TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 618.728 | Formula: C35H38N8O3
H donors: 1 H acceptors: 5 LogP: 4.7 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: CCCCc1nc2ccc(cc2c(=O)n1Cc1ccc(cc1)c1ccccc1c1n[nH]nn1)[C@]1(ON2[C@@H](C1)CCC2)C(=O)N(C)C
InChi: 1S/C35H38N8O3/c1-4-5-12-31-36-30-18-17-25(35(34(45)41(2)3)21-26-9-8-19-43(26)46-35)20-29(30)33(44)42(31)22-23-13-15-24(16-14-23)27-10-6-7-11-28(27)32-37-39-40-38-32/h6-7,10-11,13-18,20,26H,4-5,8-9,12,19,21-22H2,1-3H3,(H,37,38,39,40)/t26-,35+/m1/s1
InChiKey: KXPDQRRVSQYZSI-IJAHGLKVSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Bos taurus	Angiotensin II type 1a (AT-1a) receptor	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	399 aa	25.1 %
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	381 aa	19.7 %
Loa Loa (eye worm)	neuropeptide F receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	360 aa	22.2 %
Schistosoma mansoni	peptide (allatostatin)-like receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	314 aa	26.4 %
Schistosoma japonicum	Rhodopsin, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	355 aa	23.9 %
Brugia malayi	ORL1-like opioid receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	314 aa	20.4 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II type 1a (AT-1a) receptor	359 aa	300 aa	28.0 %
Echinococcus multilocularis	neuropeptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	319 aa	24.5 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	292 aa	25.7 %
Echinococcus granulosus	allatostatin A receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	350 aa	26.6 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	349 aa	25.5 %
Brugia malayi	GnHR receptor homolog	Angiotensin II type 1a (AT-1a) receptor	359 aa	366 aa	20.8 %
Echinococcus granulosus	thyrotropin releasing hormone receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	329 aa	23.1 %
Echinococcus multilocularis	G-protein coupled receptor, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	308 aa	22.7 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	303 aa	25.4 %
Echinococcus granulosus	neuropeptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	319 aa	24.1 %
Echinococcus granulosus	tm gpcr rhodopsin	Angiotensin II type 1a (AT-1a) receptor	359 aa	315 aa	21.0 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	350 aa	23.1 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	317 aa	20.5 %
Schistosoma japonicum	ko:K04209 neuropeptide Y receptor, invertebrate, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	324 aa	24.1 %
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	362 aa	24.3 %
Schistosoma japonicum	ko:K04135 adrenergic receptor, alpha 1a, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	346 aa	24.9 %
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	Angiotensin II type 1a (AT-1a) receptor	359 aa	315 aa	21.0 %
Schistosoma mansoni	adenoreceptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	338 aa	23.4 %
Loa Loa (eye worm)	hypothetical protein	Angiotensin II type 1a (AT-1a) receptor	359 aa	329 aa	22.2 %
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	403 aa	18.9 %
Onchocerca volvulus	E3 ubiquitin-protein ligase rpm-1 homolog	Angiotensin II type 1a (AT-1a) receptor	359 aa	339 aa	21.2 %
Echinococcus multilocularis	thyrotropin releasing hormone receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	329 aa	22.8 %
Echinococcus multilocularis	allatostatin A receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	350 aa	26.6 %
Schistosoma japonicum	ko:K04134 cholinergic receptor, invertebrate, putative	Angiotensin II type 1a (AT-1a) receptor	359 aa	325 aa	21.8 %
Schistosoma mansoni	opsin-like receptor	Angiotensin II type 1a (AT-1a) receptor	359 aa	299 aa	25.8 %
Onchocerca volvulus		Angiotensin II type 1a (AT-1a) receptor	359 aa	313 aa	24.6 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0022	0.0448	0.0812
Plasmodium falciparum	glutathione reductase	0.0046	0.2305	0.4999
Brugia malayi	hypothetical protein	0.0019	0.0263	0.0571
Trypanosoma brucei	trypanothione reductase	0.0046	0.2305	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0019	0.0263	0.0571
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0263	0.0554
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0019	0.0263	0.0255
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.5427	1
Leishmania major	trypanothione reductase	0.0046	0.2305	1
Onchocerca volvulus		0.0019	0.0263	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0263	0.0554
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0087	0.5427	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0263	0.0255
Echinococcus multilocularis	dro:myosuppressin receptor	0.0019	0.0263	0.0554
Onchocerca volvulus		0.0019	0.0263	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.0263	0.0554
