease protein 0.002 0.0057 0.0058
Schistosoma mansoni jumonji/arid domain-containing protein 0.0061 0.0611 0.064
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0148 0.1801 1
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0078 0.0842 0.1152
Echinococcus granulosus GPCR family 2 0.0048 0.043 0.044
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.017 0.0061
Echinococcus multilocularis regulator of G protein signaling 0.0038 0.0291 0.0298
Trypanosoma brucei DNA polymerase kappa, putative 0.0024 0.0108 0.088
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0302 0.0316
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0291 0.0305
Echinococcus granulosus L aminoadipate semialdehyde 0.0086 0.0956 0.0978
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0078 0.0842 0.6861
Echinococcus granulosus chromobox protein 1 0.0072 0.0765 0.0782
Trypanosoma brucei chrX additional, unordered contigs 0.0024 0.0108 0.088
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0842 0.6861
Echinococcus multilocularis bloom syndrome protein 0.0049 0.0441 0.0451
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0291 0.0298
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0599 0.0627
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.1227 0.6607
Giardia lamblia DINP protein human, muc B family 0.0078 0.0842 0.2043
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0291 0.0258
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0291 0.0258
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0842 0.6861
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0303 0.3919 1
Loa Loa (eye worm) heterochromatin protein 1 0.0072 0.0765 0.1355
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1123 0.9151
Schistosoma mansoni hypothetical protein 0.0048 0.043 0.045
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0842 0.6861
Brugia malayi Pre-SET motif family protein 0.006 0.0599 0.1061
Echinococcus granulosus beta-adrenergic receptor kinase 0.0038 0.0302 0.0309
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0638 0.3132
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0052 0.0091
Trypanosoma brucei DNA polymerase IV, putative 0.0078 0.0842 0.6861
Giardia lamblia Kinase, PLK 0.0098 0.1123 0.277
Plasmodium vivax SET domain protein, putative 0.006 0.0599 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0151 0.1841 0.3261
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.1227 0.1255
Brugia malayi Heterochromatin protein 1 0.0072 0.0765 0.1355
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1227 0.2934
Echinococcus multilocularis Regulator of G protein signaling 20 0.0038 0.0291 0.0298
Loa Loa (eye worm) hypothetical protein 0.0151 0.1841 0.3261
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0291 0.0298
Schistosoma mansoni microtubule-associated protein tau 0.0716 0.9556 1
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0098 0.1123 0.1148
Loa Loa (eye worm) jmjC domain-containing protein 0.0061 0.0611 0.1083
Schistosoma mansoni kinase 0.005 0.0465 0.0486
Loa Loa (eye worm) hypothetical protein 0.0038 0.0291 0.0516
Echinococcus granulosus bloom syndrome protein 0.0049 0.0441 0.0451
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0061 0.0611 0.0625
Leishmania major ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0132 0.1077
Brugia malayi 6-phosphofructokinase 0.0106 0.1227 0.2173
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0169 0.006
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0842 0.6861
Onchocerca volvulus 0.0072 0.076 0.1128
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.1227 0.6609
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0063 0.0638 0.5201
Brugia malayi Pre-SET motif family protein 0.0419 0.5501 0.9746
Brugia malayi Latrophilin receptor protein 2 0.0048 0.043 0.0763
Loa Loa (eye worm) hypothetical protein 0.0024 0.0108 0.0191
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0638 0.3132
Plasmodium falciparum holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0109 0.3027
Plasmodium falciparum ATP-dependent DNA helicase Q1 0.002 0.0052 0.143
Schistosoma mansoni hypothetical protein 0.0103 0.1188 0.1243
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1227 0.2173
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.043 0.044
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0098 0.1123 0.9151
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0599 0.0612
Brugia malayi A-kinase anchor protein 10, precursor 0.0038 0.0291 0.0516
Brugia malayi 6-phosphofructokinase 0.0106 0.1227 0.2173
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1227 0.1777
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1123 0.1608
Entamoeba histolytica deoxycytidyl transferase, putative 0.0078 0.0842 0.1923
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0108 0.088
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0078 0.0842 0.0881
