Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0164 | 0.5 |
Echinococcus granulosus | intermediate filament protein | 0.0031 | 0.0564 | 0.0406 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0564 | 0.0564 |
Brugia malayi | Iron-sulfur cluster assembly accessory protein | 0.0055 | 0.1522 | 0.1522 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.008 | 0.2529 | 0.2404 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.2084 | 0.2816 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0564 | 0.0564 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0164 | 0.5 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0069 | 0.2084 | 1 |
Onchocerca volvulus | 0.0055 | 0.1522 | 1 | |
Echinococcus multilocularis | lamin dm0 | 0.0031 | 0.0564 | 0.0406 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0069 | 0.2084 | 0.1952 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.2084 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0021 | 0.0164 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.2084 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0021 | 0.0164 | 0.5 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0021 | 0.0164 | 0.0164 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0069 | 0.2084 | 0.1952 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0069 | 0.2084 | 1 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.2529 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0269 | 1 | 1 |
Echinococcus granulosus | lamin | 0.0031 | 0.0564 | 0.0406 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0069 | 0.2084 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0021 | 0.0164 | 0.5 |
Echinococcus multilocularis | lamin | 0.0031 | 0.0564 | 0.0406 |
Schistosoma mansoni | intermediate filament proteins | 0.0031 | 0.0564 | 0.0586 |
Schistosoma mansoni | survival motor neuron protein | 0.0055 | 0.1522 | 0.1991 |
Echinococcus multilocularis | musashi | 0.0031 | 0.0564 | 0.0406 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.2529 | 1 |
Brugia malayi | hypothetical protein | 0.008 | 0.2529 | 0.2529 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.2529 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0069 | 0.2084 | 0.2816 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.008 | 0.2529 | 0.2404 |
Schistosoma mansoni | hypothetical protein | 0.0055 | 0.1522 | 0.1991 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0269 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0564 | 0.0564 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0021 | 0.0164 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.008 | 0.2529 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0564 | 0.0564 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0564 | 0.0564 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0164 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.6981 | 1 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0069 | 0.2084 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0021 | 0.0164 | 0.5 |
Schistosoma mansoni | lamin | 0.0031 | 0.0564 | 0.0586 |
Echinococcus granulosus | lamin dm0 | 0.0031 | 0.0564 | 0.0406 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.2529 | 0.3469 |
Echinococcus multilocularis | geminin | 0.0193 | 0.6981 | 0.6931 |
Echinococcus granulosus | geminin | 0.0193 | 0.6981 | 0.6931 |
Schistosoma mansoni | hypothetical protein | 0.0193 | 0.6981 | 1 |
Schistosoma mansoni | lamin | 0.0031 | 0.0564 | 0.0586 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0021 | 0.0164 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.008 | 0.2529 | 0.3469 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0269 | 1 | 1 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0021 | 0.0164 | 0.0164 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0021 | 0.0164 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0542 | 0.0542 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.