Onchocerca volvulus		0.0019	0.0263	0.5
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.4604	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0019	0.0263	0.0554
Schistosoma mansoni	opsin-like receptor	0.0019	0.0263	0.0255
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.0263	0.0255
Echinococcus granulosus	allatostatin A receptor	0.0019	0.0263	0.0554
Brugia malayi	GnHR receptor homolog	0.0019	0.0263	0.0571
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0263	0.0255
Echinococcus granulosus	ATP dependent Clp protease proteolytic subunit	0.0076	0.4604	1
Trypanosoma brucei	PAB1-binding protein , putative	0.0025	0.0664	0.2855
Echinococcus multilocularis	somatostatin receptor	0.0019	0.0263	0.0554
Echinococcus multilocularis	g-protein coupled receptor	0.0019	0.0263	0.0554
Echinococcus granulosus	hypothetical protein	0.0019	0.0263	0.0554
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0019	0.0263	0.0554
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0019	0.0263	0.0554
Echinococcus granulosus	orexin receptor type 2	0.0019	0.0263	0.0554
Echinococcus multilocularis	orexin receptor type 2	0.0019	0.0263	0.0554
Brugia malayi	hypothetical protein	0.0019	0.0263	0.0571
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0263	0.0255
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0263	0.0255
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Brugia malayi	larval opioid receptor	0.0019	0.0263	0.0571
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.0263	0.0554
Brugia malayi	Dopamine receptor protein 2	0.0019	0.0263	0.0571
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0019	0.0263	0.0554
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0263	0.0554
Echinococcus granulosus	neuropeptide receptor A26	0.0019	0.0263	0.0554
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0263	0.0255
Brugia malayi	hypothetical protein	0.0019	0.0263	0.0571
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2)	0.005	0.2601	0.3369
Brugia malayi	putative neuropeptide receptor NPR1	0.0019	0.0263	0.0571
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0263	0.0554
Schistosoma mansoni	growth hormone secretagogue receptor	0.0019	0.0263	0.0255
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.0263	0.0554
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Onchocerca volvulus		0.0019	0.0263	0.5
Brugia malayi	Probable ClpP-like protease	0.0076	0.4604	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0263	0.0255
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0019	0.0263	0.0571
Loa Loa (eye worm)	thioredoxin reductase	0.0046	0.2305	0.4705
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0263	0.0554
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0263	0.0554
Echinococcus granulosus	neuropeptides capa receptor	0.0019	0.0263	0.0554
Schistosoma mansoni	opsin-like receptor	0.0019	0.0263	0.0255
Echinococcus granulosus	thioredoxin glutathione reductase	0.0046	0.2305	0.4999
Echinococcus multilocularis	peptidase Clp (S14 family)	0.005	0.2601	0.5642
Brugia malayi	hypothetical protein	0.0025	0.0664	0.1443
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0076	0.4604	1
Brugia malayi	putative neuropeptide receptor	0.0019	0.0263	0.0571
Brugia malayi	hypothetical protein	0.0019	0.0263	0.0571
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.5427	1
Schistosoma mansoni	histamine h1 receptor	0.0019	0.0263	0.0255
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0019	0.0263	0.0554
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0263	0.0554
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.4604	1
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0019	0.0263	0.0255
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0019	0.0263	0.0255
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.0263	0.0554
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0019	0.0263	0.5
Echinococcus multilocularis	sex peptide receptor	0.0019	0.0263	0.0554
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Brugia malayi	hypothetical protein	0.0019	0.0263	0.0571
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0793	0.1708
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.0263	0.0554
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0263	0.0554
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.4604	1
Chlamydia trachomatis	ATP-dependent Clp protease proteolytic subunit	0.0076	0.4604	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0263	0.0255
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0019	0.0263	0.5
Echinococcus multilocularis	neuropeptide receptor A26	0.0019	0.0263	0.0554
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0263	0.0554
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.0263	0.0554
Toxoplasma gondii	hypothetical protein	0.0026	0.0793	0.1708