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0842 0.6861
Loa Loa (eye worm) hypothetical protein 0.0244 0.3116 0.5521
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0109 0.0889
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.1227 1
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0169 0.006
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0291 0.0298
Echinococcus granulosus ATP dependent DNA helicase Q1 0.002 0.0052 0.0053
Echinococcus multilocularis GPCR, family 2 0.0048 0.043 0.044
Mycobacterium ulcerans aldehyde dehydrogenase 0.0063 0.0638 0.3132
Entamoeba histolytica hypothetical protein 0.0038 0.0291 0.0478
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0052 0.0808
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0291 0.0258
Entamoeba histolytica hypothetical protein 0.0038 0.0291 0.0478
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0078 0.0842 0.433
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0291 0.0305
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0169 0.2652
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0291 0.0298
Brugia malayi PXA domain containing protein 0.0038 0.0291 0.0516
Echinococcus granulosus expressed protein 0.0732 0.9777 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase superfamily protein 0.0024 0.0109 0.171
Schistosoma mansoni chromobox protein 0.0072 0.0765 0.0801
Trichomonas vaginalis conserved hypothetical protein 0.0029 0.017 0.0061
Loa Loa (eye worm) hypothetical protein 0.0038 0.0291 0.0516
Trypanosoma cruzi ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0132 0.1077
Mycobacterium ulcerans 4'-phosphopantetheinyl transferase 0.0024 0.0109 0.0007
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1227 0.1284
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.0032 0.0221 0.3462
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0169 0.4696
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1227 0.2934
Loa Loa (eye worm) hypothetical protein 0.006 0.0599 0.1061
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0086 0.0956 0.1
Schistosoma mansoni lipoxygenase 0.002 0.0057 0.006
Loa Loa (eye worm) PXA domain-containing protein 0.0038 0.0291 0.0516
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.043 0.044
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0169 0.006
Loa Loa (eye worm) hypothetical protein 0.0038 0.0291 0.0516
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0063 0.0638 0.0653
Schistosoma mansoni chromobox protein 0.0072 0.0765 0.0801
Plasmodium falciparum DNA repair protein REV1, putative 0.0024 0.0108 0.2996
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.043 0.0763
Schistosoma mansoni hypothetical protein 0.0048 0.043 0.045
Plasmodium vivax holo-[acyl-carrier-protein] synthase, putative 0.0024 0.0109 0.1822
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3919 0.6148
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0057 0.0058
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0599 0.0612
Echinococcus granulosus dna polymerase eta 0.0104 0.1203 0.123
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0291 0.0258
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0038 0.0291 0.0516
Echinococcus multilocularis ATP dependent DNA helicase Q5 0.002 0.0052 0.0053
Trypanosoma brucei hypothetical protein, conserved 0.0024 0.0108 0.088
Schistosoma mansoni hypothetical protein 0.0048 0.043 0.045
Leishmania major DNA polymerase kappa, putative 0.0078 0.0842 0.6861
Trypanosoma cruzi DNA damage repair protein, putative 0.0024 0.0108 0.088
Echinococcus multilocularis lysine specific demethylase 5A 0.0061 0.0611 0.0625
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1227 1
Trichomonas vaginalis CAMK family protein kinase 0.0049 0.0447 0.0511
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0169 0.006
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0024 0.0108 0.1692
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0148 0.1801 1
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0291 0.0305
Trypanosoma cruzi DNA polymerase eta, putative 0.0104 0.1203 0.9803
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.043 0.0763
Schistosoma mansoni serine/threonine protein kinase 0.0098 0.1123 0.1175
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0638 0.0668
Echinococcus multilocularis A kinase anchor protein 10, mitochondrial 0.0038 0.0291 0.0298
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0108 0.088
Trypanosoma cruzi DNA polymerase kappa, putative 0.0078 0.0842 0.6861
Giardia lamblia Fructose-bisphosphate aldolase 0.0303 0.3919 1
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0599 0.0612
Loa Loa (eye worm) AGC/GRK/GRK protein kinase 0.0038 0.0302 0.0535
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0511 0.4169
Trypanosoma cruzi polo-like protein kinase, putative 0.0098 0.1123 0.9151
Leishmania major DNA polymerase eta, putative 0.0051 0.0469 0.3822
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3919 0.6148
Mycobacterium ulcerans phosphopantetheinyl transferase, PptII 0.0024 0.0109 0.0007
Echinococcus multilocularis chromobox protein 1 0.0072 0.0765 0.0782
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0169 0.0304
Schistosoma mansoni hypothetical protein 0.0048 0.043 0.045
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0098 0.1123 0.1989
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0291 0.0298
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0057 0.0058
Entamoeba histolytica serine/threonine protein kinase, putative 0.0098 0.1123 0.266
Brugia malayi phosphofructokinase 0.0106 0.1227 0.2173
Schistosoma mansoni DNA helicase recq5 0.002 0.0052 0.0054
Trichomonas vaginalis DNA polymerase eta, putative 0.0078 0.0842 0.1152
Brugia malayi Doublecortin family protein 0.002 0.0057 0.0101
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1123 0.1608
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1123 0.1608
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.1227 0.2173
Trypanosoma brucei DNA damage repair protein, putative 0.0024 0.0108 0.088
Echinococcus granulosus axis inhibition protein axin 0.0038 0.0291 0.0298
Brugia malayi Probable G protein-coupled receptor kinase F19C6.1, putative 0.0038 0.0302 0.0535
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0169 0.2827
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0291 0.0516
Brugia malayi ATP-dependent DNA helicase, RecQ family protein 0.002 0.0052 0.0091
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0169 0.0158
Loa Loa (eye worm) RGS-3 protein 0.0038 0.0291 0.0516
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0101
Echinococcus granulosus regulator of G protein signaling 7 0.0038 0.0291 0.0298
Toxoplasma gondii ATP-dependent DNA helicase, RecQ family protein 0.002 0.0052 0.0808
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3919 0.6148
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.1227 0.1255
Brugia malayi PXA domain containing protein 0.0038 0.0291 0.0516
Trypanosoma brucei unspecified product 0.0078 0.0842 0.6861
Brugia malayi hypothetical protein 0.002 0.0057 0.0101
Mycobacterium tuberculosis Conserved hypothetical protein 0.0078 0.0842 0.433
Schistosoma mansoni hypothetical protein 0.002 0.0057 0.006
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0169 0.2652
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.1227 1
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0169 0.006
Trypanosoma brucei DNA polymerase eta, putative 0.0104 0.1203 0.9803
Schistosoma mansoni DNA helicase recq1 0.002 0.0052 0.0054
Trichomonas vaginalis chromobox protein, putative 0.0072 0.0765 0.1027
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1123 0.1608
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0599 0.0627
Schistosoma mansoni rab6-interacting 0.002 0.0057 0.006
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0051 0.0469 0.7348
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0169 0.006
Trypanosoma cruzi hypothetical protein, conserved 0.0024 0.0108 0.088
Brugia malayi Regulator of G protein signaling domain containing protein 0.0038 0.0291 0.0516
Onchocerca volvulus 0.0477 0.6292 1
Schistosoma mansoni aldehyde dehydrogenase 0.0063 0.0638 0.0668
Echinococcus multilocularis beta adrenergic receptor kinase 0.0038 0.0302 0.0309
Echinococcus multilocularis lipoxygenase domain containing protein 0.002 0.0057 0.0058
Brugia malayi chromobox protein homolog 3 0.004 0.0331 0.0587
Echinococcus granulosus regulator of G protein signaling 3 0.0038 0.0291 0.0298
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0291 0.0298
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0169 0.006
Schistosoma mansoni regulator of G protein signaling 17 19 20 (rgs17 19 20) 0.0038 0.0291 0.0305
Entamoeba histolytica hypothetical protein 0.0038 0.0291 0.0478
Brugia malayi jmjC domain containing protein 0.0061 0.0611 0.1083
Echinococcus granulosus ATP dependent DNA helicase Q5 0.002 0.0052 0.0053
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0072 0.076 0.0796
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0842 0.6861
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0169 0.2827
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.1227 0.2934
Trypanosoma brucei ATP-dependent DEAD/H DNA helicase recQ, putative 0.0026 0.0132 0.1077
Echinococcus granulosus dna polymerase kappa 0.0078 0.0842 0.0861
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.1227 0.2934
Trichomonas vaginalis chromobox protein, putative 0.0044 0.0373 0.0391
Brugia malayi hypothetical protein 0.0038 0.0291 0.0516
Plasmodium vivax ADP-dependent DNA helicase RecQ, putative 0.0033 0.0226 0.3779
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1123 0.1608
Leishmania major DNA damage repair protein, putative 0.0024 0.0108 0.088
Schistosoma mansoni loxhd1 0.002 0.0057 0.006