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.0263	0.0554
Brugia malayi	hypothetical protein	0.0019	0.0263	0.0571
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0117	0.7703	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0263	0.0554
Toxoplasma gondii	thioredoxin reductase	0.0046	0.2305	0.4999
Brugia malayi	G-protein coupled receptor	0.0019	0.0263	0.0571
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Mycobacterium tuberculosis	Probable oxidoreductase	0.0117	0.7703	1
Onchocerca volvulus		0.0019	0.0263	0.5
Onchocerca volvulus		0.0019	0.0263	0.5
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Loa Loa (eye worm)	hypothetical protein	0.0076	0.4604	1
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.0263	0.0554
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2)	0.0076	0.4604	0.5514
Echinococcus granulosus	serotonin receptor	0.0019	0.0263	0.0554
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0263	0.0554
Echinococcus granulosus	neuropeptide s receptor	0.0019	0.0263	0.0554
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0263	0.0255
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0263	0.0554
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0263	0.0554
Echinococcus multilocularis	neuropeptide Y receptor	0.0019	0.0263	0.0554
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0019	0.0263	0.0255
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0019	0.0263	0.0255
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0263	0.0255
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Mycobacterium leprae	PROBABLE NADH DEHYDROGENASE NDH	0.0105	0.6808	0.8705
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0019	0.0263	0.0554
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0263	0.0554
Onchocerca volvulus		0.0019	0.0263	0.5
Onchocerca volvulus		0.0019	0.0263	0.5
Echinococcus granulosus	sex peptide receptor	0.0019	0.0263	0.0554
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0019	0.0263	0.0554
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0263	0.0255
Echinococcus multilocularis	neuropeptide receptor	0.0019	0.0263	0.0554
Brugia malayi	RE15519p	0.0019	0.0263	0.0571
Onchocerca volvulus		0.0019	0.0263	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0263	0.0255
Brugia malayi	hypothetical protein	0.0019	0.0263	0.0571
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0019	0.0263	0.0571
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0263	0.0554
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0019	0.0263	0.0554
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0117	0.7703	1
Plasmodium vivax	ATP-dependent Clp protease proteolytic subunit, putative	0.0026	0.0793	0.1708
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0263	0.0554
Plasmodium vivax	ataxin-2 like protein, putative	0.0025	0.0664	0.1427
Schistosoma mansoni	hypothetical protein	0.0019	0.0263	0.0255
Echinococcus multilocularis	serotonin receptor	0.0019	0.0263	0.0554
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.0263	0.0554
Toxoplasma gondii	ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein	0.0076	0.4604	1
Mycobacterium tuberculosis	Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP)	0.005	0.2601	0.3369
Schistosoma mansoni	hypothetical protein	0.0019	0.0263	0.0255
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0263	0.0554
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0019	0.0263	0.0554
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Brugia malayi	neuropeptide F receptor	0.0019	0.0263	0.0571
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0664	0.1427
Echinococcus granulosus	neuropeptide receptor	0.0019	0.0263	0.0554
Echinococcus granulosus	fmrfamide receptor	0.0019	0.0263	0.0554
Brugia malayi	hypothetical protein	0.0019	0.0263	0.0571
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0019	0.0263	0.0554
Brugia malayi	ORL1-like opioid receptor	0.0019	0.0263	0.0571
Plasmodium falciparum	thioredoxin reductase	0.0046	0.2305	0.4999
Onchocerca volvulus		0.0019	0.0263	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0019	0.0263	0.0554
Echinococcus multilocularis	thioredoxin glutathione reductase	0.0046	0.2305	0.4999
Schistosoma mansoni	opsin-like receptor	0.0019	0.0263	0.0255
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0019	0.0263	0.0554
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0019	0.0263	0.0571
Echinococcus multilocularis	ATP dependent Clp protease proteolytic subunit	0.0076	0.4604	1
Brugia malayi	G-protein coupled receptor	0.0019	0.0263	0.0571
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0019	0.0263	0.0571
Brugia malayi	G protein-coupled receptor	0.0019	0.0263	0.0571
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0263	0.0255
Echinococcus granulosus	g protein coupled receptor	0.0019	0.0263	0.0554
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.5427	1
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.5427	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0019	0.0263	0.0554
Onchocerca volvulus		0.0019	0.0263	0.5
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0019	0.0263	0.0554
Wolbachia endosymbiont of Brugia malayi	ATP-dependent Clp protease proteolytic subunit	0.0076	0.4604	1
Mycobacterium tuberculosis	NADPH-dependent mycothiol reductase Mtr	0.0046	0.2305	0.2985
Onchocerca volvulus		0.0019	0.0263	0.5
Echinococcus multilocularis	allatostatin A receptor	0.0019	0.0263	0.0554
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0263	0.0554
Brugia malayi	follicle stimulating hormone receptor	0.0019	0.0263	0.0571
Mycobacterium tuberculosis	Probable dehydrogenase	0.0105	0.6808	0.8837
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.5427	1
Plasmodium vivax	glutathione reductase, putative	0.0046	0.2305	0.4999
Leishmania major	hypothetical protein, conserved	0.0025	0.0664	0.2855
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0263	0.0554
Echinococcus granulosus	neuropeptide FF receptor 2	0.0019	0.0263	0.0554
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0105	0.6808	0.8837
Brugia malayi	Dopamine receptor protein 1	0.0019	0.0263	0.0571
Entamoeba histolytica	hypothetical protein	0.0022	0.0448	0.5
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0087	0.5427	1
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0263	0.0255
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0019	0.0263	0.0554
Schistosoma mansoni	neuropeptide f receptor 76f	0.0019	0.0263	0.0255
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0263	0.0255
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0019	0.0263	0.0255
Entamoeba histolytica	iron-sulfur flavoprotein, putative	0.0022	0.0448	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0019	0.0263	0.0554
Onchocerca volvulus		0.0019	0.0263	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Brugia malayi	neuropeptide F receptor	0.0019	0.0263	0.0571
Echinococcus granulosus	g-protein coupled receptor	0.0019	0.0263	0.0554
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0019	0.0263	0.0255
Schistosoma mansoni	neuropeptide receptor	0.0019	0.0263	0.0255
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0019	0.0263	0.0255
Schistosoma mansoni	myosin xvIII	0.0019	0.0263	0.0255
Brugia malayi	Dopamine receptor	0.0019	0.0263	0.0571
Echinococcus multilocularis	serotonin receptor	0.0019	0.0263	0.0554
Echinococcus multilocularis	neuropeptide s receptor	0.0019	0.0263	0.0554
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.5427	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0263	0.0255
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0019	0.0263	0.0554
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0263	0.0255
Trypanosoma cruzi	trypanothione reductase, putative	0.0046	0.2305	1
Entamoeba histolytica	modulator of drug activity B homolog, putative	0.0022	0.0448	0.5
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.0263	0.0255
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0087	0.5427	1
Schistosoma mansoni	hypothetical protein	0.0019	0.0263	0.0255
Schistosoma mansoni	amine GPCR	0.0019	0.0263	0.0255
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0019	0.0263	0.0554
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.5427	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0019	0.0263	0.0255
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0026	0.0793	0.1708
Giardia lamblia	NADPH oxidoreductase, putative	0.0087	0.5427	1
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0117	0.7703	1
Plasmodium falciparum	ataxin-2 like protein, putative	0.0025	0.0664	0.1427
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0664	0.2855
Echinococcus granulosus	somatostatin receptor	0.0019	0.0263	0.0554
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0019	0.0263	0.0255
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0019	0.0263	0.0255
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0263	0.0554
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0263	0.0554
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.5427	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0019	0.0263	0.0554
Schistosoma mansoni	neuropeptide F-like receptor	0.0019	0.0263	0.0255
Trichomonas vaginalis	FMN-dependent NADH-azoreductase, putative	0.0022	0.0448	0.0812
Echinococcus granulosus	dro:myosuppressin receptor	0.0019	0.0263	0.0554
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Onchocerca volvulus		0.0019	0.0263	0.5
Brugia malayi	Thioredoxin reductase	0.0046	0.2305	0.5008
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.0263	0.0554
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0105	0.6808	0.8837