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0057 0.056 0.0573
Trypanosoma brucei DNA polymerase kappa, putative 0.0054 0.0511 0.4169
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1227 0.1777
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0291 0.0258
Echinococcus multilocularis RUN 0.002 0.0057 0.0058
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0169 0.0061
Schistosoma mansoni regulator of G protein signaling 3 rgs3 0.0038 0.0291 0.0305
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3919 0.6148
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.1227 0.6607
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0148 0.1801 1
Toxoplasma gondii 4'-phosphopantetheinyl transferase domain-containing protein 0.0024 0.0109 0.171
Trichomonas vaginalis conserved hypothetical protein 0.004 0.0331 0.0323
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0086 0.0956 0.1693
Trichomonas vaginalis set domain proteins, putative 0.0477 0.6292 1
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0291 0.0305
Brugia malayi latrophilin 2 splice variant baaae 0.0103 0.1188 0.2104
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0842 0.6861
Onchocerca volvulus Serine\/threonine kinase homolog 0.0098 0.1123 0.1709
Brugia malayi Bloom's syndrome protein homolog 0.0049 0.0441 0.0781
Brugia malayi Protein kinase domain containing protein 0.0429 0.5645 1
Loa Loa (eye worm) ATP-dependent DNA helicase 0.002 0.0052 0.0091
Leishmania major DNA polymerase kappa, putative 0.0024 0.0108 0.088
Schistosoma mansoni jumonji domain containing protein 0.0061 0.0611 0.064
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0024 0.0108 0.1692
Brugia malayi serine/threonine-protein kinase plk-2 0.0098 0.1123 0.1989
Echinococcus granulosus lipoxygenase domain containing protein 0.002 0.0057 0.0058
Trichomonas vaginalis DNA helicase recq1, putative 0.0049 0.0441 0.0501
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0098 0.1123 0.1148
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1227 0.1777
Schistosoma mansoni lipoxygenase 0.0057 0.056 0.0586
Plasmodium falciparum LCCL domain-containing protein 0.002 0.0057 0.1585
Treponema pallidum fructose-bisphosphate aldolase 0.0303 0.3919 1
Schistosoma mansoni terminal deoxycytidyl transferase 0.0078 0.0842 0.0881
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0599 0.0627
Onchocerca volvulus 0.0032 0.0212 0.0248
Brugia malayi ImpB/MucB/SamB family protein 0.0104 0.1203 0.2131
Loa Loa (eye worm) AGC/GRK/BARK protein kinase 0.0038 0.0302 0.0535
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0169 0.2652
Loa Loa (eye worm) hypothetical protein 0.002 0.0057 0.0101
Echinococcus multilocularis axis inhibition protein axin 0.0038 0.0291 0.0298
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.1227 0.1777
Brugia malayi regulator of G-protein signaling egl-10 0.0038 0.0291 0.0516
Schistosoma mansoni regulator of G protein signaling 0.0038 0.0291 0.0305
Schistosoma mansoni rab6-interacting 0.002 0.0057 0.006
Echinococcus multilocularis ATP dependent DNA helicase Q1 0.002 0.0052 0.0053
Echinococcus granulosus chromobox protein 1 0.0072 0.0765 0.0782
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0169 0.4696
Onchocerca volvulus 0.0086 0.0956 0.1441
Brugia malayi Calcitonin receptor-like protein seb-1 0.0151 0.1841 0.3261
Trichomonas vaginalis CAMK family protein kinase 0.0098 0.1123 0.1608
Echinococcus granulosus lysine specific demethylase 5A 0.0061 0.0611 0.0625
Loa Loa (eye worm) hypothetical protein 0.0103 0.1188 0.2104
Schistosoma mansoni axis inhibition protein axin 0.0038 0.0291 0.0305
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0842 0.6861
Echinococcus granulosus A kinase anchor protein 10 mitochondrial 0.0038 0.0291 0.0298
Trichomonas vaginalis DNA helicase recq, putative 0.0049 0.0441 0.0501
Echinococcus multilocularis regulator of G protein signaling 7 0.0038 0.0291 0.0298
Trypanosoma brucei unspecified product 0.0054 0.0511 0.4169
Trypanosoma brucei DNA polymerase kappa, putative 0.0078 0.0842 0.6861
Echinococcus multilocularis dna polymerase eta 0.0104 0.1203 0.123
Echinococcus multilocularis regulator of G protein signaling 3 0.0038 0.0291 0.0298
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0078 0.0842 0.0861
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.1227 0.1284
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0063 0.0638 0.3127
Entamoeba histolytica recQ family helicase, putative 0.0026 0.0132 0.006
Schistosoma mansoni serine/threonine protein kinase 0.0038 0.0302 0.0316
Trichomonas vaginalis regulator of G protein signaling 5, rgs5, putative 0.0038 0.0291 0.0258
Schistosoma mansoni polycystin 1-related 0.002 0.0057 0.006
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0303 0.3919 0.6148

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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