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0019	0.0263	0.0554
Brugia malayi	dihydrolipoyl dehydrogenase, mitochondrial precursor, putative	0.0016	0.0008	0.0018
Echinococcus granulosus	7TM GPCR rhodopsin	0.0019	0.0263	0.0554
Brugia malayi	hypothetical protein	0.0019	0.0263	0.0571
Schistosoma mansoni	amine GPCR	0.0019	0.0263	0.0255
Plasmodium falciparum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.4604	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0019	0.0263	0.0554
Brugia malayi	Melatonin receptor type 1A	0.0019	0.0263	0.0571
Echinococcus granulosus	neuropeptide receptor	0.0019	0.0263	0.0554
Schistosoma mansoni	peptidase Clp (S14 family)	0.0076	0.4604	0.4599
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0019	0.0263	0.0554
Schistosoma mansoni	biogenic amine receptor	0.0019	0.0263	0.0255
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0105	0.6808	0.8837
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812
Onchocerca volvulus		0.0019	0.0263	0.5
Plasmodium vivax	thioredoxin reductase, putative	0.0046	0.2305	0.4999
Mycobacterium ulcerans	ATP-dependent Clp protease proteolytic subunit	0.0076	0.4604	1
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.5427	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0019	0.0263	0.0255
Loa Loa (eye worm)	hypothetical protein	0.0025	0.0664	0.0924
Brugia malayi	AKH receptor	0.0019	0.0263	0.0571
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.5427	1
Echinococcus granulosus	peptidase Clp S14 family	0.005	0.2601	0.5642
Loa Loa (eye worm)	glutathione reductase	0.0046	0.2305	0.4705
Trypanosoma cruzi	PAB1-binding protein , putative	0.0025	0.0664	0.2855
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0019	0.0263	0.0571
Onchocerca volvulus		0.0019	0.0263	0.5
Schistosoma mansoni	adenoreceptor	0.0019	0.0263	0.0255
Echinococcus multilocularis	fmrfamide receptor	0.0019	0.0263	0.0554
Echinococcus granulosus	neuropeptide Y receptor	0.0019	0.0263	0.0554
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.5427	1
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0105	0.6808	0.8837
Giardia lamblia	NADPH oxidoreductase, putative	0.0087	0.5427	1
Brugia malayi	sulfakinin receptor protein	0.0019	0.0263	0.0571
Echinococcus granulosus	7tm_1 domain containing protein	0.0019	0.0263	0.0554
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.5427	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0019	0.0263	0.0554
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0019	0.0263	0.0255
Trichomonas vaginalis	NAD(P)H dehydrogenase, putative	0.0022	0.0448	0.0812
Toxoplasma gondii	LsmAD domain-containing protein	0.0025	0.0664	0.1427
Mycobacterium leprae	PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP)	0.005	0.2601	0.2616
Onchocerca volvulus		0.0019	0.0263	0.5
Brugia malayi	Serotonin receptor	0.0019	0.0263	0.0571
Brugia malayi	glutathione reductase	0.0046	0.2305	0.5008
Trichomonas vaginalis	conserved hypothetical protein	0.0065	0.3769	0.694
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0019	0.0263	0.0255
Echinococcus multilocularis	g protein coupled receptor	0.0019	0.0263	0.0554
Mycobacterium tuberculosis	Probable reductase	0.0105	0.6808	0.8837
Echinococcus multilocularis	G protein coupled receptor 139	0.0019	0.0263	0.0554
Brugia malayi	Serotonin receptor	0.0019	0.0263	0.0571
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0019	0.0263	0.0554
Brugia malayi	G protein-coupled receptor F59B2.13	0.0019	0.0263	0.0571
Schistosoma mansoni	amine GPCR	0.0019	0.0263	0.0255
Schistosoma mansoni	amine GPCR	0.0019	0.0263	0.0255
Schistosoma mansoni	amine GPCR	0.0019	0.0263	0.0255
Treponema pallidum	ATP-dependent Clp protease proteolytic subunit	0.0076	0.4604	1
Trichomonas vaginalis	conserved hypothetical protein	0.0087	0.5427	1
Brugia malayi	hypothetical protein	0.0019	0.0263	0.0571
Trichomonas vaginalis	modulator of drug activity B, putative	0.0022	0.0448	0.0812
Giardia lamblia	NADPH oxidoreductase, putative	0.0087	0.5427	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0019	0.0263	0.0554
Echinococcus granulosus	G protein coupled receptor 139	0.0019	0.0263	0.0554
Trichomonas vaginalis	conserved hypothetical protein	0.0022	0.0448	0.0812

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 57 nM	In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.	ChEMBL.	No reference
IC50 (functional)	= 57 nM	In vitro Angiotensin II receptor antagonism in bovine adrenal cortex tissue.	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

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External resources for this compound

No external resources registered for this compound

Bibliographic References

No literature references available for this target.

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Detailed information for compound 66757